CLUSTAL W(1.81) multiple sequence alignment ENSP00000314420/1-1290 ------------------------------------MSGPLEGADGGGDPRPGESFCPGG ENSMUSP00000021271/1-1291 ------------------------------------MSGPLEGADGGGDPRPGEPFCPGG ENSRNOP00000053964/1-1293 ------------------------------------MSGPLEGADGGGDPRPGEPFCPGG ENSCPOP00000011999/1-1273 SSETDPTYSLSQASRPLGASAVASPPSLFCFPHGPDMSGPLEGADGGGDPGSGESFCPGE XP_004857537.1/1-1283 ------------------------------------MSGPLEGADGGGDPRPGESFCPRE ************** .**.*** ENSP00000314420/1-1290 VPSPGPPQHRPCPGPSLADDTDANSNGSSGNESNGHESRGASQRSSHSSSSGNGKDSALL ENSMUSP00000021271/1-1291 VPSPGAPQHRPCPGPSLADDTDANSNGSSGNESNGPESRGASQRSSHSSSSGNGKDSALL ENSRNOP00000053964/1-1293 VPSPGAPQHRPCPGPSLADDTDANSNGSSGNESNGHESRGASQRSSHSSSSGNGKDSALL ENSCPOP00000011999/1-1273 VPSPGPPQHRPCPGPSLADDTDANSNGSSGNESNGHESRGASQRSSHSSSSGNGKDSALL XP_004857537.1/1-1283 VPSPGPPQHRPCPGPSLADDTDANSNGSSGNESNGNESRGASQRSSHSSSSGNGKDSALL *****.***************************** ************************ ENSP00000314420/1-1290 ETTESSKSTNSQSPSPPSSSIAYSLLSASSEQDNPSTSGCSSEQSARARTQKELMTALRE ENSMUSP00000021271/1-1291 ETTESSKSTNSQSPSPPSSSIAYSLLSASSEQDNPSTSGCSSEQSARARTQKELMTALRE ENSRNOP00000053964/1-1293 ETTESSKSTNSQSPSPPSSSIAYSLLSASSEQDNPSTSGCSSEQSARARTQKELMTALRE ENSCPOP00000011999/1-1273 ETTESSKSTNSQSPSPPSSSIAYSLLSASSEQDNPSTSGCSSEQSARARTQKELMTALRE XP_004857537.1/1-1283 ETTESSKSTNSQSLSPPSSSIAYSLLSASSEHDNPSTSGCSSEQSARARTQKELMTALRE ************* *****************:**************************** ENSP00000314420/1-1290 LKLRLPPERRGKGRSGTLATLQYALACVKQVQANQEYYQQWSLEEGEPCSMDMSTYTLEE ENSMUSP00000021271/1-1291 LKLRLPPERRGKGRSGTLATLQYALACVKQVQANQEYYQQWSLEEGEPCAMDMSTYTLEE ENSRNOP00000053964/1-1293 LKLRLPPERRGKGRSGTLATLQYALACVKQVQANQEYYQQWSLEEGEPCAMDMSTYTLEE ENSCPOP00000011999/1-1273 LKLRLPPERRGKGRSGTLATLQYALACVKQVQANQDYYQQWSLEEGEPCAMDMSTYTLEE XP_004857537.1/1-1283 LKLRLPPERRGKGRSGTLATLQYALACVKQVQANQDYYQQWSLEEGEPCAMDMSTYTLEE ***********************************:*************:********** ENSP00000314420/1-1290 LEHITSEYTLQNQDTFSVAVSFLTGRIVYISEQAAVLLRCKRDVFRGTRFSELLAPQDVG ENSMUSP00000021271/1-1291 LEHITSEYTLRNQDTFSVAVSFLTGRIVYISEQAGVLLRCKRDVFRGARFSELLAPQDVG ENSRNOP00000053964/1-1293 LEHITSEYTLRNQDTFSVAVSFLTGRIVYISEQAGVLLRCKRDVFRGARFSELLAPQDVG ENSCPOP00000011999/1-1273 LEHITSEYTLRNQDTFSVAVSFLTGRIVYISEQASVLLRCKRDVFRGARFSELLAPQDVG XP_004857537.1/1-1283 LEHITSEYTLRNQDTFSVAVSFLTGRIVYISEQAGVLLRCKRDVFRGARFSELLAPQDVG **********:***********************.************:************ ENSP00000314420/1-1290 VFYGSTAPSRLPTWGTGASAGSGLRDFTQEKSVFCRIRGGPDRDPGPRYQPFRLTPYVTK ENSMUSP00000021271/1-1291 VFYGSTTPSRLPTWGTGTSAGSGLKDFTQEKSVFCRIRGGPDRDPGPRYQPFRLTPYVTK ENSRNOP00000053964/1-1293 VFYGSTTPSRLPTWGTGTSAGSGLKDFTQEKSVFCRIRGGPDRDPGPRYQPFRLTPYVTK ENSCPOP00000011999/1-1273 VFYGSTAPSRLPTWGAGASTGSGLKDFTQEKSIFCRIRGGPDRDPGPRYQPFRLTPYVTK XP_004857537.1/1-1283 VFYGSTAPSRLPTWGTGASAGSGLKDFTQEKSVFCRIRGGPDRDPGPRYQPFRLTPYVTK ******:********:*:*:****:*******:*************************** ENSP00000314420/1-1290 IRVSDGAPAQPCCLLIAERIHSGYEAPRIPPDKRIFTTRHTPSCLFQDVDERAAPLLGYL ENSMUSP00000021271/1-1291 IRVSDGAPAQPCCLLIAERIHSGYEAPRIPPDKRIFTTRHTPSCLFQDVDERAAPLLGYL ENSRNOP00000053964/1-1293 IRVSDGAPAQPCCLLIAERIHSGYEAPRIPPDKRIFTTRHTPSCLFQDVDERAAPLLGYL ENSCPOP00000011999/1-1273 IRVSDGAPAQPCCLLIAERIHSGYEAPRIPPDKRIFTTRHTPSCLFQDVDERAAPLLGYL XP_004857537.1/1-1283 IRVSDGAPAQPCCLLIAERIHSGYEAPRIPPDKRIFTTRHTPSCLFQDVDERAAPLLGYL ************************************************************ ENSP00000314420/1-1290 PQDLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGF ENSMUSP00000021271/1-1291 PQDLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGF ENSRNOP00000053964/1-1293 PQDLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGF ENSCPOP00000011999/1-1273 PQDLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGF XP_004857537.1/1-1283 PQDLLGAPVLLFLHPEDRPLMLAIHKKILQLAGQPFDHSPIRFCARNGEYVTMDTSWAGF ************************************************************ ENSP00000314420/1-1290 VHPWSRKVAFVLGRHKVRTAPLNEDVFTPPAPSPAPSLDTDIQELSEQIHRLLLQPVHSP ENSMUSP00000021271/1-1291 VHPWSRKVAFVLGRHKVRTAPLNEDVFTPPAPSPAPSLDSDIQELSEQIHRLLLQPVHSS ENSRNOP00000053964/1-1293 VHPWSRKVAFVLGRHKVRTAPLNEDVFTPPVPSPAPSLDSDIQELSEQIHRLLLQPVHSS ENSCPOP00000011999/1-1273 VHPWSRKVAFVLGRHKVRTAPLNEDVFTPPGSSSALSLDSDIQELSEQIHRLLLQPVHSS XP_004857537.1/1-1283 VHPWSRKVAFVLGRHKVRTAPLNEDVFTPPAPSPALSLDSDIQELSEQIHRLLLQPVHSS ****************************** .*.* ***:*******************. ENSP00000314420/1-1290 SPTGLCGVGAVTSPGPLHSPGSSSDSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLF ENSMUSP00000021271/1-1291 SPTGLCGVGPLMSPGPLHSPGSSSDSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLF ENSRNOP00000053964/1-1293 STTGLCGVGPLMSPGPLHSPGSSSDSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLF ENSCPOP00000011999/1-1273 SPTGLCGVGPVASPGPLRSPGSSSDSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLF XP_004857537.1/1-1283 SPPGLCGVGPVASPGPLHSPGSSSDSNGGDAEGPGPPAPVTFQQICKDVHLVKHQGQQLF *..******.: *****:****************************************** ENSP00000314420/1-1290 IESRARPQSRPRLPATGTFKAKALPCQSPDPELEAGSAPVQAPLALVPEEAERKEASSCS ENSMUSP00000021271/1-1291 IESRAKPPPRPRLLATGTFKAKVLPCQSPNPELEVAPVPDQASLALAPEEPERKETSGCS ENSRNOP00000053964/1-1293 IESRAKPPPRPRLLATGTFKAKVLPCQSPNPELEVAPAPDQASLALAPEEPERKESSGCS ENSCPOP00000011999/1-1273 IESRARPPPQPRLPATGTFKAKALPLQPRDAEPEAVPAPSQAPLALAPEEAERKEASGCS XP_004857537.1/1-1283 IESRARPPPRPRLPATGTFKAKALPSQSRNPELEAVPAPIQSPLSLAPEEAERKETSSCS *****:* .:*** ********.** *. :.* *. ..* *:.*:*.***.****:*.** ENSP00000314420/1-1290 YQQINCLDSILRYLESCNLPSTTKRKCASSSSYTTSSASDDDRQRTGPVSVGTKKDPPSA ENSMUSP00000021271/1-1291 YQQINCLDSILRYLESCNIPSTTKRKCASSSSYTASSASDDDKQRAGPVPVGAKKDPSSA ENSRNOP00000053964/1-1293 YQQINCLDSILRYLESCNIPNTTKRKCA-SSSCTASSASDDDKQRAGPVPVGAKKDTSSA ENSCPOP00000011999/1-1273 YQQINCLDSILRYLESCNIPSTTKRKCASSSSYTASSASDDDKQRTGPVPVGAKKDSPSA XP_004857537.1/1-1283 YQQINCLDSILRYLESCNIPSTTKRKCASSSSCTASSASDDDKQRTGPVPVGAKKDPPSA ******************:*.******* *** *:*******:**:***.**:***..** ENSP00000314420/1-1290 ALSGEGATPRKEPVVGGTLSPLALANKAESVVSVTSQCSFSSTIVHVGDKKPPESDIIMM ENSMUSP00000021271/1-1291 MLSGEGATPRKEPVVGGTLSPLALANKAESVVSVTSQCSFSSTIVHVGDKKPPESDIIMM ENSRNOP00000053964/1-1293 VLSGEGATPRKEPVVGGTLSPLALANKAESVVSVTSQCSFSSTIVHVGDKKPPESDIIMM ENSCPOP00000011999/1-1273 VLAGEGAAPRKEPVVGGTLSPLALANKAESVASVTSQCSFSSTIVHVGDKKPPESDIIMM XP_004857537.1/1-1283 LLSGEGATPRKEPVVGGTLSPLGLANKAESVVSVTSQCSFSSTIVHVGDKKPPESDIIMM *:****:**************.********.**************************** ENSP00000314420/1-1290 EDLPGLAPGPAPSPAPSPTVAPDPAPDAYRPVGLTKAVLSLHTQKEEQAFLSRFRDLGRL ENSMUSP00000021271/1-1291 EDLPGLAPGPAPSPAPSPTVAPDPTPDAYRPVGLTKAVLSLHTQKEEQAFLNRFRDLGRL ENSRNOP00000053964/1-1293 EDLPGLAPGPAPSPAPSPTVAPDPAPDAYRPVGLTKAVLSLHTQKEEQAFLSRFRDLGRL ENSCPOP00000011999/1-1273 EDLSGY---------------------AYRPVGLTKAVLSLHTQKEEQAFLSRFRDLGRL XP_004857537.1/1-1283 EDLPGLALGPALSPAPSPTVAPDPAPDAYRPVGLTKAVLSLHTQKEEQAFLSRFRDLGRL ***.* ************************.******** ENSP00000314420/1-1290 RGLDSSSTAPSALGERGCHHGPAPPSRRHHCRSKAKRSR--HHQNPRAEAPCYVSHPSPV ENSMUSP00000021271/1-1291 RGLDTSSVAPSAP---GCHHGPIPPGRRHHCRSKAKRSRHHHHQTPRPETPCYVSHPSPV ENSRNOP00000053964/1-1293 RGLDTSSVAPSAP---GCHHGPIPSGRRHHCRSKAKRSR--HHQTPRPETPCYVSHPSPV ENSCPOP00000011999/1-1273 RGLDSSSTAPWAP---GCHHSPTPPSRRHHCRSKAKRSR--HHQTSRAEAPCYVSHASSV XP_004857537.1/1-1283 RGLDGSSTAPSAPGERGCHHGPTPPSRRHHCRSKAKRSR--RHQTSRAEAPCYVPHPSPV **** **.** * ****.* *..************* :**..*.*:****.*.*.* ENSP00000314420/1-1290 PPSTPWPTPPATTPFPAVVQPYPLPVFSPRGGPQPLPPAPTSVPPAAFPAPLVTPMVALV ENSMUSP00000021271/1-1291 PSSGPWPPPPATTPFPAMVQPYPLPVFSPRGGPQPLPPAPTSVSPATFPSPLVTPMVALV ENSRNOP00000053964/1-1293 PSSGPWPPPPATTPFPAVVQPYPLPVFSPRGGPQPLPPAPTSVSPATFPSPLVTPMVALV ENSCPOP00000011999/1-1273 PPSGPWPPPPADSTFPAVVQPYSLPVFSPRGSPQPLPPAASSVPPAAFSAPLVTPVVALV XP_004857537.1/1-1283 PPSGPWPPPPATTPFPAVVQPYPVPVFSPRGGPQPLPTAPTSVPPATFSTPLVTPVVALV *.* ***.*** :.***:****.:*******.*****.*.:**.**:*.:*****:**** ENSP00000314420/1-1290 LPNYLFPTPSSYPYGALQTPAEGPPTPASHSPSPSLPALAPSPPHRPDSPLFNSRCSSPL ENSMUSP00000021271/1-1291 LPNYLFPTPPSYPYGVSQAPVEGPPTPASHSPSPSLPPPPLSPPHRPDSPLFNSRCSSPL ENSRNOP00000053964/1-1293 LPNYLFPSPTSYPYGVSQAPVEGPPTPASHSPSPSLPPPPPSPPHRPDSPLFNSRCSSPL ENSCPOP00000011999/1-1273 LPNYLFPTPSSYPYGVHQAPAESPLTPASHSPSPSLLPLPPSPPHRPDSPLFNSRCSSPL XP_004857537.1/1-1283 LPNYLFPTPSSYPYGVHQAPAEGPPTPASHSPSPSLLPLPPSPPHHPDSPLFNSRCSSPL *******:*.*****. *:*.*.* *********** . . ****:************** ENSP00000314420/1-1290 QLNLLQLEELPRAEGAAVAGGPGSSAGPPPPS-AEAAEPEARLAEVTESSNQDALSGSSD ENSMUSP00000021271/1-1291 QLNLLQLEESPRTEGGAAAGGPGSSAGPLPPS-EETAEPEARLVEVTESSNQDALSGSSD ENSRNOP00000053964/1-1293 QLNLLQLEESPRTEGGAAAGGPGSSAGPLPPS-EESAEPEPRLVEVTESSNQDALSGSSD ENSCPOP00000011999/1-1273 QLNLLQLEEPSRTEAGAVAGGPGSSAGPPPPI-EEAAEPETRLVEVTESSNQDALSGSSD XP_004857537.1/1-1283 QLNLLQLEEPSRTEGGAVAGGPGSSAGPPPPSAEEAAEPETRLVEVNESSNQDALSGSSD ********* .*:*..*.********** ** *:****.**.**.************* ENSP00000314420/1-1290 LLELLLQEDSRSGTGSAASGSLGSGLGSGSGSGSHEGGSTSASITRSSQSSHTSKYFGSI ENSMUSP00000021271/1-1291 LLELLLQEDSRSGTGSAASGSLGSGLGSGSGSGSHEGGSTSASITRSSQSSHTSKYFGSI ENSRNOP00000053964/1-1293 LLELLLQEDSRSGTGSAASGSLGSGLGSGSGSGSHEGGSTSASITRSSQSSHTSKYFGSI ENSCPOP00000011999/1-1273 LLELLLQEDSRSGTGSAASGS------------PHEGGSTSASITRSSQSSHTSKYFGSV XP_004857537.1/1-1283 LLELLLQEDSRSGTGSAASGSLGSGLGSGSGSGSHEGGSTSASITRSSQSSHTSKYFGSI ********************* .*************************: ENSP00000314420/1-1290 DSSEAEAGAARGGAEPGDQVIKYVLQDPIWLLMANADQRVMMTYQVPSRDMTSVLKQDRE ENSMUSP00000021271/1-1291 DSSEAEAGAARARTEPGDQVIKCVLQDPIWLLMANADQRVMMTYQVPSRDAASVLKQDRE ENSRNOP00000053964/1-1293 DSSEAEAGAAQARTEPGDQVIKYVLQDPIWLLMANADQHVMMTYQVPSRDAASVLKQDRE ENSCPOP00000011999/1-1273 DSSEAEAGAAQARAEPGDQVIKYVLQDPIWLLMANADQHVMMTYQVPSRDMASVLKQDRE XP_004857537.1/1-1283 DSSEAEAGAAQAQAEPGDQVIKYVLQDPIWLLMANADQHVMMTYQVPSRDMASVLKQDRE **********:. :******** ***************:*********** :******** ENSP00000314420/1-1290 RLRAMQKQQPRFSEDQRRELGAVHSWVRKGQLPRALDVMACVDCGSSTQDPGHPDDPLFS ENSMUSP00000021271/1-1291 RLRAMQKQQPRFSEDQRRELGAVHSWVRKGQLPRALDVTACVDCGSSVQDPGHSDDPLFS ENSRNOP00000053964/1-1293 RLRAMQKQQPRFSEDQRRELGAVHSWVRKGQLPQALDVTACVDCGSSVQDPGHSDDPLFS ENSCPOP00000011999/1-1273 RLRAMQKQQPRFSDDQRRELGAVHSWVRKGQLPQALDVTACVDCGSSTQDPGHSDHPLFS XP_004857537.1/1-1283 RLRAMQKQQPRFSEDQRRELGAVHSWVRKGQLPQALDVMACVDCGSSTQDPGHSDHPLFS *************:*******************:**** ********.*****.*.**** ENSP00000314420/1-1290 ELDGLGLEPMEEGGGEQGSS-------GGGSGEGEGCEEAQGGAKASSSQDLAMEEEEEG ENSMUSP00000021271/1-1291 ELDGLGLEPMEEGGGEGGGC-----GVGGGGGDGGEEAQTQIGAKGSSSQDSAMEEEEQG ENSRNOP00000053964/1-1293 ELDGLGLEPMEEGGGEGGGVGGGGGGVGGGGGDGGEEAQTQIGTKGSSSQDSAMEEEEQG ENSCPOP00000011999/1-1273 DLDGLGLEPM------------------------GEEPRAQTGAKVSGSQDSAMEEEEQG XP_004857537.1/1-1283 ELDGLGLEPMEEGGGE---------------GEGGEEPGAQAEAKVSGSQDSAMEEEEQG :********* :* :* *.*** ******:* ENSP00000314420/1-1290 RSSSSPALPTAGNCTS ENSMUSP00000021271/1-1291 GGSSSPALPAEENSTS ENSRNOP00000053964/1-1293 GSSSSPALPAEENGTS ENSCPOP00000011999/1-1273 GSSSSPALPAAENGTS XP_004857537.1/1-1283 GSSSSPTLPTAENGTS .****:**: * **