CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000044827/1-1344 MAEMKSPTKAEPATPAEAAQ-----SDRHSLLEHSREFLDFFWDIAKPDQETRLRATEKL ENSRNOP00000021134/1-1344 MAEMKSPTKAEPASPAEAPQ-----GDRRSLLEHSREFLDFFWDIAKPDQETRLRATEKL ENSP00000370968/1-1332 ---MESRDPAQPMSPGEATQSGARPADRYGLLKHSREFLDFFWDIAKPEQETRLAATEKL ENSCPOP00000012791/1-1323 MAEIRSPKVAEPAPPGGAMS-----ADRHGLLEHSREFLDFFWDIAKPHQQTRLEATEKL XP_004857299.1/1-1340 MAVKKGSEVAEPAPPGGATS-----ADRHGLLEHSREFLDFFWDIAKPQQQTRLEATEKL .. *:* .*. * . .** .**:***************.*:*** ***** ENSMUSP00000044827/1-1344 LEYLRTRP-NDSEMKYALKRLITGLGVGREAARPCYSLALAQLLQSFEDIPLCDILDQIQ ENSRNOP00000021134/1-1344 LEYLRTRP-SDSEMKYALKRLITGLGVGREAARPCYSLALAQLLQSFEDIQLCDILGQIQ ENSP00000370968/1-1332 LEYLRGRP-KGSEMKYALKRLITGLGVGRETARPCYSLALAQLLQSFEDLPLCSILQQIQ ENSCPOP00000012791/1-1323 LAYLRARP-EGSERKYALKRLITGLGVGREAARPCYSMALAQLLQSFEDIPLCSILEQVQ XP_004857299.1/1-1340 LTYLRARPEEGSEMKYALKRLITGLGVGREAARPCYSVALAQLLQSFEDIPLCSILEQVQ * *** ** ..** ****************:******:***********: **.** *:* ENSMUSP00000044827/1-1344 EKYSLQAMNKAMMRPSLFANLFGVLALFQSGRLVKDKEALMKSVQLLKILSQHPNHLQGQ ENSRNOP00000021134/1-1344 EKYNLQAMNKAMMRPTLFANLFGVLALFQSGRLVKDKEALMKCVRLLKILSHHYNHLQGQ ENSP00000370968/1-1332 EKYDLHQVKKAMLRPALFANLFGVLALFQSGRLVKDQEALMKSVKLLQALAQYQNHLQEQ ENSCPOP00000012791/1-1323 EKYDLNTAKKATIRPVLFANLFGVLALFQSGRLMKDQKALMKSVKLLQVLSHHYNHLQGQ XP_004857299.1/1-1340 EKYELHTVKKAMIRPALFANLFGVLALFQSGRLVKDQKALMKSVKLLQVLSHHHNHLQGQ ***.*: :** :** *****************:**::****.*:**: *::: **** * ENSMUSP00000044827/1-1344 PIKALVDILSEVPESMFQEILPKVLKGNMKVILRSPKYLELFLLAKQRVPTKLESLMGSV ENSRNOP00000021134/1-1344 PVKALVDILSEVPESMFQEILPKVLKGDMKVILSSPKYLELFLLARQRVPAELESLVGSV ENSP00000370968/1-1332 PRKALVDILSEVSKATLQEILPEVLKADLNIILSSPEQLELFLLAQQKVPSKLKKLVGSV ENSCPOP00000012791/1-1323 PLQALVDILSEVPEAMFEELLPKILRADFSVILSSPRHLELFLLAYRKVPSKLKSWMGSI XP_004857299.1/1-1340 PMQALVDILSEVPEAMFEEILPKILKADLNVVLSSPKHLELFLLASQKVPAKLESLMGPV * :*********.:: ::*:**::*:.::.::* **. ******* ::**::*:. :*.: ENSMUSP00000044827/1-1344 DLFSEDNIPSLVNILKVAANSVKKEHKLPNVALDLLRLALKESRFELFWKKVLEEGLLKN ENSRNOP00000021134/1-1344 DLFSEDNIPSLVNILKVAANSVKKEQKLPDVALNLLRLALQENKFERFWKEVLEEGLLKK ENSP00000370968/1-1332 NLFSDENVPRLVNVLKMAASSVKKDRKLPAIALDLLRLALKEDKFPRFWKEVVEQGLLKM ENSCPOP00000012791/1-1323 DLFTDENMPRLVNVLRLAATSAKKENKLPNVALDLLRLALKENKFPSFWKEVLEQGLLTK XP_004857299.1/1-1340 DLFTDENIPRLVNVLKSAAPSVKKENKLPNVALDLLRLALKEDKFLWFWKEVVEQGLLTK :**:::*:* ***:*: ** *.**:.*** :**:******:*.:* ***:*:*:***. ENSMUSP00000044827/1-1344 PSWTSSYMCFRLLGASLPLLSEEQLQLVMRGDLIRHFGENMVISKPQNLFKIIPEISTYV ENSRNOP00000021134/1-1344 PSYTSSYMCFRLLGASLPLLSDEQLQLVMRGDLIRHFGEHMVVSKSQNPLRFIPEISAYV ENSP00000370968/1-1332 QFWPASYLCFRLLGAALPLLTKEQLHLVMQGDVIRHYGEHVCTAKLPKQFKFAPEMDDYV ENSCPOP00000012791/1-1323 ASWPASFLCFRLLGAALPLLSKEQLQLVMRGDLARHFGEHMVTAKLSSQSKFIPEMSEYV XP_004857299.1/1-1340 PSWPTSFLCFRLLGTALPLLSKEQLQLVMQGDLARHFGEHMVTAKLSHQSKFVSEMSEYV :.:*::******::****:.***:***:**: **:**:: :* :: .*:. ** ENSMUSP00000044827/1-1344 GTFLEGCQDDPKRQLTMMVAFTTITNQGLPVMPTFWRVTRFLNAEALQSYVAWLRDMFLQ ENSRNOP00000021134/1-1344 GTFLEGCQDDPKRQFTVMVAFTAITNQGLPVMPTFWRVTRFLNTEALQNYVTWLRDMFLQ ENSP00000370968/1-1332 GTFLEGCQDDPERQLAVLVAFSSVTNQGLPVTPTFWRVVRFLSPPALQGYVAWLRAMFLQ ENSCPOP00000012791/1-1323 GTFLEGCQDDPARQLSVMVAFSSITNQGLPVMPTFWRVTKFLSSQALRDYMAWLQDMFLR XP_004857299.1/1-1340 GTFLEGCQDDPERQLLVLVAFSSITNQGLPVMPTFWRVTRFLSPQALQDYVAWLQDMCLQ *********** **: ::***:::******* ******.:**.. **:.*::**: * *: ENSMUSP00000044827/1-1344 PDLNSLVDFSTANQKRAQDASLNVPERAVFRLRKWIIHRLVSLVDHLHLEKDEAVVEQIA ENSRNOP00000021134/1-1344 PDLDSLVDFSTANQKRVQVASLNVPERTVFRLRKWIIHRLVSLVDHLHLEKDEAVVEQIA ENSP00000370968/1-1332 PDLDSLVDFSTNNQKKAQDSSLHMPERAVFRLRKWIIFRLVSIVDSLHLEMEEALTEQVA ENSCPOP00000012791/1-1323 PNLDCLVDFSTANQKREQDASFNSPERAVFRLRKWIIHRLVSLLDTLQLEKEETLVEQVA XP_004857299.1/1-1340 PSLDSLIDFSTVNQKRVQDASFNTPERATFRLRKWIVHRLVSLLDTLHLEKEEALVEQVA *.*:.*:**** ***: * :*:: ***:.*******:.****::* *:** :*::.**:* ENSMUSP00000044827/1-1344 RFCLFHAFFKTKKATPQIPETKQHFSFPLDDRNRGVFVSAFFSLLQTLSVKFRQTPDLAE ENSRNOP00000021134/1-1344 RFCLFHAFFKTKKATPQIPETKQHFSFPLEDGNRGVIVSAFFSLLQTLSVKFRQTPDLAE ENSP00000370968/1-1332 RFCLFHSFFVTKKPTSQIPETKHPFSFPLENQAREAVSSAFFSLLQTLSTQFKQAPGQTQ ENSCPOP00000012791/1-1323 RFCLFHSFFKTKKPTGQIPETKQQFSLDMDSRIREFFVNAFFSLLQTLTTKSRHVPGQAH XP_004857299.1/1-1340 RFCLFHSFFKTKKPTSQIPETKQQFSFPVDSRTREFFTSAFFSLLQILSTKFRHIPDQAQ ******:** ***.* ******: **: ::. * . .******* *:.: :: *. :. ENSMUSP00000044827/1-1344 NGKPWTYRLVQLADMLLNHNRNVTSVTSLTTQQRQAWDQMMSTLKELEARSSETRAIAFQ ENSRNOP00000021134/1-1344 NGKPWTYRLVQLADMLLKHNRNVANVTPLTAQQRQAWDQMMSTLKELEAQSSETRAIAFQ ENSP00000370968/1-1332 GGQPWTYHLVQFADLLLNHSHNVTTVTPFTAQQRQAWDRMLQTLKELEAHSAEARAAAFQ ENSCPOP00000012791/1-1323 SGHPWIYRLVQLADMLLNHSRNVAIITPFTTQQRQAWDHMLETLKELEARSSEPKAAAFQ XP_004857299.1/1-1340 GGQPWIYRLVQLADTLLNHSRNVAIVTPFTTQQRQAWDQMLETLKELEACSSEAKATAFQ .*:** *:***:** **:*.:**: :*.:*:*******:*:.******* *:*.:* *** ENSMUSP00000044827/1-1344 HLLLLVGLHIFKSPAESCDVLGDIQTCIKKSMEQNPRRSRSRAKASQEPVWVEVMVEILL ENSRNOP00000021134/1-1344 HLLLLVGLHLFKSPAESCDVLGDIQTCIKKSMEQNLRRSRSRAKASQEPVWVEVMVEILL ENSP00000370968/1-1332 HLLLLVGIHLLKSPAESCDLLGDIQTCIRKSLGEKPRRSRTKTIDPQEPPWVEVLVEILL ENSCPOP00000012791/1-1323 HLLLLVGLHLFKSPTESCDLLGDIQTCIKKSMGEKTRRSRSKAINAKEPPWVEVMVE--- XP_004857299.1/1-1340 HLLLLVGIHLFKSPTESCDLLGDIQTCIKKSMGEKTRRSRSKAISSQEPPWVEVMVEILL *******:*::***:****:********:**: :: ****::: .:** ****:** ENSMUSP00000044827/1-1344 SLLAQPSNLMRQVVRSVFGHICPHLTPRCLQLILAVLSPVTNEDEDDNVVVTDDADEKQL ENSRNOP00000021134/1-1344 SLLAQPSNLMRQVVRSVFGHVCSHLTPRGLQLILAVLNPETNEDEEDNVVVT-DTDEKQL ENSP00000370968/1-1332 ALLAQPSHLMRQVARSVFGHICSHLTPRALQLILDVLNPETSEDENDRVVVTDDSDERRL ENSCPOP00000012791/1-1323 ----KPSNLMRQVARSVFGHICSHLTPRALQLILNVLNPEANQDEDDAVVVTDDSDEKQL XP_004857299.1/1-1340 SLLSQPSNLMRQVARSVFGHICSHLTPRALQLILNVLNPEENQDEDDAVVVTDDSDEKQL :**:*****.******:*.***** ***** **.* .:**:* **** *:**::* ENSMUSP00000044827/1-1344 QHGEDEDSDNEDNKNSESDMDSEDGEESEEEDRDKDVDPGFRQQLMEVLKAGNALGGVDN ENSRNOP00000021134/1-1344 KHGEDADSDSEDSKNSESDVDSEDGEESEEEDRDKDVDPGFRQQLMEVLQAGNALGGEEE ENSP00000370968/1-1332 KGAEDKSEEGEDNRSSESEEESE-GEESEEEERDGDVDQGFREQLMTVLQAGKALGGEDS ENSCPOP00000012791/1-1323 MDAEDESSDSKD-ENSESEA-------------DEHVDPGFRQQLMEVLQAGKALGGEDS XP_004857299.1/1-1340 KDAEDDGSDSKE-ENSESEVDSE-GEESEEEERDEHVDPGFRQQLMEVLQAGKALGEVDS .** ..:.:: ..***: * .** ***:*** **:**:*** :. ENSMUSP00000044827/1-1344 EE-EEELGDEAMMALDQNLASLFKEQKMRIQARNEEKNKLQKEKKLRRDFQIRALDLIEV ENSRNOP00000021134/1-1344 E--EEELGDEAMMALDQNLASLFAEQKMRIQARHEEKNKLQKEKQLRRDFQIRALDLIEV ENSP00000370968/1-1332 EN-EEELGDEAMMALDQSLASLFAEQKLRIQARRDEKNKLQKEKALRRDFQIRVLDLVEV ENSCPOP00000012791/1-1323 E--EEELSDEAMMALDESLSSLFAEQKLRIQAQRDEKNKLQKEKTLRRDFQIRVLDLVEV XP_004857299.1/1-1340 EEDEEELSDEAMMALDESLSSLFAEQRLRLQARRDEKNKLQKEKALRRDFQIRVLDLIEV * ****.********:.*:*** **::*:**:.:********* ********.***:** ENSMUSP00000044827/1-1344 LVTKQPEHPLILELLEPLLNVIQHSMR-SKGSTKQEQDLLHKTARIFMHHLCRARRYCHE ENSRNOP00000021134/1-1344 LVTKQPEHPLILELLEPLLNIIQRSMR-SRGSTKQEQDLLHKTARIFMHHLCRARHYCHE ENSP00000370968/1-1332 LVTKQPENALVLELLEPLLSIIRRSLR--SSSSKQEQDLLHKTARIFTHHLCRARRYCHD ENSCPOP00000012791/1-1323 LVTRQPESPLVLELLEPLLNIIQRSMR-SGGSSKQEQDLLHKTARIFMHHLCRSRHYCRD XP_004857299.1/1-1340 LVTRQPENPLILELLEPLLNIIRNSMRSSSSSSKQEQDLLHKTARIFMQHLCRARHYCHD ***:*** .*:********.:*:.*:* .*:************** :****:*:**:: ENSMUSP00000044827/1-1344 VGPCAEALHAQVERLVQQAGSQADASVALYYFNASLYLLRVLKGNTNKRH-QDGHKLHGA ENSRNOP00000021134/1-1344 VEPGAEALHAQVERLVQQAGNQADASVALYYFNASLYLLRVLKGNTTKRY-QDGQKLEGA ENSP00000370968/1-1332 LGERAGALHAQVERLVQQAGRQPDSPTALYHFNASLYLLRVLKGNTAEGCVHETQEKQKA ENSCPOP00000012791/1-1323 VGHCTSALHGQVERLVRQAGQQADSSVTLYYFNASLYLLRVLKGSANKKHVPGGQQQQGT XP_004857299.1/1-1340 MGHCAAALHTQVERLVRQAGQQADSSVALYYFNASLYLLRVLKGNATKKHMLESQQCQGA : : *** ******:*** *.*:..:**:*************.: : :: . : ENSMUSP00000044827/1-1344 DT----EDSEDQAANCLDLDFVTRVYSASLESLLTKRNSSLTVPMFLSLFSRYP---VIC ENSRNOP00000021134/1-1344 DIKSEPKDSEVQTTSCLDLDFVTRVYSASLESLLTKRNSPLTIPMFLDLFSRYP---VIC ENSP00000370968/1-1332 GTDPSHMPTGPQAASCLDLNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHP---VLC ENSCPOP00000012791/1-1323 GASDVPEDSDSQTTNCLDLDLVAPVYSAALSSFLTKRNSPFTVPMFLSLFSRYPPSQTIC XP_004857299.1/1-1340 GPNHGPEDTSPQTASCLDLDLVTPVYLAALSSFLTKRNSPLTVPMFLSLFSRYP---VIC . : *::.****::*: ** ::*.*:******.:*:****.****:* .:* ENSMUSP00000044827/1-1344 KNLLPVLAQHVAGPSRPRHQAQACLMLQKTLSARELRVCFEDPEWEQLITQLLGKATQTL ENSRNOP00000021134/1-1344 KNLLPIVVQHVAGSSRPRHQAQACLLLQKALSARELRVCFEDPEWEQLISQVLGKTTQTL ENSP00000370968/1-1332 QSLLPILVQHITGPVRPRH--QACLLLQKTLSMREVRSCFEDPEWKQLMGQVLAKVTENL ENSCPOP00000012791/1-1323 KRLLPVLLQCLAGSSRARQQTQACLLLQKTLSARELRVCFEDPEWEPLIGQVLAKVTENL XP_004857299.1/1-1340 KNLLPVLVQRMAGSTRARQ--QACLLLQKTLSARELRGCFEDPEWEQLIGQVLAKVTENL : ***:: * ::*. *.*: ****:***:** **:* *******: *: *:*.*.*:.* ENSMUSP00000044827/1-1344 QTLGEAQSKGEHQKELSILELLNTLLRTVNHEKLSVDLTAPLGVLQSKQQKLQQSLQQGN ENSRNOP00000021134/1-1344 QTLGEAQSKGEHQRELSILELLNTVFRIVNHEKLSVDLTAFLGMLQGKQQKLQQNLQQGN ENSP00000370968/1-1332 RVLGEAQTKAQHQQALSSLELLNVLFRTCKHEKLTLDLTVLLGVLQGQQQSLQQ----GA ENSCPOP00000012791/1-1323 RELGEAQSKSENQKQLTSLELLNTLLRIIHHEELAVDLTALLGVLQGQQQRLRQSLQQGE XP_004857299.1/1-1340 CTLGEAQSRSEHQKQLSSLELLNTLFKMIHHEKLTVDLTTLLGVLRGQQQSLQQSLQQGE *****::.::*: *: *****.::: :**:*::***. **:*:.:** *:* * ENSMUSP00000044827/1-1344 HSSGSNRLYDLYWQAMRMLGVQRPKSEKKNAKDIPSDTQSPVSTKRKKKGFLPETKKRKK ENSRNOP00000021134/1-1344 HSSGSSRLYDLYWQAMNLLGVQRPKSEKKNVKDIPSDSQSPISTKRKKKGFLPETKKRKK ENSP00000370968/1-1332 HSTGSSRLHDLYWQAMKTLGVQRPKLEKKDAKEIPSATQSPISKKRKKKGFLPETKKRKK ENSCPOP00000012791/1-1323 HSIGSSRLYDLYWQAMKMLGVQRPKVEKKDTKEVPGTSESPISTKRKKKGFLPETKKRKK XP_004857299.1/1-1340 HSSGSSRLYDLYWQAMKMLGVQRPKVEKKDTKAVPNVSESPISMKRKKKGFLPETKKRKK ** **.**:*******. ******* ***:.* :*. ::**:* **************** ENSMUSP00000044827/1-1344 LKSEGTTPEKNAASQQDAVTEGAMPAATGKDQPPSTGKKKRKRVKASTPS--QVNGITGA ENSRNOP00000021134/1-1344 LKSEGTTSEKKAASQQDAVTEGAMPAATGKDQPPSTGKKRRKRVKANTPS--QVNGVTVA ENSP00000370968/1-1332 RKSEDGTPA-----------EDGTPAATGGSQPPSMGRKKRNRTKAKVPA--QANGTPTT ENSCPOP00000012791/1-1323 RKLEAAAPEEGAKP------EGATPVATGGNQPPSTGKKKRRRAKAKGLAQPQVNGTPAT XP_004857299.1/1-1340 RKLEEATPEEGATP------KGATPVATGGDQPPSTG-KKRKRMKAKVLAQPQGDGTPAA * * :. :.. *.*** .**** * *:*.* **. : * :* . : ENSMUSP00000044827/1-1344 KSPAPSNPTLSPST-PAKTPKLQKKKEKLSQVNGATPVSPIEPESKKHHQEALSTKEVIR ENSRNOP00000021134/1-1344 KSPAPNNPTLSPSTPPAKTPKVQKKKEKLSQVNGSTPVSPVEPESKK-HQKALSTKEVKR ENSP00000370968/1-1332 KSPAPGAPTRSPST-PAKSPKLQKKNQKPSQVNGA-PGSPTEPAGQKQHQKALPKKGVLG ENSCPOP00000012791/1-1323 KSPAPGAPALSPST-PAKTPELKKKSKRLSRVNGDTPVSPTEPSGKEQHQKVLAKKGISG XP_004857299.1/1-1340 KSPGPDTLTLSPST-PAKTPELQKKSRKLSQVNGNTPVSPTEPSGEKQHLKSLSEKGISG ***.*. : **** ***:*:::**..: *:*** * ** ** .:: * : *. * : ENSMUSP00000044827/1-1344 KSPHPQSALPKKRARLSLVSRSPSLLQSGVKKR-RVASRRVQTP-- ENSRNOP00000021134/1-1344 RS--SQSALPKKRARLSLVSRSPSLLQSGIRKR-RVARRRVQTP-- ENSP00000370968/1-1332 KS--PLSALARKKARLSLVIRSPSLLQSGAKKKAQTLRFTISSSKK ENSCPOP00000012791/1-1323 KS--PQSTLPRKRSRLSVV-RSPSLFQSGAKKK-KSLRKKLRTP-- XP_004857299.1/1-1340 KS--PQSALSRKKARLSLV-RSPSLFQSGGRKK-KLLRQQLKTP-- :* . *:*.:*::***:* *****:*** :*: : : :.