CLUSTAL W(1.81) multiple sequence alignment ENSP00000301819/1-1321 MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAIS ENSMUSP00000035100/1-1314 MSSDDSSLMASIIYYSQEKYFHHVLQAANVGLERYSSDPALQFFRAYGILGEDHIHDAIS ENSRNOP00000051323/1-1314 MSSDDSSLMASIIYYCQEKYFHHVLQAANVGLERYSCDPVLQFFRAYGVLGEDRIHDAIS ENSCPOP00000012682/1-1305 ----SSSTQAGIIYYSQEKYFRHVQRAAAVGLEKFSNDPVLQFFKAYGVLREERIQDAIN XP_004835293.1/1-1321 MCSSDSSLLAGIIYYSQEKYFRHVQQAAAVGLQKFSNDPVLQFFKSYGVLREERVQDAIS .** *.****.*****:** :** ***:::* **.*:**::**:* *::::***. ENSP00000301819/1-1321 DLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFL ENSMUSP00000035100/1-1314 ELEGIQSHPDTSLCAVIALLSAHKSCDTIDIEAVQELESSLKEIRRSASSTALYYASLFL ENSRNOP00000051323/1-1314 ELESLQSHPDTSLCAVIALLYAHKCCDTIDAEAIQELDSSLKEIRRTASGMALYYASLFL ENSCPOP00000012682/1-1305 ELENVRGHPDLSLCSIIALLYAHRRCETLDREAIQELESELKEVHRLASETALYYAGLFL XP_004835293.1/1-1321 ELENIRGHPDLSLCSVMALLYAHKCCEIVDREAIQELETSLKEVREQASETALYYAGLFL :**.:: *** ***: :**: **: *: :* **:***: .***::. .* *****.*** ENSP00000301819/1-1321 WLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDV ENSMUSP00000035100/1-1314 WFMGHHDKAREYVDHMLKVSSGSKEGYVLKGWVDLTSSKPHVVKKSIKYLEQGTQDTKDV ENSRNOP00000051323/1-1314 WFMGHHDKAREYVDHMLKVSSGSKEGYVLKGWVDLTSNKPHVVKKSIKYLEQGTQDTKDV ENSCPOP00000012682/1-1305 WLIGRHDKAKEYVDHMLKVSSSSREGCVLKGWVDLTSEKPHLVKKSIKYLEQGIQSNKDV XP_004835293.1/1-1321 WLIGRHDKAREYVDHMLNASSSFREGYVLKGWVDLTSEKPHIVKKSIKYLEQGMQSNKDV *::*:****:**:*:**: * . :*. **:*******.*** .**:*:***** *..*** ENSP00000301819/1-1321 LGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRI ENSMUSP00000035100/1-1314 LGLMGKATYFMTQQNFSGALEVANQVTLACSNFLPALVLKMKLFLARQDWDQTIETGQRI ENSRNOP00000051323/1-1314 LGLMGKAKYFMTQQNFSGALEVVNQVTLAYSNFLPALVLKMKLFLARQDWEQTIETGQRI ENSCPOP00000012682/1-1305 LGLMGKATYLMMQQNYSGALDTVNQISLASGSFLPALILKMQLFLAQQDWEQMIETVHRI XP_004835293.1/1-1321 LGLMGKATYLMIQQNYSGALDVVNQISTASGSFLPALVLKMRLFLAQQDWEQTMETTHRI ******* *:* ***:* **:..**:: : ..*****:***:****:***:* :* :** ENSP00000301819/1-1321 LEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLK ENSMUSP00000035100/1-1314 LEKDENNIDAWQILAVHELVKEGNTDR--------AADRVRNLIKALETGEPHNPNLHLK ENSRNOP00000051323/1-1314 LEKDENNIDAWQILAVHELVKEGNTDR--------AADRVRNLIKALETGEPQNPNLHLK ENSCPOP00000012682/1-1305 LEKDDSNIDACQILAVHQLMREGNVTT--------ATDHVRNLIKALERREPQNPSLHLK XP_004835293.1/1-1321 LEKDESNIDACQILTVHELVREGNMTT--------ATDNVRNLIKALEMREPQNPSLQLK ****:.**** ***:**:* :*** *::.********* **.**.*:** ENSP00000301819/1-1321 KIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEA ENSMUSP00000035100/1-1314 KILVISRLCGRHQVVHRLVSGFLERIFMATPSCALVATELGYLFILHQQVKEACLWYKEA ENSRNOP00000051323/1-1314 KILAVSRLCGRHQVVHRLVSGFLERTFMATPSCALVATELGYLFILQQQVKEASLWYKEA ENSCPOP00000012682/1-1305 KVLVICRLCGRHRAILQLVSNFMERIFLAVPSCAQVATELGYLFILQNQEKEAALWYSKA XP_004835293.1/1-1321 KILVISRLCGRHRAILRLVSSFMERIFLAMPSCAQVATELGYLFILQNQEKEAALWYSEA *::.:.**** *:.: **..*:** *:* ** . ***********::* *** ***.:* ENSP00000301819/1-1321 MKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHK ENSMUSP00000035100/1-1314 MKLEENRLAALAGSIWCQILQGQLEEAAHQLEFLKEVQQSLGKSELLVFLQALVAAKKQR ENSRNOP00000051323/1-1314 MKLEENRLAALAGSIWCQILQGQLEEAAHQLEFLKEVQLSLGKSEVLVFLQALVAAKKQK ENSCPOP00000012682/1-1305 MKLGENSMAALAGTIWCHILKDELEEAEHQLEFLKEVQQSLGRSEVLVFLQALLASKKHK XP_004835293.1/1-1321 MKLGENSVAALTGTIWCHILKDELEEAEHQLEFLKEVQQSLGRSEVLVFLQALLASKKHK *** :: :*.*:* * *:**:..**** ::******** ***:**:*:*****: ::*:: ENSP00000301819/1-1321 GEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIV ENSMUSP00000035100/1-1314 LEQEATALLKEAVEVHFSSMQGLALSPEYFEKLDPLFLVCIAKEYLHFCPKQPRSPGQLV ENSRNOP00000051323/1-1314 LEQEATALLKEAVELHFSNMQGLALSPEYFEKLDPLFLVCIAKEYLHFCPKQPRSPGQLV ENSCPOP00000012682/1-1305 GEQEVTALLQEAAELHFSNVQGLPLSPQYLEKLDPPFLVCIAKEYLQFCPKQPRAPGQLV XP_004835293.1/1-1321 GEQEVTALLQEVVELHFSHLQGLPLSPEYLEKLDPPFLVCIAKEYLQFCPKQPRAPGQLV *:*.****:*..*:*** :**:.*..:*:***** ********** ******* ***:* ENSP00000301819/1-1321 SPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSGELENAQSILQRCLELDPASVDAHL ENSMUSP00000035100/1-1314 SPLLKQVAMILSPVVKVAPAMMEPLYVTAQVKFLSGELENAQSTLQRCLELDPTFVDAHL ENSRNOP00000051323/1-1314 SPLLKQVAMILSPVVKVAPAMMEPLFVTAQVKFLSGELENAQSTLQRCLELDPTFVDAHL ENSCPOP00000012682/1-1305 SPLLKQAALILNPVVKAAPALIDPLYVMGQVQYLSGELENAQSTVQRCLELDPTSTDAHL XP_004835293.1/1-1321 SPLLKQAAVILSPVVRAAPALPDPLYVMGQVKYLSGELENAQSTIQRCLELDPTSADAHL ******.*:**.***:.***: :**:: .**:: ********* :********: .**** ENSP00000301819/1-1321 LMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVI ENSMUSP00000035100/1-1314 LMSQIYLAQGNFAMCSHCLELGVSHNFQVRDHPLYHFIKARALNKTGDYAEAIKTLKMII ENSRNOP00000051323/1-1314 LMSQIYLAQGNFAMCSHCLELGVSHNFQVRDHPLYHFIKARALNKTGDYAEAIKTLKMII ENSCPOP00000012682/1-1305 LMAQIYLVQGNFAMCSHCLELGVSHNFQVRDHPLYHLIKARALNKSGDYQEAIKTLKMIM XP_004835293.1/1-1321 LLAQIYLAQGNFAMCSHCLELGVSHNFQVRDHPLYHFIKARALSKSGDYQEAIKTLKMIM *:.****.****.** ********************:******.*:*** ********:: ENSP00000301819/1-1321 KLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEE ENSMUSP00000035100/1-1314 KVPTSKAEEGRKSQSPSVRPSERASILLELVEALRLNGELHEATKIMQDAINEFSGTPEE ENSRNOP00000051323/1-1314 KVPTSKAEEGRKSRGPSVRPSERASILLELVEALRLNGELHEATKIMQDAINEFSGTPEE ENSCPOP00000012682/1-1305 KLPTLKAEEGRKTRRPFVQPSERVSILLELVSALRLNGELHEATKVMQDAIIEFSGTTEE XP_004835293.1/1-1321 KLPTLKTEESRKIRGPSVQPSERVSILLELVDALRLNGELHEATKVMQDTINEFSGTAEE *:*: * **.** * *:**:*.*******.*************:***:* **.**.** ENSP00000301819/1-1321 NRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYR ENSMUSP00000035100/1-1314 MRITVANVDLALSKGNVDLALNMLRGITPKQPCYTEAKEKMASIYLHTRKDVRLYIGCYV ENSRNOP00000051323/1-1314 MRITVANVDLALSKGNADLALNMLRGITPKQPCYTEAKEKMASIYLHTRKDVRLYIGCYM ENSCPOP00000012682/1-1305 ISITIANVDLALSKGNVDLALSMLKDITSKQPCYMEAKEKMASIYLQNRKDTYLYIGCYR XP_004835293.1/1-1321 IRITIANVDLALSKGNMDLALSMLRNITPKQPCYTEAKEKMASIYLHSRKDTCLYIGCYR **:*****.***** *:**.**:.* .**.** **:****.***:. :* *** ** ENSP00000301819/1-1321 ELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYT ENSMUSP00000035100/1-1314 ELCEHLPGPHSSLLLGDAFMNIQEPEKALEVYDEAYRKNPHDASLVSRIGQAYVKTHQYA ENSRNOP00000051323/1-1314 ELCEHLPGPHSSLLLGDAFMNIQEPEKALEVYDEAYRKNPHDASLVSRIGQAYVKTHQYA ENSCPOP00000012682/1-1305 ELCEHLPGPHTSLLLGDAFMKIQEPEKALEVYNEAYKKNPHDASLVSRIGQAYVKTHQYS XP_004835293.1/1-1321 ELCEHLPGPHTSLLLGDAFMNIQEPEKALEVYNEAYKKNPHDASLVSRIGQAYVKTHQYS **********:*******:*.* *********:***::*******.****:****:***: ENSP00000301819/1-1321 EAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDI--------VQDIP ENSMUSP00000035100/1-1314 KAINYYEAAQKISGQDFLCCELAELLLKLKKYHKAEKVLKQALERDS-------GVKDIP ENSRNOP00000051323/1-1314 KAINYYEAAQKISGQDFLCCELAELLLKLKKYHKAEKVLKQALERDS-------GVKDIP ENSCPOP00000012682/1-1305 KAINYYEAAQKISGQDSLCCDLAELLLKLKKFNKAEKVLKQALEHDF--------VKDIP XP_004835293.1/1-1321 KAINYYEAAQKISGLDFLCCDLAELLLKLKKFNKAEKVLKQALGHDSTNLSFLLAVKDIP :**:********.* * ***:*.:******* :********** :* *:*** ENSP00000301819/1-1321 SMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASI ENSMUSP00000035100/1-1314 SMINEVKCLLLLAKVYKSHKKEEVMETLNLALDLQSRILKRVPLEQSEMIPFQNQLAASI ENSRNOP00000051323/1-1314 SLMDEVKCLLLLAKVYKSHKKEDVMETLNQALDLQSRILKRVPLEQPEMIPSQNQVAASI ENSCPOP00000012682/1-1305 SMMNDVKCLLLLAKVYKSYKREEVSETLNKALNLQSRILKRVPLEQPEMLPSQKQLAASI XP_004835293.1/1-1321 SMMNDVKCLLLLAKVYKSYKKEEVLETLNKALNLQSRILKRVPLEQPEMLPSQKQLAASI *::::*************:*:* * **** **:*************.**:* *:*:**** ENSP00000301819/1-1321 CIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQ ENSMUSP00000035100/1-1314 CIQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLE ENSRNOP00000051323/1-1314 CVQIGEHHLADKDYDSAMKSYKDALAYSPTDSKVVLELAQLYLLQGQLDLCEQHCAPLLE ENSCPOP00000012682/1-1305 CMLFGEFYWAEKDYARAEQSYKEALSYSPIDNKVVLELARLSLLQGYLDSCEQHCTVLLQ XP_004835293.1/1-1321 CMLFGEFYSAEKDYAKAVQSYRDALSYSPTDNKVVLELAHLSLLQGYLDLSEQHCVILLQ *: :.*.: *:*:* * :**::.::* * *.**:****:* ** * ** .**:*. **: ENSP00000301819/1-1321 TEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIP ENSMUSP00000035100/1-1314 MEQTHERAAVMLADLMFRRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAP ENSRNOP00000051323/1-1314 MEQTHERAAVVLADLMFRKQNYETAINLYRQVLEKAPDNFLVLNKLIDLLRRSGKLEEAP ENSCPOP00000012682/1-1305 TDQTHESASVVMADLMFRKQNYDAAFNLYHQVLEKAPDNFLVLDKLIDLLRRSGTLEEAP XP_004835293.1/1-1321 TDQAHETASLMMADLMFRKQNYEAAINLYHQVLEKAPDNFSVLDKLIDLLRRSGKLDEAP :* ** *::::******:*::::*:***:********** **.**:*******.*:: * ENSP00000301819/1-1321 AFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQI ENSMUSP00000035100/1-1314 AFFELAKKVSSRVPLEPGFNYCQGIYFWHIGQPNEALRFLNKARKDSTWGQLATCYMVQI ENSRNOP00000051323/1-1314 AFFELAKKVSSRVPLEPGFNYCQGIYCWHIGQPNEALRFLNKARKDSTWGQLATCYMVQI ENSCPOP00000012682/1-1305 AFFQSAQKMSSRVPMEPGFNYCRGIYCWHIGQPNQALKFLNKARKDITWGQKANYYMVHI XP_004835293.1/1-1321 AFFQLVKKMSSRVSMEPGFNYCRGIYCWHIGQPNQALKFLNKARKDITWGQRANYYMVHI ***: .:*:****.:*******:*** *******:**:******** **** * :**:* ENSP00000301819/1-1321 CLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQG ENSMUSP00000035100/1-1314 CLNPDNEIVGGEAFESLVGDSNSASRKESQQHGVRTAEKLLREFYPHSESGQTQLRLLQN ENSRNOP00000051323/1-1314 CLNPDNEIVGGEAFESLVGDSNSASRKESQQHGVRTAEKLLREFYPHSESGQTQLRLLQS ENSCPOP00000012682/1-1305 CLNPDNELVGGEAFENQLTKS----KKESEQQGIRTAEKLLRDFYPLSASGQTQLRLLQS XP_004835293.1/1-1321 CLNPDNEIMGGEAFENQLTNTNSTARKESEQQGVRTAEKLLRDFYPLSVIGQTQQRLLQS *******::******. .: :** :*:*: *******:*** * .*** ****. ENSP00000301819/1-1321 LCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTP ENSMUSP00000035100/1-1314 LCLLATREKANVEVALGAFIEMAQAEKDSIPALLAMAQAYILLKQVPKARTQLKRLAKVP ENSRNOP00000051323/1-1314 LCLLATREKANIEVALGAFIEMAQAEKDNIPALLAMAQAYVLLKQVPKARTQLKRLAKVP ENSCPOP00000012682/1-1305 LCLLTTREKANVEAALGAFLEIAQAEKDSVPALLGMAQACVLLKQIPKARTQLKRLAKAP XP_004835293.1/1-1321 LCLLATREKANMEAALGAFLEIAQAEKDSIPALLGVSQACMLLKQVPKARTQLKRLAKVP ** *:******:*.***:*:::******.:****.::** ::***:**** *******.* ENSP00000301819/1-1321 WVLSEAEDLEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSY ENSMUSP00000035100/1-1314 WTVDEAEDLEKSWLLLADIYCQGGKFDLALELLRRCLQYNKSCCRAYEYMGFIMEKEQSY ENSRNOP00000051323/1-1314 WMLDEAEDLEKSWLLLADIYCQGGKFDLALELLRRCLQYNKSCCRAYEYMGFIMEKEQSY ENSCPOP00000012682/1-1305 WTLAEAEDLEKSWLLLADIYCSGGKFDLATELLRHCIQYNKSCYKAYEYMGFIMEKEQSY XP_004835293.1/1-1321 WTLVEAEDLERSWLLLADIYSSGGKFDLASELLRRCIQYNKSCYKAYEYMGFIMEKEQSY * : ******:*********..*.***** ****:*:****** :*************** ENSP00000301819/1-1321 KDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEIL ENSMUSP00000035100/1-1314 KDAATNYELAWKYSHQANPAIGFKLAFNYLKDKKFVDAIEVCHSVLTEHPKYPKIREEIL ENSRNOP00000051323/1-1314 KDAATNYELAWKYSHQANPAIGFKLAFNYLKDKKFVDAIEVCHSVLTEYPNYPKIREEIL ENSCPOP00000012682/1-1305 KDAATSYELAWKYSHQANPAIGFRLAFNYLKAKKFVEAIEVCHNVLREHPSYPKIREEIL XP_004835293.1/1-1321 KDAATNYELAWKYSHQANPAIGFRLAFNYLKDKKFVQAIEVCHNVLREHPSYPKIREEIL ***.*.*:*******:*******:******* ****:***:*:.** *:*.********* ENSP00000301819/1-1321 EKARRSLRP ENSMUSP00000035100/1-1314 EKAQGSLRP ENSRNOP00000051323/1-1314 EKAQGSLRP ENSCPOP00000012682/1-1305 EKAQKSLRP XP_004835293.1/1-1321 EKARRSLKP ***: **:*