CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000086459/1-1597 MRDAIAEPVPPPALADTPAAAMEELRPAPPPQPEP-------DPECCPAARQECMLGESA ENSRNOP00000062453/1-1387 ------------------------------------------------------------ ENSP00000375986/1-1608 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA ENSCPOP00000012054/1-1541 --------------------------------------------------RQECMLGDST XP_004869054.1/1-1544 MREVIAELVPFPAFAVTPAAAMEEPPPSPQEP----------EPECSLVARQECILGDSA ENSMUSP00000086459/1-1597 RKSMESDPEDFSDETNTETLYGTSPPSTPRQMKRLSAKHQRNSAGRPASRSNLKEKMNTP ENSRNOP00000062453/1-1387 --------------------------------------------------------MNTP ENSP00000375986/1-1608 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP ENSCPOP00000012054/1-1541 CKSPESDPEYFSDETNTENLYGTSPPSTPRQMKRMSAKHQRNNVGRPASRSSLKEKMNAP XP_004869054.1/1-1544 CKSPESDPEYFSDETNTENLYSTSPPSTPRQMKRMSAKHQRNNVGRPASRSNLKEKMNAP **:* ENSMUSP00000086459/1-1597 SQSPHKDLGKGVETVEEYSYKQEKKIRATLRTTERDHKKNAQCSFMLDSVAGSLPKKSIP ENSRNOP00000062453/1-1387 SQSPHKDLGKGVEAVEEYSYKQGKKTRATLRTTERDHKKNAQCSFMLDSVAGSLPKKSIP ENSP00000375986/1-1608 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP ENSCPOP00000012054/1-1541 NQPPHKDTGKAVENVEEYSYKQEKKIRATLRTTERDHKKNVQCSFMLDSVSGSLPKKSIP XP_004869054.1/1-1544 NQPPHKDTGKTAENMEDYSYKQEKKIRATLRTTERDHKKNVQCSFMLDSVSGSLPKKSIP .*.**** ** .* :*:***** ** **:*******:***.*********.********* ENSMUSP00000086459/1-1597 DVDLNKPYLSLGCSNAKLPVSMPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSK ENSRNOP00000062453/1-1387 DVDLNKPYLSLGCSNAKLPVSMPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSK ENSP00000375986/1-1608 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK ENSCPOP00000012054/1-1541 DVDLNKPYLSLGCSNAKIPVSVPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSK XP_004869054.1/1-1544 DVDLNKPYLSLGCSNAKIPVSVPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSK *****************:***:******.******************************* ENSMUSP00000086459/1-1597 KKDREQRGQENTAAFWFNRSNELIWLELQAWHAGRTINDQDLFLYTARQAIPDIINEILT ENSRNOP00000062453/1-1387 KKDREQRGQENTAAFWFNRSNELIWLELQAWHAGRTINDQDLFLYTARQAIPDIINEILT ENSP00000375986/1-1608 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT ENSCPOP00000012054/1-1541 KKDREQRGQENTSAFWFNRSNELIWLELQAWHAGRTINDQDLFLYTARQAIPDIINEILT XP_004869054.1/1-1544 KKDREQRGQENTSAFWFNRSNELIWLELQAWHAGRTINDQDLFLYTARQAIPDIINEILT ************:.**:************************:****************** ENSMUSP00000086459/1-1597 FKVNYGSIAFSSNGAGFNGPLVEGQCRTPQETNRVGCSSYHEHLQRQRVSFEQVKRIMEL ENSRNOP00000062453/1-1387 FKVNYGSAAFSRNGAGFNGTSLEGQCRTLHGTNSLGCSTYHEHLQRQRVSFEQVKRIMEL ENSP00000375986/1-1608 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL ENSCPOP00000012054/1-1541 FKVNYGSFPFVRNGASFNGTSVEGPHQAPYGTKNVGYSSYHEHLQRQRVSFEQVKRIMEL XP_004869054.1/1-1544 FKVNYGSFPFIRNGASFNGTSIEGPCKAPYETKNVGYSTYHEHLQRQRVSFEQVKRIMEL ***:*** .* : *.***. :** :: *: :* *::******************** ENSMUSP00000086459/1-1597 LEYMEALYPSLQALQKDYERYAAKDFEDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS ENSRNOP00000062453/1-1387 LEYMEALYPSLQALQKDYERYAAKDFEDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS ENSP00000375986/1-1608 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS ENSCPOP00000012054/1-1541 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS XP_004869054.1/1-1544 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS ***:***************:******:********************************* ENSMUSP00000086459/1-1597 DIGWPVFEIPSPRPSKGYEPEDEVEDTEVELRELESGTEESDEEPTPSPRVPELRLSTDA ENSRNOP00000062453/1-1387 DIGWPVFEIPSPRPSKGYEPEEEGEDTEGELRELESGTEESDEERSPNPRVPELRLSADT ENSP00000375986/1-1608 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN ENSCPOP00000012054/1-1541 DIGWPVFEIPSPRPSKGNDPEDEGCYTEGRLKELESSMDESDEEHSSDPGVSEIRTSIDN XP_004869054.1/1-1544 DIGWPVFEIPSPRPSKGNEPEDEGDDTEGELKELESSMDESEEEQISDPGVPEIRTSADN ***************** :** * ** .*:****. :**:** ..* *.*:* . * ENSMUSP00000086459/1-1597 ILDSRSQGCVSRKLERLESEEDSIGWGTADCGPEA--SRHCLTSIYRPFVDKALKQMGLR ENSRNOP00000062453/1-1387 ILDSHSQGCASRKLERLESEEDSVGWGIADCGPEA--SRHCLTSIYRPFVDKALKQMGLR ENSP00000375986/1-1608 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR ENSCPOP00000012054/1-1541 RLDVQLHDCASKKLERLESEEEPVGWGAAEYSTEAGFSKHCLTSIYRPFVDKALKQMGLR XP_004869054.1/1-1544 SSDVQLQDCASRKFERLESEEEPMGWGAADYSTEAGFSRHCLTSIYRPFVDKALKQMGLR * : :.* *:*:******::.:*** .: ..** *:********************* ENSMUSP00000086459/1-1597 KLILRLHKLMNGSLQRARVALVKDDRPVEFSDFPGPMWGSDYVQLSGTPPSSEQKCSAVS ENSRNOP00000062453/1-1387 KLILRLHKLMNGSLQRARVALVKDDRPVEFSDFPGPMWGSDYVQLSGTPPSSEQKCSAVS ENSP00000375986/1-1608 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS ENSCPOP00000012054/1-1541 KLILRLHKLMHGSLQRARIALIKSDHPGEFSEFPDPMWGSDYVQLSRTPPSSEQKCSSVS XP_004869054.1/1-1544 KLILRLHKLMDGSLQRARIALVKSDHPVEFSEFPDPMWGSDYVQLSRTPPSSEQKCSSVS **********.*******:**:*.*:* ***:**.*********** ******:***:** ENSMUSP00000086459/1-1597 WEELRAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK ENSRNOP00000062453/1-1387 WEELRAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQ---------- ENSP00000375986/1-1608 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK ENSCPOP00000012054/1-1541 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK XP_004869054.1/1-1544 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK ****:********************************************* ENSMUSP00000086459/1-1597 GGLLMKQYYQFMLQEVLGGLEKTDCNMDAFEEDLQKMLMVYFDYMRSWIQMLQQLPQASH ENSRNOP00000062453/1-1387 ---------------------------------------VYFDYMRSWIQMLQQLPQASH ENSP00000375986/1-1608 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH ENSCPOP00000012054/1-1541 GGLLMKQYYQFMLQEVLEDLEKTDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH XP_004869054.1/1-1544 GGLLMKQYYQFMLQEVLDDLEKTDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH ********************* ENSMUSP00000086459/1-1597 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLESGLQESCAELWTS ENSRNOP00000062453/1-1387 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLDSGLQESCAELWIS ENSP00000375986/1-1608 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS ENSCPOP00000012054/1-1541 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS XP_004869054.1/1-1544 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEVGLQESCAEFWTS **********************************************: ********:* * ENSMUSP00000086459/1-1597 ADDNGAADELRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFVLSASARE ENSRNOP00000062453/1-1387 ADDNGAADELRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFVLSASARE ENSP00000375986/1-1608 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD ENSCPOP00000012054/1-1541 ADDTSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFTFSAPVRD XP_004869054.1/1-1544 ADDTSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFILSAPVRD ***..*:**:****************************************** :**..*: ENSMUSP00000086459/1-1597 LLDALKAKQYVKVQIPGLENLHVFVPDSLAEEKKIILQLLNAATGKDCSKDPDDVFMDAF ENSRNOP00000062453/1-1387 LLDVLRAKQYVKVQIPGLENLHVFVPDSLAEEKKIILQLLNAATGKDCSKDPDDVFVDAF ENSP00000375986/1-1608 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY ENSCPOP00000012054/1-1541 LLDVLKAKQYVKVQIPGLENLQVFVPDTLAEEKGIILQLLNAAAGKDCSKDPDDLLIDVF XP_004869054.1/1-1544 LLDVLKAKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNATAGKDCSKDPDDVLIDAF ***.*::**************::****:***** ********::*******.**:::*.: ENSMUSP00000086459/1-1597 LLLTKHGDRARDSEDGWGTWEARAVKIVPQVETVDTLRSMQVDNLLLVVMESAHLVLQRK ENSRNOP00000062453/1-1387 LLLTKHGDRARDSEDGWSTWEARAIKIVPQVETVDTLRSMQVDNLLLVVMESAHLVLQRK ENSP00000375986/1-1608 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK ENSCPOP00000012054/1-1541 LLLTKHGDRARDSDDGWGTWEAQTVKVMPQVETVDTLKNMQVDNLLLVVMQSAHLTIQRK XP_004869054.1/1-1544 LLLTKHGDRARDSDDGWGSWEAQPVKIVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK *************:*.*.:***:.:*::*********:.***********:****.:*** ENSMUSP00000086459/1-1597 AFQQSIEGLMTVRHEQTSSQPIIAKGLQQLKNDALELCNRISDAIDRVDHMFTLEFDAEV ENSRNOP00000062453/1-1387 AFQQSIEGLMTVHHEQTSSQPVIAKALQQLKNDALELCNRISDAIDRVDHMFTLELDAEV ENSP00000375986/1-1608 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV ENSCPOP00000012054/1-1541 AFQQSIEGLMTLRQEQTSSQPVIATALQQLKNDALHLCNRISDAIDRVDHMFTSEFDAEV XP_004869054.1/1-1544 AFQQSIEGIMTLLQEQTSSQPVIATALQQLKNDALELCNRISDAIDRVDHMFTSEFDAEV ********:**: :*******:**..*********.******:********** *:**** ENSMUSP00000086459/1-1597 EESESATLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFAQKWMNYVLTK ENSRNOP00000062453/1-1387 EESESATLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFAQKWMNYVLTK ENSP00000375986/1-1608 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK ENSCPOP00000012054/1-1541 DESE-VTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFKQKIGDRYISFARKWMNYVLTK XP_004869054.1/1-1544 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDRYISFARKWMNYVLTK :*** .********************************:*****:*****:********* ENSMUSP00000086459/1-1597 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT-- ENSRNOP00000062453/1-1387 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT-- ENSP00000375986/1-1608 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL ENSCPOP00000012054/1-1541 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT-- XP_004869054.1/1-1544 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT-- ********************************************************** ENSMUSP00000086459/1-1597 --AIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFSTRSVPSDARTHGNSVAAAAAVAAAA ENSRNOP00000062453/1-1387 --AIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGF-------------------------- ENSP00000375986/1-1608 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV ENSCPOP00000012054/1-1541 --AIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGFSTRSVSSDMRSHGS------------ XP_004869054.1/1-1544 --AIHRNSPRPVKVPRCHSDPPNPHLIIPTPEGF-------------------------- *********:********************** ENSMUSP00000086459/1-1597 TTAAGRPGPGGGDSVPAKPVNTAPDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERD ENSRNOP00000062453/1-1387 --------------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERD ENSP00000375986/1-1608 AAS--RPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERD ENSCPOP00000012054/1-1541 TTS--RPGPFGGDAVPPKPISTAPDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERD XP_004869054.1/1-1544 --------------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERD ********************************** ENSMUSP00000086459/1-1597 EPAYPRSDSSGSTRRSWELRTLISQTKDSASKQGPIEAIQKSVRLFEERRYREMRRKNII ENSRNOP00000062453/1-1387 EPAYPRSDSSGSTRRSWELRTLISQTKDSASKQGPIEAIQKSVRLFEERRYREMRRKNII ENSP00000375986/1-1608 EPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNII ENSCPOP00000012054/1-1541 EPAYPRGDTSGSTRRSWELRTLISQTKDTASKQGPIEAIQKSVRLFEEKRYREMRRKNII XP_004869054.1/1-1544 EPAYPRGDTSGSTRRSWELRTLISQTKDTASKQGPIEAIQKSVRLFEEKRYREMRRKNII ******.*:****************:**:*** ***************:*********** ENSMUSP00000086459/1-1597 GQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQP ENSRNOP00000062453/1-1387 GQVCDTPKSYDNIMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQP ENSP00000375986/1-1608 GQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQP ENSCPOP00000012054/1-1541 GQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQP XP_004869054.1/1-1544 GQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQP ************:*********************************************** ENSMUSP00000086459/1-1597 NDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEH ENSRNOP00000062453/1-1387 NDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEH ENSP00000375986/1-1608 NDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEH ENSCPOP00000012054/1-1541 NDHKTIKETADELKIFEGIKHSNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEH XP_004869054.1/1-1544 NDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEH *********************.************************************** ENSMUSP00000086459/1-1597 VIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGE ENSRNOP00000062453/1-1387 VIRLYSKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGE ENSP00000375986/1-1608 VIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGE ENSCPOP00000012054/1-1541 VIRLYSKQITTAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGE XP_004869054.1/1-1544 VIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGE *****:**** ************************************************* ENSMUSP00000086459/1-1597 VNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKV ENSRNOP00000062453/1-1387 VNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEFEHNFQIMYKV ENSP00000375986/1-1608 VNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKV ENSCPOP00000012054/1-1541 VNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKV XP_004869054.1/1-1544 VNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKV *************************************************:********** ENSMUSP00000086459/1-1597 GMGHKPPIPERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFVKVCTDEE ENSRNOP00000062453/1-1387 GMGHKPPIPERLSPEGKDFLSHCLESDPKIRWTASQLLDHAFVKVCTDEE ENSP00000375986/1-1608 GMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE ENSCPOP00000012054/1-1541 GMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE XP_004869054.1/1-1544 GMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE ***************** ***********:**********:*********