CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000023068/1-1248 MGHLELLLVENFKSWRGRQVIGPFKRFTCIIGPNGSGKSNVMDALSFVMGEKTTNLRVKN ENSRNOP00000043834/1-1247 MGHLELLLVENFKSWRGRQVIGPFKRFTCIIGPNGSGKSNVMDALSFVMGEKTTNLRVKN ENSP00000350036/1-1235 MAHLELLLVENFKSWRGRQVIGPFRRFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKN ENSCPOP00000012928/1-1231 MGYLDLLLVENFKSWRGRQVIGPFKRFTCIIGPNGSGKSNVMDALSFVMGEKITNLRVKS XP_004845462.1/1-1237 MGYLKVLLVENFKSWRGRQVIGPFERFTCIIGPNGSGKSNIMDALSFVMGEKITNLRVKS *.:*.:******************.***************:*********** :*****. ENSMUSP00000023068/1-1248 IQELIHGAHTGKPVSSSASVTIIYIEDSGEEKTFTRIIRGGCSEYHFGDKPVSRSVYVAQ ENSRNOP00000043834/1-1247 IQELIHGAHIGKPVSSSASVTIIYVEDSGEEKTFTRIIRGGCSEFHFGDKPVSRSVYVAQ ENSP00000350036/1-1235 IQELIHGAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAE ENSCPOP00000012928/1-1231 IQELIHGAHVGKPVSSSASVKIVYVEESGEEKTFARIIRGGCSEFRFGDNLVTRSAYVAE XP_004845462.1/1-1237 IQELIHGAHVGKPVSSSASVRIVYVEESGEEKTFARIIRGGCSEFYFGDNPVTRSAYIAE ********* ***:****** *:*:*:*******:*********: *.*: *:**.*:*: ENSMUSP00000023068/1-1248 LENIGIIVKAQNCLVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEE ENSRNOP00000043834/1-1247 LENIGIIVKAQNCLVFQGTVESISMKKPKERTQFFEEISTSGEFIGEYEAKKKKLQKAEE ENSP00000350036/1-1235 LEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEE ENSCPOP00000012928/1-1231 LEKIGIIGRARNCLVFQGAVESISMKKPKERTQFFEAISTSGELVGEYEEKKRKLQKAEE XP_004845462.1/1-1237 LEKIGIIGKARNCLVFQGTVELISMKKPKERTRFFEEISTSGELMEEYEEKKRKLQKAEE **:**** :*:*******:** **:*******:*** ******:: *** **:******* ENSMUSP00000023068/1-1248 DAQFHFNVKKNVAAERKHAKIEKEEAEHYQNLLEELKINKIQLMLFQLYYNEEKINVLNT ENSRNOP00000043834/1-1247 DAQFHFNRKKNVAAERKHAKIEKEEAEHYQSLLEELKTNKIQLMLFQLYYNEEKINVLNT ENSP00000350036/1-1235 DAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNT ENSCPOP00000012928/1-1231 DAQFNFNKKKNAAAERKHAKLEKEEAERYQSLLEELKLNKIQLQLFQLYHNEKTIHSLIV XP_004845462.1/1-1237 NAQFNFNKKKNAAAERKHAKLEKEEADRYQSLLEELKTNKIQLQLFQLYHNEKKIHFLNV :***:** *** ****::**:*****::**.****** ***** *****:**:.*: * . ENSMUSP00000023068/1-1248 ELEQMDGNLSVVKDTLSHHENIFKAKKKDYGMLTRQLQQTAKELKSVEAILNQKRPQYIK ENSRNOP00000043834/1-1247 ELEHMDRNLSVVKDTLSHHENIIKAKKKDYGMLTRQLQQTAKELKSVEAVLNQKRPQYIK ENSP00000350036/1-1235 KLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIK ENSCPOP00000012928/1-1231 ELEHVNRDLSATEESRAHHEDIVKAKKKEHGVLTRQLQHTEKELKSLETLLNQKRPQYIK XP_004845462.1/1-1237 ELEHVNRDLSVMKESHFHHENIVKAKKKEHGMLTRQLQQTEKELKSLEALLNQKRPQYIK :**::: :**. .:: ***:*.**:**::*:******:* *****:*::********** ENSMUSP00000023068/1-1248 AKENTSHHLKKLDLSKKLITDNEKQCSKQEDGIRALVAELADLDRAWKSFEKQMEEKILQ ENSRNOP00000043834/1-1247 AKENTSHHLKKLDLSKKLITDNEKQCAKQEDGIRALVAELVDLDRAWRSFEKQMEEKILH ENSP00000350036/1-1235 AKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILH ENSCPOP00000012928/1-1231 AKENTSHHLRKLELSKKSIKDCEEQCSKQEGDIRALQTEAADLDSAWKSFEEQTKE-FLH XP_004845462.1/1-1237 AKENTSHHLKKLDISKKSIKDCEKQCSKQEDDIRALQAELVDLDSAWKSFEKQIEEEILH *********:**:::** *.* *:**:***..*:** :* .*** **:***:* :* :*: ENSMUSP00000023068/1-1248 KGRDIELENSQLDRYKLLKEQVRRKVGIMTQQLEKLQWEQKAEKERLAFEKRRHGDTQGN ENSRNOP00000043834/1-1247 KGRDIELENSQLDRYKELKEQVRRRVGIMTQQLEKLQWEQKAEKERLAFERRRHGDTQGN ENSP00000350036/1-1235 KKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGN ENSCPOP00000012928/1-1231 KERGAELEASQLDRYKELKEQVRKKVAIMTQQLEKLQWQQKAEKERLALEKRRHGEVQGN XP_004845462.1/1-1237 KERGIELEPSQLDHYKELKEQVRKKVAIMTQQLKKLQWEQKAEKERLALEKRRHGEVQGN * *. *** ****:** ******::*. *****:****:**:::****:*:****:.*** ENSMUSP00000023068/1-1248 LKQIKEQIEEHKKRIEKLEEYTKTCMDCLEDKKQQEEALKKEIENTKSRMSEVNEELSLI ENSRNOP00000043834/1-1247 LKQIKEQIEEHKKRIEKLEEYTKTCMDCLEDKKQQEEALIKEIDNTKSRMSEVNEELSLI ENSP00000350036/1-1235 LKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLI ENSCPOP00000012928/1-1231 LKQIKEQIEDHKKRIDKLEEYTKTCMEFLEEKRQQEETLLDEIGKAKSRMSEVNEELNRI XP_004845462.1/1-1237 LKQIKEQIEDHKKRIEKLEEYIKTCMDFLNEKRQHEETLVDEIGKAKSRMSDVNEELNRI *********:*****:***** ****: *::*:*:**:* .** ::*****:.****. * ENSMUSP00000023068/1-1248 RNELQNAGIDNHEGKRQQKRAEVLEHLKRLYPDSVFGRLLDLCHPIHKKYQLAVTKLFGR ENSRNOP00000043834/1-1247 RNELQNAGIDNHEGKRQRKRAEVLEHLKRLYPDSVFGRLLDLCHPIHKKYQLAVTKLFGR ENSP00000350036/1-1235 RSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGR ENSCPOP00000012928/1-1231 MSDLQNAGIDNHEGKRELKRAEVLEHLKRLYPDSVFGRLLDLCHPIHKKYQLAVTKIFGR XP_004845462.1/1-1237 MSDLQNAGIDKHEGKREQKRAEVLEHLKRLYPDSVFGRLLDLCHPIHKKYQLAVTKLFGR .:*******.*****: *********************:****************:*** ENSMUSP00000023068/1-1248 YMVAIVVASEKIAKDCIRFLKAERAEPETFLALDYLDIKPINERLREIKGCKMMIDVIKT ENSRNOP00000043834/1-1247 YMVAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLREIKGCKMMIDVIKT ENSP00000350036/1-1235 FITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKT ENSCPOP00000012928/1-1231 YMVAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMMVDVIKT XP_004845462.1/1-1237 YMVAIVVTSEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLREIKGCKMMIDVIKT ::.****:***:********* *************************:*****::***** ENSMUSP00000023068/1-1248 QFPQLKKVIQFVCGNGLVCETVEEARHIAFGGPERRKAVALDGTLFLKSGVISGGSSDLK ENSRNOP00000043834/1-1247 QFPQLKKVIQFVCGNGLVCETVEEARHIAFGGPERRKAVALDGTLFLKSGVISGGSSDLK ENSP00000350036/1-1235 QFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLK ENSCPOP00000012928/1-1231 QFPPLKRVIQFVCGNGLVCETVEEARHTAFGGPERRKTVALDGTLFLKSGVVSGGSSDLK XP_004845462.1/1-1237 QFPQLKKVIQFVCGNGLVCETVEEARHIAFGGPERRKTVALDGTLFLKSGVISGGSSDLK *** **:**************:***** *:.****:*:*************:******** ENSMUSP00000023068/1-1248 HKALCWDEKELHNLRDKRSQLVQELKELMKTLRKETDLKQIQTLVQGTNTRLKYSQNELE ENSRNOP00000043834/1-1247 HKALCWDEKELHSLRDKRNQLVQELKELMKTLRKETDLKQIQALVQGTNTRLKYSQNELE ENSP00000350036/1-1235 YKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELE ENSCPOP00000012928/1-1231 HKARCWDEKELKNLRDQRSKLAQELKDLMKTLRKEIDLKQIQTLAQGTHTRLRYSQSELD XP_004845462.1/1-1237 HKARCWDEKELKNLRDRRNQLVQELKDLMKILRKETDLKQIQTLAQGTHTRLRYSQSEVE :** *******:.***:*.: **** *** **** ******:* ***:***:***.*:: ENSMUSP00000023068/1-1248 MIKKKHLATFYREQSQLQSELLNIDSQCTMLSEGINKQQQKIEEFQDKIDEVEDDIFQDF ENSRNOP00000043834/1-1247 MIKKKHLATFYREQSQLQSELLNIDSQCTMLSEGINKQQQKIEEFQDKIDKVEDDIFQDF ENSP00000350036/1-1235 MIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHF ENSCPOP00000012928/1-1231 ILKKKHLAAAYREQSQLQSELLNTESQCAMLSEGIQEQQQRIEEFQEKIDKIEDEIFHDF XP_004845462.1/1-1237 IIKKKHLVAAHREQSQLQSELLNIESQCAMLSEGIKEQQQRIEGFQEKINKVEDEIFHDF ::*****.: ::*********** :*** ******:::*::*: **:**:::**:**:.* ENSMUSP00000023068/1-1248 CEEIGVENIREFENKHVKQQQENDQKRLEFEKQKTRLNIQLEYSRNQLKKKLNNIDTLKT ENSRNOP00000043834/1-1247 CEEIGVENIREFENKHVKQQQENDQKRLEFEKQKTRLNIQLEYSRNQLKKKLNKIDTLKT ENSP00000350036/1-1235 CEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKE ENSCPOP00000012928/1-1231 CEEIGLENIREFENKHVKQQQEIDQKRLEFEKQKTRLNIQLEYSRNLLKKRLSKISALKE XP_004845462.1/1-1237 CEEIGLENIREFENKHVKQQQEIDQKRLEFEKQKTRLNIQLEYSRSLLKKKLSKINTLKE *****:************:*** ***************:******. ***:*.:*.:** ENSMUSP00000023068/1-1248 TIQKGKEDIDNLKKTEEECLKIVEELMVKQEQIKEVLATQSSNIEKIHIQIEEERKKVLA ENSRNOP00000043834/1-1247 TIQKGREDIDNLKKTEEECLKIVEELMVKQEQVKEVLATQSSNIEKIHIQIEEERKKFLA ENSP00000350036/1-1235 TIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLA ENSCPOP00000012928/1-1231 SVQKGREDTDRLKKVEDDCLRVVDELMAKQKQLKDVLVTQNSSAEKVQTQIEEERKKFLA XP_004845462.1/1-1237 TIQKSGEDIDSLKKIEDNCLQVVDELMAKQKQLKDIFVTQNSSAQKVQSQLEEERKKFLA ::**. ** * *** *::**: *:***.**:*:*:: .**.*. :*:: *:******.** ENSMUSP00000023068/1-1248 VDREVGKLQKEVVIIQGSLEQKLLEKHNLLLDCKVQDIDISLVLGSLEDIIEMEL-TETE ENSRNOP00000043834/1-1247 VDREVGKLQKEVVIIQGSLEQKQLEKHNLLLDCKVQDIDISLMLGSLEDIIEVEL-TETE ENSP00000350036/1-1235 VDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAE ENSCPOP00000012928/1-1231 VDREVGKLQKKVVIIQTSLEQRRLEKHNMLLDCKVQDIEIRLLSGSLDDIIEVELGTETE XP_004845462.1/1-1237 VDREVGKLQKEVVIIQTSLEQKRLERHNMLLDCKVQNIEITLLLGSLDDIIEVELGTETE **********:** ** ****: **:**:*******:*:* *: ***:****:*: **:* ENSMUSP00000023068/1-1248 STQATADIYEKEASIQIDYSPLREDLKALQSDKEVEAHLTLLLQQVASQENTLLKTTAPN ENSRNOP00000043834/1-1247 STQATADIYEKEASIQIDYSPLREDWKALQSDKEVEAHLTLLLQQVASQENTLLKTAAPN ENSP00000350036/1-1235 STQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPN ENSCPOP00000012928/1-1231 STQATTDIYEREAALEVDYGPLREDLKALESEKEVEAHLELLVQQVASQEDNLLKTAAPN XP_004845462.1/1-1237 STQATTDIYEKEAAMEVDYSPLQEDLKALLSDKEVEARLVLLVQQVASQEENLLKTAAPN ***** ****:* ::::**..*:** *** *::*:**:* **:*******: ****:*** ENSMUSP00000023068/1-1248 LRAQENLKTVRDKFQESADVFEASRKEARICRQEFEQVKRRRYDAFSQCFEHISVSIDQI ENSRNOP00000043834/1-1247 LRAQENLKAVRDKFQESADAFEASRKEARICRQEFEQVKRRRYDAFSQCFEHISVSIDQI ENSP00000350036/1-1235 LRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQI ENSCPOP00000012928/1-1231 LRALENLKMVRDKFQESIDAFEASRKEARMCRQEFEQVKKRRFDLFSQCFEHVSVSIDHI XP_004845462.1/1-1237 LRALQKLKTVRDKFQESTDAFEASRKEARMCRQEFEQVKKRRYDLFNQCFEHVSVSIDHI *** ::** ******** *.*********:*********:**:* *.*****:*:***:* ENSMUSP00000023068/1-1248 YKKLCRNNSAQAFLSPENPEEPYLDGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAV ENSRNOP00000043834/1-1247 YKKLCRNNSAQAFLSPENPEEPYLDGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAV ENSP00000350036/1-1235 YKKLCRNNSAQAFLSPENPEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAV ENSCPOP00000012928/1-1231 YKKLCRNNSAQAFLSPENPEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALALLLAV XP_004845462.1/1-1237 YKKLCRNHSAQAFLSPENPEEPYLEGISYNCVAPGKRFMPMDNLSGGERCVAALALLFAV *******:****************:***********************:********:** ENSMUSP00000023068/1-1248 HSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQSQEQFQMIIISLKEEFYSKADALIGVY ENSRNOP00000043834/1-1247 HSFRPAPFFVLDEVDAALDNTNIGKVSGYIKEQSQEQFQMIIISLKEEFYSRADALIGVY ENSP00000350036/1-1235 HSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQTQDQFQMIVISLKEEFYSRADALIGIY ENSCPOP00000012928/1-1231 HSFRPAPFFVLDEVDAALDNTNIGKVSSYIREQTQEQFQMIIISLKEELYSRADALIGVY XP_004845462.1/1-1237 HSFRPAPFFVLDEIDAALDNTNIGKVSSYIREQTQEQFQMIIISLKEELYSRADALIGVY *************:*************.**:**:*:*****:******:**:******:* ENSMUSP00000023068/1-1248 PEHNECMFSHVLTLDLSKYPDTEDQEGSRSHRKPRVPRVSMSPKSPQSR ENSRNOP00000043834/1-1247 PEHDECMFSHVLTLDLSKYPDTEDQEGSRSHRKPRA-RVSQSPQSPQSR ENSP00000350036/1-1235 PEYDDCMFSRVLTLDLSQYPDTEGQESSKRHGESR-------------- ENSCPOP00000012928/1-1231 PEHDRGMCSRVLTLDLRPYPDSEGGQGGRGHR----------------- XP_004845462.1/1-1237 PEHDGVLFSQVLTLDLRPYPDKEEGQGSRGRREPQPQ------------ **:: : *:****** ***.* :..: :