CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000046843/1-1033 -----------------------------------MGSQPPPPGSPLSREEGEAPPLVPA ENSRNOP00000063561/1-1042 -----------------------------------MGSQPPPLGSPLSREEGEAPPLAPA ENSCPOP00000012342/1-1016 -----------------------------------QGSQPPPPGSPLSREEGDAPSPSPV ENSP00000353735/1-1045 -----------------------------------MGSQP-PLGSPLSREEGEAPPPAPA XP_004838441.1/1-1077 MRWQSGDCVLTRGACGGVLFLPCPHAASGKERFPLQGSQP-PPGSPLSREEGNAPPPAPA **** * *********:**. *. ENSMUSP00000046843/1-1033 EEGRRRSRRVRLRGSCRHRPSLLSRRELASNGPAVPATASSEIMASAAKEFKMDNFSPKA ENSRNOP00000063561/1-1042 EEGRRRSRRVRLRGSCRHRPSLLGRRELASSGPAVPATASSEIMASAAKEFKMDNFSPKA ENSCPOP00000012342/1-1016 AGGRRRSRRVRLRGCCRHRPSFPGRGELSSSASAGPAPASSEIMASAAKEFKMDNFSPKA ENSP00000353735/1-1045 SEGRRRSRRVRLRGSCRHRPSFLGCRELAASAPARPAPASSEIMASAAKEFKMDNFSPKA XP_004838441.1/1-1077 AEGRRRSRRVRLRGSCRHRPSFLGRRELSSSAPAGPAPASSEIMASAAKEFKMDNFSPKA ************.******: . **::...* **.********************** ENSMUSP00000046843/1-1033 GTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQP ENSRNOP00000063561/1-1042 GTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQP ENSCPOP00000012342/1-1016 GTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQP ENSP00000353735/1-1045 GTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQP XP_004838441.1/1-1077 GTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQP ************************************************************ ENSMUSP00000046843/1-1033 FDSIFHSVRAEDDFKEYVLRPSYNGSFTNPEVRRFRYRTTMTRERSASLYS-PSSTVSRR ENSRNOP00000063561/1-1042 FDSIFHSVRAEDDFKEYVLRPSYNGSFTAPEVRRFRYRTTMTRERNASLYS-PSSTVSRR ENSCPOP00000012342/1-1016 FDSIFHSVRAEDDFKEYVLRPQYNSS-DTPNARRFRYRTTMTRERSASLHSASSSTLSRR ENSP00000353735/1-1045 FDSIFHSVRAEDDFKEYVLRPSYNGSFVTPD-RRFRYRTTLTRERNASVYS-PSGPVNRR XP_004838441.1/1-1077 FDSIFHSVRAEDDFKEYVLRPSYNGSFATPDGRRFRYRTTMTRERSASVYS-PSSTLSRR *********************.**.* *: ********:****.**::* .*..:.** ENSMUSP00000046843/1-1033 TTTPPDSGVLFEGLGISTRPRDVDIPQFMRQMALRGPTTTDERSLRKIQEQDIINFRRTL ENSRNOP00000063561/1-1042 TSTPPDSGVLFEGLGISTRPRDVDIPQFMRHMALRGPTATDERSLRKVQEQDIINFRRTL ENSCPOP00000012342/1-1016 TTTPPDSGVVFERLG---RSRD-EFPQFMRQIAMMRQHTTGERSLRKIQEQDIINFRRTL ENSP00000353735/1-1045 TTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPTTADERSLRKIQEQDIINFRRTL XP_004838441.1/1-1077 TTTPPDSGVLFEGLDISTRHRDVEIPQLMRQIAIRRQHTSDERSLRKIQEQDIINFRRTL *:*******:** *. * ** ::**:**::*: ::.******:************ ENSMUSP00000046843/1-1033 YRAGVRVRSIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHII ENSRNOP00000063561/1-1042 YRAGVRVRSIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHII ENSCPOP00000012342/1-1016 YRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHII ENSP00000353735/1-1045 YRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHII XP_004838441.1/1-1077 YRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHASLVNIVQHII ****.***.****************************************.********** ENSMUSP00000046843/1-1033 MSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCP-PSSE ENSRNOP00000063561/1-1042 MSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCP-PSSE ENSCPOP00000012342/1-1016 MSNVTRYDLESQAFVSDLRPFLLNRTDHFIHEFVSFARSPFNMAAFDQHANYDCPAP-YE ENSP00000353735/1-1045 MSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYE XP_004838441.1/1-1077 MSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYE **************************:******:********************* * * ENSMUSP00000046843/1-1033 EGSRSDSSVITISPDEAETQELDMNASTVRQAPWDDETPGPSYSSSEQVHVGVSSLLNSS ENSRNOP00000063561/1-1042 EGSRSDSSVITISPDEAEAQELDVNVSTIRQAPWDDETPGPSYSNSEQVHVGVSSLLNSS ENSCPOP00000012342/1-1016 EGSHSDSSVITISPDETETQELDINVATVSQAPWDDETPGPSYSSSEQVHVAMSSLLNTS ENSP00000353735/1-1045 EGSHSDSSVITISPDEAETQELDINVATVSQAPWDDETPGPSYSSSEQVHVTMSSLLNTS XP_004838441.1/1-1077 EGSHSDSSVITISPDETETQEQDINEATVSQAPWDDETPGPSYSSSEQVHVAMSSLLNTS ***:************:*:** *:* :*: **************.****** :*****:* ENSMUSP00000046843/1-1033 DSSDEELVSGGTTSQIQGVQTNDDVNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSE ENSRNOP00000063561/1-1042 DSSDEELVSGGAASQIQGVQANDDVNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSE ENSCPOP00000012342/1-1016 DSSDEEVVTGRTPSRLQDVQTNEDLNNDS-DSSDNCVIVGFVKPLAERTPELVELSSDSE ENSP00000353735/1-1045 DSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVIVGFVKPLAERTPELVELSSDSE XP_004838441.1/1-1077 DSSDEELVTGGAPSQIQGVQTNEDLNNDS-DSSDNCVIVGFVKPLAERTPELVELSSDSE ******:*:* :.*::*.**:*:*:**** .***************************** ENSMUSP00000046843/1-1033 ELGPYEKVETVKTQEQEQSYSSGDSDVSRASSPRSVLGKDEQMSKSHCDSDTRISSKKEE ENSRNOP00000063561/1-1042 ELGSYEKMETVKTQEQEQSYSSGDSDASRASSPRSVLGKDEQMGKSHCDSDTRINSKKEE ENSCPOP00000012342/1-1016 ELGSYGKMETVKMQEQEQSYSSVDSDISRGSTPHSVLGKDEQMNKSHCESSTRIKSKKEE ENSP00000353735/1-1045 DLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLGKDEQINKGHCDSSTRIKSKKEE XP_004838441.1/1-1077 ELGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLGKDEQMNKGHCDSGTRIKSKREE :**.* *:**** ********* *** ** *:*:********:.*.**:*.***.**:** ENSMUSP00000046843/1-1033 KRSTSLPAPRD-SSSTRGDRVCSPYNHRHRKGGRSRSSDSRSQSRSGHDPRNHRK-HGKK ENSRNOP00000063561/1-1042 KRSTSLSTPRD-SSSTRGDRACSPYNHRHRKGGRSRSSDSRSQSRSGHDQRNHRKHHGKK ENSCPOP00000012342/1-1016 KR---LSATRDLSSSMRGDRVYSPYNHRHRKRGRSRSSDSRSQSRNGHDRRNHRKHHGKK ENSP00000353735/1-1045 KRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSSDSRSQSRSGHDQKNHRKHHGKK XP_004838441.1/1-1077 KRSTSLSSPRDLSSSMRGDRVCSPYNHRHRKRGRSRSSDSHSQSRSGHDQRNYRKHHGKK ** *.:.*: .** ****. ********* ********:****.*** :*:** **** ENSMUSP00000046843/1-1033 RLRNKRSRSRESSSRPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRR ENSRNOP00000063561/1-1042 RLKNKRSRSRESSSKPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRR ENSCPOP00000012342/1-1016 RMKSKRSRSRE-SSRPRGRRDKRRSRTRESSWSRRSQTLSLSSESTSRSRSRSSDHSKRR ENSP00000353735/1-1045 RMKSKRSRSRE-SSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESTSRSRSRSSDHGKRR XP_004838441.1/1-1077 RMKSRRSRSRE-SSRSKGRRDKKRSRTRDSSWSRRSQTLSLSSESSSRSRSRSSDHSK-R *::.:****** **:.:.*:**:*****:************** *:**********.* * ENSMUSP00000046843/1-1033 SRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRI ENSRNOP00000063561/1-1042 SRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRI ENSCPOP00000012342/1-1016 SQSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHFSRQSLSPEFRV ENSP00000353735/1-1045 SRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRV XP_004838441.1/1-1077 SQSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRKTLSRAHYSRQSSSPEFRV *:***************:***********************:******:**** *****: ENSMUSP00000046843/1-1033 QSFSERTNARKK-NHSERKYYYYERRRSRSVSSNRSRTTSAGPDRVRNEKPGGKRKYKTR ENSRNOP00000063561/1-1042 QSFSERTNARRK-NHSERKYYYYERHRSRSVSSNRSRTTSAVPDRMRNEKPGGKRKYKTR ENSCPOP00000012342/1-1016 QSFSERINARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGPDRVRNEKPGGKRKYKTR ENSP00000353735/1-1045 QSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGTDRVRNEKPGGKRKYKTR XP_004838441.1/1-1077 QSFSERTNARKKNNHSERKYYYYEKHRSRSLSSNRSRTASTGTDRVRNEKPGGKRKYKTR ****** ***:* ***********::****:*******:*: .**:************** ENSMUSP00000046843/1-1033 HLEGTSEEAQPAREFTSKGKDSHYQK--SKLDGSYKNESDSFSDSRSSDRETKHKRRRRR ENSRNOP00000063561/1-1042 HLEDTNEEAQPSRAFASRVKESHYQK-PSKLDGGSKDESDSFSDSRPSDRETKHKRRKRR ENSCPOP00000012342/1-1016 HLEGANEVAQPSREFASKVKDSHYQKSSSKFDGSYKNESDSFSDSRSSDRETKHKRRKKR ENSP00000353735/1-1045 HLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNESDTFSDSRSSDRETKHKRRKRK XP_004838441.1/1-1077 HLEGSNEVVQPSREFASKVKDSHYQKSSSKFDGSYKNESDSFSDSRSSDRDTKRKRRKRR ***.:.* .**:* *:*: *:***** **:**. *:***:*****.***:**:***::: ENSMUSP00000046843/1-1033 TRSLSVEIVYEGKATDTSKHHKKKKKKHKKKHKKHHGDNTSRSPVVITIDSDSDGESEVK ENSRNOP00000063561/1-1042 ARSLSVEIVYEGKATDTSKHHKKKKKKHKKKHRKHHGDNTSRSPVVITIDSDSDGDAGVK ENSCPOP00000012342/1-1016 TRSLSVEIVYEGKATDTTKHHK-----------KHHEDN-THSPVVITIDSDSDKDSEIK ENSP00000353735/1-1045 TRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDNASRSPVVITIDSDSDKDSEVK XP_004838441.1/1-1077 TRSLSVEIVYEGKATDTSKHHKKKKKKHKKKHKKHHGDN-TRSPVVITIDSDSDKDSEVK :****************:**** *** ** ::************ :: :* ENSMUSP00000046843/1-1033 AGIECSNGSLPQPIQD-------GAFETKDVVTIEDELGVLDKDCDVTALADDL-STSQT ENSRNOP00000063561/1-1042 ASVECSQSSLPQPGQDEVSTPSSEAFETKDVVTIEDELAVEDKECDVTALTNDL-STSQA ENSCPOP00000012342/1-1016 ADLECDNRGPQDSMQR--------LSETKDVVTIEDEFGILDKECGTTTLTNNLNNASKI ENSP00000353735/1-1045 EDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFGVLDKECDIATLSNNLNNANKT XP_004838441.1/1-1077 ADMECDNNGTQDSLQNEFLAPSLEPLEAKDIVTIEDEFSVLDKECDITTLTNNLNNANKT . **.: . :. * *:**:**** *:.: **:*. ::*:::* .:.: ENSMUSP00000046843/1-1033 VENCDSPAVPVEQTLDVREESTFASDLESQSSN-VSIQAEPSRPVPSPRTSLSSVSPGRD ENSRNOP00000063561/1-1042 VESSESPPVSVEQTLDVREDSTFASDVESQSSN-ASIPTEPSRPLPSPRTSLSSVSPGRD ENSCPOP00000012342/1-1016 VGSIPPQAASVEQTLDVREECIYASDLENQPVN-VSIQTEPSNHLPSPRT-LLSVTLDRD ENSP00000353735/1-1045 VDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQTEPSRQLPSPRTSLMSVCLGRD XP_004838441.1/1-1077 VGDIPPQTASAEQTLDVREECTFASVLENQSSN-VSIQIEPSNHLPSPRTSLLSVSLGRD * . . ....********:. :.* :*.*. * .*: ***. :***** * ** .** ENSMUSP00000046843/1-1033 CDVS ENSRNOP00000063561/1-1042 CDMS ENSCPOP00000012342/1-1016 CGMS ENSP00000353735/1-1045 CDMS XP_004838441.1/1-1077 CDMS *.:*