CLUSTAL W(1.81) multiple sequence alignment XP_004860129.1/1-1294 ----------------------------------MESQPDLWMESNYPQASWENITLWCR ENSCPOP00000012993/1-1305 ----------------------------------MEPQPELWIESNYPQAPWENITLWCR ENSP00000359940/1-1341 MTLDRPGEGATMLKTFTVLLFCIRMSLGMTSI-VMDPQPELWIESNYPQAPWENITLWCR ENSMUSP00000033442/1-1317 ----------MMLRTFTLLLLCIWLNPGMTSL-AVESQPELWIESNYPQAPWENITLWCK ENSRNOP00000010325/1-1320 ----------MMLRTFTLLLLCIWLNRGMTSMAAVESQPELWIESNYPQAPWENITLWCK ::.**:**:*******.********: XP_004860129.1/1-1294 SPSQTSSKFLLLKDKTQISSFCPSYKTFQASFFLGVLTESNTGLYRCCYWKETGWSKPSK ENSCPOP00000012993/1-1305 SPSRISSKFLLLKDKTQMTWIRPSYKTFQASFLLGALTESNTGFYRCCYWKETGWSKPSK ENSP00000359940/1-1341 SPSRISSKFLLLKDKTQMTWIRPSHKTFQVSFLIGALTESNAGLYRCCYWKETGWSKPSK ENSMUSP00000033442/1-1317 SPSRVSSKFLLLKDNSQMTWIRPPYKTFQVSFFIGALTESNTGLYRCCYWKEKGWSKPSK ENSRNOP00000010325/1-1320 SPSRVSSKFLLLKDNTQMTWIHPPYKTFQVSFFIGALTESNTGLYRCCYWNEKGWSKPSK ***: *********::*:: : *.:****.**::*.*****:*:******:*.******* XP_004860129.1/1-1294 ILKLEEPGQRPKPIFWIQAERSPLAGCNVNALCHGWLQDLVFMLFKEGYAEPVDYQVPTG ENSCPOP00000012993/1-1305 ILELEAPGQLPKPIFWIQAETPPLLGCNVNVLCHGWLQDLVFMLFKEGYAEPVDYQVPTG ENSP00000359940/1-1341 VLELEAPGQLPKPIFWIQAETPALPGCNVNILCHGWLQDLVFMLFKEGYAEPVDYQVPTG ENSMUSP00000033442/1-1317 ILELEAPGQLPKPIFWIQAETPPLPGCNVNIFCHGWLQDLVFMLFKEGYTEPVDYQVPTG ENSRNOP00000010325/1-1320 ILELEAPGQLPKPIFWIQAETPPFPGCNVNILCHGWLQDLVFMLFKEGYTEPIDYQVPTG :*:** *** ********** ..: ***** :*****************:**:******* XP_004860129.1/1-1294 TVAIFSIDNMTPEKEGAYLCHTNIQMLPTLWSKPSNPLKLVVAGLYPKPTLTAYPGPILA ENSCPOP00000012993/1-1305 RVAIFSIDNMTPEKEGVYICRTHIQMLPTLWSEPSNPLKLVVAGLYPKPTLTAYPGPIMA ENSP00000359940/1-1341 TMAIFSIDNLTPEDEGVYICRTHIQMLPTLWSEPSNPLKLVVAGLYPKPTLTAHPGPIMA ENSMUSP00000033442/1-1317 TMAIFSIDNLAPENEGVYICRTHIQMLPTLWSEPSNPLKLVVAGLYPKPTLTAHPGPILA ENSRNOP00000010325/1-1320 TMAIFSIDNLAPENEGIYICRTHIQMLPTLWSEPSNPLKLVVAGLYPKPTLTAHPGPILA :*******::**.** *:*:*:*********:********************:****:* XP_004860129.1/1-1294 PGESLDLRCQGPIYGITFALMKLEDLDKSFYHKKPIKNEARFFFQTLTIHDSGHYLCFYY ENSCPOP00000012993/1-1305 PGESLSLRCQGPIYGMTFALMRLEDMEKSFYHKEPIKNEAYFFFPTLKIHDSGRYLCFYY ENSP00000359940/1-1341 PGESLNLRCQGPIYGMTFALMRVEDLEKSFYHKKTIKNEANFFFQSLKIQDTGHYLCFYY ENSMUSP00000033442/1-1317 PGESLSLRCQGPIYGMTFALMRLEDLKKSFYHKKPIKNEAYFYFQDLKIQDTGHYLCFYY ENSRNOP00000010325/1-1320 PGESLSLRCQGPIYGMTFALMRLEDLKKPYYYKKPIKNEAYFYFQALKTQDTGHYLCFYY *****.*********:*****::**:.*.:*:*:.***** *:* *. :*:*:****** XP_004860129.1/1-1294 DGSYRGSLFSDILKIWVTDAFPKTWVLAPPSPVVLMGQNVSLRCRGSVDGVGLALHKKGE ENSCPOP00000012993/1-1305 DGSYRGSLLSDILKIWVTDALPKTWLLARPSPVVLMGQNISLKCRGSVDGVGLALYKKGE ENSP00000359940/1-1341 DASYRGSLLSDVLKIWVTDTFPKTWLLARPSAVVQMGQNVSLRCRGPVDGVGLALYKKGE ENSMUSP00000033442/1-1317 DGSYRGSLLSDILKIWVTDTFPKTWLLVQPSPVIQMGQNVSLRCGGLMDGVGLALYKKGE ENSRNOP00000010325/1-1320 DGSYRGSLLSDILKIWVTDTFPKTWLLVQPSPVIQMGQNVSLRCGGLMDGVGLALHKKGE *.******:**:*******::****:*. **.*: ****:**:* * :*******:**** XP_004860129.1/1-1294 ETPLQFLGATSINDNKPFFLHNVTHHDACIYSYHYCLTWKTSIRMGTHNTVELVVV---- ENSCPOP00000012993/1-1305 DKPVQFLDATSVIDNKPFLLHGVTHHDAGIYSCNYHLTWKTSIRMVTHNTVELLVVGKYK ENSP00000359940/1-1341 DKPLQFLDATSIDDNTSFFLNNVTYSDTGIYSCHYLLTWKTSIRMPSHNTVELMVVD--K ENSMUSP00000033442/1-1317 EKPLQFLDASSNTGNNSFFLKNVTYRDAGIYSCHYYLTWKTSIKMATYNTVELMVV---- ENSRNOP00000010325/1-1320 EKPLQFLDATSNTGNNSFFLKNVTYRDAGIYSCHYYLTWKTSIKMATYNTVELIVV---- :.*:***.*:* .*..*:*:.**: *: *** :* *******:* ::*****:** XP_004860129.1/1-1294 -------AWPSTAFKRGKVITLQCRVSHPVLEFSLEWEERATFHKFSVDGDFIITNVEGK ENSCPOP00000012993/1-1305 PPKHCLSAWPSTVFKQAKAITLQCPVSHPVLEFFLEWEERATFHKFLEDGDFIITNIEGK ENSP00000359940/1-1341 PPKPSLSAWPSTVFKLGKAITLQCRVSHPVLEFSLEWEERETFQKFSVNGDFIISNVDGK ENSMUSP00000033442/1-1317 -------AWPSSVFKVGKTITLQCRVSHPVLEFSLEWEERTTFQKFSVDGDFLITDIEGQ ENSRNOP00000010325/1-1320 -------AWPSSVFKVGKTITLQCRVSHPVLEFSLEWEETTTFQKFSVDGDFIITNIEGQ ****:.** .*.***** ******** ***** **:** :***:*::::*: XP_004860129.1/1-1294 STGTYSCSYRTEALPNIWSHHSEPLKLMGPA--GVLTWNYVLNEAFRLSLIIQLVALLLV ENSCPOP00000012993/1-1305 RTGTYSCSYHVEVHPNVWSHCSEPLKLIGPA--GFLTWNSILDEAIRLSLMTELAALLLV ENSP00000359940/1-1341 GTGTYSCSYRVETHPNIWSHRSEPLKLMGPA--GYLTWNYVLNEAIRLSLIMQLVALLLV ENSMUSP00000033442/1-1317 GTGTYSCSYRIEAHPNTWSHRSKPLKLVGPA--GFLTWNSILNEAVRVSLTMQLASLLLL ENSRNOP00000010325/1-1320 GTGTYSCSYRIESHANIWSHRSEPLKLVGPAVTGFLPWNSILNEAIRVSLTVQFLSLLLL ********: * .* *** *:****:*** * *.** :*:**.*:** :: :***: XP_004860129.1/1-1294 LLWIRYKCWRLRIREAWLLGIAQRVTMLFIVTALLCC-----GLCNGVLTEETEIIMPTP ENSCPOP00000012993/1-1305 LLWIRWKCRRLRIREAWLLETAQGVTMLFIVAALLCC-----GLCNGVLTEETEIIMPTP ENSP00000359940/1-1341 VLWIRWKCRRLRIREAWLLGTAQGVTMLFIVTALLCCAISFAGLCNGVLIEETEIVMPTP ENSMUSP00000033442/1-1317 VVWIRWKCRRLRLREAWLLGTAQGVAMLFILMALLCC-----GLCNGALTEEIEIVMPTP ENSRNOP00000010325/1-1320 VLWLQWKCRRLRLREAWLLGTAQGVAMLVILIALLCC-----GLCNGALTEEIEIIMPTP ::*:::** ***:****** ** *:**.*: ***** *****.* ** **:**** XP_004860129.1/1-1294 KPELWAETNFPLAPWKNLTLWCRSPSGSTKEFVLLKDGTGWIATRPASEQVRAAFPLGAL ENSCPOP00000012993/1-1305 KPELWAETNFPLAPWENLTLWCRSPSGSTKEFVLLKDGTGWIATRRASEQVRAAFPLGEL ENSP00000359940/1-1341 KPELWAETNFPLAPWKNLTLWCRSPSGSTKEFVLLKDGTGWIATRPASEQVRAAFPLGAL ENSMUSP00000033442/1-1317 KPELWAETNFPLAPWKNLTLWCRSPSGSTKEFVLLKDGTGWIATRPASEQVRAAFPLGAL ENSRNOP00000010325/1-1320 KPELWAETNFPQAPWKNVTLWCRSPSGSTKEFVLLKDGTGWIATRPASEQVRAAFPLGAL *********** ***:*:*************************** ************ * XP_004860129.1/1-1294 SQSHTGSYHCHSWEEMAVSEPSEALELVGTDILPKPVISASPPVWGQELQIRCKGWLAGM ENSCPOP00000012993/1-1305 TQSHRGSYHCHSWEEMAVSEPSEALELVGTDILPKPVISASPPIRGQELQIRCKGWLAGM ENSP00000359940/1-1341 TQSHTGSYHCHSWEEMAVSEPSEALELVGTDILPKPVISASPTIRGQELQLRCKGWLAGM ENSMUSP00000033442/1-1317 THSHTGSYHCHSWEEMAVSEPSEALELVGTDILPKPVISASLPIRGQELQIRCKGWLEGL ENSRNOP00000010325/1-1320 TQSHTGSYHCHSWEEMAVSEPSEALELVGTDILPKPVISASLPIRGQELQIRCKGWLEGL ::** ************************************ .: *****:****** *: XP_004860129.1/1-1294 EFALYKEGEQEPVQQLGAVGREAFFTIRRMEDKDEGNYSCRTHTATLPFKWSEPSEPLEL ENSCPOP00000012993/1-1305 EFALYRDGEQEPVQQLGAVGREAFFIIRRMEDKDEGNYSCRTHTATLPFKWSEPSEPLEL ENSP00000359940/1-1341 GFALYKEGEQEPVQQLGAVGREAFFTIQRMEDKDEGNYSCRTHTEKRPFKWSEPSEPLEL ENSMUSP00000033442/1-1317 GFALYKKGEQEPVQQLGAVGREAFFTIQRMEDKDEGNYSCRTHTEMQPFKWSEPSEPLEL ENSRNOP00000010325/1-1320 GFALYKMGEQEPVQQLGAVGREAFFTIQRMEDKEEGNYSCRTHTEKQPFKWSEPSAPLEL ****: ****************** *:*****:********** ******** **** XP_004860129.1/1-1294 VIKEMYPKPFFKTWASPVVPLGGRVTFNCSTPHQHMSFILYKDGNEIASSDRSWENPGAN ENSCPOP00000012993/1-1305 VIKEMYPKPFFKTLGSPQVTLGARVTFNCSTPHQHMSFILYKDDNEIASSDRSWANPGPS ENSP00000359940/1-1341 VIKEMYPKPFFKTWASPVVTPGARVTFNCSTPHQHMSFILYKDGSEIASSDRSWASPGAS ENSMUSP00000033442/1-1317 VIKEMYPKPFFKTWASPVVTPGSRVTFNCSTSHEHMSFILYKDGNEIASSDLAWGNPGGS ENSRNOP00000010325/1-1320 VIKELYPKPFFKTWASPVVTPGSRVTFNCSTSREHMSFILYKDGNEIASSDPVWGNPGTS ****:******** .** *. *.********.::*********..****** * .** . XP_004860129.1/1-1294 AAYFLIISVGIGDGGNYSCRYYDFDIWSEPSNTVELVVTEFFPKPTLLAQPGPVVLPGEN ENSCPOP00000012993/1-1305 SAHFLIVSVGIGDGGNYSCRYYDFDTWSEPSDPVELVVTEFYPKPILLAQPGPVVFPGKD ENSP00000359940/1-1341 AAHFLIISVGIGDGGNYSCRYYDFSIWSEPSDPVELVVTEFYPKPTLLAQPGPVVFPGKS ENSMUSP00000033442/1-1317 TAHFLIISVGIGDGGNYSCRYYDFSIWSEPSNPVELVVTEFYPKPTLLAQPGPVVLPGKN ENSRNOP00000010325/1-1320 TAHFLIISVGIGDGGNYSCRYYDFSIWSEPSDPVELIVTEFYPKPTLLAQPGPVVLPGKN :*:***:*****************. *****:.***:****:*** *********:**:. XP_004860129.1/1-1294 VTLRCQGTLKDMRFALFQEGTQVPLQFQSASGNSADFLLHTVREKDSGNYSCIYYETTMS ENSCPOP00000012993/1-1305 VTLHCQGNLKGMRFALLREGTKAPLQFQSAAGSSADFLLHTVGAEDSGNYSCIYYETTMS ENSP00000359940/1-1341 VILRCQGTFQGMRFALLQEGAHVPLQFRSVSGNSADFLLHTVGAEDSGNYSCIYYETTMS ENSMUSP00000033442/1-1317 VTLRCQGIFQGMRFALLQEGTHTPLQFQSTSGTSADFLLHTVGAQDFGNYSCVYYETTMS ENSRNOP00000010325/1-1320 VTLRCQGIFQGMRFALLQEGAHAPLQFQSASGTSVDFLLHTVGAEDFGNYSCVYYETTMS * *:*** ::.*****::**::.****:*.:*.*.******* :* *****:******* XP_004860129.1/1-1294 NRGSYFSMPLMIWVTDTFPKPWLFAEPSSVVPMGQNVTLWCQGPVHGVGYILHKEGEAIS ENSCPOP00000012993/1-1305 NRGSYLSTPLMIWVTDTFPKPWLFAEPSSVVSMGQNVTLWCQGPFHGVGYILHKEGEATS ENSP00000359940/1-1341 NRGSYLSMPLMIWVTDTFPKPWLFAEPSSVVPMGQNVTLWCRGPVHGVGYILHKEGEATS ENSMUSP00000033442/1-1317 NRGSSLSTPLMIWVTDTFPRPWLSAEPSSVVTMGQNVTLWCQGPVRGVGYILHKEGEATS ENSRNOP00000010325/1-1320 NRGSYLSTPLMIWVTDTFPRPWLSAEPSSVVTMGQNVTLWCQGPVHGVGYILHKEGEATS **** :* ***********:*** *******.*********:**.:************ * XP_004860129.1/1-1294 KQLWGSASNDGAFPITSITGASTGHYSCCYHPDWTSPVKIQPSNTLELIVTGLLPKPSLL ENSCPOP00000012993/1-1305 RQLWGSTSNDGAFPITSVSDANIGRYSCCYHPDWTSSIRIQPSNTLELMVTGLLPKPILL ENSP00000359940/1-1341 MQLWGSTSNDGAFPITNISGTSMGRYSCCYHPDWTSSIKIQPSNTLELLVTGLLPKPSLL ENSMUSP00000033442/1-1317 MQLWGSTSNEGAFPIINISGASIGRYSCCYHPDWMSPIKIQPSNTLELIVTGLLPKPSLL ENSRNOP00000010325/1-1320 MQLWDSTSNEGAFPIINISGASIGRYSCCYHPDWMSPIKIQPSNTLELIVTGLLPKPSLL ***.*:**:***** .::.:. *:********* *.::*********:******** ** XP_004860129.1/1-1294 AQPGPMVAPGENMTLQCQGELPDSTYVLLKEGTRAPLEHQRPSGYRADFWMPVVRGEDSG ENSCPOP00000012993/1-1305 AHPGPMVVPGENMTLQCQGELPDSTFFLLKEGIQAPLEHQRPIGYRADFWMPVVRSEDSG ENSP00000359940/1-1341 AQPGPMVAPGENMTLQCQGELPDSTFVLLKEGAQEPLEQQRPSGYRADFWMPAVRGEDSG ENSMUSP00000033442/1-1317 VQPGPMVAPGENVTLQCQGELPDSTFVLLKEGTRQPLEQQRPSGYRADFWMPVVRDQDSG ENSRNOP00000010325/1-1320 VQPGPMVVPGENMTFQCQGELPDSTFVLLKEGTQQPIEQQRPSGYRADFWMPVVRDQDSG .:*****.****:*:**********:.***** : *:*:*** *********.**.:*** XP_004860129.1/1-1294 IYSCVYYLDSAPFSASNHSDSLEIWVTDKPPKPSLSAWPNTVFKLGKDITLQCRGPLPGV ENSCPOP00000012993/1-1305 IYSCVYYLDSAPLAASYPSTSLEIWVTDKPPKPSLSAWPNTVFKLGKDITLQCRGPLPGV ENSP00000359940/1-1341 IYSCVYYLDSTPFAASNHSDSLEIWVTDKPPKPSLSAWPSTMFKLGKDITLQCRGPLPGV ENSMUSP00000033442/1-1317 VYSCVYYLDSAPLVASNHSNSLEIWVTDKPPKPSLSAWPSTIFKLGKDITLQCRGPLPGV ENSRNOP00000010325/1-1320 VYSCVYYLDSAPLVASNHSNSLEIWVTDKPPKPSLSAWPSTVFKLGKDITLQCRGPLPGV :*********:*: ** * *******************.*:****************** XP_004860129.1/1-1294 EFVLEHDGEEAPQLFSEDGDFVINNVEGKGIGNYSCSYRLQASPDIWSEPSDPLELVGAA ENSCPOP00000012993/1-1305 EFVLEHDGEEAPQQFSENGDFVINNVEGKGIGNYSCSYRLQASPDIWSEPSDSLELVGAA ENSP00000359940/1-1341 EFVLEHDGEEAPQQFSEDGDFVINNVEGKGIGNYSCSYRLQAYPDIWSEPSDPLELVGAA ENSMUSP00000033442/1-1317 EFVLEHDGEEAPQQFSEDGDFVIDNLEGKGIGNYSCSYRLQAYPDIWSEPSDTLELVGAA ENSRNOP00000010325/1-1320 EFVLEHDGEEAPQQFSEDGDFVIGNMEGKGIGNYSCSYRLQAYPDIWSEPSDSLELVGAA ************* ***:*****.*:**************** *********.******* XP_004860129.1/1-1294 GPAAQECTVGNIVRSTLIVVVVVALGVVLAIEWKKWPRLRTRGSDTDGRDQTIVLEECNQ ENSCPOP00000012993/1-1305 GPAAQECTVGNIVRSSLIVVVVVALGVVLAIEWKKWPRLRTRGSETDGRDQTIVLEECNQ ENSP00000359940/1-1341 GPVAQECTVGNIVRSSLIVVVVVALGVVLAIEWKKWPRLRTRGSETDGRDQTIALEECNQ ENSMUSP00000033442/1-1317 GPVAQECTVGNIVRSTLIVVVVVALGIVLAVEWKKWPRLRTRGSETDGRDQTVVLEECNQ ENSRNOP00000010325/1-1320 GPVAQECTVGNIVRSTLIVVVVVALGIVLAIEWKKWPRLRTRGSETDGRDQTIVLEECNQ **.************:**********:***:*************:*******:.****** XP_004860129.1/1-1294 EGEPGTTTNSPSSTSQGISMEITVPV ENSCPOP00000012993/1-1305 EGEPGTTTNSPSSTSQGISVELPVPI ENSP00000359940/1-1341 EGEPGTPANSPSSTSQRISVELPVPI ENSMUSP00000033442/1-1317 EGEPGTTTNSPSSASQEVSVELTVPI ENSRNOP00000010325/1-1320 DGEPGTATNSPSSALQGVSVEQTVPI :*****.:*****: * :*:* .**: