CLUSTAL W(1.81) multiple sequence alignment ENSP00000344115/1-784 MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEK ENSMUSP00000034339/1-784 MQRLTELATALGAFLGLLAVAAM--AGPNFPQIDTPNMLPAHHRQKRDWIWNQMHIDEEK ENSRNOP00000017983/1-717 ------------------------------------------------------------ ENSCPOP00000012089/1-709 ------------------------------------------------------------ XP_004843169.1/1-782 -----MLTTALGTYMGLLVAASV--AGCDPTQLDTLSLPCIHRRQKRDWIWNQMHVDEEK ENSP00000344115/1-784 NTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTA ENSMUSP00000034339/1-784 NESLPHYVGKIKSNVNRQNAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTA ENSRNOP00000017983/1-717 ---------QIKSNVNRQNAKYVLQGEQAGKIFRVDADTGDVLAYERLDREKVSEYFLTA ENSCPOP00000012089/1-709 ------------------NAKYVLKGEAANNIFKVNPDTGDVFAFARLDREKVSSYPLVA XP_004843169.1/1-782 TDPLPYYVGKLKSSVNRKNATYVLKGEAANSIFQVNADTGDVYAFARLDREKVSEYSLVA **.*:*:** ...:* *:.:**:* * *****::*.* *.* ENSP00000344115/1-784 VIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADD ENSMUSP00000034339/1-784 LIVDKNTNKNLEQPSSFTVKVHDINDNWPVFSHQVFNASVPEMSAIGTSVIRVTAVDADD ENSRNOP00000017983/1-717 LIVDKKTNKNLEQPSSFTVKVHDVNDNWPVFTHQVFNASVPEMSAIGTSVIRVTATDADD ENSCPOP00000012089/1-709 LIVDKDTDKDLESPSSFTIKVHDINDNWPVFTQQLFNASVLEMSPGGTSVMRLTAVDADD XP_004843169.1/1-782 LIVDKDTNKNLEPPSNFTIKVHDINDNWPVFTHRLFNASVLEMSPGGTSVMRLTAVDADD :****.*.::** **.**:****:*******::::***** * *. ****: :**.**** ENSP00000344115/1-784 PTVGDHASVMYQILKGKEYFAIDNSG-RIITITKSLDREKQARYEIVVEARDAQGLRGDS ENSMUSP00000034339/1-784 PTVAGHATVLYQIVKGNEYFSIDNSG-LIFTKIKNLDREKQAEYKIVVETQDALGLRGES ENSRNOP00000017983/1-717 PTVAGHATVLYQMVKGNEYFAIDNSG-LIFTKDKNLDRETRAEYKIVVEAQDAQGLRGES ENSCPOP00000012089/1-709 PTVAEHTTVMYQILKGGENFAIDNSERLITTTKQNLDREVQARYEIVVEARDAQGLRGES XP_004843169.1/1-782 PTVADHATVMYQILKGGENFAIDNSG-LISTAKQNLDREVQASYEIVVEARDAEGLQGES ***. *::*:**::** * *:**** * * :.**** :* *:****::** **:*:* ENSP00000344115/1-784 GTATVLVTLQDINDNFPFFTQT-KYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSIL ENSMUSP00000034339/1-784 GTATVMIRLEDINDNFPVFTQS-TYTFSVPEDIRVGKPLGFLTVVDPDEPQNRMTKYSIM ENSRNOP00000017983/1-717 GTATVLIRLEDINDNFPIFTQS-TYTFSVPEDIRVGKPLGSLSVEDPDEPQNRMTKYSIM ENSCPOP00000012089/1-709 GTATVLIILQDINDNFPIFTQPAVYTFEVPEDTRVGSSVGSLFVEDPDEPQNRMTKFEIV XP_004843169.1/1-782 GTATVLITLQDVNDNFPIFAQP-MYTFVVPEDIRVGSSVGSLFVEDPDEPQNRKTKFDIV *****:: *:*:*****.*:*. *** **** ***..:* * * ******** **:.*: ENSP00000344115/1-784 RGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAG-NRA ENSMUSP00000034339/1-784 QGEYRDTFTIETDPKRNEGIIKPTKSLDYEVIQQYTFYIEATDPTIRYEYLSSTSGKNKA ENSRNOP00000017983/1-717 QGEYRDTFTIETDPDRNEGIIKPTKPLDYELIQQYTFHIEATDPTIRLGYLSSTAGKNKA ENSCPOP00000012089/1-709 QGEYRDTFSIETDPTRNEGIIKPKKPLDFEFIQKYSFVIEATDPTINLKYVRGLSGKNKA XP_004843169.1/1-782 QGEYRDTFTIDTDPTRNEGIIKPMKPLDYELIQKYSFVVEATDPTINLGYLRGITGKNKA :*:*:*:*:*:*:* :******* *.**:* **:*:* :******* *: :* *:* ENSP00000344115/1-784 QVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQ ENSMUSP00000034339/1-784 MVTINVLDVDEPPVFQRHFYHFKLPENQKKPLIGTVVAKDPDKAQRSIGYSIRKTSDRGQ ENSRNOP00000017983/1-717 KIIINVLDVDEPPVFQRRFYHFHLPENKKKPLIGTVVAKDPDKAQRSIGYSIRKTSDRGQ ENSCPOP00000012089/1-709 QVIINILDVDEPPVFQKRFYHFRLKENQKKHLVGSVLAKDPDKAGNKIEYTIRKTSDKGQ XP_004843169.1/1-782 RVVINILDVDEPPVFQKRFYHFLLNENQKKNLIGSVLAKDPDKAGRNIGYSIRKTSDKGQ : **: ******:**: **** * **:** *:*:*:* *** * ..* *:**:***:** ENSP00000344115/1-784 FFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAP ENSMUSP00000034339/1-784 FFRITKQGNIYNEKELDRETYAWYNLTVEANELDSRGNPVGKESIVQVYIEVLDENDNPP ENSRNOP00000017983/1-717 YFRITKQGNIYNEKELDRETHAWYNLTVEANELDSRGNPVGKESIVQIYIEVLDENDNAP ENSCPOP00000012089/1-709 FFRITKQGDIYSEKQLDREIHPWYNLTVEANELDSNGKLTGKESIVQVHVEVLDENDNAP XP_004843169.1/1-782 FFRITKQGDIHCEKELDREIYPWHNLTVEANELDPNGNPTGKESIVQVHIEVLDENDNAP :**:**:*:*: **:**** :.*:******:***. *. .*******:::********.* ENSP00000344115/1-784 EFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTEN-NFTLTDNHDNTANI ENSMUSP00000034339/1-784 EFAQPYEPKVCENAAQGKLVVQISATDKDVVPVNPKFKFALKNEDSNFTLINNHDNTANI ENSRNOP00000017983/1-717 EFAQPYEPKVCENAAQGKLVVQISATDKDVVPVNTKFKFALKNEDSNFTLINNHDNTANI ENSCPOP00000012089/1-709 EFAQPYDPRVCENAVQGKLVVQISAVDKDVTPQNVKFKFALGTDNSNFTLIDNRDNTANI XP_004843169.1/1-782 EFAQPYEPKVCENAAQGKLVVQISAVDKDITPQNVKFKFALGTDDSNFTLIDNHDNTANI ***:**:*:*****.:*:**:**** ***:.* * **** * .:: **** :*:****** ENSP00000344115/1-784 TVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGV ENSMUSP00000034339/1-784 TVKYGQFNREHAKFHYLPVLISDNGVPSLTGTSTLTVGVCKCNEQGEFTFCEEMAAQAGV ENSRNOP00000017983/1-717 TVKYGQFNREHTKFHYLPVLISDNGMPSLTGTGTLTVAVCKCNEQGEFTFCEEMAAQAGV ENSCPOP00000012089/1-709 TVKYGPFDRDHAKFHYLPVLISDNGSPSLTSTNTLTVVVCKCNQQGTFTFCEEAVAQVGV XP_004843169.1/1-782 TVKYGPFDREHAKFYYLPVLISDNGSPSLTGTSTLTVVVCKCNQQGTFTFCEEAVAQAGV ***** *:*:*:*.::***:***** ** *.*.**** *****:** *****: .**.** ENSP00000344115/1-784 SIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTT ENSMUSP00000034339/1-784 SIQALVAIFLCILTITVITLLIILRRRIRKQAHAHSKSALEIHEQLVTYDEEGGGEMDTT ENSRNOP00000017983/1-717 SIQALVAIFLCILTITVITLLIFLRRRLRKQAHAHSKSALEIHEQLVTYDEEGGGEMDTT ENSCPOP00000012089/1-709 SIQALVAIFLCILTIAVITLLIFLRRRLRKQAHAHGKCVTEIHEQLVTYDEEGGGEMDTT XP_004843169.1/1-782 SIQALVAIFLCILTITVITLLFFLRRRLRKQARAHGKGVTEIHEQLVTYDEEGGGEMDTT ****:***:******:*****::****:****:**.* . ******************** ENSP00000344115/1-784 SYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHA----PGAHGGPGEMAAMIEVK ENSMUSP00000034339/1-784 SYDVSVLNSVRGGSTKPLRSTMDARPAVYTQVQKPPRLA----PGLHGGPREMATMIDVK ENSRNOP00000017983/1-717 SYDVSVLNSVRTGSNKPLRSTMDARPAVYTQVQKPPRLA----PSLHGGPREMATMIEVK ENSCPOP00000012089/1-709 SYDVSVLNSVRSGTTKAPLSMMDARPPMYSKVQKPPRLA----PGMHGGPGEMATMIEVK XP_004843169.1/1-782 CYDVSVLNSARSGAAKPLRSVLDARQPIYAKAQKPPRVAPGVMPGVHGGPGEMAAMIEVK .********.* * *. . :*** .:*::.***** * *. **** ***:**:** ENSP00000344115/1-784 KDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAE ENSMUSP00000034339/1-784 KEEADNDGGGPPYDTLHIYGYEGAESIAESLSSLSTNSSDSDIDYDFLNDWGPRFKMLAE ENSRNOP00000017983/1-717 KEEADNDGGGPPYDTLHIYGYEGTESIAESLSSLSTNSSDSDIDYDFLNDWGPRFKMLAE ENSCPOP00000012089/1-709 KDEADHDGGVPPYDTLHIYDYEGSESIAESLSSLGTDSTDSDIDYDFLNDWGPRFKMLAE XP_004843169.1/1-782 KDEADHDGGGPPYDTLHIYDYEGSESIAESLSSLGTDSTNSDIDYDFLNDWGPRFKMLAE *:***:**. *********.***:**********.*:*::**:***************** ENSP00000344115/1-784 LYGSDPREELLY ENSMUSP00000034339/1-784 LYGSDPQEELII ENSRNOP00000017983/1-717 LYGSDPQEELII ENSCPOP00000012089/1-709 LYGSNPWDEMV- XP_004843169.1/1-782 LY-SNPWDDLVY ** *:* ::::