CLUSTAL W(1.81) multiple sequence alignment ENSP00000351596/1-1564 MSSKEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQ ENSCPOP00000012376/1-1563 MSSKEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQ XP_004841750.1/1-1564 MSSKEVKAALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQ ENSMUSP00000089045/1-1563 MSSKEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQ ENSRNOP00000058722/1-1403 MSSKEVKTALKSARDAIRNKEYKEVLKHCKTVLKQEKDNYNAWVFIGVAAAELGQPDQAQ *******:****************.************:*************** ****** ENSP00000351596/1-1564 SAYKKAAELEPDQLLAWQGLANLYEKYNHINAKDDLPGVYQKLLDLYESVDKQKWCDVCK ENSCPOP00000012376/1-1563 GAYKKAVELEPDQLLAWQGLASLYEKCSQMNAKDDLPGVYQKLLDLYESVDKQKWCDVCK XP_004841750.1/1-1564 GAYKKAVELDPDQLLAWQGLASLYEKCNHMNAKDDLPGVYQKLLDLYESVDKQKWCDVCK ENSMUSP00000089045/1-1563 GAYKKAAELEPEQLLAWQGLASLYEKCNQVNAKDDLPGVYQKLLDLYESADRQKWCDVCK ENSRNOP00000058722/1-1403 GAYKKAAELEPEQLLAWQGLASLYEKCNHINAKDDLPGVYRKLLDLYESVDKQKWCDVCK .*****.**:*:*********.**** .::**********:********.*:******** ENSP00000351596/1-1564 KLVDLYYQEKKHLEVARTWHKLIKTRQEQGAENEELHQLWRKLTQFLAESTEDQNNETQQ ENSCPOP00000012376/1-1563 KLVDLYHQEKKHLEVARTWHKLIKTRQEEGADKQELYQLWRKLTQLLAESIEDQNNETQQ XP_004841750.1/1-1564 KLVDLYHQEKKHLEVARTWHRLIKTRQEEGADDQELHQLWRKLTQLLAESTEYQNNETQQ ENSMUSP00000089045/1-1563 KLVALYHQEKKHLEVARTWHRLIKTRQEDGADRQELYELWRKLSQLLAENIEDQNNETQQ ENSRNOP00000058722/1-1403 KLVDLYHQEKKHLEVARTWYRLIKARQEDGADRQELYELWRKLSQLLSEDAEDQNDETQQ *** **:************::***:***:**: :**::*****:*:*:*. * **:**** ENSP00000351596/1-1564 LLFTAFENALGLSDKIPSEDHQVLYRHFIQSLSKFPHESARLKKACEGMINIYPTVQYPL ENSCPOP00000012376/1-1563 LLLTAFENALGLSDQIPSEDHQQLYRHFIQCLSKFPHETARLKKACEGMINTYPTVHYPL XP_004841750.1/1-1564 LLLTAFENALGLSDQIPSEDHQLLYRHFIQCLSKFPHEAARLKKACEGMINIYPTVQYPL ENSMUSP00000089045/1-1563 MLLTAFENALDLADNIPSEDHQVLYRNFIQCLSKFPHETTKLKKACEEMIAIYPTVQYPL ENSRNOP00000058722/1-1403 MLLTAFENALDLADNVPSEDHQVLYRNFIQYLSKFPHEMTRLKKACEGMITMYPAVQYPL :*:*******.*:*::****** ***:*** ******* ::****** ** **:*:*** ENSP00000351596/1-1564 EVLCLHLIESGNLTDEGQQYCCRLVEMDSKSGPGLIGLGIKALQDKKYEDAVRNLTEGLK ENSCPOP00000012376/1-1563 EVLCLHLIESGNITDEGQQYFCKLLEMNSKSGPALIGIGIKALQDKKYEDAVRSLTEGLE XP_004841750.1/1-1564 EVLCLHLIESGYVTDEGQQYFYKLVEMNSKSGPGLIGIGIKALQDKKYEEAVRNLTEGLK ENSMUSP00000089045/1-1563 EVICLYLIDSGSLTSEGHQYCCKLVEMNSKSGPGLIGLGIIALQDKKYEDAVRHLTEGLK ENSRNOP00000058722/1-1403 EVICLYLIDSGSLTDEGHQYCYKLVEMNSKSGPGLIGLGIRALQDKKYEDAISHLTEGLK **:**:**:** :*.**:** :*:**:*****.***:** ********:*: *****: ENSP00000351596/1-1564 ESPVCTSGWYHLAEAQVKMHRPKEAVLSCSQALKIVDNLGASGNSLYQRNLCLHLKAEAL ENSCPOP00000012376/1-1563 ARPLCTHGWYHLAKAQIKMHRPKEAVLSCNQALKNIDDAGVPGSSLRQKNPCLCLKAEAL XP_004841750.1/1-1564 ESPLCTNGWYHLAEVQVKMHRPKEAVLSCNQALKNIDNPGVPGGSLQQKNSCLCLKAEAL ENSMUSP00000089045/1-1563 ESPVCIAGWCHLAEAQVKMHRPKEAILSCNQALKTIDNFGASGGNLHQKNLCLRLKAEAL ENSRNOP00000058722/1-1403 ESPLCIAGWCHLAEVQVKVHRPKEAILSCNRALKTIDNLGASGGSLHQKNLCLRLKAEAL *:* ** ***:.*:*:******:***.:*** :*: *..*..* *:* ** ****** ENSP00000351596/1-1564 IKLSDYDSSEEAIRTLDQISDADNIPGLLVLKSLAYRNKGSFDEAAKIMEDLLSSYPDLA ENSCPOP00000012376/1-1563 IKLSDSESSEEAIRTLDQVSDANNIPGLLVLKSLAYLNKGSLDEATKIMEDLLLSHPNLA XP_004841750.1/1-1564 IKLSDSESSEEAIRILDQVSDANNVPGLLVLQSLAYLNKGSLDDATKIMEDLLLSHPNLA ENSMUSP00000089045/1-1563 LKLSDGASSEEAVRTLDQVSDVDNTPGLLVLQGLACLNTGAVDKATKIMEDLVTSYPDLA ENSRNOP00000058722/1-1403 LKLSDCASLEEAVHILDQLSDTDNTPGLLVLQGLACLNTGAIDKATKIMEDLVASYPDLS :**** * ***:: ***:**.:* ******:.** *.*:.*.*:******: *:*:*: ENSP00000351596/1-1564 EVHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGEETRKDKTKALT ENSCPOP00000012376/1-1563 EAHALEALIHFAKKDYLQAEKCLQIAIEKDAEVAEYHYQLGLTYWLMGEETRKDKGKALT XP_004841750.1/1-1564 AAHALEALIHLTKKDYLQAEKCFQRAIEKDADVAEYHYQLGLTYWFMGEETRKDKTKALT ENSMUSP00000089045/1-1563 EAHALEGRVHFTKKDYVQAEVSFQRALEKDAEVAEYHYQLGLTYWFMGEETRKDKTKALT ENSRNOP00000058722/1-1403 EAHALEAYVHFTKKDYVQAETSFQRALEKDAEVAEYHYQLGLTYWLMGEETRKDRTKALN .****. :*::****:*** .:* *:***::*************:********: ***. ENSP00000351596/1-1564 HFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGCYRKAFELDDTDAESGAAAVDLSVE ENSCPOP00000012376/1-1563 HFLKAARLDTYMGKVFCYLGHYYKDVAGDKNRARGCYRKAFELDDTDTESGAAAVDLSVE XP_004841750.1/1-1564 HFLKAARLDTYMGKVFCYLGHYYRDVAEDKSRARGCYRKAFELDDTDTESGAAAVDLSVE ENSMUSP00000089045/1-1563 HFLKAARLDAHMGKVFCYLGHYYRDVAGDRNRARGCYRKAFELDDNDAESGAAAVDLSLE ENSRNOP00000058722/1-1403 HFLKAARLDAHMGKVFCYLGHYYRDVAGDRNRARGCYRKAFELDDSDAESGAAAVDLSVE *********::************:**. *:.**************.*:**********:* ENSP00000351596/1-1564 LEDMEMALAILTTVTQKASAGTAKWAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNC ENSCPOP00000012376/1-1563 LEDTETALAILTTVTQKASAGTAKWAWLRRGLHYLKAGQHSQAVADLQAALRADPKDFNC XP_004841750.1/1-1564 LEDTESALAVLTTVTQKASAGAAKWAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNC ENSMUSP00000089045/1-1563 LEDTETALAILTAVTQKASAGAAKWAWLRRGLYHLKAGQHSQAVADLQAALRADPKDCNC ENSRNOP00000058722/1-1403 LEDTETALAILTAVTQKASSGAAKWAWLRRGLYYLKAGHHSQAVADLQAALRADPKDCNC *** * ***:**:******:*:**********::****:****************** ** ENSP00000351596/1-1564 WESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIK ENSCPOP00000012376/1-1563 WESLGEAYLSRGGYTTALKSFTKASELNPKSTYSVFKVAAIQQTLGKYKEAIAQYQLIIK XP_004841750.1/1-1564 WESLGEAYLSRGGYTTALKSFTRASELNPESIYSVFKVAAIQQILGKYKEAIAQYQLIIK ENSMUSP00000089045/1-1563 WESLGEAYLSRGGYTTALKSFMKASELNPDSTYSVFKVAAIQQILGRYSEAIAQYQLIIK ENSRNOP00000058722/1-1403 WESLGEAYLSRGSYTTALKSFTRASELSPDSTYSVFKVAAIQQILGRYSEAIAQYQLIIK ************.******** :****.*.* *********** **:*.**:****:*** ENSP00000351596/1-1564 KKEDYVPALKGLGECHLMMAKAALVDYLDGKAVDYIEKALEYFTCALQHRADVSCLWKLA ENSCPOP00000012376/1-1563 EKEDYVPALKGLGECHLMMAKAALVDYLDGKAVDYIEKSLEYFTWALQYRADASCLWKLV XP_004841750.1/1-1564 KKEDYVPALKGLGECYLLMAKAALVDYLDGRAIDYTEKALEYFTWALQHRADVSCLWKLV ENSMUSP00000089045/1-1563 MKEDYVPALKGLGECHLLLGKVALVDFLDGKAVDYVEQALGYFTRALQHRADVSCLWKLV ENSRNOP00000058722/1-1403 KEEDYVPALKGLGECHLMLGKAALVDFLDGKAVDYVEQALGYFTRALQHRADVSCLWKLM :*************:*::.*.****:***:*:** *::* *** ***:***.****** ENSP00000351596/1-1564 GDACTCLYAVAPSKVNVHVLGVLLGQKEGKQVLKKNELLHLGGRCYGRALKLMSTSNTWC ENSCPOP00000012376/1-1563 GDACTSLYAVSPSKVNVNVLGVLLGQKEGKQMLKKNELIHLGGRCYGRALKLMSTSNTWC XP_004841750.1/1-1564 GDACTSLYAVSPTKVNINVLGVLLGQKEGKQALKKNELLHLGGRCYGRALKLMSTSNTWC ENSMUSP00000089045/1-1563 GDACTCLHPVSPSKVHVHVLGALLGQKEGQEVLKKEELLSLGGRCYGRALKLMSTSNTWC ENSRNOP00000058722/1-1403 GDACTCLHPVSPAKVNVRVSGALLGQQEGQEVLRKDELLHLGGRCYGRALKLMSTSNTWC *****.*:.*:*:**::.* *.****:**:: *:*:**: ******************** ENSP00000351596/1-1564 DLGINYYRQAQHLAETGSNMNDLKELLEKSLHCLKKAVRLDSNNHLYWNALGVVACYSGI ENSCPOP00000012376/1-1563 DLGINYYRQAQHLAETGNNMSDLKELLEKSLQCLKKAVRLDSKNHLYWNALGVVACYSGI XP_004841750.1/1-1564 DLGINYYRQAQQLAETGSNTSDLKELLEKSLHCLKKAVRLDSHNHLYWNALGVVACYSGI ENSMUSP00000089045/1-1563 DLGINYYRQVQHLAETGSSMSDLTELLEKSLHCLKKAVRLDSNNHLHWNALGVVACYRGV ENSRNOP00000058722/1-1403 DLGINYYRQAQHLAETGSSMNDLTELLEKSLHCLKKAVRLDSNNHLYWNALGVVTCYHGV *********.*:*****.. .**.*******:**********:***:*******:** *: ENSP00000351596/1-1564 GNYALAQHCFIKSIQSEQINAVAWTNLGVLYLTNENIEQAHEAFKMAQSLDPSYLMCWIG ENSCPOP00000012376/1-1563 GNYALAQHCFIKSIHSEQINAVAWTNLGVLYLANEKIEQAHEAFKMAQSLDPSYLMCWIG XP_004841750.1/1-1564 RNYALAQHCFIKSIQSEQINAVAWTNLGVLYLANENIEQAHEAFKMAQSLDPSYLMCWIG ENSMUSP00000089045/1-1563 GNYALAQHCFIKSIQAEQINAAAWTNLGVLYLATENIEQAHEAFKMAQSLDPSYLLCWIG ENSRNOP00000058722/1-1403 GNYALAQHCFIKSIQAEQINAAAWTNLGVLYLATENIEQAHEAFQMAQSLDPSYLLCWIG *************::*****.**********:.*:********:**********:**** ENSP00000351596/1-1564 QALIAEAVGSYDTMDLFRHTTELNMHTEGALGYAYWVCTTLQDKSNRETELYQYNILQMN ENSCPOP00000012376/1-1563 QALIAETIGSYDTMDLFRHTTELNMHTEGAIGYAYWVCTTLQDKSNRETELYQYNILQMN XP_004841750.1/1-1564 QALIAETVGSYDTMDLFRHTTELCMHTEGAIGYAYWVCTTLQDKSNRGTELYQYNILQMN ENSMUSP00000089045/1-1563 QALIAERVGSYDTMDLFRHTTELSMHTEGAIGYAYWVCTTLQDKSNRETELYQYNILEMN ENSRNOP00000058722/1-1403 QALIAERIGSYETMDLFRHTTELSMHTEGAIGYAYWVCTTLQDKSNRETELYQYNILQMN ****** :***:*********** ******:**************** *********:** ENSP00000351596/1-1564 AIPAAQVILNKYVERIQNYAPAFTMLGYLNEHLQLKKEAANAYQRAILLLQTAEDQDTYN ENSCPOP00000012376/1-1563 AIPAAQVVLCKYVGRIQNYAPAFTMLGYLNEHLQLKKEAAEAYQRAILLLQTAEDRDTYN XP_004841750.1/1-1564 AVPAAQVVLCKYVERIQNYAPAFTMLGYLNEHLQLKKEAADMYQRAILLLQTAEDRDTYN ENSMUSP00000089045/1-1563 AIPAAQGVLCKYVERIQNSASAFTMLGYLNEHLQLKKEAAEAYQRATTLLHSAEDQNTYN ENSRNOP00000058722/1-1403 AVPAAQGVLCKYVERIQNYAPAFTMLGYLNEHLQLKREAAEAYQRATALLHSAEDQHTYN *:**** :* *** **** *.***************:***: **** **::***:.*** ENSP00000351596/1-1564 VAIRNYGRLLCSTGEYDKAIQAFKSTPLEVLEDIIGFALALFMKGLYKESSKAYERALSI ENSCPOP00000012376/1-1563 VAIRNYGRVLCSIGEYDKAIHAFKSTPLEDLEEIIGFALALFMKGQYTESSKAYERALSI XP_004841750.1/1-1564 VTVRNYGRLLCSIGEYDKAIQAFKSTPLEELEDIIGFALALFMKGLYTESSKAYERALSV ENSMUSP00000089045/1-1563 VAVRNWGRLLCSIGDYDRAIQAFKSTPLVELEDIIGFALALFMKGLYKESGSAYERALAV ENSRNOP00000058722/1-1403 VTVRNWGRLLCSIGDYDKALQAFKSTPLAELEDIIGFALALFMKGLYKESSTAYERALTV *::**:**:*** *:**:*::******* **:************ *.**..******:: ENSP00000351596/1-1564 VESEQDKAHILTALAITEYKQGKTDVAKTLLFKCSILKEPTTESLQALCALGLAMQDATL ENSCPOP00000012376/1-1563 VESEQDKAHILTALAITEYKQGKMDVAKSLLFKCSILKEPTTESLQTLCALGLAMQDATL XP_004841750.1/1-1564 VESEQDKAHILTALAITEYKQGKLDVAKSLLFKCSILKEPSTESLQTLCALGLAMQDATL ENSMUSP00000089045/1-1563 CKSEQDKAHILTAMAIVEYKQGKMDAAKSFLFKCSILKEPTAESLQALCALGLAMRDATL ENSRNOP00000058722/1-1403 CKSEQDKAHILTAMAVTEYKQGKMDAAKSLLFKCSILKEPTAESLQVLCALGLAMQDATL :***********:*:.****** *.**::**********::****.********:**** ENSP00000351596/1-1564 SKAALNELLKHIKHKDSNYQRCLLTSAIYALQGRSVAVQKQISKAVHSNPGDPALWSLLS ENSCPOP00000012376/1-1563 SKAALNELLKHIKHKDSDYPQCLLTLAIYALQGASAAVQRQASRAVHSNPADPALWALLS XP_004841750.1/1-1564 SKAALNELLKHVKHKDGDYRRCLLTSAIHALQGRSVAVQRQASKAVHSNPADPALWALLS ENSMUSP00000089045/1-1563 SKAALNELLKHIKRRN-DYHSCLLMSAIYALQGHSVAVQRQVAKAVHSNPADPALWSLLS ENSRNOP00000058722/1-1403 SKAALNELLKHIKQKN-DYHRYLLTSAIYALQGHSVAVQRQVAKAVHSNPADPALWSLLS ***********:*::: :* ** **:**** *.***:* ::******.*****:*** ENSP00000351596/1-1564 RVVAQYAQRNAKGGVVAGNVAHILDSNHGKKALLYTAVNQLAMGSSSAEDEKNTALKTIQ ENSCPOP00000012376/1-1563 RVVAQHTQRSAKGGAVAGNVAHILDSNHGKKALLYTAVNQLAMGSTSVE-EKNIALKTIQ XP_004841750.1/1-1564 RVVAQYAQQNAKGGAVAGNVAHILDSNHGKKALLYTAVNQLAMGSSSAENEKNVALKTIQ ENSMUSP00000089045/1-1563 RIVAQYTQRSAKGGAVAGNVAHILDLNHGKKALLYTAVNQLAMGSSTAEDKSNTALKTIQ ENSRNOP00000058722/1-1403 RIVAQYTQQNAKGGAVAGSVAHILDSNHGKKALLYTAVNQLAMGGSTAEDKSSTALKTIQ *:***::*:.****.***.****** ******************.::.* :.. ****** ENSP00000351596/1-1564 KAALLSPGDPAIWAGLMAACHADDKLALVNNTQPKRIDLYLALLSAVSASIKDEKFFENY ENSCPOP00000012376/1-1563 KAALLSPGDPAVWAGLMAACHADDKLALVNSTPPKRMDLYLALLSAVSASMKDKKCLENY XP_004841750.1/1-1564 KAALLSPGDPAVWAGLMAACHADDKLALVNNTQPKRMDLYLALLSAVSASIKDKKFLENY ENSMUSP00000089045/1-1563 KAAFLSPDDPAVWAGLMAACHADDKLALLNNTQPKRVDLYLALRSAVAASLKDKEILQNY ENSRNOP00000058722/1-1403 KAAFLSPDDPAVWAGLMAACHADDKLALVSNTQPKRVDLYLALQSAVSASLKDKENLQNY ***:***.***:****************:..* ***:****** ***:**:**:: ::** ENSP00000351596/1-1564 NQSLEKWSLSQAVTGLIDTGRISEAETLCTKNLKSNPDQPAVILLLRQVQCKPLLESQKP ENSCPOP00000012376/1-1563 NQSLEKWCLSQAVTGLLDTGRIAEAESLCTQNLKSKPDQPAVILLLRQVQCKSLLQSQKP XP_004841750.1/1-1564 NQSLEKWCLSQVVTSLLDTGRTAEAESLCTKNLKSNPDQPAVLLLLRQVQCKSLLESQKP ENSMUSP00000089045/1-1563 NQSLEKWSFSQVVTGLIDTGKTSEAESLCTQSLKSNPDQPAVILLLRQVQCMSLLESQKP ENSRNOP00000058722/1-1403 NLLLEKWSFSQAVTGLIDTGKISEAESLCTKNLKSNPDQPAVILLLRQVQCTSLLASQKP * ****.:**.**.*:***: :***:***:.***:******:******** .** **** ENSP00000351596/1-1564 LPDAVLEELQKTVMSNSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQLASQRGSWSGKL ENSCPOP00000012376/1-1563 LPDAVLEELQKTVLSNSTSVPAWQWLAQVYQSQGMMSAAEMCYRKSLQVASQQGSWSGKL XP_004841750.1/1-1564 LPDAVLEELQKAVKSNSTSVPAWQWLAQVYQSQGMMSAAEMCYRKSLQVASQQGSWGGKL ENSMUSP00000089045/1-1563 LPDAVLEELQKTVMSNSTSVPAWQWLAQVYQSQGMMGAAEMCYRKSLQVASQQGNWSGKL ENSRNOP00000058722/1-1403 LPDAVLEELQKTVMSNSTSVPAWQ------------------------------------ ***********:* ********** ENSP00000351596/1-1564 SSLLRLALLALKVCMANISNDHWPSLVQEATTEALKLCFCPLAVLLQALLQFKRKMGARE ENSCPOP00000012376/1-1563 SSLLKLALLALEVCMANISSDHWPSLVQEATAEALKLCFCPLAVLLQALLQFSRKMGARE XP_004841750.1/1-1564 SSLLKLALLALEVCMANISSDHWPSLVQEATAEALKLCFCPLAVLLQALLQFNRKMGARE ENSMUSP00000089045/1-1563 SSLLKLALLALEVCMANVSGDHWSSLVQEATSEALKVCFSPLAVFLQALLQFNRKMGARE ENSRNOP00000058722/1-1403 ------------------------------------------------------------ ENSP00000351596/1-1564 TRRLLERVVYQPGYPKSIASTARWYLLRHLYAKDDYELIDVLVNNAKTHGDTRALELNQR ENSCPOP00000012376/1-1563 TRRLLERVVYQPGYPKSMASTARWYLLRHLYAKNDYELIDVLVKNAETHRDKRALELNQK XP_004841750.1/1-1564 TRRLLERVVYQPGYPKSIVSTARWYLLRHLYAKNDYELIDVLVKNAETHRDTRALELNQK ENSMUSP00000089045/1-1563 TRRLLERIVYQTGYPSSIVSAARWYLLRHLYAKDDPELIDVLVRNAETHGDKRILELNRK ENSRNOP00000058722/1-1403 ------------------------------------------------------------ ENSP00000351596/1-1564 LSSQ ENSCPOP00000012376/1-1563 LSSE XP_004841750.1/1-1564 LSSQ ENSMUSP00000089045/1-1563 LSAQ ENSRNOP00000058722/1-1403 ----