CLUSTAL W(1.81) multiple sequence alignment ENSP00000373565/1-1179 MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALAEGGSEAYSRFLATEGAPDFLCPEE ENSMUSP00000059839/1-1209 MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALTEGGPEAYNRFLASEGAPDFLCPEE ENSRNOP00000044153/1-1209 MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALTEGGQEAYNRFLASEGAPDFLCPEE ENSCPOP00000011994/1-1156 MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALMEGGREAYNRFLASEGAPDFLSPEE XP_004837861.1/1-1176 MARRSQSSSQGDNPLAPGYLPPHYKEYYRLAVDALTEGGAEAYSRFLASEGAPDFLCPEE *********************************** *** ***.****:*******.*** ENSP00000373565/1-1179 LEHVSRHLRPPQYVTREPPEGSLLDVDMDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGT ENSMUSP00000059839/1-1209 LEHVSRHLQPPQYVAREPPEGTPSDVDMDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGT ENSRNOP00000044153/1-1209 LEHVSRHLQPPQYVSREPPEGAPPDVDMDGSSGTYWPVDSDQAVPELDLGWPLTFGFQGT ENSCPOP00000011994/1-1156 LEHVCRHLTPPQHVARELPEGSPPDVDMDGSSGTYWPENSDQAVPELDLGWPLTFGFQGT XP_004837861.1/1-1176 LEHVSRHLQPPQHVARELPEGSPPDVDMDGSSGTYWPVNSDQAVPELDLGWPLTFGFQGT ****.*** ***:*:** ***: ************* :********************* ENSP00000373565/1-1179 EVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYIL ENSMUSP00000059839/1-1209 EVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYIL ENSRNOP00000044153/1-1209 EVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYIL ENSCPOP00000011994/1-1156 EVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLGEVLEAAARRVPVYIL XP_004837861.1/1-1176 EVTTLVQPPPPDSPSIKDEARRMIRSAQQVVAVVMDMFTDVDLLSEVLEAAARRVPVYIL ********************************************.*************** ENSP00000373565/1-1179 LDEMNAQHFLDMADKCRVNLQHVDFLRVRTVAGPTYYCRTGKSFKGHVKEKFLLVDCAVV ENSMUSP00000059839/1-1209 LDEMNAQHFLDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHLKEKFLLVDCAVV ENSRNOP00000044153/1-1209 LDEMNAQHFLDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHLKEKFLLVDCAVV ENSCPOP00000011994/1-1156 LDEMNAQHFMDMADKCRVNLHHVDFLRVRTVAGPTYYCRTGKSFKGHVKEKFLLVDCAVV XP_004837861.1/1-1176 LDEMNAQHFLDMADKCRFNLHHVDFLRVRTVAGPTYYCRTGKSFKGHLKEKFLLVDCAVV *********:*******.**:**************************:************ ENSP00000373565/1-1179 MSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAAALARMDAYALA ENSMUSP00000059839/1-1209 MSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGALARMDAYALA ENSRNOP00000044153/1-1209 MSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGALARMDAYALT ENSCPOP00000011994/1-1156 MSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGALARMDAYALA XP_004837861.1/1-1176 MSGSYSFMWSFEKIHRSLAHVFQGELVSSFDEEFRILFAQSEPLVPSAGALARMDTYALA ************************************************.******:***: ENSP00000373565/1-1179 PYAGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREEPP ENSMUSP00000059839/1-1209 PYSGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREELQ ENSRNOP00000044153/1-1209 PYSGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRRDELQ ENSCPOP00000011994/1-1156 PYSGAGPLVGVPGVGAPTPFSFPKRAHLLFPPPREEGLGFPSFLDPDRHFLSAFRREEMP XP_004837861.1/1-1176 PYSGAGPLVGVPGVGAPTPFSFPKRAHLLFQPPREEGLGFPSFLDPDRHFLSAFRREEIP **:*************************** *************************:* ENSP00000373565/1-1179 RMPGGALEPHAGLRPLSRRLEAEAGPAGELAGARGFFQARHLEMDAFKRHSFAT-EGAGA ENSMUSP00000059839/1-1209 RMPGGALEPHTGLRPLAR--PTEAGPFGELAGPRGFFQSRHLEMDAFKRHSYATPDGAGA ENSRNOP00000044153/1-1209 RMPGGALEPHTGLRPLAR--PGEAGPLGELPGPRGFFQSRHLEMDAFKRHSYTAADGAGA ENSCPOP00000011994/1-1156 RGPGGILEQHTGLRPLSRRLDPEIGPSGELSGTRGFF-ARHLEMDAVKRHSYAAVDGTGA XP_004837861.1/1-1176 RGPGGILEPHAGMRSLSRRLDMEAGPSGEPPGTRGFFQARHLEMDAFKRHSYTAADGAGA * *** ** *:*:*.*:* * ** ** .*.**** :*******.****::: :*:** ENSP00000373565/1-1179 VENFAAARQVSRQTFLSHGDDFRFQTSHFHRDQLYQQQYQWDPQLTPARPQGLFEKLRGG ENSMUSP00000059839/1-1209 VENFAAARQVSRQTFLSHGDDFRFQTSHFQRDQLYQQHYQWDPQFAPARPQGLFEKLRAG ENSRNOP00000044153/1-1209 VENFAAARQVSRQTFLSHGDDFRFQTSHFQRDQLYQQHYQWDPQFAPARPQGLFEKLRAG ENSCPOP00000011994/1-1156 VENFAAARQVSRQTFLSHGDDFRFQTSHFHRDQLYQQHYQWDPQLNPTRPQGLFEKIRAG XP_004837861.1/1-1176 VENFAAARQVSRQTFLSHGDDFRFQTSHFHRDQLYQQHYQWDPQLNPTRPQGLFEKIRAG *****************************:*******:******: *:********:*.* ENSP00000373565/1-1179 RAGFADPDDFTLGAGPRFPELGPDGHQRLDYVPSSASREVRHGSDPAFAPGPRGLEPSGA ENSMUSP00000059839/1-1209 RPGFADPDDFALGAGHRFPELGADVHQRLEYVPSSASREVRHGSDPAFGPSPRGLEPSGA ENSRNOP00000044153/1-1209 RPGFADPDDFALGAGHRFPELGADVHQRLEYVPSSASREVRHGSDPAFGPSPRGLEPSGA ENSCPOP00000011994/1-1156 RPGFPDHDDFTLGAGLRFPELGPDGHQRLEYVPSSASREVRQGSDPVFGPGQRGLEPGGA XP_004837861.1/1-1176 RPGFADHDDFTLGAGPRFPELGPDGHQRLEYVPSSASREARHGSDPAFGPGPQGLEPGGV *.**.* ***:**** ******.* ****:*********.*:****.*.*. :****.*. ENSP00000373565/1-1179 PRPNLTQRFPCQAAARPGPDPAPEAEPERRGGPEGRAGLRRWRLASYLSGCHGEDGGDDG ENSMUSP00000059839/1-1209 SRPNLGQRFPCQATLRQGLDTASEAEPERRGGPEGRAGLRHWRLASYLSGCHG-DGGEEG ENSRNOP00000044153/1-1209 SRPNLGQRFPCQATLRQGLDTATEAEPERRGGPEGRAGLRHWRLASYLSGCHG-DGGEEG ENSCPOP00000011994/1-1156 LHPNLGQRFPCQAVVRQGPDPAMETEPERKGGTEGRAGLRHWRLASYLSGCHGEDTGEEG XP_004837861.1/1-1176 LRPNLGQRFPCQAVVRQGADPAVETETQRKGGAEGRAGLRHWRLASYLSGCHGEDTGEEG :*** *******. * * *.* *:*.:*:**.*******:************ * *::* ENSP00000373565/1-1179 LPAPMEAEAYEDDVLAPGGRAPAGDLLPSAFRVPAAFPTKVPVPGPGSGGNG--PEREGP ENSMUSP00000059839/1-1209 L--PMEAEACEDEVLAPGGR----DLLPSAFRTPAAFPAKGPKPGSGS-GGGDSSEREGP ENSRNOP00000044153/1-1209 L--PMEAEACEDEVLAPGGR----DLLPSTFRTPAPFPAKGPKPGSGS-GGGDSSEREGP ENSCPOP00000011994/1-1156 LSLPMEAEVYEDDVLAPTGRAPAGDLLPSAFRAPTAFPAKGPVPGPGS-GGG--AEREGV XP_004837861.1/1-1176 LPMPMEVEVCEDDVLAPAGRATAGDLLPSAFRVPTAFPAKGPVPGSGS-GDG--AEREGV * ***.*. **:**** ** *****:**.*:.**:* * **.** *.* .**** ENSP00000373565/1-1179 EEPGLAKQDSFRSRLNPLVQRSSRLRSSLIFST-SQAEGAAGAAAA-TEKVQLLHKEQTV ENSMUSP00000059839/1-1209 EETSLAKQDSFRSRLNPLIQRSSRLRSSLIFAS--QAEGAVGTAAATTEKVQLMHKEQTV ENSRNOP00000044153/1-1209 EETGLIKQDSFRSRLNPLIQRSSRLRSSLIFAS--QAEGTAGTTAATTEKVQLMHKEQTI ENSCPOP00000011994/1-1156 EEAGLAKQDSFRSRLNPIIQRSSRLRSSLIFASQAQAEGVGGAAGGTTEKVQLLHKEQTI XP_004837861.1/1-1176 EEAGLAKQDSFRSRLNPLIQRSSRLRSSLIFASQAQAEGTGGAMGATTEKVQLLHKEQTI **..* ***********::************:: ****. *: .. ******:*****: ENSP00000373565/1-1179 SETLGPGGEAVRSAASTKVAELLEKYKGPARDPGGGAGAITVASHSKAVVSQAWREEVAA ENSMUSP00000059839/1-1209 SETLGPSGEAVRSSASAKVAELLEKYKGPARDPGGAGGAVTSSSHSKAVVSQAWREEVVA ENSRNOP00000044153/1-1209 SETLGPSGEAVRSSASAKVAELLEKYKGPARDPGGAGGAITASSHSKAVVSQAWREEVVA ENSCPOP00000011994/1-1156 SETLGPGGEAVRSTASAKVAELLEKYKGPARDTG---GAVTVSSHSKAMVSQTLQEEVTA XP_004837861.1/1-1176 NETLGPGGEAMRSTASAKVAELLEKYKGPARETG---GAVTVSSHSKAVVSQMLREEVAA .*****.***:**:**:**************:.* **:* :*****:*** :***.* ENSP00000373565/1-1179 PGAVGGERRSLESCLLDLRDSFAQQLHQEAERQPGAASLTAAQLLDTLGRSGSDRLPSRF ENSMUSP00000059839/1-1209 PGGAGTERRSLESCLLDLRDSFAQQLHQEAERHPGAASLTAAQLLDTLG--GTDRLPSRF ENSRNOP00000044153/1-1209 PGGAGAERRSLESCLLDLRDSFAQQLHQEAERHPGAASLTAAQLLDTLG--GTDRLPSRF ENSCPOP00000011994/1-1156 PGAGGCERRSLESCLLDLRDSFAQQLHQEAERQPGAASLTAAQLLDTLGRSGADRLPSRF XP_004837861.1/1-1176 AGTGGCERRSLESCLLDLRDSFAQQLHQEAERQPGAASLTATQLLDTLGRSGADRLPSRF .* * **************************:********:******* *:******* ENSP00000373565/1-1179 LSAQSHSTSPQGLDSPLPLEGSGAHQVLHNESKGSPTSAYPERKGSPTP----------- ENSMUSP00000059839/1-1209 LSAQGRSLSPQGRDSP-PPEGLGTHQLPYSEPKGNPTPAYPERKGSPTPAYPERKGSPTP ENSRNOP00000044153/1-1209 LSAQGRSLSPQGRDSP-PPEGLGTHQLPYSEPKGSPTPAYPERKGSPTPAYPERKGSPTP ENSCPOP00000011994/1-1156 LSAQGSSTSPQGWDSP-PPDGPGAHQVPHSEPKGSPTLAYPERKGSPTP----------- XP_004837861.1/1-1176 LSAQGRSTSPQGRDSP-PPDRPGAHQVLHSEPRGSPTLAYPERKGSPTP----------- ****. * **** *** * : *:**: :.*.:*.** *********** ENSP00000373565/1-1179 ---------------------------------GFSTRRGSPTTGFIEQKGSPTSAYPER ENSMUSP00000059839/1-1209 AYPERKGSPTPAYPERKGSPTQAYPERKGSPTSGFPNRRGSPTTGLMEQKGSPTSTYPDR ENSRNOP00000044153/1-1209 AYPERKGSPTPAYPERKGSPTPAYPERKGSPTSGFPNRRGSPTTGLMEQKGSPTSTYPDR ENSCPOP00000011994/1-1156 ---------------------------------GFPNRRGSPTTGFVEQKGNPTSSYPEH XP_004837861.1/1-1176 ---------------------------------GFANRRGSPTTGFVEQKGNPTSPYPER **..********::****.***.**:: ENSP00000373565/1-1179 RGSPVPPVPERRSSPVPPVPERRGSLTLTISGESPKAGPAEEGPSGPMEVLRKGSLRLRQ ENSMUSP00000059839/1-1209 RGSPVPPVPERRGSPVPPVPERRGSLTFA--GESSKTGPTEEVSSGPMEVLRKGSLRLRQ ENSRNOP00000044153/1-1209 RSSPVPPVPERRGSPVPPVPERRGSLTFA--GESSKTGPTEEVSGGPMEVLRKGSLRLRQ ENSCPOP00000011994/1-1156 ------------------------SLTLALPVESPKATPTEEVAVGPMEVLRKGSLRLRQ XP_004837861.1/1-1176 RSSPVPPVPERRSSPGPPVPERRGSLTLALAAESPKTTPTEEVAGGPMEVLRKGSLRLKQ ***:: **.*: *:** . *************:* ENSP00000373565/1-1179 LLSPKGERRMEDEGGFPVPQENGQPESPRRLSLGQGDSTEAATEERGPRARLSSATANAL ENSMUSP00000059839/1-1209 LLSPKNERRGEDEGSFPTPQENGQPESPRRPSLSRGDSTEAAAEERGSRVRLASATANAL ENSRNOP00000044153/1-1209 LLSPKSERRGEDEVSFPAPQENGQPESPRRPSLSRGDSTEAAAEERGSRVRLASATANAL ENSCPOP00000011994/1-1156 LLSPKSERRGEGEGSFPVLQENGQPESPRRPSLGRSDSTEAAGDERNPRARIASATANAL XP_004837861.1/1-1176 LLSPKNEPHGEGEGSFPVLQENGQPESPQRPSLGRGDSTEAAGDERGPRARLTSATANAL *****.* : *.* .**. *********:* **.:.****** :**..*.*::******* ENSP00000373565/1-1179 YSSNLRDDTKAILEQISAHGQKHRAVPAPSP----GPTHNSPELGRPPAAGVLAPDMSDK ENSMUSP00000059839/1-1209 YSSNLRDDTKAILEQISAHGQKHRGVPAPGP------AHSSPDVGRPTTAGDLAPDMSDK ENSRNOP00000044153/1-1209 YSSNLRDDTKAILEQISAHGQKHRAVPAPGP------AHNSSDVGRPTTAGDLAPDMSDK ENSCPOP00000011994/1-1156 YSSNLRDDTKAILEQISAHGQKHRGVPVPGPVPVLDPTHSSPELGHPPAAGGLAPDMSDK XP_004837861.1/1-1176 YSSNLRDDTKAILEQISAHGQKHRGVPAPGP----DPTRSSPELGHVIAAGGLAPDMSDK ************************.**.*.* ::.*.::*: :** ******** ENSP00000373565/1-1179 DKCSAIFRSDSLGTQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKEEASS ENSMUSP00000059839/1-1209 DKCSAIFRSDSLGTQGRLSRTLPGSAEERDRLLRRMESMRKEKRVYSRFEVFCKKDEAGS ENSRNOP00000044153/1-1209 DKCSAIFRSDSLGTQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKEDAGS ENSCPOP00000011994/1-1156 DKCSAIFRSDNQGPQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKDEAGS XP_004837861.1/1-1176 DKCSAIFRSDSMGAQGRLSRTLPASAEERDRLLRRMESMRKEKRVYSRFEVFCKKDEAGG **********. *.*********.*******************************::*.. ENSP00000373565/1-1179 PGAGEGPAEEGTRDSKVGKFVPKILGTFKSKK ENSMUSP00000059839/1-1209 SGAGDNLADEDTRDSKMGKFVPKILGTFKSKK ENSRNOP00000044153/1-1209 SAAGDNLADEDTRDSKMGKFVPKILGTFKSKK ENSCPOP00000011994/1-1156 PGAGDSLVEEDARDSKVGKFMPKILSTFKGKK XP_004837861.1/1-1176 PGSGDNLV-EDARDSKVGKFMPKILGTFKGKK ..:*:. . *.:****:***:****.***.**