CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000012584/1-1351 MAELSEPEGPVDWKERCVALESQLIKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAF ENSP00000282406/1-1493 MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAF XP_004839422.1/1-1345 MAVF-----PGFWR---------------------------------------------- ENSMUSP00000039628/1-1491 MEEPSEPEGLIDWKERCVALEAQLMKFRVQASKIRELLADKMQQLERQVIDAERQAEKAF ENSRNOP00000006832/1-1487 MEESSDPERPIDWKERCVALEAQLMKFRVQASKIRELLADKMQQLERQVIDAERQAERAF * *: ENSCPOP00000012584/1-1351 QQVQVMEEKLKTANIQTSESETRL-YKKCQDLESLIQEKDDIIQNLELQLEEQKQIRIQE ENSP00000282406/1-1493 QQVQVMEDKLKAANIQTSESETRL-YNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQE XP_004839422.1/1-1345 ----------------IAESEASLGYNK-------------------------------- ENSMUSP00000039628/1-1491 QEVQVMEEKLKAANIQTSESETRL-YKKCQDLESVMQEKDDIIQNLALRLEEQKQVRIQE ENSRNOP00000006832/1-1487 QEVQVMEEKLKAANIQTSESETRL-YKKCQDLESVMQEKDDLIQNLALRLEEQKQVRIKE :***: * *:* ENSCPOP00000012584/1-1351 AKIIEEKAAKIKEWVTIKLNELELDNQNLRLINQKQNEEIRAIQSKLQGFKDLNKREYLN ENSP00000282406/1-1493 AKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQG-KKSSTVS XP_004839422.1/1-1345 -------------------------------------------------VQG-KKLSAVS ENSMUSP00000039628/1-1491 AKIIEEKAAKIKEWVTVKLNELEVENQNLRFINQTQTEEIRAIQSKLQELQE-KKISCVS ENSRNOP00000006832/1-1487 AKTIEEKAAKIKEWVTVKLNELEVENQNLRFINQTQTEELRAIQSKLQELQE-KKVSCVS .: :* . :. ENSCPOP00000012584/1-1351 KPESCT-----QVNVG---------PERGRQKELSQQARDHGQWVPISIVDAMLVFSSNI ENSP00000282406/1-1493 TLKLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSV XP_004839422.1/1-1345 TPKLSEGQRLSSLTFGCFSSRARSPPQIVKYEEVSKLSPKEPEFTEGKDIEEVEILEKSA ENSMUSP00000039628/1-1491 SPKTSEGQR--NLTFGCFLSRAKSPPCVVRCEEVSKMASNEPEITEGRCVEEMEIAEKPA ENSRNOP00000006832/1-1487 SPKPSEGQRLSSLTFGCFLSRAKSPPCAVRSEEASKMASSEPEFAEARCVEEMEIAEKPA . : . .:..* * : :* *: : .. : . :: : : .. ENSCPOP00000012584/1-1351 ------------VLH---------------------------LPV--------------- ENSP00000282406/1-1493 DNQVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRS XP_004839422.1/1-1345 DNQVQESDRGPRTLHQAPCSSEQNRKTRTSCATDGGTSQNSGAPVSDWSSDEEDESKERP ENSMUSP00000039628/1-1491 DNQVQENSRSQRKLHETSCSSEQNQKTRASFAMDGGTSQNSGVPVSDWSSDEDDGSKGRS ENSRNOP00000006832/1-1487 DNQVQENSRSQRKLLETSCGSEHNRKTGASFVADGGTPEHSGLPVSDWSSDDDDGSKGRS * ** ENSCPOP00000012584/1-1351 -------------------------------------FLKDYRGLIKP------------ ENSP00000282406/1-1493 KSRCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEA XP_004839422.1/1-1345 KSRCTSTLSSHTSEEGVQCGRLGSEAYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEA ENSMUSP00000039628/1-1491 KSRCTSTLSSHTSEEGGQCGRLGSEAYLTASDDSSSIFEEETFDGNRPEQKKLCSWQQKA ENSRNOP00000006832/1-1487 KSRCTSTLSSHTSEEGGQCGRPGSEAYLTASDDSSSIFEEETFDANRPQHKKLYSWQQKA * :: . :* ENSCPOP00000012584/1-1351 ---------------------GISLEVFKVVYHMQLYGSVTALCFIEANTPSPILSPALV ENSP00000282406/1-1493 QWKALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRLDYSSSSS--EANTPSPILTPALM XP_004839422.1/1-1345 QWKAQNSLLGKGSCESSKNEYDSSSDELKKRFQSQRLDYSSSSS--EANTPSPILTPALT ENSMUSP00000039628/1-1491 PWKAQGN-LAKGRSQSGVKEQDSSSDELNKKFHSQRLDYTSSSS--EANTPSPILTPALT ENSRNOP00000006832/1-1487 PWKAPSN-LAKGSSQSEVKQRDSSSDELNKKFQSQRLDYSSSSS--EANTPSPILTPALT . * : :: :: * . :: . *********:*** ENSCPOP00000012584/1-1351 PKHPNLLPGK-RTPLAPSARLPPPRLRIPNAFSKSVALAKRHLSQPQLSSDRMFGTNRNA ENSP00000282406/1-1493 PKHPNSLSGK-GTQLVPSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNA XP_004839422.1/1-1345 PKHPNSLPGK-GTSLVPSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNA ENSMUSP00000039628/1-1491 PRYPNSLPGKGGAPLVPPPFQPPPKLRVPNVFSISVALTKRHLSQPQLCSDRMFGTNRNA ENSRNOP00000006832/1-1487 PKHPNSLPGK-GTPLVPPPFLPPPKLRIPNVFSISVALTKRHLSQPQLCSDRMFGMNRNA *::** *.** : *.*.. ***:**:**.** ****:*********.****** **** ENSCPOP00000012584/1-1351 ISMIRPLKPQETDLDLIDCDG-EVLENMDTSCDDGLFSCVSLE-SPYADDQEPGDSAKKA ENSP00000282406/1-1493 ISMIRPLRPQETDLDLVDGDSTEVLENMDTSCDDGLFSYDSLD-SPNSDDQEHCDSAKKV XP_004839422.1/1-1345 ISMIRPLRPQETDLDLVDGDS-EILDNMDTSCDDGLFSYDSLE-SPYSDDQEICDSAKKA ENSMUSP00000039628/1-1491 ISMIRPLRPQETDLDVVDGDGAEAVNRMDTGCDDGLFSYDSQDPPPCADDQENSEAPKKA ENSRNOP00000006832/1-1487 ISMIRPLRPQETDLDMVDGDRAEAVDIMDTGCGD-LFSYDSQD-PPSAEDPENSEATKKA *******:*******::* * * :: ***.*.* *** * : .* ::* * ::.**. ENSCPOP00000012584/1-1351 AASKPPTPPLHRFPSWESRIYAVAKSGIRMSEACNMEN---DSATMLSNSTSGLYTSLIY ENSP00000282406/1-1493 AYSKPPTPPLHRFPSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIY XP_004839422.1/1-1345 ASSKPPTPPLHRFPSWEGRIYAVAKSGIQMSEAFNMENVNKNSATMLSYTTSGLYTSLIY ENSMUSP00000039628/1-1491 PCNKPPTPPLHRFPSWESRIYAVAKSGIRVSEAFNMEHANKNSADILSYSAASLYTSLIY ENSRNOP00000006832/1-1487 SCSKPPTPPLHRFPSWESRIYAVAKSGIRVSEAFNMENANKNAASLLSHSVAGPYMSLIY . .**************.**********::*** *** ::* ** :.:. * **** ENSCPOP00000012584/1-1351 KNLTTPVYTTLKGKATQISSNAFQDDDS-SEEEDGSRCSLQT-SELEPRRRSGPGSPRPL ENSP00000282406/1-1493 KNMTTPVYTTLKGKATQISSSPFLDDSSGSEEEDSSRSSSRT-SESDSRSRSGPGSPRAM XP_004839422.1/1-1345 KNLTTPVYTTLKGKATQISSSPFQDDSSGSEDEDSSRCSSRT-SESDPRSRSGPGSPRAL ENSMUSP00000039628/1-1491 KNMTTPVYTTLKGKATQISSSPFLDDSSGSDEEDSSRSSSRL-SESDARSRSGPSSPRAM ENSRNOP00000006832/1-1487 KNVTTPVYTTLKGKATQISTSPFLDDSSGSDEEDGSRASSRSQSESETRSRSGPNSPRAM **:****************:..* **.* *::**.**.* : ** :.* ****.***.: ENSCPOP00000012584/1-1351 KRGVSLTSVASENDYAIPPDAYSTDTECAQPEQKLPKTCSSSSENG--EPLEKSGYLLKM ENSP00000282406/1-1493 KRGVSLSSVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNEPLEKSGYLLKM XP_004839422.1/1-1345 KRGVSLTSVASESDYAIPPDAYSTDTECSQPEQKLPKTCSSSSDNGKNEPLEKSGYLLKM ENSMUSP00000039628/1-1491 KRGVSDSSAASESDYAIPPDAYPIDAECSQPEQKLLKTCLASCDNGKNEPLEKSGYLLKM ENSRNOP00000006832/1-1487 KRGVSDS---SEGDYAIPPDAYSIDTECSQPEQKLLKTCSTSSDNGKSELLEKSGYLLKM ***** : **.*********. *:* :****** *** :*.:** * ********** ENSCPOP00000012584/1-1351 SGKVKTWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSIVRGDNKQTVQLMTEKH ENSP00000282406/1-1493 SGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKH XP_004839422.1/1-1345 SSKVKTWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKH ENSMUSP00000039628/1-1491 SVRVKTWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLATEKH ENSRNOP00000006832/1-1487 SGRLKTWRRRWFVLKGGELLYYRSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKH * ::*:*:**************:*********************:********** **** ENSCPOP00000012584/1-1351 TYYLSADLPMLSRTLPRVLGTFV-LLTGYPADRRGGIKNGISGWYTFVKHGYSKRVWCIL ENSP00000282406/1-1493 TYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTKVKHGYSKRVWCTL XP_004839422.1/1-1345 TYYLTADSPNILEEWIKVLQNVLRVQAANPLFLQPEGKPTVKGLLTKVKHGYSKRVWCTL ENSMUSP00000039628/1-1491 TYYLTADSPNILEEWIKVLQSVLRVQAANPLCLQPEGKPAVKGLLTKVKHGYSKRVWCML ENSRNOP00000006832/1-1487 TYYLTADSPNILEEWIKVFQNVLRVQAANPLCLQPEGKPTVKGLLTKVKHGYSKEVWCTL ****:** * : . :*: ..: : :. * : * :.* * *******.*** * ENSCPOP00000012584/1-1351 IGKMLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTVVVHPKD ENSP00000282406/1-1493 IGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKD XP_004839422.1/1-1345 IGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHHTIVVHPKD ENSMUSP00000039628/1-1491 VGKVLYYFRNQEDKFPLGQLKLWEAKVEEVDRSCDSDEDYETRGCYLLSTHYTIIVHPKD ENSRNOP00000006832/1-1487 VGKCLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYETSGRCLLSTHYTIIVHPKD :** *****.*********:*********************: * *****:*:::**** ENSCPOP00000012584/1-1351 QGPTYLLIGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIEGEPSSQIWRHPTL ENSP00000282406/1-1493 QGPTYLLIGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTL XP_004839422.1/1-1345 QGPTYLLIGSKYEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIEGEPSSQIWRHPTL ENSMUSP00000039628/1-1491 QGPTYLLIGSKHEKEAWLYHLTVAAGSNNINVGSEFEQLVCKLLNIEGEPSSQIWRHPML ENSRNOP00000006832/1-1487 QGPTYLLIGSKHEKEAWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIEGEPSSQIWRHPML ***********:**::*************:****************:*********** * ENSCPOP00000012584/1-1351 CHSKEGILSPLTSLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTH ENSP00000282406/1-1493 CHSKEGIISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTH XP_004839422.1/1-1345 CHSKEGILFPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTH ENSMUSP00000039628/1-1491 CHSKEGILSPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQVCLTH ENSRNOP00000006832/1-1487 CHSKEGILCPLTSLPSEALQTEAIKLFKTCQLFINAVVDSPAIDYHISLAQSALQVCLTH *******: ***:***********************.******************:**** ENSCPOP00000012584/1-1351 PELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADS ENSP00000282406/1-1493 PELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADS XP_004839422.1/1-1345 PELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADS ENSMUSP00000039628/1-1491 PELQNEICCQLIKQTRRRQLQNQPGPLQGWQLLALCVGLFLPHHPFLWLLQLHLQRNADS ENSRNOP00000006832/1-1487 PELQSEICCQLIKQTRRRQQQNQAGPLQGWQLLALCVGLFLPHHPFLWLLQVHLQRSADS ****.************** ***.**************************::**:*.*** ENSCPOP00000012584/1-1351 RTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGLYQ ENSP00000282406/1-1493 RTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQ XP_004839422.1/1-1345 RTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGLYQ ENSMUSP00000039628/1-1491 RTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSRPFSIPVHFMNGLYQ ENSRNOP00000006832/1-1487 RTEFGKYAIYCQRCVERTLQNGDREARPSRMEILSTLLRNPYHHSRPFSIPVHFMNGIYQ ****************** ************************** ***********:** ENSCPOP00000012584/1-1351 VVGFDASTTVEEFLNTLNQDTGMRKPVLSGFALFTDDPAGRDLEHCLQGNIKICDIISKW ENSP00000282406/1-1493 VVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKW XP_004839422.1/1-1345 VVGFDASTTVEEFLNTLNQDTGMRKPALSGFALFTDDPSGRDLEHCLQGNIKICDIISKW ENSMUSP00000039628/1-1491 VVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKW ENSRNOP00000006832/1-1487 VVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKW **************************. **********:********************* ENSCPOP00000012584/1-1351 EQASKEQQPGKCEGTRTVRLTYKNSRLYFSMQAHGETDREKLLLMYQTNEQIINGLFPLN ENSP00000282406/1-1493 EQASKEQQPGKCEGTRTVRLTYKN-RLYFSVQARGETDREKLLLMYQTNDQIINGLFPLN XP_004839422.1/1-1345 EQASKEQQPGKCEGTRTVRLTYKS-RLYFSMQTYGETDREKLLLMYQTNEQIINGLFPLN ENSMUSP00000039628/1-1491 EQASKEQQPGKCEGSRTVRLTYKN-RLYFSVQARGETDREKTLLLYQTNDQIINGLFPLN ENSRNOP00000006832/1-1487 EQASKELQPGKCEGSRTVRLTYKN-RLYFSMQARGETDREKLLLLYQTNEQIINGLFPLN ****** *******:********. *****:*: ******* **:****:********** ENSCPOP00000012584/1-1351 KDLAVEMAALLAQVEIGDFERPFSTPEGHVTNQCKANQTLKQVIEKFYPKRYRDSFTEEQ ENSP00000282406/1-1493 KDLALEMAALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQ XP_004839422.1/1-1345 KDLALEMAALLAQVEIGDFERPFSTPAGHVTNQCKANQTLKQVIEKFYPKSYRDSCTEEQ ENSMUSP00000039628/1-1491 KDLALEMAALLAQVDIGDFERPFSTPAGPVTNQCKANQTLKQVIERFYPKRYREGCSEEQ ENSRNOP00000006832/1-1487 KDLALEMAALLAQVDIGDFERPFSTPAGHVTNQCKANQTLKQVVEKFYPKRYREGCSEEQ ****:******:**:*********** * ******.*******:*:**** **:. :*** ENSCPOP00000012584/1-1351 LRQLYQRLSTRWMALRGRSGVDCVRIYLTVARKWPFFGAKLFFAKPITPPSLGNAFMWLA ENSP00000282406/1-1493 LRQLCQRLSTRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLA XP_004839422.1/1-1345 LRQLYQRLSTRWMALRGRSAADCVRIYLTVARKWPFFGAKLFFAKPITPLSLGNTVIWLA ENSMUSP00000039628/1-1491 LRQLYQRLSTKWMALRGHSAADCIRIYLTVARKWPFFGAKLFFAKPIAPSSLGNNCVWLA ENSRNOP00000006832/1-1487 LRQLYQRLSTRWMALRGHSTTDCIRIYLTVARKWPFFGAKLFLAKPSVSGALRSNV-YLI **** *****:******:* .**:******************:*** .. :* . :* ENSCPOP00000012584/1-1351 INENGLSILEFNSMRLLISYAYKNLMTFGGYQDDFMVVINNLHSKDKPTEKLLFAMAKPK ENSP00000282406/1-1493 VHEDGLSLLEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKDKPTEKLLFAMAKPK XP_004839422.1/1-1345 INENGLSILEFNSMRLLVSYAHRSLTTFGGYQDDFMVVINNSHSKDKPTEKLLFTMAKPK ENSMUSP00000039628/1-1491 VHENGLSILEYTSMRLVTSYMYKGLMTFGGYQEDFMVVV-STQSKDRPTEKLLFAMAKHK ENSRNOP00000006832/1-1487 VYGTINSSLLFSLKRLVTGYVYKSVMTFGGYQEDFMVVI-STQAKDRPTEKLLFAMAKPK : * * :. **: .* ::.: ******:*****: . ::**:*******:*** * ENSCPOP00000012584/1-1351 ILEITLLIASYINNFHQQKAAFHHLSAPALLSVKPQEPQARAKGSQHLLPSSRPTKGPTL ENSP00000282406/1-1493 ILEITLLIASYINNFHQQKAAFHHLSAPALLSAQTRGPQARMMGSQPLLSSSRPTKGPTL XP_004839422.1/1-1345 ILEITLLIASYINNFHQQKAAFHHLSAPALLSIKAQEPQARVMGSQPLLSSSRPTKGPTL ENSMUSP00000039628/1-1491 ILEITLLIASYINSFHQQKTTFHHLSAPALLSPRTQAPQARVMGSQPPLSNSRPTKGPTL ENSRNOP00000006832/1-1487 ILEITLLIASYINNFYQQKAAFHHLSAPALLSAKVQEPQAKAMGSQPLLSNNRPTKGPTL *************.*:***::*********** : : ***: *** *...******** ENSCPOP00000012584/1-1351 L ENSP00000282406/1-1493 L XP_004839422.1/1-1345 L ENSMUSP00000039628/1-1491 L ENSRNOP00000006832/1-1487 L *