CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000112725/1-1065 MGEIEGTYRALPTSGTRLGGQTAIGVSTLEPEQSLSPRMQEKHMRIRVKLLDSTVELFDI ENSRNOP00000024440/1-1060 MGEIEGTYRTLPTSGTRLGGQTAIGVSTLEPEQALSPKMQEKHMHIRVKLLDSTVEIFDI ENSP00000264042/1-1054 MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI ENSCPOP00000012005/1-1052 MGEIEGTYRVLQTAGTRLGAQTPIGVSTLEPGQMLSPKMQEKHMHVRVKLLDNTVEIFDI XP_004868543.1/1-1059 MGEIEGTYPVLQTAGTRLGVQTPMGVSTLEPGQILSPRVQEKHARVRVKLLDNTVEIFDI ******** .* *:* *** **.:******* * * *::**** ::******.*:*:*** ENSMUSP00000112725/1-1065 EPKCDGQVLLTQVWKHLNLIECDYFGLEFKNVQSYWIWLEPMKPIIRQVRKPKNAVLRLA ENSRNOP00000024440/1-1060 EPKCDGQVLLTQVWKHLNLIECDYFGLEFKNVQSYWIWLEPMKPIIRQVRKPKNAVLRLA ENSP00000264042/1-1054 EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA ENSCPOP00000012005/1-1052 EPKCDGQVLLAQVWKHLNLMECDYFGLEFQNIQSYWIWLEPMKSIIRQIHRPKNAILRLA XP_004868543.1/1-1059 EPKCDGQVLLTQLWKHLNLIECDYFGLEFQNIQSYWIWLEPMKPVIKQIRRPKNAVLRLA **********:*:**:***:******:**:* ***********.:*:*:::***.:**** ENSMUSP00000112725/1-1065 VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCTANTAALLISHLLQSEIGDYDETLD ENSRNOP00000024440/1-1060 VKFFPPDPGQLQEEYTRYLFALQLRRDLLEERLTCTATTSALLISHLLQSEIGDYDETLD ENSP00000264042/1-1054 VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD ENSCPOP00000012005/1-1052 VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCAVTTAALLTSHLLQAEIGDYDETLD XP_004868543.1/1-1059 VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCAATTAALLTSHLLQAEIGDYDETLD ************************:**********: .*:*** *****:********** ENSMUSP00000112725/1-1065 REHLKANEYLPNQEKSLEKILDFHQRHTGQTPAESDFQVLEIARKLEMYGIRFHMASDRE ENSRNOP00000024440/1-1060 REHLKANDYLPNQEQSLDKILDFHQRHTGQTPADSDFQVLEIARKLEMYGIRFHMASDRE ENSP00000264042/1-1054 REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE ENSCPOP00000012005/1-1052 REHLKATVYLPSQEQVLEKILAFHRRHMGQTPAESDFQVLEIARKLEMYGIRFHTASDRE XP_004868543.1/1-1059 REHLKANVYLPSQEQAFEKILAFHRRHTGQTPAESDFQVLEIARKLEMYGIRFHTASDRE *****.. ***.*:: ::*** **::* *****:******************** ***** ENSMUSP00000112725/1-1065 GTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL ENSRNOP00000024440/1-1060 GTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL ENSP00000264042/1-1054 GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL ENSCPOP00000012005/1-1052 GTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL XP_004868543.1/1-1059 GTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL ****:******************************************************* ENSMUSP00000112725/1-1065 GSRDECKNFWKICVEYHTFFRLSDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYVKDGGM ENSRNOP00000024440/1-1060 GSRDECKNFWKICVEHHTFFRLSDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYIRDGGT ENSP00000264042/1-1054 GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM ENSCPOP00000012005/1-1052 GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYIRDGGM XP_004868543.1/1-1059 GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYIKDGGM ***************:****** *******************************.:*.* ENSMUSP00000112725/1-1065 KRIPYERRHSKTRTSLHALTVDLPKQSVSFTDGLRTSASLSSANVSFYPPPSSSLSPPGL ENSRNOP00000024440/1-1060 KRIPYERRHSKTRTSLHTLTGDLPKQSISFTDGLRTSASLSSANASFYPPPTS-LSSPGL ENSP00000264042/1-1054 KRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANA-FYSLSPSTLVPSGL ENSCPOP00000012005/1-1052 KRIPYERCHNRIRTSIRAPTADLPKQSISFTEGLRPSASVSSANASFYPSPTS---PPSR XP_004868543.1/1-1059 KRIPYERWHSKTRSSIHVLTADLPKQSISFTEDLR-SASLSSANASSYPLATSPLLPPGL ******* *.: ::*::. * ******:**.:.** .** ****. *. ..* ... ENSMUSP00000112725/1-1065 PNLKDSSSSLVDPQAPVI-----KSTAAERSSGPSSSDGPSTQSAHLPGPPVLRPGPGFS ENSRNOP00000024440/1-1060 PSVKDSSSSPVDPQAPHI-----KSTAAERSSRPSSSEGPSTQSAHLPGPPVLQPGPGFS ENSP00000264042/1-1054 PEFKDSSSSLTDPQVSYV-----KSPAAERRSG-AVAGGPDTPSAQPLGPPALQPGPGLS ENSCPOP00000012005/1-1052 ADFKDSSGSLADPQAPCISSAAVKNEATRKSSG--ATEGSSAPSAQPPGSPAVPSGPGLA XP_004868543.1/1-1059 PDFKDSSSSLMDPLAPCI-SAAVKNAAMMRNSE--AAGGPSAPSAQPPRSPALQSSPGLA ...****.* ** .. : *. * : * : *..: **: .*.: ..**:: ENSMUSP00000112725/1-1065 MDSPQPSPSSLKSHLSLCPELQAALSTAEQGASPVLSPVLSGAGTARMDNQEEQKHKHMP ENSRNOP00000024440/1-1060 VDSPQPSPSSLKSRLSLSPERQASLSTAEQGSSPVLSPVLSGTGTARMDNQEEQKHKHTS ENSP00000264042/1-1054 TKSPQPSPSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDC-EEPRHKRVP ENSCPOP00000012005/1-1052 MDSPQPSPSSQKSPLSLSPPFQVALGPAERGSSPLLSPVLSDAGGTRAEDQDEPRNKRIP XP_004868543.1/1-1059 MDSPQPSPSSQKSPLSLSPVFQVALAPPELASSPLLSPVLSDAGGPRTEDQEELRHKHMP .******** ** ***.* *..*...* .:**:******.:* . : :* ::*: . ENSMUSP00000112725/1-1065 EDEAYFIAKEILATERTYLKDLEVITVWFRSVLIKEEAMPAALMALLFSNIDPVYEFHRG ENSRNOP00000024440/1-1060 EDEAYFIAKEIVATERTYLKDLEVITVWFRSVVIKEEAMPAALMTLLFSNIDPIYEFHRG ENSP00000264042/1-1054 ADEAYFIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRG ENSCPOP00000012005/1-1052 EDEAYFIAKEILATERTYLKDLEVITVWFRSAVVKEDAMPAALMTLLFSNIDPVYEFHRG XP_004868543.1/1-1059 EDEAYFIAKEILATERTYLKDLEVITVWFRSAVVKEDAMPAALMTLLFSNIDPVYEFHRG ******.***:*******************.::**:****:**:********:****** ENSMUSP00000112725/1-1065 FLHEVEQRLALWEGPSSAHLKGDHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATK ENSRNOP00000024440/1-1060 FLHEVEQRLALWEGPSS----GDHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATK ENSP00000264042/1-1054 FLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATK ENSCPOP00000012005/1-1052 FLHEVEHRLTLWEGLSITHTKDDYQRIGDILLRNMRQLKEFISYFQRHDEVLTELEKATK XP_004868543.1/1-1059 FLHEVEHRLAVWEGLSIAHTKDDHQRIGDILLKNMRQLKDFTSYFQRHDKVLAELEKATK **:***:**::*** * ..:********:******:* *******:**:******* ENSMUSP00000112725/1-1065 HCKKLEAVYKEFELQKVCYLPLNTFLLKPVQRLVHYRLLLSRLCAHYSPGHRDYADCHEA ENSRNOP00000024440/1-1060 HCKRLEAVYKEFELQKVCYLPLNTFLLKPVQRLVHYRLLLNRLCTHYSPEHEDYTDCHEA ENSP00000264042/1-1054 RCKKLEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDA ENSCPOP00000012005/1-1052 CCKKLEAVYKEFELQKVCYLPLNTFLLKPIQRLVHYRLLLGRLCRHYAPGHRDYADCCDA XP_004868543.1/1-1059 HGTKLEAVYKEFELQKVCYLPLNTFLLKPIQRLVHYRLLLSRLCRHYTPGHHDYADCHDA .:*************************:***:****** *** **:* *.**:** :* ENSMUSP00000112725/1-1065 LKAITEVTTELQQSLTRLENLQKLTELQRDLVGVENLIAPGREFIREGCLHKLTKKGLQQ ENSRNOP00000024440/1-1060 LKAITEVTTELQQSLTRLENLQKLTELQRDLVGVENLIAPGREFIREGCLHKLTKKGLQQ ENSP00000264042/1-1054 LKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQ ENSCPOP00000012005/1-1052 LKAITGVTATLQHSLIRLENLQKLTELQRDLVGVENLIAPGREFIREGCLHKLTKKGLQQ XP_004868543.1/1-1059 LETITEVTTTLQHSLIQLENLQRLMELQRDLVGVENLIAPGREFIREGCLHKLTKKGLQQ *::** **: **: * :*****:* ********:************************** ENSMUSP00000112725/1-1065 RMFFLFSDMLLYTSKSVTGASHFRIRGFLPLRGMLVEESENEWSVPHCFTIYAAQKTIVV ENSRNOP00000024440/1-1060 RMFFLFSDMLLYTSKSVTGASQFRIRGFLPLRGMLVEDSENEWSVPHCFTIYAAQKTIVV ENSP00000264042/1-1054 RMFFLFSDMLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVV ENSCPOP00000012005/1-1052 RMFFLFSDMLLYTSKGIMGSSHFRIRGLLPLRGMLVEESENEWSVPHCFTIYAAHKTIVV XP_004868543.1/1-1059 RMFFLFSDMLLYTSKGIMGSSHFRFRGLLPLRGMLVEESENEWPAPHCFTIYAAQKTIVV ***************.: *:*:**:**:***:*****:*:***..*********:***** ENSMUSP00000112725/1-1065 AASTRLEKEKWMQDLNAAIQAAK--TIGDSPPVLLGGPVYTRTPRSSDEVSLEES--EDG ENSRNOP00000024440/1-1060 AASTRLEKEKWMQDLNAAIQAAK--SAGDTPAVLLGGPVYTRSPRSSDEVSLEDS--EDG ENSP00000264042/1-1054 AASTRLEKEKWMLDLNSAIQAAK--SGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDA ENSCPOP00000012005/1-1052 AASTRLEKEKWMLDLNTAIQAAK-SNGSDVSLEV----LCTHTPRSTGEVMLEQELKDTT XP_004868543.1/1-1059 AASTRQEKEKWVLDLSTAIQAAKSSSGGDVSPGLPGSPLCMRSPRSSDEVVLEQEPGDPT ***** *****: **.:****** . .* . : : :.***..** **:. : ENSMUSP00000112725/1-1065 RGNRGSLEGNSQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSNGWQKLW ENSRNOP00000024440/1-1060 RGTRGSLEGNSQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSNGWQKLW ENSP00000264042/1-1054 RGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLW ENSCPOP00000012005/1-1052 QGPGGSLEGQGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNTNGWQKLW XP_004868543.1/1-1059 QGPGGSLEGLGQHRANTTIHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNTNGWQKLW :* .**** .*******:*********************************::****** ENSMUSP00000112725/1-1065 VVFTNFCLFFYKTHQDDYPLASLPLLGYSVSLPREADSIHKDYVFKLQFKSHVYFFRAES ENSRNOP00000024440/1-1060 VVFTNFCLFFYKTHQDDYPLASLPLLGYSVSLPREADSIHKDYVFKLQFKSHVYFFRAES ENSP00000264042/1-1054 VVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAES ENSCPOP00000012005/1-1052 VVFTNFCLFFYKTHQDDHPLASLPLLGYSVSIPKEADGIHKDYVFKLQFKSHVYFFRAES XP_004868543.1/1-1059 VVFTNFCLFFYKTHQDDHPLASLPLLGYSVSVPREADGIHKDYVFKLQFKSHVYFFQAES *****************:*************:*:***.******************:*** ENSMUSP00000112725/1-1065 KYTFERWMDVIKRASSSPGRPPSFTQDCSHHSPGLEAEIREKEACPSPCLDKNL ENSRNOP00000024440/1-1060 KYTFERWMEVIKRASSSPGRPPSFTQDCSHLSPGLEAEVREKEACPSLCLDKNL ENSP00000264042/1-1054 KYTFERWMEVIQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE---------- ENSCPOP00000012005/1-1052 KYTFERWMEVIERASSSRG-TPSPTQDDPRPFSGLEETPKGKE----------- XP_004868543.1/1-1059 KYTFKRWMEVIESASSSCG-APSPAQDSPWPCSGLEGALKGKEE---------- ****:***:**: **** * .** .** . .*** : **