CLUSTAL W(1.81) multiple sequence alignment ENSRNOP00000043911/1-958 MAPKRQSAILPQPETQTRCCPEAGGQVGLSRPAEGSTFLVLRSDSGFRASVHFSLSSVDR ENSMUSP00000041025/1-878 ---------------MEHRKPGTG-----QRAPKDEKEMVRR--------------AIQK ENSP00000291906/1-889 ------------MEEGAPRQPGPS-----QWPPEDEKEVIRR--------------AIQK ENSCPOP00000012472/1-877 -----------------------------QRPLEDEKEVIRR--------------AIQK XP_004849246.1/1-880 ------------MEEGARRQAGPG-----PRPLEDEKEVIRR--------------AIQK . :... :: * :::: ENSRNOP00000043911/1-958 EVCVSYAQLRVVVWCFPRGLLGSVCFLHSSCEVHNPISGMPRGSSVEQALGSMLAVVTST ENSMUSP00000041025/1-878 EL-----------------------------KIKEGMENMRRVATDRRHLGHVQQLLRAS ENSP00000291906/1-889 EL-----------------------------KIKEGVENLRRVATDRRHLGHVQQLLRSS ENSCPOP00000012472/1-877 EL-----------------------------KIKEGMENLRRAATDRRHVGHIQQLLQSC XP_004849246.1/1-880 EL-----------------------------KIKEGMENLRSVATDRRHLGHVQQLLQSS *: :::: :..: :: .: :* : :: : ENSRNOP00000043911/1-958 NPWIRRCMCWRSLCLGAVRFLSGVFSESVQKSCTAVYDDQSSRMGWKKKEQQEAIEHIDE ENSMUSP00000041025/1-878 N------------------------------------------------------RRLEQ ENSP00000291906/1-889 N------------------------------------------------------RRLEQ ENSCPOP00000012472/1-877 N------------------------------------------------------RRLEQ XP_004849246.1/1-880 N------------------------------------------------------RRLEQ * .:::: ENSRNOP00000043911/1-958 VQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLG ENSMUSP00000041025/1-878 LHGELRELHAQV-------------LLPASA----EPVTSEPQPRAEQ----------SR ENSP00000291906/1-889 LHGELRELHARI-------------LLPGPGPGPAEPVASGPRPWAEQ----------LR ENSCPOP00000012472/1-877 LHGQLRELHTRV-------------LLPSPAVRCTEPVASGPWPRAEQ----------SK XP_004849246.1/1-880 LHSELRELHARI-------------LLPGLA----EPVASGPRLRAEQ----------SK ::.:: .*: : * * ::. * . ENSRNOP00000043911/1-958 EEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKETG ENSMUSP00000041025/1-878 ARLSEALHRQLQVEL----KVKQG------------AENMI-----HTCASGTP------ ENSP00000291906/1-889 ARHLEALRRQLHVEL----KVKQG------------AENMT-----HTCASGTP------ ENSCPOP00000012472/1-877 ARHLEALQKQLQVEL----KVKQG------------AENMT-----HTCAFGTP------ XP_004849246.1/1-880 ARHLEALRRQLQVEL----KVKQG------------AENMT-----HTYASGTP------ . ***: :**: .:*.* ** * * * ENSRNOP00000043911/1-958 ARHRQGRERKLLAAAQQMLKDSQLKVALLRMKISGLEASGSPE--------PGPDLLAEE ENSMUSP00000041025/1-878 ------KERKLLAAAQQMLKDSQLKVALLRMKISSLESSGSPE--------PGPDLLAEE ENSP00000291906/1-889 ------KERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPE--------PGPELLAEE ENSCPOP00000012472/1-877 ------KERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGLSVPRTPGPELLAEE XP_004849246.1/1-880 ------KERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPE--------PGPELLAEE :************:**************.**:***** ***:***** ENSRNOP00000043911/1-958 LQHRLRIEAAVAAGAKNVVKLLGGQRIQDRKALAEAQAQLQESSQKLDLLRLALELLLER ENSMUSP00000041025/1-878 LQHRLRVEAAVAAGAKNVVKLLGGQRMQDRKALAEAQAQLQESSQKLDLLRLALELLLER ENSP00000291906/1-889 LQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQ ENSCPOP00000012472/1-877 LRHRLHIEAAVAEGAKNVVKLLGGRRMQDRKALAEAQAQLQESLQKLDLLQLALERLLEG XP_004849246.1/1-880 LQHRLHIEAAVAEGAKNVVKLLGGRRTQDRKALAEAQAQLQESSQKLDLLRLALDQLLES *:***::***** *********..:* **************** ******:***: *** ENSRNOP00000043911/1-958 LPPTHSLRSRVTRELRMAMLGNPQPLGTLVKPIALTG----------------------- ENSMUSP00000041025/1-878 LPPTHSLRSRVTQELWMAMLGNPQPLGTLVKPIALTGTLQVRLLGCKDLLVAVPGRSPMA ENSP00000291906/1-889 LPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAA ENSCPOP00000012472/1-877 LPPSHPLHSRVARELRMATLGNPQPSGTLVKPTALTGTLQVHLLGCEQPLAAVPGRSPVA XP_004849246.1/1-880 LPPAHPLRGRVARKLRVAVLGNTQPAGTLVKPTALTGTLQVHLLGCEKPLAVVPGRSPVA ***:*.*:.**:::* * * .** ** *** **** ENSRNOP00000043911/1-958 --------------------------EVLAVLKVDNRVVGQTGWGLVAEKSWDQAFSISL ENSMUSP00000041025/1-878 VLAGSPSESWLRTRSRQQRGGGELASEVLAVLKVDNRVVGQTGWGLVAEKSWDQSFIISL ENSP00000291906/1-889 ALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPL ENSCPOP00000012472/1-877 ALASSPSEGWLRARARQQRGRGELASEVLAVLKVDNRVVGQTGWGQVAERCWDQTFAIPL XP_004849246.1/1-880 ALAGSPSEGWLWARARQQRSGGELSSELLAVLKVDNRAVGQTGWGQVAERCWDQTFAIPL *:*********.******* ***:.***:* *.* ENSRNOP00000043911/1-958 DR------------------------------------------------VTFCEPVIER ENSMUSP00000041025/1-878 DRARELEIGVHWRDWRQLCGVAFLKLEDFLDNACHQLSLSLVPQGRLFAQVTFCEPVIER ENSP00000291906/1-889 ERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIER ENSCPOP00000012472/1-877 EHARELEVGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLMPQGRLFVQVTFCDPVPER XP_004849246.1/1-880 ERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGRLFVQVTFCDPVLER :: ****:** ** ENSRNOP00000043911/1-958 RPRLQRQRRVFSKRRGQDFLRASQMNLSMTAWGRLVMSLLPPCSSPSTVSPPKGCPSAAA ENSMUSP00000041025/1-878 RPRLQRQRCIFSKRRGRDFMRASQMNLSMAAWGRLVMSLLPPCSSPNTASPPKGRPSTAV ENSP00000291906/1-889 RPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPT ENSCPOP00000012472/1-877 RPRLQRQKRIFSKQRGQDFLRASQMNLSMAAWGRLVMSLLPPCSSPSTISPRKECPQTSA XP_004849246.1/1-880 RPRLQRQKRVFSKRRGQDFLRASQMNLSMAAWGRLVMSLLPPCSSPSTTSPPKGCSQTPT *******. :***:**:**:*******.*:*******.********.* ** * . :.. ENSRNOP00000043911/1-958 C--ETSSSASPSMVMRLPAPCDWAQTFPSYSNFRPVKTLPGEDMKPPPKPPRLYL-QEPA ENSMUSP00000041025/1-878 C--GTPSAASP-------------------SNFLPMKTLSKEDTKPPPKPPRLYL-QEPA ENSP00000291906/1-889 TLREASDPATP-------------------SNFLPKKTPLGEEMTPPPKPPRLYLPQEPT ENSCPOP00000012472/1-877 TPYGTTKPASP--------------------CHLPKKTPTGQELQPPPKPPRLFLPQEPV XP_004849246.1/1-880 APRGAFEPPSP--------------------STLPKKTPLGEEIQPPPKPPRLFLAQE-- : ...:* * ** :: ********:* ** ENSRNOP00000043911/1-958 P-GTPCTKRPHMDPRTGVAPPLAALSTRNPPQLQDFRCLAVLGRGHFGKVLLVQYKGTGK ENSMUSP00000041025/1-878 P-GTPCTKRPHMDPRPAVVPALAALSTRKPPRLQDFRCLAVLGRGHFGKVLLVQYKGTGK ENSP00000291906/1-889 SEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGK ENSCPOP00000012472/1-877 PEETPCNKRPHMEPRTRQAPALVAS----PARLQDFHCLAVLGRGHFGKVLLVQFKGTGK XP_004849246.1/1-880 --ETPRTKRPHMEPRPGLVPAPPPSPARRPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGK ** .*****:**. *. . *.:****:*****************:***** ENSRNOP00000043911/1-958 YYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACIQTSSHACFVTEFLP ENSMUSP00000041025/1-878 YYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHACFVTEFLP ENSP00000291906/1-889 YYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVP ENSCPOP00000012472/1-877 YYAIKALKKQEVLSRDEVESLYCEKRILEAVGRTGHPFLLSLLACFQTSSHTCFVTEFVQ XP_004849246.1/1-880 YYAIKALKKQEVLSRDEVESLYCEKRILEAVGRTGHPFLLSLLACFHTSSHACFVTEFVQ *************.***::**********:** ************::****:******: ENSRNOP00000043911/1-958 GGDLMMQIHEDVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADF ENSMUSP00000041025/1-878 GGDLMAQIHEDVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLKIADF ENSP00000291906/1-889 GGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADF ENSCPOP00000012472/1-877 GGDLMMQIHEDVFPEPQACFYLACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADF XP_004849246.1/1-880 GGDLMMQIHEDVFPEPQARFYLACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADF ***** ************ **:*************:************************ ENSRNOP00000043911/1-958 GLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLV------GDT ENSMUSP00000041025/1-878 GLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDT ENSP00000291906/1-889 GLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDT ENSCPOP00000012472/1-877 GLCKEGIGFGDRTSTFCGTPEFLAPEVLTQETYTRAVDWWGLGVLLYEMLVGECPFPGDT XP_004849246.1/1-880 GLCKEGIGFGDRTSTFCGTPEFLAPEVLTQETYTRAVDWWGLGVLLYEMLVGECPFPGDT *******************************:******************* *** ENSRNOP00000043911/1-958 EDEVFECIVNADVPCPHFLSAQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFR---- ENSMUSP00000041025/1-878 EEEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFRTTNW ENSP00000291906/1-889 EEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNW ENSCPOP00000012472/1-877 EEEVFDCIVNTDALYPHFLSAQALELIQKLLQKCPEQRLGAGQQDAEEIKVQPFFRATDW XP_004849246.1/1-880 EEEVFDCIVNTDAPYPHFLSVQALELIQKLLQKCPEQRLGAGDQDAEEIKAQPFFRVTDW *:***:***. *. * ***.*.**:*******.**:*****::******.***** ENSRNOP00000043911/1-958 ---------PPFVPTLCGPADLRYFEGEFTSLPPTLTPPVPRRSLSARQQAAFRDFDFVS ENSMUSP00000041025/1-878 QALLARTVQPPFVPTLCGPADLRYFEGEFTSLPPTLTPPVSQSSLTARQQAAFRDFDFVS ENSP00000291906/1-889 QALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVS ENSCPOP00000012472/1-877 QALLARAVQPPFVPILCGPADLRYFEGEFTGLPPALTPPGPRSPLSARQQAAFQDFDFVS XP_004849246.1/1-880 QALLARAVQPPFVPTLCGPADLRYFEGEFTGLLPALTPPGPRSPLSAHQQAAFQDFDFVS ***** ***************.* *:**** .: *:*:*****:****** ENSRNOP00000043911/1-958 KRFLES ENSMUSP00000041025/1-878 EQFLES ENSP00000291906/1-889 ERFLEP ENSCPOP00000012472/1-877 ECF--- XP_004849246.1/1-880 ERFLQP : *