CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000136343/1-1523 MDRLC------GSGELGSKFWDSNLSIYTNTPDLTPCFQNSLLAWVPCIYLWAALPCYLF ENSRNOP00000003977/1-1522 MDRLC------GSGELGSKFWDSNLTVYTNTPDLTPCFQNSLLAWVPCIYLWAALPCYLF ENSP00000285238/1-1527 MDALC------GSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLL ENSCPOP00000011969/1-1534 SPTLVEEPWGNGFSSSGLAFWDSNLSVYTDSPDLTPCFQNSLLAWVPCIYLWVALPFDLL XP_004859792.1/1-1519 MDSLC-----------GSKFWDSNLTVYTDNPDLTSCFQNSLLAWVPCIYLWAALPCYLL * * ******:::*:.****.****************.*** *: ENSMUSP00000136343/1-1523 YLRHHQLGYIVLSWLSRLKTALGVLLWCVSWVDLFYSFHGLIHGSSPAPVFFVTPLVVGI ENSRNOP00000003977/1-1522 YLRHHRLGYIVLSCLSRLKTALGVLLWCISWVDLFYSFHGLVHGSSPAPVFFITPLLVGI ENSP00000285238/1-1527 YLRHHCRGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGV ENSCPOP00000011969/1-1534 YLRHHHNGYIVLSHLSRLKTAVGVLLWCVSWADLFYSFHGMVHGRPPAPVFFITPLVVGI XP_004859792.1/1-1519 YLRHHHHGYIILSHLSRVKTALSVSLWCVSWLDLFYSFHSLIHGGAPAPIFFVTPLVVGI ***** ***:** **::* .:.* ***:** *******.::** .***:**:***:**: ENSMUSP00000136343/1-1523 TMLLATLLIQYERLRGVQSSGVLIIFWLLCVICAIIPFRSKILSALAEGKILDPFRFTTF ENSRNOP00000003977/1-1522 TMLLATLLIQYERLRGVRSSGVLIIFWLLCVICAIIPFRSKILLALAEGKILDPFRFTTF ENSP00000285238/1-1527 TMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTF ENSCPOP00000011969/1-1534 TMVLATLLIQYERLRGVRSSGVLIIFWFLCVICAIVPFRSKILSARAEGTISDPFRFTTF XP_004859792.1/1-1519 TMVLATLLIQYERLRGVQSSGVLIIFWFLCVVCAIVPFRSKILSAMAEGTIADPFRFSTF **:***********:**:*********:***:***:******* * *** * *****:** ENSMUSP00000136343/1-1523 YIYFALVFCALILSCFKEKPPLFSPENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRP ENSRNOP00000003977/1-1522 YIYFALVLCAFILSCFQEKPPLFSPENLDTNPCPEASAGFFSRLSFWWFTKLAILGYRRP ENSP00000285238/1-1527 YIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHP ENSCPOP00000011969/1-1534 YIYFALVLSALILSCFREKSPLFSPKSSDPNPCPEASAGFLSRLCFWWFTRLAILGYRRP XP_004859792.1/1-1519 YIYFALVLSALILSCFREKPPLFSLKN-DPNRCPEASAGFLSRLTFWWFTSLAILGYRRP **:****:.*:**:**:**.*:** :. *.* **:****:*** ***** :** ***:* ENSMUSP00000136343/1-1523 LEDRDLWSLSEEDCSHKVVQRLLEAWQKQQNQASRS--QTATAEPKIPGEDAVLLKPRPK ENSRNOP00000003977/1-1522 LEDSDLWSLSEEDCSHKVVQRLLEAWQKQQTQASGP--QTAALEPKIAGEDEVLLKARPK ENSP00000285238/1-1527 LEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARH-KASAAPGKNASGEDEVLLGARPR ENSCPOP00000011969/1-1534 LEEKDLWSLNEDDCSHRVVQQMLEAWQKQERQTAGS-EAAEALGKKVCVEGEVLLGDRPQ XP_004859792.1/1-1519 LKDQDLWSLNEEDCSRQVVQQLLEAWQKQERQTAGRAKAAEALGKKVSAEDEVLLGSQPR *:: *****.*:* *: ***::****:**: *:: : : : *. *** :*: ENSMUSP00000136343/1-1523 SKQPSFLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTAPTWWGFLLA ENSRNOP00000003977/1-1522 TKKPSFLRALVRTFTSSLLMGACFKLIQDLLSFINPQLLSILIRFISDPTAPTWWGFLLA ENSP00000285238/1-1527 PRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA ENSCPOP00000011969/1-1534 AQQPSFLWVLLTTFSSNLLISACFKLIQDLLSFVNPQLLSMLIQFISNPEAPSWWGFLLA XP_004859792.1/1-1519 ARKPSFLWALGITFASSFLTGSFFKLIQDLLSFVNPQLLSMLIRFIPNPEAPSWWGFLLA .::**** .* ** *.:* .: *:***:**.*:******:**:**.:* **:*****:* ENSMUSP00000136343/1-1523 GLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLM ENSRNOP00000003977/1-1522 GLMFVSSTMQTLILHQHYHCIFVMALRIRTAIIGVIYRKALTITNSVKREYTVGEMVNLM ENSP00000285238/1-1527 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM ENSCPOP00000011969/1-1534 GLMFVCALVQTLILHQYYHCIFVSALRVRTGVIGVIYRKALVITNSVKRESTVGEIVNLM XP_004859792.1/1-1519 GLMFVSSMTQTLVLNLCYQCVFVAALRIRTGIIGVIYKKALLITNSVKRESTVGEIVNLM ****:.: *:*:*: *: :** .::.**.::****:*** ******* ****:**** ENSMUSP00000136343/1-1523 SVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKM ENSRNOP00000003977/1-1522 SVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKM ENSP00000285238/1-1527 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM ENSCPOP00000011969/1-1534 SVDAQRFMDVFPFLNLLWATPLQVILAIYFLWQILGPSVLAGVGLMVLLIPLNGAVAMKM XP_004859792.1/1-1519 SVDAQRFMDVFPFLFLLWSAPLQVSLAIYFLWQILGPSVLAGVALMVLLIPLNSAVAMKM *********: **: ***::***: ******** ****.****..:*******.**::** ENSMUSP00000136343/1-1523 KTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQA ENSRNOP00000003977/1-1522 KTYQVQQMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEGIRQSELQLLRKGAYLQA ENSP00000285238/1-1527 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT ENSCPOP00000011969/1-1534 HAYQVKQMNLKDSRIKLMTEILGGIKVLKLYAWEPSFLQQVEGIRQGELQLLRKGTYLQA XP_004859792.1/1-1519 RAYQVQQMKFKDSRIKLMSEILAGIKVLKLYAWEPSFLEQVESIRQSELRVLRKGTYLQA :::**:**::********:*** ************:**:**:.***.**::**..:**:: ENSMUSP00000136343/1-1523 ISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLT ENSRNOP00000003977/1-1522 ISTFIWVCTPFMVTLITLGVYVCVDKNNVLDAEKAFVSLSLFNILKIPLNLLPQLISGMT ENSP00000285238/1-1527 TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT ENSCPOP00000011969/1-1534 VSTFIWVCTPFLVTLITLGVYVCVDQDNVLDAEKAFVSLALFNILKNPLNMLPRLISGLT XP_004859792.1/1-1519 ISTFIWLCTPFLVTLITLGVYVCVDQNNVLDAEKAFVSVSLFDILKGPLNTLPILITGMT :** *:*:**:****** *** ** .***********::**:**: *** ** **:.:* ENSMUSP00000136343/1-1523 QASVSLKRIQDFLNQNELDPQCVERKTISPGYAITIHNGTFTWAQDLPPTLHSLNIQIPK ENSRNOP00000003977/1-1522 QTSVSLKRIQDFLNQDELDPQCVERKTISPGRAITIHNGTFSWSKDLPPTLHSLNIQIPK ENSP00000285238/1-1527 QASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPK ENSCPOP00000011969/1-1534 QANVSLKRIQHFLSQDEIDPQCVERKTISPGYTITIHGGTFTWAQDLPPTLHSLDIQIRK XP_004859792.1/1-1519 QAKVSLQRIQRFLSQDELNPQCVERKTISPGSAITIHNGTFTWAQDLPPTLHSLDIQVLK *:.***:*** **.*:*::**.********* :****.***:*::*********:**: * ENSMUSP00000136343/1-1523 GALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQ ENSRNOP00000003977/1-1522 GALVAVVGPVGCGKSSLVSALLGEMEKLEGAVSVKGSVAYVPQQAWIQNCTLQENVLFGQ ENSP00000285238/1-1527 GALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGK ENSCPOP00000011969/1-1534 GALVAVVGPVGCGKSSLISALLGEMEKLEGTVSVKGSVAYVPQLAWIQNCTLQENVLFGQ XP_004859792.1/1-1519 GALVAVVGPVGCGKSSLVSALLGEMEKLEGTVSVKGSVAYVPQQAWIQNCTLQENVLFGR *****************:************ * :********* ***************: ENSMUSP00000136343/1-1523 PMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFL ENSRNOP00000003977/1-1522 PMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFL ENSP00000285238/1-1527 ALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFL ENSCPOP00000011969/1-1534 AMNPKRYQQALEACALLADLKMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSNADIFL XP_004859792.1/1-1519 AMNPKRYQQALEGCALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSEADIFL .:*******:** *******.:********************************:*:*** ENSMUSP00000136343/1-1523 LDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAGGQVSEMG ENSRNOP00000003977/1-1522 LDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQITEMG ENSP00000285238/1-1527 LDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMG ENSCPOP00000011969/1-1534 LDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVMADGQVSEMG XP_004859792.1/1-1519 LDDPLSAVDTHVAKHIFDHVIGPEGMLAGKTRVLVTHGISFLSQTDFIIVLANGQVSEMG *********:********:******:****************.*******:*.**::*** ENSMUSP00000136343/1-1523 HYSALLQHDGSFANFLRNYAPDED-----QEDHEAALQ-NANEEVLLLEDTLSTHTDLTD ENSRNOP00000003977/1-1522 HYSELLQHDGSFANFLRNYAPDEN-----QEANEGVLQ-HANEEVLLLEDTLSTHTDLTD ENSP00000285238/1-1527 PYPALLQRNGSFANFLCNYAPDED--QGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTD ENSCPOP00000011969/1-1534 PYSELMQRDGSFANFLRNYTFDEGPVEEQQVLHRMALE-NGDEEVLLIEDTLSTHTDVTD XP_004859792.1/1-1519 PYSALLEHNGSFANFLRNYSPDED--QEPHKDHRMALE-VEDEEVLLIEDTLSTHTDLTD *. *::::******* **: **. .*: ::*.**:*****.***:** ENSMUSP00000136343/1-1523 NEPAIYEVRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAE ENSRNOP00000003977/1-1522 TEPAIYEVRKQFMREMSSLSSEGEGQNRPVLKRYTSSLEKEVPATQTKETGALIKEEIAE ENSP00000285238/1-1527 NDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQ-VTEAKADGALTQEEKAA ENSCPOP00000011969/1-1534 TEPALFQVQKQLMRQLSTMSSDGEGQARPVLRRHQSASEAEQ-VAKAKETGTLIQEEKAE XP_004859792.1/1-1519 TEPPLYEVQEQFMRQLSSMSSDGEGQVR--LRRHLSVSEKAA-QVKAMEAGVLVQEEKVE .:* : *::*:**::*::**:** * * ::: . * .:: *.* :** . ENSMUSP00000136343/1-1523 TGNVKLSVYWDYAKSMGLCTTLSICLLYGGQSAAAIGANVWLSAWSNDAEEHGQQNKTSV ENSRNOP00000003977/1-1522 TGNVKLSVYWDYAKSVGLCTTLFICLLYAGQNAVAIGANVWLSAWTNDVEEHGQQNNTSV ENSP00000285238/1-1527 IGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSL ENSCPOP00000011969/1-1534 TGTVKLSVFWDYAKAVGLWTTLAICVLYTGQSAASIGANVWLSEWTNEATMDSRQNNTSL XP_004859792.1/1-1519 TGRVKLSVFWDYAKAVGLCTTLAICLLYAAQSAAAIGASVWLSDWANEAAMGSRQNNTSL * *:***:*****::** *** **:** .*.*.:***.**** *:*:. .:**:**: ENSMUSP00000136343/1-1523 RLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILN ENSRNOP00000003977/1-1522 RLGVYATLGILQGLLVMLSAFTMVVGAIQAARLLHTALLHNQIRAPQSFFDTTPSGRILN ENSP00000285238/1-1527 RLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILN ENSCPOP00000011969/1-1534 RLGVYAALGILQGVLVMLSAFTMAMGGVQAACLLHHRLLQNKMQSPQSFYDTTPSGRILN XP_004859792.1/1-1519 RLGVYATLGILQGILVMVAAFTMAVGAVQAARLLHHKLLQNKIRSPQSFYDTTPSGRILN ******:******.***::*::*. *.:*** :** **:*::::****:********** ENSMUSP00000136343/1-1523 RFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYV ENSRNOP00000003977/1-1522 RFSKDIYVIDEVLAPTILMLFNSFYTSISTIVVIVASTPLFCVVVLPLAVFYGFVQRFYV ENSP00000285238/1-1527 CFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYA ENSCPOP00000011969/1-1534 RFSRDIYVIDELLAPTILMLFNSLYTSLSILVIIVASTPLFLVVIVPLAVFYGFVQRFYV XP_004859792.1/1-1519 CFSKDIYVIDEVLAPTILSLFNVFHNTFSILVVIMASTPLFTVVIVPLAVLYIFVQRFYV **:****:**:***.** *:* :..::* :::*:****** **::****:* :*****. ENSMUSP00000136343/1-1523 ATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIA ENSRNOP00000003977/1-1522 ATSRQLKRLESVSRSPIFSHFSETVTGTSVIRAYGRVQDFKVLSDAKVDSNQKTTYPYIA ENSP00000285238/1-1527 ATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYII ENSCPOP00000011969/1-1534 ATSRQLKRLESISRSPIYSHFSETVTGTSVIRAYGRTEDFKVLSDIKVDTNQKSCYSSIA XP_004859792.1/1-1519 ATSRQLKRLESASRSPIFSHFSETVTGTSVIRAYGRTEDFRVLSDIKVDTNQKSCYSYII *********** *****:*********:******.* .**.::** *** **:: *. * ENSMUSP00000136343/1-1523 SNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDL ENSRNOP00000003977/1-1522 SNRWLGVHVEFVGNCVVLFSALFAVIGRNSLNPGLVGLSVSYALQVTLSLNWMIRTLSDL ENSP00000285238/1-1527 SNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDL ENSCPOP00000011969/1-1534 SNRWLGVHVEFVGNCVVLFAALFAVIGRNSLSPGLVGLSVSYALQVTVALNWMIRMMSDL XP_004859792.1/1-1519 SNRWLSMRVEFVGNCMVFFAAMFAVIGRSSLSPGLVGLSVSYALQVTMSLNWLIRVMSDL *****.: *******:*:*:*:******.**.**********:****.:***:** :*** ENSMUSP00000136343/1-1523 ESNIIAVERVKEYSKTKTEAPWVVESNRAPEGWPTRGMVEFRNYSVRYRPGLELVLKNVT ENSRNOP00000003977/1-1522 ESNIIAVERVKEYSKTETEAPWVLESNRAPEGWPRSGVVEFRNYSVRYRPGLELVLKNLT ENSP00000285238/1-1527 ESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLS ENSCPOP00000011969/1-1534 ESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPLHGEVEFRNYSVRYRPGLELVLRNLS XP_004859792.1/1-1519 ESNIVAVERVKVYSKTETEAPWVVEGSRPPEGWPQRGEVEFRNYSVRYRPGLELVLKNLS ****:****** ****:******:*..*.***** * **************:***:::: ENSMUSP00000136343/1-1523 VHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIP ENSRNOP00000003977/1-1522 LHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIFIDGLNVAHIGLHDLRSQLTIIP ENSP00000285238/1-1527 LHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIP ENSCPOP00000011969/1-1534 LCVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIFIDGLNVANIGLHDLRSQLTIIP XP_004859792.1/1-1519 LCVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGDIFIDGLNVADIGLQDLRSQLTIIP : *:*****************************:*:* *******.***:********** ENSMUSP00000136343/1-1523 QDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQ ENSRNOP00000003977/1-1522 QDPILFSGTLRMNLDPFGRYSDEDIWRTLELSHLSAFVSSQPTGLDFQCSEGGDNLREAR ENSP00000285238/1-1527 QDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQ ENSCPOP00000011969/1-1534 QDPILFSGTLRMNLDPFGRYSEEDIWQALELSHLHAFVKSQPAGLDFQCSEGGENLSVGQ XP_004859792.1/1-1519 QDPVLFSGTLRMNLDPFGQYSEEDIWRALELSHLHAFLRSQPAGLDFQCTEGGDNLSVGQ ***:************** **:**** :****** :*: ***:******:***:** .: ENSMUSP00000136343/1-1523 RQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLN-TIMD ENSRNOP00000003977/1-1522 PPLIHMGMCLSQMC-IYGLSVGLSGLTEVGGVHVTADLSST-QRVGQASRARRLDFFFFL ENSP00000285238/1-1527 RQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLN-TIMD ENSCPOP00000011969/1-1534 RQLVCLARALLRKSRILVLDEATAAIDLETDDLIQATIRTQFEACTVLTIAHRLN-TIMD XP_004859792.1/1-1519 RQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFETCTVLTIAHRLN-TIMD *: :. .* : . : *. . :.: . : . : : : : *:**: :: ENSMUSP00000136343/1-1523 YNRVLVLDKGVVAEFDSPVNLIAAGGIFYGMAKDAGLA ENSRNOP00000003977/1-1522 LARVLVLDKGVVAEFDSPVNLIAAGGIFYGMAKDAGLA ENSP00000285238/1-1527 YTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA ENSCPOP00000011969/1-1534 YTRVLVLDRGVVAEFDSPANLIAARGIFYGMARDAGLA XP_004859792.1/1-1519 YTRVLVLDRGALAEFDTPTNLIAARGIFYGMARDAGLA ******:*.:****:*.***** *******:*****