CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000040945/1-1240 MPTLWSPSTQ---HHGSSSGSESSPLQKSVRRAQMALSPCSSSI--LPCDDRDSQGTAEW ENSRNOP00000041918/1-1256 MPTLWSPSTQ---HHGSSSGSMSSPLRKSVRCAQMALSPCSSNI--QPCDDRDSQGTAEW ENSP00000400359/1-1225 ---------------------MSSPLQRAVGDTKRALSASSSSSASLPFDDRDSNHTSEG ENSCPOP00000012038/1-1225 ---------------------ASSPLAKNCRRYPEALSASSSSSINMSCEDKDSDLASEG XP_004840270.1/1-1241 MPTLKSSGSSPQLHSSSSPSSVSSSLQRTVGVAQRALSASSSSSINLPCEDKDSELASKG **.* : ***..**. . :*:**: ::: ENSMUSP00000040945/1-1240 DSPS--TNEDSDFEDSLRRNVKKRAAKQPPKAVPAAKHRKKQSRIVSSGNGKNESVPSTN ENSRNOP00000041918/1-1256 DSSS--TSEDSDFEDSLRRNVRKRAAKRPPKAIPVAKHPKKQSHIVPGGNDKNKSVPPTS ENSP00000400359/1-1225 NGDSLLADEDTDFEDSLNRNVKKRAAKRPPKTTPVAKHPKKGSRVVHR-HSRKQSEPPAN ENSCPOP00000012038/1-1225 GSPSLSADEGSDFENSLRHSVKKRRAKRPHRTAPVAKHPKKRSQIVCH-NGQKKPDIPAC XP_004840270.1/1-1241 AGPSLSGDEGSDFEDSLRRNVKKRRAKRPHKTTPVAKHPKKGSQIICR-KVQKKSELPAC . * .*.:***:**.:.*:** **:* :: *.*** ** *::: : :::. .: ENSMUSP00000040945/1-1240 YLFDAVKAARSCMQSLVDEWLDNYKQDENAGFLELINFFIRACGCKSTVTPEMFKTMSNS ENSRNOP00000041918/1-1256 DLFDAVKAARSCAQSLVDEWLENYKQDENAGFLELVNFFIRACGCKSTVTPEMFKTMSNS ENSP00000400359/1-1225 DLFNAVKAAKSDMQSLVDEWLDSYKQDQDAGFLELVNFFIQSCGCKGIVTPEMFKKMSNS ENSCPOP00000012038/1-1225 DLFDAVKAAKSDMQTLVDEWLESYKQDEDTGFLELVNFFIRSCGCKGTVTPEMFKKMSNS XP_004840270.1/1-1241 DLFDAVKAAKSDMQSLVDEWLESYKQDEDTGFLELVNFFIRSCGCKGTVTPEMFKKMSNS **:*****:* *:******:.****:::*****:****::****. *******.**** ENSMUSP00000040945/1-1240 EIIQHLTEEFNEDSGDYPLTAPGPSWKKFQGSFCEFVKTLVYQCQYSLLYDGFPMDDLIS ENSRNOP00000041918/1-1256 EIIQHLTEEFNEDSGDYPLTAPGPSWKKFQGSFCEFVKTLVCQCQYSLLFDGFPMDDLIS ENSP00000400359/1-1225 EIIQHLTEQFNEDSGDYPLIAPGPSWKKFQGSFCEFVRTLVCQCQYSLLYDGFPMDDLIS ENSCPOP00000012038/1-1225 KIIRHLTEQFNEDSGDYPLTASGPSWKKFQGSFCEFVRTLVYQCQYSLLYDGFPMDNLIS XP_004840270.1/1-1241 EVIRHLTEQFNEDSGDYPLTASGPSWKKFQGSFCEFVKMLVCQCQYSLLYDGFPMDNLIS ::*:****:********** *.***************: ** *******:******:*** ENSMUSP00000040945/1-1240 LLIGLSDSQVRAFRHTSTLA--AMKLMTSLVKVALQLSLHKDNNQRQYEAERNKGPEQRA ENSRNOP00000041918/1-1256 LLIGLSDSQVRAFRHTSTLA--AMKLMTSLVKVALQLSLHKDNNQRQYEAERNKGPEQRA ENSP00000400359/1-1225 LLTGLSDSQVRAFRHTSTLA--AMKLMTSLVKVALQLSVHQDNNQRQYEAERNKGPGQRA ENSCPOP00000012038/1-1225 LLTGLSDSQVRAFRHTSTLAGKAMKLMTSLVRVALQLSLHKDNNQRQYESERNKGPEQRA XP_004840270.1/1-1241 LLTGLSDSQVRAFRHTSTLA--AMKLMTSLVRVALQLSLHKDNSQRQYESERNKGPEQRS ** ***************** *********:******:*:**.*****:****** **: ENSMUSP00000040945/1-1240 PERLESLLEKRKEFQENQEDIEGMMNAIFRGVFVHRYRDILPEIRAICIEEIGYWMQSYS ENSRNOP00000041918/1-1256 PERLESLLEKRKEFQENQEEIEGMMNAIFRGVFVHRYRDILPEIRAVCIEEIGCWMQSYS ENSP00000400359/1-1225 PERLESLLEKRKELQEHQEEIEGMMNALFRGVFVHRYRDVLPEIRAICIEEIGCWMQSYS ENSCPOP00000012038/1-1225 PERLESLLEKRKELQEHQEEIEGMMNAIFRGVFVHRYRDILPEIRAICIGEIGCWMQSYS XP_004840270.1/1-1241 PERLESLLEKRKELQEHQEEIEGMMNAIFRGVFVHRYRDILPEIRAICIEEIGCWMQSYG *************:**:**:*******:***********:******:** *** *****. ENSMUSP00000040945/1-1240 TSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELSLRMELFTNRFKDRMVSMVM ENSRNOP00000041918/1-1256 TSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELSSRMELFTNRFKDRMVSMVM ENSP00000400359/1-1225 TSFLTDSYLKYIGWTLHDKHREVRLKCVKALKGLYGNRDLTTRLELFTSRFKDRMVSMVM ENSCPOP00000012038/1-1225 SSFLTDSYLKYIGWTLHDKNRDVRLTCLKALQGLYSNKELTARLELFTSRFKDRMVSMVM XP_004840270.1/1-1241 TSFLTDSYLKYIGWTLHDKHRDVRLTCLKALQGLYSNRELTARLELFTSRFKDRMVSMVM :***.**************:::***.*:*** ***.*::*: *:****.*********** ENSMUSP00000040945/1-1240 DRECEVAVEAIRLLTLILKNMEGVLTSADCEKIYSIVYISNRAMASSAGEFVYWKIFHPE ENSRNOP00000041918/1-1256 DRESEVAVEAIRLLTLILKNMEGVLTSADCEKIYSIVYISNRAMASSAGEFVYWKIFHPE ENSP00000400359/1-1225 DREYDVAVEAVRLLILILKNMEGVLTDADCESVYPVVYASHRGLASAAGEFLYWKLFYPE ENSCPOP00000012038/1-1225 DREYDVAVEAVKLLILILKNMEGVLTSTDCESIYPVVYASNRALAAAAGEFLYWKLFYPE XP_004840270.1/1-1241 DREYDVAVEAVRLLILILKNMEGVLTSADCESVYPVVYASHRPLAAAAGEFLYWKLFYPE *** :*****::** ***********.:***.:*.:** *:* :*::****:***:*:** ENSMUSP00000040945/1-1240 CGAKAVSDRERRRSPQAQKTFIYLLLAFFMESEHHNHAAYLVDSLWDCAGSYLKDWESLT ENSRNOP00000041918/1-1256 CGAKAVSGRERRRSPQAQRTFIYLLLAFFMESEHHDHAAYLVDSLWDCAGSYLKDWESLT ENSP00000400359/1-1225 CEIRMMGGREQRQSPGAQRTFFQLLLSFFVESELHDHAAYLVDSLWDCAGARLKDWEGLT ENSCPOP00000012038/1-1225 FEMRAMGSRERHRSLHAQRTFFHLLLDFFLESELHDHAAYLVDSLWDCAGRHLKDWESLT XP_004840270.1/1-1241 FEMRAVFGRERHRSPHAQRTFFHLLLYFFMEVELHDHATYLVDSLWDCAGPHLKDWESLT : : .**:::* **:**: *** **:* * *:**:*********** *****.** ENSMUSP00000040945/1-1240 NLLLQKDQNLGDMQERMLIEILVSSARQAAEGHPPVGRITGKKSLTAKERKLQAYDKMKL ENSRNOP00000041918/1-1256 SLLLQKDQNLGDMQERMLIEILVSSARQAAEGHPPVGRITGKKSLTAKERKLQAYDKVKL ENSP00000400359/1-1225 SLLLEKDQNLGDVQESTLIEILVSSARQASEGHPPVGRVTGRKGLTSKERKTQADDRVKL ENSCPOP00000012038/1-1225 SLLLEKNQNLSDMQENTLIEILVSSARQAVEGHPPVGRVSGRKSLSAKERKVQADDKVKL XP_004840270.1/1-1241 SLLLEKDQNLSDVQENTLIEILVSSARQAVEGHPPVGRVSGRKGLSAKERKVQADDKVKL .***:*:***.*:** ************ ********::*:*.*::**** ** *::** ENSMUSP00000040945/1-1240 AEHLIPLLPQLLAKFSADAENVAPLLQLLSYFDLSIYCTQRLEKHLELLLQQLQEVVVKH ENSRNOP00000041918/1-1256 AEHLIPLLPQLLAKFSADAENVAPLLRLLSYFDLNIYCTQRLEKHLELLLQQLQEVVVKH ENSP00000400359/1-1225 TEHLIPLLPQLLAKFSADAEKVTPLLQLLSCFDLHIYCTGRLEKHLELFLQQLQEVVVKH ENSCPOP00000012038/1-1225 TDHLIPLLPQLVAKFSADPEKVAPLLQLLKYFDLSIYCTRRLEKHLELLLQQLQEVVVKH XP_004840270.1/1-1241 TEHLIPLLPQLLAKFSADAEKVAPLLQLLNYFDLSIYCTGRLEKHLELLLQQLQEVVVKH ::*********:******.*:*:***:**. *** **** ********:*********** ENSMUSP00000040945/1-1240 VEPEVLEAAAHALYLLCKPEFTFFSRVDFARSQLVDFLTDRFQQELDDLMQSSFLDEDEV ENSRNOP00000041918/1-1256 VEPEVLEAAAHALYLLCKPEFTFFSRVDFARSQLVDLLTDRFQQELDDLMQSSFLDEDEV ENSP00000400359/1-1225 AEPAVLEAGAHALYLLCNPEFTFFSRADFARSQLVDLLTDRFQQELEELLQSSFLDEDEV ENSCPOP00000012038/1-1225 TEPPVLEAGAQALYLLCKPEFTFFSRVDFARSQLVDLLTDRFQQELEELLQSSFIDEDEA XP_004840270.1/1-1241 TEPPVLEAGAQALYVLCKPEFTFFSRVDFARSQLVDLLTDRFQQELEELLQSSFLDEDEV .** ****.*:***:**:********.*********:*********::*:****:****. ENSMUSP00000040945/1-1240 YSLTATLKRLSAFYNAHDLTRWEISEPCSRLLRKAVDTGEVPHQVILPALTLVYFSILWT ENSRNOP00000041918/1-1256 YSLTATLKRLSAFYNAHDLTRWEISEPCSRLLRKAVDTGEVPHQVILPALTLVYFSILWT ENSP00000400359/1-1225 YNLAATLKRLSAFYNTHDLTRWELYEPCCQLLQKAVDTGEVPHQVILPALTLVYFSILWT ENSCPOP00000012038/1-1225 YSLAATLKRLSALYNAHDLTRWELYDPCYRLLRKAVDTGQVPHQVILPALTLIYFSILWT XP_004840270.1/1-1241 YSLTATLKRLSAFYNAHDLTRWELYDPCYRLLRKAVDTGEVPHQVILPALTLVYFSILWT *.*:********:**:*******: :** :**:******:************:******* ENSMUSP00000040945/1-1240 VTHISES-TSHKQLMSLKKRMVAFCELCQSCLSDVDPEIQEQAFVLLSDLLLIFSPQMIV ENSRNOP00000041918/1-1256 VTHISES-TSQKQLMSLKKRMVAFCELCQSCLSDVDPEIQEQAFVLLSDLLLIFSPQMVV ENSP00000400359/1-1225 LTHISKSDASQKQLSSLRDRMVAFCELCQSCLSDVDTEIQEQAFVLLSDLLLIFSPQMIV ENSCPOP00000012038/1-1225 LNHVSGSGGSQKQLLSLKGRMVAVCELCQNCLSDVDLEIQEQAFVLLSDLLLIFSPQMIA XP_004840270.1/1-1241 LTHISGSGGSQKQLLSLKGKMVAVCELCQNYLSGVDLQIQEQAFVLLTDLLLIFSPQMIA :.*:* * *:*** **: :***.*****. **.** :*********:**********:. ENSMUSP00000040945/1-1240 GGRDFLRPLVFFPEATLQSELASFLMDHVFLQPGELGNGQSQEDHVQIELLHQRRRLLAG ENSRNOP00000041918/1-1256 GGRDFLRPLVFFPEATLQSELASFLMDHVFLQPGELGNGQSQEDHVQIELLHQRRRLLAG ENSP00000400359/1-1225 GGRDFLRPLVFFPEATLQSELASFLMDHVFIQPGDLGSGDSQEDHLQIERLHQRRRLLAG ENSCPOP00000012038/1-1225 GGREFLRPLIFFPEATLQSELASFLMDHVFLQSGDLGPGQTLDDHIQIEQLHQRRRLLAG XP_004840270.1/1-1241 GGRDFLRPLIFFPEATLQSELASFLMDHVFLQSGDLGSGQTQDDHKQIEQLNQRRRLLAG ***:*****:********************:*.*:** *:: :** *** *:******** ENSMUSP00000040945/1-1240 FCKLLLYGVLELDAASDVFKHYNKFYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLY ENSRNOP00000041918/1-1256 FCKLLLYGVLELDAASDVFKHYNKFYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLY ENSP00000400359/1-1225 FCKLLLYGVLEMDAASDVFKHYNKFYNDYGDIIKETLTRARQIDRSHCSRILLLSLKQLY ENSCPOP00000012038/1-1225 FCKLLLYGVLELDAASDVFKHYNKFYNDYGDIIKETLTRARQIDRRHCSGILLLSLKQLY XP_004840270.1/1-1241 FCKLLLYGVLELDAASDVFKHYNKFYNDYGDIIKETLTRARQIDRSHCSRILLLSLKQLY ***********:**************:****************** :** ********** ENSMUSP00000040945/1-1240 TELIQEQGPQGLTELPAFIEMRDLARRFALSFGPQQLHNRDLVVMLHKEGIKFSLSELPP ENSRNOP00000041918/1-1256 TELIQEQGPQDLTELPAFIEMRDLARRFALSFGPQQLHNRDLVVMLHKEGIKFSLSELPP ENSP00000400359/1-1225 TELLQEHGPQGLNELPAFIEMRDLARRFALSFGPQQLQNRDLVVMLHKEGIQFSLSELPP ENSCPOP00000012038/1-1225 TELLQEQGPQGLSELPAFMEMRDLARRFALSFGPQQLQNRDIVVKLHKEGIKFSLSELSP XP_004840270.1/1-1241 TELLQEQGPQGLSELPAFMEMRDLARKFALSFGPQQLQNRDIVMKLHREGIKFSLSELPP ***:**:***.*.*****:*******:**********:***:*: **:***:******.* ENSMUSP00000040945/1-1240 AGSSHEPPNLAFLELLSEFSPRLFHQDKRLLLSYLEKCLQRVSKAPNHPWGPVTTYCHSL ENSRNOP00000041918/1-1256 AGSSREPPNIAFLELLSEFSPRLFHQDKQLLLSYLEKCLQRVSMAPSHPWGPVTTYCHSL ENSP00000400359/1-1225 AGSSNQPPNLAFLELLSEFSPRLFHQDKQLLLSYLEKCLQHVSQAPGHPWGPVTTYCHSL ENSCPOP00000012038/1-1225 AGSSDAPPNLAFLELLSEFSPRLFHQDKQLLLSYLEKCIQRIPRTPGHPWGPVTTYCRSL XP_004840270.1/1-1241 SGSSDEPPNLAFLELLSEFSPRLFHQDKQLLLSYLEKCLQRVPQTPGCPWGPVTTYRHSL :*** ***:******************:*********:*::. :*. ******** :** ENSMUSP00000040945/1-1240 HPLEITAEASPRGPPHSKKRCVEGPCRPQEEE-SSSQEESLQLNSGPTTPTLTSTAVKRK ENSRNOP00000041918/1-1256 HLVENTAEASSQGPPHSKKRCIEVPRRLQEEE-SSSQGESLQLNSGPTTPTLTSTAVKRR ENSP00000400359/1-1225 SPVENTAETSPQVLPSSKRRRVEGPAKPNREDVSSSQEESLQLNSIPPTPTLTSTAVKSR ENSCPOP00000012038/1-1225 SPVETTAETSPQGHSRSKKRRIEGPSKHQGGA----QEESLQLSSVPPTPTLTSTAVKNK XP_004840270.1/1-1241 SPVESTAEANPQGHSRSKKRRIEGPSKHQRAD----QEESLQLNSVPPTPTLTSTAVKSK :* ***:..: . **:* :* * : : * *****.* *.********** : ENSMUSP00000040945/1-1240 QSLRTVGKKQKG----------------RPGPGPGPGPELICSQQLLGTQRLKMSSAPCF ENSRNOP00000041918/1-1256 QSPRTVGKRQKGGPGPGPGPGPGPGPGPGPGPGPGPGPELICSQQLSGTQRLKMSSAPCF ENSP00000400359/1-1225 QPLWGLKEMEEE---------------------DGSELDFAQGQPVAGTERSRFLGPQYF ENSCPOP00000012038/1-1225 QPLGVLGEAEEE---------------------NGLESEFTHSQLFSGTQRPRLSSAQHF XP_004840270.1/1-1241 QPLGVLGETEEE---------------------DGLESEFSQSRFLSGTQRPRFSGAQYF *. : : :: * :: .: . **:* :: .. * ENSMUSP00000040945/1-1240 QIRCDPSGSGLGKQLTRLSLMEEDE--EEELRLLD---EEWQRGDKMLHSPSSPSEHGLD ENSRNOP00000041918/1-1256 QIRCDPSGSGLGKQMTRLSLMEEDE--EEELRLLD---EEWQCGDKLLHSPSSPSEHGLD ENSP00000400359/1-1225 QTPHNPSGPGLGNQLMRLSLMEEDE--EEELEIQDESNEERQDTDMQASSYSSTSERGLD ENSCPOP00000012038/1-1225 QTPYSSSGPDLDNKLTRVSLGNFQEFLRSSLKISTLCREEWQDTKKQSGSHSSLGENGLD XP_004840270.1/1-1241 QTSSSPSGPGLDNKLTRLSLMEEDE---EELESLDESSEEWQNTKKQPGSHSSLSEHGLD * ..**..*.::: *:** : :* ..*. ** * . * ** .*.*** ENSMUSP00000040945/1-1240 LLDTTELNMEDF ENSRNOP00000041918/1-1256 LLDTTELNMEDF ENSP00000400359/1-1225 LLDSTELDIEDF ENSCPOP00000012038/1-1225 LLDTTELNIEDF XP_004840270.1/1-1241 LLDSTELNIEDF ***:***::***