CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000111418/1-1396 MPPPLLPKRSKLETEKAQSNKITPREEQQSEKIGKSNHAASSSSSST------QGAVKRR ENSRNOP00000003954/1-1408 ICIKMLPKRSKLETEKPQSIKITPREEQQSEKIGKSNHTASASSQ---------GTIKKR ENSP00000365210/1-1395 MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKR ENSCPOP00000012799/1-1236 ------------------------------------------------------------ XP_004872082.1/1-1318 --MPLPPQSFKPETKKFQSSKIVPSDHSQSKKMGENYQAKISPSSPQ-------RTFKKR ENSMUSP00000111418/1-1396 SVFEDVTNASHSQCVQSKED-NIELKSHVSKRTKK-----GVGEVTQKKIKSSKMGHVTS ENSRNOP00000003954/1-1408 SAFEDVTNASYVQCVQPKED-NTELKSHISKRTRK-----GVGEITQKKIKSSKLGHVTS ENSP00000365210/1-1395 SAFEDLTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGLAKKNKRNLKWHKLEVTPV ENSCPOP00000012799/1-1236 --------AFQSQPAQSKKEANKEFVKDVPKMINRSQH-LELARYTEMNNKRYKLELSPV XP_004872082.1/1-1318 SAFEDLTNAFQTQPVQSKKEINKEFGKDVPKTISKSKHALELARYTEMNKKRYKLELTSA * * .*.*:: * *: . :.* : :.. .: : * *: . ENSMUSP00000111418/1-1396 LSN-------MEKEFILDIPNKPKTLTTEEPSVFQKTLVLNEEPATKETCLMRK--TLKS ENSRNOP00000003954/1-1408 LSN-------VEKEFILDIPNKPKTLTTEEPPVFPKTLVLNEQHATEETSLMRK--TLKS ENSP00000365210/1-1395 VASTTVVPNIMEKPLILDISTTSKTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLKK ENSCPOP00000012799/1-1236 VASTPSVPNILEKPLLLDVSTNSQTPTVGEVSFVKRSLLLEEETSMKETTFITQ--SLKK XP_004872082.1/1-1318 VASTASVPKILEKSLLLDVTTNSQTPTIEEVSFVTKPLILKEEPSTEVTTLIKK--SLKK ::. :** ::**:....:* . * ... :.*:*:*: : : :: : :**. ENSMUSP00000111418/1-1396 CAFHQETLLMEKPLTLLVETEDYNEFDTELMTSKKKDKPEDPTIIEEMTDLKKSVIRKVT ENSRNOP00000003954/1-1408 CAFYQETFLMEKPQTLLEKTKDYKEFDSELMTSRRKDKPEEATIIEEMTDLKEPDLGKVT ENSP00000365210/1-1395 CSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCA--- ENSCPOP00000012799/1-1236 CTNPGESSLLEKSLSLLEETDD-NEFVIEPVTFGKKHIPKEAAITKKKSSLKK-MCT--- XP_004872082.1/1-1318 CTNPGEAFLLEKSLSLQEETDSDDDFVIKPVTFGKKHKSNEAAITKKTLSLKK-MST--- *: * *:** .* ::.. . * : :* :.. .::.:* :: .**: ENSMUSP00000111418/1-1396 LTSSPLWLKNKHVVQEEKPVIQEKSSFKKISLVSNVVTTKEKPPVKKPHFRKKKPTTEMK ENSRNOP00000003954/1-1408 LTSSPLYLKNKHAVQEEKHAIQGKSSFKKKSLAMKVVTTKENSPVKKPHFRKKKPTTELK ENSP00000365210/1-1395 -------SQRKQSCQEESLAVQD-VNMEEDSFFMESMSF------------KKKPKTEES ENSCPOP00000012799/1-1236 -------YQGKQSCLEELVTLQG-SCVEEGSFSMELMNL------------RKKPKTEES XP_004872082.1/1-1318 -------YQRKQSCLEELVILQD-SNVEEGSFSVELMNL------------KKKPKTEKL : *: ** :* .:: *: : :. :***.** ENSMUSP00000111418/1-1396 SLLQEP-SLEEKYNTQEDASILKKPQVLQENTNNKDATLTEPVTFKGKHSANEATHTKKP ENSRNOP00000003954/1-1408 SLLQEQSSLQEKYNTQGDASILKKPRVLQKNINNKVDTLTEPVTLKRKHSTNEAIHTKKL ENSP00000365210/1-1395 IPTHKLSSLKKKCTIYGKICHFRKPPVLQT-------TICGAMSSIKKPTTEKETLFQEL ENSCPOP00000012799/1-1236 STTKMPLHLSGKHTTMEKISNMIKPALLQKNTSEEELVTKEPSTIMREPTANKQSFSWEP XP_004872082.1/1-1318 SSPKKPLSLSSKCTTMEKISNTIKPVLLEKITSEKKLITKEPSAFMRNPTADKESLSCKP : *. * . . . ** :*: . : : :::: : ENSMUSP00000111418/1-1396 SSSKNNPDPQGKGTNLRPLRVHPVTYENEPMSSKKSTTKKKDSHFHGPSVLPDKHSPQME ENSRNOP00000003954/1-1408 SSSKNNHDTQGKGTNLRPLGVQPVTHENEPLSSKKSTTKKKDSHFHGPSVLPDKHSPQMK ENSP00000365210/1-1395 SVLQEKHTTEHEMSIL-----------------KKSLALQK-TNFKEDSLV--KESLAFK ENSCPOP00000012799/1-1236 SAVKEKHTTQQEIPIL-----------------KKSLPLQEKTDFEEDSLF--KDLPTF- XP_004872082.1/1-1318 SAFKEKHTTKQEISNW-----------------KKSLTLQEKTDFKDKSLV--KELSTFK * ::: .: : . *** . :: :.*. *:. *. : ENSMUSP00000111418/1-1396 VSTVKKSLALPNPTTEEKMLHFPVATVLEKQHNMGEAP-CLKKPS-------------PL ENSRNOP00000003954/1-1408 VSTAKNSLALQNPTTEEMMLHFPVAPVLKMGQNMEEAP-CLKKPS-------------PL ENSP00000365210/1-1395 ----------KKPSTEEAI----MMPVILKEQCMTEGKRSRLK---------------PL ENSCPOP00000012799/1-1236 -------------TPEEAT--FPTSPVFGKEKCMIQGKLCTTHEK-------------PL XP_004872082.1/1-1318 ----------QKPTTEEAT--LTASPVFGRTECTVQRKICTTHEKKYTIYGMQSHLKNPL :.** .*: . : . : ** ENSMUSP00000111418/1-1396 RKQQQLPKRRRFFSNSAVQETVIRKPLFFKMST-TEKDPPSQWPSALPKKHISPGELSKQ ENSRNOP00000003954/1-1408 RKQQQLPKRSRSFSKCAVQETVTSKSLSFKKSN-TKKDPSFQGPFALQKKRNSPGKLSKQ ENSP00000365210/1-1395 VLQEITSG----------EKSLIMKPLSIKEKPSTEKESFSQEPSALQKKHTTQEEVSIL ENSCPOP00000012799/1-1236 EVKEVISG----------EKSLNTKPLSFKRNTITE---FYQEPSALQEKHTTQADVELL XP_004872082.1/1-1318 EVQEVISG----------EESLSTKPLSFKRNRITE---FYQEPSALQEKHTTQEEVSTL :: . :::: *.* :* . *: * * ** :*: : .:. ENSMUSP00000111418/1-1396 KKQHVSPKHNMEEDSQCWLDSAFKKQL-SREEPASTHTPLKLEMQQAITKETGFHLRNPL ENSRNOP00000003954/1-1408 KKRYVPPKHCMEKDSHFQLDSAFKKQH-IREEPASTHKPLILEMQ-QTTKGTEFRLRNPL ENSP00000365210/1-1395 KEPSSLLKSPTEE-SPFDEALAFTKKC-TIEEAPPTKKPLILKRK-HATQGTMSHLKKPL ENSCPOP00000012799/1-1236 KKPLGLQENMNNEASFVMEAVSFKKHCITIENVTPSKKHLPLKNKQHTTQQTVSHLKEPL XP_004872082.1/1-1318 KKRVALQKSPTETESLFQESLAFQKQC-NTEKATPSKKPLPLKKQQHTTQGTVSHLKKPL *: : : * :* *: *: ..::. * *: : *: * :*::** ENSMUSP00000111418/1-1396 VLPTVTSEAKSLTKEPPSFREQNTSLLKRKSTTHTITLQQ-AQSEWQEMTDEDRNLFSIK ENSRNOP00000003954/1-1408 VLPTVTSGTKSLTKEPPSFKKENTPLLKRKCATHTITLQQ-AQLELEETTGEDRNLFSTR ENSP00000365210/1-1395 ILQT-TSGEKSLIKEPLPFKEEKVSLKK-KCTTQEMMSICPELLDFQDMIGEDKNSFFME ENSCPOP00000012799/1-1236 VLQTVTSEEKSTIEDPLSFKE-NIFLKKIKCTTQAMCRWI-DLSDWQDIIAKDRNSVLVK XP_004872082.1/1-1318 VLQTVTSEEKSPIKEPLSFKEVNMSLKKKKCTTEATPQWI-DLSDWQDIIVKEKNSFFMK :* * ** ** ::* .*:: : * * *.:*. : :: :::* . . ENSMUSP00000111418/1-1396 PGSHRKEPIPEFLQNPLPPNENCLISQKLSHS------MPFASQKTTSQERAHRKESVA- ENSRNOP00000003954/1-1408 PELHKKEPTPGLLQDPLPQNENCLIPQQLSFS------MPLDSQKITSQERAHSKESVT- ENSP00000365210/1-1395 PMSFRKNPTTE--ETVLTKTSLSLQEKKITQGKMSHLKKPLVLQKITSEEESFYKKLLPF ENSCPOP00000012799/1-1236 PVSSTKKCTAK--KAVFTNAPSSMKKKQTTQG------------KTTLEDESLCKKLLPF XP_004872082.1/1-1318 QVSSTKKGTTE--KVVLTKTPSYLKKKQTTQR------------KTTSEEESLCKKLLPF *: . : :. : :: : * * ::.: *: :. ENSMUSP00000111418/1-1396 ---SNDDKNFFSQD---LFSPFSSADEDTLKFHKSLDFQEQVDRKNDS-HKKMFDSQ-DS ENSRNOP00000003954/1-1408 ---SNDDNNFFSQD---LFSPFSSTDEDTLKFHKSLDFQEKVDRKNDS-PTKMSDSQ-DS ENSP00000365210/1-1395 KMKSTTEEKFLSQEPSALKEKHTTLQEVSLS-KESLAIQEKATTEEEF-SQELFSLHVKH ENSCPOP00000012799/1-1236 KKKPTTKEEFLFREQSALKEKHTTFQEVTLS-RKPIALQEKTNTEEKFLSQELFSLHVNP XP_004872082.1/1-1318 KKKPTTEEKFLAQERSASKEKHTTFQEVSLS-RKQIAFQEKTTTEEESYSKEPFSLHVKP .. .::*: :: . .:: :* :*. :: : :**:. ::. : . : . ENSMUSP00000111418/1-1396 VSEEESFLRKLFCKDRCSSTEELSQERTVALEQEFLLIKILNENTSSDVDEPLSHQSPHI ENSRNOP00000003954/1-1408 VSEEESFLRKLFCKGRHSSSEESSQERPVALEQEFLLKKVLNENTSSDVEGPLSHQSPHI ENSP00000365210/1-1395 TNKSGSLFQEALVLQEKTDAEEDSLKNLLALQEK-----------STMEEESLINKLLAL ENSCPOP00000012799/1-1236 TNKDESLFQKAVVLQEETGIKKLSLKKPLAFHEK-----------STMAEESLCNKLSVL XP_004872082.1/1-1318 TNKDESLFQKAVILQEKTNTKKES----LALHEK-----------STMTEESLFNRLSVL ..:. *:::: . . :. :: * :*:.:: *: : .* :: : ENSMUSP00000111418/1-1396 QNHSDTTKEALE---------ASEALEAPEALETLEALVASED---LEEPLNILEELSTE ENSRNOP00000003954/1-1408 QNHSGTTKEALEALDALEALDALEALEASETLEALEALEASGA---LEEPLNIQEELSSE ENSP00000365210/1-1395 KEELS----------------AEAATNIQTQLSLKKKSTSHGKVFFLKKQLALNETINEE ENSCPOP00000012799/1-1236 KKEPS----------------AKEATSTERQLPINNKPTAQGQAHLLKEQLSLHENITDN XP_004872082.1/1-1318 KKEPS----------------AKGAASIDRQLPIKNELTAHEQAFLLKEQLALHEKITND ::. . * * . * : : *:: * : * :. : ENSMUSP00000111418/1-1396 NMVALMKMLVTEDE----STKDSFSGNYTAAREAHAEKSLSLEETSINEAATLKESLSSQ ENSRNOP00000003954/1-1408 DIVAIMKSLITEDE----SIKEAFIRSYTTATEAPAEKSLSLEETSINEVATLKEPLSSQ ENSP00000365210/1-1395 E-FLNKQPLALEGYPSIAEGETLFKKLLAMQEEPSIEKEAVLKEPTIDTEAHFKEPLALQ ENSCPOP00000012799/1-1236 EGFLIKEALALQEY--VGNEKALFRETLTMQEKLSTQKEAVL-EHTTDIEVNFNQLSAMQ XP_004872082.1/1-1318 EMYLIKEPLALQEY--VGSEKGLFKEPLTMQEKLSTQKETAFKEHTTDIEAHFNELLAMQ : : * : . : * : : :*. : * : : . ::: : * ENSMUSP00000111418/1-1396 EKHRAELVTVLKEL-----------LVLMKNPSLKRVAL-----AFQENPSNNVETLLRE ENSRNOP00000003954/1-1408 EKHRAELVTVLKEL-----------LVLVKNPRLERLAL-----AFQENPPSNVETLLRE ENSP00000365210/1-1395 EEPSTEKEAVLKEPSVDTEAHFKETLALQEKPSIEQEALFKRHSALWEKPSTEKETIFKE ENSCPOP00000012799/1-1236 EKPSPEKEPIFQEP-----------LDLQEKPTIEEGTIF--------------KAFLKE XP_004872082.1/1-1318 EKPSIEIGPVFQEP-----------VNLQEKPTIEE------------------EGFFIE *: * .:::* : * ::* ::. : :: * ENSMUSP00000111418/1-1396 VLALVENSTADEST-------LQ-----------------EKPSTKTDVTPKELLALEEN ENSRNOP00000003954/1-1408 VLALVEKSTGEEST-LNEPLALQ-----------------EKLSTKAELSPKELLALEDN ENSP00000365210/1-1395 SLDLQEKPSIKKETLLKKPLALKMSTINEAVLFEDMIALNEKPTTGKELSFKEPLALQES ENSCPOP00000012799/1-1236 PLTFQLKSNIEDEV----PSILE-----------------ENPTEKEDTLPETLLFLGTS XP_004872082.1/1-1318 PLALQEKAGLESEAMLKEPLALQ-----------------EKPSTEMETALKEPLSLQEK * : :. .... *: *: : : : * * . ENSMUSP00000111418/1-1396 SSNKKANPMDS-LSFDHKPDTEMGEIARMVLTDE-------------EYNIDTLYERVLA ENSRNOP00000003954/1-1408 PSFKKASPQGS-LTFDHKPDIEKDEITRMSFSFE-------------EFSIDSLYEKVLA ENSP00000365210/1-1395 PTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGTINEAFLFEDMIT ENSCPOP00000012799/1-1236 PHMPSDTVESRTGEFSAANMSSVGESIASESGSK-----------------------MPS XP_004872082.1/1-1318 PSTEKEAILKEPLAFQKKSNMEDEVLSKEPLALQ----------EKSTINVPFFFQNMLA . . . . : : : ENSMUSP00000111418/1-1396 LSQGLIAADQLSFTDLQNFEETKIVDEEEFFKSFLVFENKNSPNMSSNAFESRTDNSS-A ENSRNOP00000003954/1-1408 LSEGFTTTEQLSFTDLQNFDESKIVDEEDIFKSFFVFENENNPNLSSNGFESRKDNSS-A ENSP00000365210/1-1395 LNEKPTTGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESITEKSSIA ENSCPOP00000012799/1-1236 LSQSRTHMEMKGFFVVLEVTTSKECSQGDFSFAFISNSTVYSKYLYSQGPTVYLGKLSLS XP_004872082.1/1-1318 MNEKPTIENELSFQEPLALEENFANKEDIFPETFLILE--NSPRVSSNAVESSTDKFNAA :.: . .* . . .: : :*: . . : * : . : ENSMUSP00000111418/1-1396 IMPSSKAFNPVENSNPY-VSSSKSFKSTLGAKETEITIQDDSDSLERIEKEGQDPLLNTI ENSRNOP00000003954/1-1408 PMPSLEAFNSVMNSEPC-VSATKSSQSSLGGKETEVIILDDSDTQESFVKEDSDLLLSST ENSP00000365210/1-1395 TMTSVGKSRTTTESSACESASDKPVSPQAKGTPKEITPREDID------EDSSDPSFNPM ENSCPOP00000012799/1-1236 VISASYKFQGFKELQNKETVGEKSIIPNI--VSKQMTTLEDTD------KDHCDSSFSSV XP_004872082.1/1-1318 NMSSVGK------SGANESGSKIPFSPQSR-TQKEINTLEAIG------KDHHDPSFSSV :.: . . . .:: : . :: * :.. ENSMUSP00000111418/1-1396 YAKDVFNYLKEREEKFLVQKYMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKI ENSRNOP00000003954/1-1408 YAKNIFIYLKEREEKFIVTKYMDEQMELTSDMRAILVDWMVEVQANFRMSHETLYLAVKL ENSP00000365210/1-1395 YAKEIFSYMKEREEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKL ENSCPOP00000012799/1-1236 YANEIFSYLKDREEKFILEKYMKRQTEITSDMRAILVDWLVEVQMSFDMSHETLYLAVKL XP_004872082.1/1-1318 YAKEIFSYLKDREEKFILKKYMKRQTEITSDMRAILVDWLVEVQMSFNMSHETLYLAVKL **:::* *:*:***:*:: .**. * *:***********:**:* .* *:*********: ENSMUSP00000111418/1-1396 MDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSI ENSRNOP00000003954/1-1408 MDRYLMKAQCEKNHLQLLGSTAYMIAAKFEESYPPSLTEFLYICEDLYPKSEMVSLERNI ENSP00000365210/1-1395 VDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINI ENSCPOP00000012799/1-1236 VDHYLMKALCTKDKLQLLGSTAFLIAAKFEELISPCVDDFLYICEDMYQRHEMLAMEMRI XP_004872082.1/1-1318 VDHYLMKELCRKDKLQLLGSTAFLIAAKFEELFPPCVDDFLYVCEDMYQRHEMIAMEMSI :* **** * *::*****:*:::******* .* : :*:::*:* * : :::::* * ENSMUSP00000111418/1-1396 LQTLNFDINIPTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASF ENSRNOP00000003954/1-1408 LKTLNFDINIPIAYHFLRRYASCIHASMKTLTLSRFICEMTLQEYDYIDERPSKLAAASF ENSP00000365210/1-1395 LNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASL ENSCPOP00000012799/1-1236 LQTLKFDINIPVAYRFLRRYAVCLNTSMKTLTLARFICEMTLQKYDYVHVRASKLAAASF XP_004872082.1/1-1318 LKTLKFDINIPVAYHYLRRYALCLNVSMKTLTLSRFICEMTLQKYDYVHERASKLAAASF *:.*: ***** **.:***** *::..******:*:*******:*.*:. :.*******: ENSMUSP00000111418/1-1396 ILALYMRNLSNC-VPTLEYFTGYKMAELHILVRKLNHLLNFRSHSILKNVFEKYSEETYF ENSRNOP00000003954/1-1408 ILALYMRNLKDC-VPSLEYSTGYQLAELHILVRKLNHLLNFRSRTVLKNVFEKYSEETYF ENSP00000365210/1-1395 LLALYMKKL-GYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLKAVYYKYSHPVFF ENSCPOP00000012799/1-1236 LLALYMKKLKNYWAPLLEYYSGYMTFELHPLVRQLNILLTFNCCDRLKTVYTKYSQKIFF XP_004872082.1/1-1318 LLALYMKKLKNY-APLLEFYSGYTTFELHPLVRQLNILLTYHYCDRLKTVYTKYSHEKFF :*****::* . .* **. :** *** ***:** **.: ** *: ***. :* ENSMUSP00000111418/1-1396 EVAKIPPLSKQDLENLLNCALFH----- ENSRNOP00000003954/1-1408 EVAKIPPLSMKDLEDLLNCALFS----- ENSP00000365210/1-1395 EVAKIPALDMLKLEEILNCDCEAQGLVL ENSCPOP00000012799/1-1236 EVTKIPPLDMMILDEIL----------- XP_004872082.1/1-1318 EVTKTPPLDIATLDEIFMY--------- **:* *.*. *::::