CLUSTAL W(1.81) multiple sequence alignment ENSP00000437554/1-1182 MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRERIDELERRLDELSAENRSLWEHQQLL ENSMUSP00000038653/1-1195 MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLL ENSRNOP00000018902/1-1194 MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLL ENSCPOP00000012370/1-1137 MKSLLKNPVRAVLYLKELTAIVQNRQSFFHTQR-RIDELERRLDELSAENRSLWEHQQLL XP_004837604.1/1-1191 MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLL *:***:******************:**::**** ************************** ENSP00000437554/1-1182 QAQPPPGLV-PPSSAPLPAAPATAPAAAAR-----AQEPLQDQGQRSAAAPHPAPDRPPR ENSMUSP00000038653/1-1195 QAQPPPGLVPPPPSAPLPAPAVTAPAAAA------AQEPLQDHGQLIPASP-----EPPL ENSRNOP00000018902/1-1194 QAQPPPGLV-PPPSAPLPAPAATAPAATA------AQEPLQDHGQLIPATP-----EPPL ENSCPOP00000012370/1-1137 QIE--------------------------------AQEPLQDHGQ--------------L XP_004837604.1/1-1191 QAQPPPGLV-APASAPLRAPASISPAAPAAGAVAAAQEQLQDHGQLPPVAAPPSPEQPPL * : *** ***:** ENSP00000437554/1-1182 QHHGQLLEQPQRGPGSRAH----TPQSPHKHLGTQGAVTDKEKERPPSCCAAAGALLQHK ENSMUSP00000038653/1-1195 QHHGQLLAQPQPAPSSRVQ----TPQSPHQHPVAPGAIADKEKERPSSCCAAAGALLQHA ENSRNOP00000018902/1-1194 QHHGQLLAQPQPAPSSRVQ----TPQSPHQHPVAPGAVADKEKERPSSCCAAAGALLQHA ENSCPOP00000012370/1-1137 QHHGQLSAQPQSGPGGRGSPTPVAPPAP----GDTWALADKEKERPPSVALPPEP-PSAQ XP_004837604.1/1-1191 QHHGQLGAQSQPGAVSRAH----LPQSPRQHLVTLGAVADKEKERAPSCCAAAGALLPHK ****** *.* .. .* * :* *::******..* . .. . ENSP00000437554/1-1182 SPSALGKGVLSRRPENETVLHQFCCPAAD-----ACSDLASQSDGSCTQAGGGMEDSVVA ENSMUSP00000038653/1-1195 SPAALGKGVLSRRPENETVLHQFCCPAADTEQKPACSDLASQSDGSCAQAGGGMEDSVV- ENSRNOP00000018902/1-1194 SPAALGKGVLSRRPKNETVLHQFCCPAADTEQKPACSDLASQSDGSCAQAGGGMEDSVV- ENSCPOP00000012370/1-1137 SSAALGKGVLSRRPENETVLHQFCCPAADAEQKPACSDLASQSDGSCAQASGGMEDS--- XP_004837604.1/1-1191 SSAALGKGVLSRRPENETVLHQFCCPAADAEQKPTCSDLASQSDGSCAQAGGGMEDF--- *.:***********:************** :************:**.***** ENSP00000437554/1-1182 AAAVAAGRPSAHAPKAQAQELQEEEERPGAGAASPRAGPQHKASPGRQQPALATALCPHA ENSMUSP00000038653/1-1195 -AAVAAGRPSAHAPKAQAPELQQEEERPGAVG-SPRAGPLRAASPGRQQPALATALCSHT ENSRNOP00000018902/1-1194 -AAVAAGRPSAHAPKAQAPELQQEEERPGAVG-SPRAGPLRAASPGQQQPALATALCSHT ENSCPOP00000012370/1-1137 --AVAAGRPSAHAPKAQAQELQEEEERPGAGGASPRAGPHRAASPGQQQPALATAPCSHT XP_004837604.1/1-1191 --AVAAGRPSVHAPKAEAQELQEEEERPGAGGASPRAGLHRAASPGQQQPALATAPCSHT ********.*****:* ***:******* . ***** : ****:******** *.*: ENSP00000437554/1-1182 PAASDYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLES ENSMUSP00000038653/1-1195 PAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLES ENSRNOP00000018902/1-1194 PAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLES ENSCPOP00000012370/1-1137 PGASDYELSLDLKNKQIEMLEHKYGGHVVSRRAACTIQTAFRQYQLSKNFEKIRNSLLES XP_004837604.1/1-1191 PGASDYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLES *.**:**********************:******************************** ENSP00000437554/1-1182 RLPRRISLRKVRSPTAESLAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQ ENSMUSP00000038653/1-1195 RLPRRISLRKVRAPTAESLVAEKALLEGCGLLGLPLGRSPSLPPTFAGSLTELEDSFTEQ ENSRNOP00000018902/1-1194 RLPRRISLRKVRAPTAESLVAEKALLESCGLLGLPLGRSPSLPPTFAGSLTELEDSFTEQ ENSCPOP00000012370/1-1137 RLPRRISLRKVRAPTAESLAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQ XP_004837604.1/1-1191 RLPRRISLRKVRAPTAESLAAEKALMEGYGLMGLPLVRSPSLPPTFAGTLTELEDSFTEQ ************:******.*****:*. **:**** ***********:*********** ENSP00000437554/1-1182 VQSLAKSIDDALSTWSLKTMCSLRESGAYQLHQALQAAAGPPGLEAE--GRAPESAGPGP ENSMUSP00000038653/1-1195 VQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAAAREPES-GPGS ENSRNOP00000018902/1-1194 VQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETE-AAREPDS-GPGS ENSCPOP00000012370/1-1137 VQSLAKSIDDALSTWSLKTMCSLQEGSAYQIHQALHAGSGQPGLEVE--MQEPEGAGPGP XP_004837604.1/1-1191 VQSLAKSIDDALSTWSLKTMCSLQEGGAYQIHQALHAGSGQPSLEAE--MQEPENAGPGP ***********************:*..***:****:..:* *.**.* : *:. ***. ENSP00000437554/1-1182 GDDAAETPGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPA ENSMUSP00000038653/1-1195 GD---EAGGLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTAQATAEPA ENSRNOP00000018902/1-1194 GD---EAGSLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTAQATAEPA ENSCPOP00000012370/1-1137 GDETTESAGLPQGHSSTLMMAFRDVTVQIANQNISVSSSTALSVANCLGVQTAQAAAEPT XP_004837604.1/1-1191 GDEGTEAAGLPQGHGGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGVQTAQAAAEPA ** *: .** .*..*********************************.**.**.***: ENSP00000437554/1-1182 AGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGAADG----------ATAPKTEE ENSMUSP00000038653/1-1195 AAQAEQEDTADQEVSEVPASEQMDPPSEDS--EAAESRAQSAQEPAVAQAVVEEAVATEA ENSRNOP00000018902/1-1194 AVQTEQGDAATQEVSEVPASELMDPPVEDS--EAAESGAQSAHEPTVAEAVVEEAVATEA ENSCPOP00000012370/1-1137 PSKGEQG-----EAKEVPAKGQEDTPAEVTDAEVATGQAPDTHQPVAAEALVEQAVAAEA XP_004837604.1/1-1191 TSKGEQG-----EAREVPTMGQGDAPGEDTGAEAAAGRAPGSPQPVAAEAVMEEAVAAEA . : ** *. *.*: *.. * : *.* . * . * :* ENSP00000437554/1-1182 EEEEEETAEVGRGAEAEAGD-LEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRY ENSMUSP00000038653/1-1195 EEEEEGAKQAGKGAEAEGGDNSEQLSSSSASTKSAKSSSEASAAASKEALQAVILSLPRY ENSRNOP00000018902/1-1194 EEEEEGAGQAGKGAEAEVGDNSEQLSSSSASTKSAKSGSEVSAAASKEALQAVILSLPRY ENSCPOP00000012370/1-1137 EEEEE-AGEAGKRAEAEAGENSEQLSSSSTSTKSAKSGSEVSAAASKEALQAMILSLPRY XP_004837604.1/1-1191 EEEEE-AGEAGKGAETEVGGNSEQLSSSSTSTKSAKSGSEVSAAASKEALQAMILSLPRY ***** : :.*: **:* * *******:*******.**.**:***:****:******* ENSP00000437554/1-1182 HCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQ ENSMUSP00000038653/1-1195 HCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQ ENSRNOP00000018902/1-1194 HCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQ ENSCPOP00000012370/1-1137 HCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQ XP_004837604.1/1-1191 HCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQ ********:*************************************************** ENSP00000437554/1-1182 RKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVE ENSMUSP00000038653/1-1195 RKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVE ENSRNOP00000018902/1-1194 RKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVE ENSCPOP00000012370/1-1137 RKGLSRQMVGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVE XP_004837604.1/1-1191 RKGLSRQMVGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVE ********:**************************.************************ ENSP00000437554/1-1182 RLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRN ENSMUSP00000038653/1-1195 RLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRN ENSRNOP00000018902/1-1194 RLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRN ENSCPOP00000012370/1-1137 RLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRN XP_004837604.1/1-1191 RLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRN ************************************************************ ENSP00000437554/1-1182 LRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVC ENSMUSP00000038653/1-1195 LRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVC ENSRNOP00000018902/1-1194 LRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVC ENSCPOP00000012370/1-1137 LRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVC XP_004837604.1/1-1191 LRGVDDGADIPRELVVGIYERIQQKELRSNEDHVTYVTKVEKSIVGMKTVLSVPYRRLVC ***************************:************************:*:***** ENSP00000437554/1-1182 CSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQL ENSMUSP00000038653/1-1195 CSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHL ENSRNOP00000018902/1-1194 CSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHL ENSCPOP00000012370/1-1137 CSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSASTYTFCKSVGLLGMQFHL XP_004837604.1/1-1191 CSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKCASTYTFCKSVGLLGMQFHL ****************************************.: ******:******:*:* ENSP00000437554/1-1182 FENEYYSHGITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWE ENSMUSP00000038653/1-1195 FENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWE ENSRNOP00000018902/1-1194 FENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWE ENSCPOP00000012370/1-1137 FENEYYSHGITLVTPLSGLEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWE XP_004837604.1/1-1191 FENEYYSHGITLVTPLSGAEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWE ************.***** ***************************************** ENSP00000437554/1-1182 LEKQQGTKTLSFKPCGAQGDPQSKQGSPT--AKREAALRERPAESTVEVSIHNRLQTSQH ENSMUSP00000038653/1-1195 LEKQQGTKTLSVRSAGAQGDPQSKQGSPT--AKREAMAGEKAAESSGEVSIHNRLQTSQH ENSRNOP00000018902/1-1194 LERQQGTKTLSARSAGAQGDPQSKQGSPT--AKREAMAGEKATESSGEVSIHNRLQTFQH ENSCPOP00000012370/1-1137 LEKQQGTKTLSFKSGGAQVEPQSKQGSPTVKAKRDAALGEKPAESPGEVSIHNRLQTSQH XP_004837604.1/1-1191 LEKQQGTKTLSFKSREAQVDPQSKQGSPT--AKRDTALGEKPTESPGEVSIHNRLQTSQR **:******** :. ** :********* ***:: *:.:**. ********** *: ENSP00000437554/1-1182 NSGLGAERG--APVP--------PPDLQPSPPRQQTPPLPPPPPTPPGTLVQCQQIVKVI ENSMUSP00000038653/1-1195 SPKLGVERGAPAPSPPTS-PPPLPPDPQPSPLREQPPPLPLPPPTPPGTLVQCQQIVKVI ENSRNOP00000018902/1-1194 SPKLGVERGAPAPSPPTSPPPPLPPDPQPSPLREQPPPLPLPPPTPPGTLVQCQQIVKVI ENSCPOP00000012370/1-1137 NSRLGAETGAPAPAP--------MPDPQPSPLREQPPLLPPLPPTPPGTLVQCQQIVKVI XP_004837604.1/1-1191 SSRLGAERG--APVP--------LPDPQPSPVREQ-PPLPPLPPTPPGTLVQCQQIVKVI .. **.* * ** * ** **** *:* * ** ****************** ENSP00000437554/1-1182 VLDKPCLARMEPLLSQALSCYTSSSSDSCGSTPLGGPGSPVKVTHQPPLPPPPPPYNHPH ENSMUSP00000038653/1-1195 VLDKPCLARMEPLLSQALSCYASSSSDSCGSTPLRGPGSPVKVIHQPPLPPPPPPYNHPH ENSRNOP00000018902/1-1194 VLDKPCLARMEPLLSQALSCYASSSSDSCGSTPLRGPGSPVKVIHQPPLPPPPPPYNHPH ENSCPOP00000012370/1-1137 VLDKPCLARMEPLLSQALSCYTSSSSDSCSSTPLGGPGSPVKVIHQPP------------ XP_004837604.1/1-1191 VLDKPCLARMEPLLSQALSCYTSSSSDSCGSTPLGGPGSPAKVIHQPPLPPPPPPYNHPH *********************:*******.**** *****.** **** ENSP00000437554/1-1182 QFCPPGSLLHGHRYSSGSRSLV ENSMUSP00000038653/1-1195 QFCPPGSMLLRRRYSSGSRSLV ENSRNOP00000018902/1-1194 QFCPPGSLLLRRRYSSGSRSLV ENSCPOP00000012370/1-1137 QFCPPGSLLHRRRYSSGSRSLV XP_004837604.1/1-1191 QFCPPGSLLHRRRYSSGSRSLV *******:* :**********