CLUSTAL W(1.81) multiple sequence alignment ENSRNOP00000061854/1-1054 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS ENSCPOP00000011921/1-1011 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS XP_004856172.1/1-1049 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS ENSP00000310094/1-1235 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS ENSMUSP00000112963/1-1240 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS ************************************************************ ENSRNOP00000061854/1-1054 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK ENSCPOP00000011921/1-1011 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK XP_004856172.1/1-1049 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK ENSP00000310094/1-1235 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK ENSMUSP00000112963/1-1240 YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK ************************************************************ ENSRNOP00000061854/1-1054 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN ENSCPOP00000011921/1-1011 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN XP_004856172.1/1-1049 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN ENSP00000310094/1-1235 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN ENSMUSP00000112963/1-1240 KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN ************************************************************ ENSRNOP00000061854/1-1054 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN ENSCPOP00000011921/1-1011 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN XP_004856172.1/1-1049 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN ENSP00000310094/1-1235 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN ENSMUSP00000112963/1-1240 SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN ************************************************************ ENSRNOP00000061854/1-1054 ESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA ENSCPOP00000011921/1-1011 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA XP_004856172.1/1-1049 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA ENSP00000310094/1-1235 ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA ENSMUSP00000112963/1-1240 ESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA ***.******************************************************** ENSRNOP00000061854/1-1054 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEELTPCSQEAEPYMHRAGTLTSLESSHSV ENSCPOP00000011921/1-1011 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEE------EAEPYMHRAGTLTSLESSHSV XP_004856172.1/1-1049 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEE------EAEPYMHRAGTLTSLESSHSV ENSP00000310094/1-1235 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEE------EAEPYMHRAGTLTSLESSHSV ENSMUSP00000112963/1-1240 VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEELTPCSQEAEPYTHRAGTLTSLESSHSV ********************************* ***** *************** ENSRNOP00000061854/1-1054 PSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEEEGPESREMAMMQEGEHTVTSH ENSCPOP00000011921/1-1011 PSMSISASSQSSSVNSLADASD------------------------MAMMQEGEHTVTSH XP_004856172.1/1-1049 PSMSISASSQSSSVNSLADASDN--EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSH ENSP00000310094/1-1235 PSMSISASSQSSSVNSLADASDN--EEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSH ENSMUSP00000112963/1-1240 PSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEEEGPESREMAMMQEGEHTVTSH ********************** ************** ENSRNOP00000061854/1-1054 SSIIHRLPGSDNLYDDPYQPEMTPGPLQPPAAPPTSTSSSSARRRAYCRNRDHFATIRTA ENSCPOP00000011921/1-1011 SSIIHRLPGSDNLYDDPFQPEITPGPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTA XP_004856172.1/1-1049 SSVIHRLPGSDSLYDDPFQPEITPGPLQPSTAPAPASTTSSARRRAYCRNRDHFATIRTA ENSP00000310094/1-1235 SSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTA ENSMUSP00000112963/1-1240 SSIIHRLPGSDNLYDDPYQPEMTPGPLQPPAAP-PTSTSSSARRRAYCRNRDHFATIRTA **:********.*****:***:**.****.:** .::::********************* ENSRNOP00000061854/1-1054 SLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQR ENSCPOP00000011921/1-1011 SLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQR XP_004856172.1/1-1049 SLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQR ENSP00000310094/1-1235 SLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQR ENSMUSP00000112963/1-1240 SLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQR *************************************************.********** ENSRNOP00000061854/1-1054 AGFGTEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKE ENSCPOP00000011921/1-1011 AGFGAEAEKLARRHQAIGEKEARAAQTEERKFQQHILGQQKKELAALLEAQKRTYKLRKE XP_004856172.1/1-1049 AGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKE ENSP00000310094/1-1235 AGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKE ENSMUSP00000112963/1-1240 AGFGTEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKE ****:*********************:********************************* ENSRNOP00000061854/1-1054 QLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLL ENSCPOP00000011921/1-1011 QLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLL XP_004856172.1/1-1049 QLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLL ENSP00000310094/1-1235 QLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLL ENSMUSP00000112963/1-1240 QLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLL ************************************************************ ENSRNOP00000061854/1-1054 ARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQT ENSCPOP00000011921/1-1011 ARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQT XP_004856172.1/1-1049 ARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQT ENSP00000310094/1-1235 ARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQT ENSMUSP00000112963/1-1240 ARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQT ************************************************************ ENSRNOP00000061854/1-1054 ELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKE--------LQIKKQF---------- ENSCPOP00000011921/1-1011 ELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKE--------LQIKKQF---------- XP_004856172.1/1-1049 ELGNQLEYNKRREQELRQKHAAQVRQQPKSLKSKE--------LQIKKQF---------- ENSP00000310094/1-1235 ELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIE ENSMUSP00000112963/1-1240 ELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQLPMG--LPATGALGPLSTGTPSE ******************************** : * : ENSRNOP00000061854/1-1054 -------------------------------QETCKIQTRQYKALRAHLLETTPKAQ-HK ENSCPOP00000011921/1-1011 -------------------------------QETCKIQTRQYKALRAHLLETTPKAQ-HK XP_004856172.1/1-1049 -------------------------------QETCKIQTRQYKALRAHLLETTPKAQ-HK ENSP00000310094/1-1235 QQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHG ENSMUSP00000112963/1-1240 EQPCSSGQEAILDQRMLGEEEEAVPERRILGKEGTTLEPEEQRILGEEMGTFSSSPQKHR :* .::..: : * . :...* * ENSRNOP00000061854/1-1054 SLLK-------------RLKEEQTRKLAILAEQYDQSIS------EMLSSQALRLDETQE ENSCPOP00000011921/1-1011 SLLK-------------RLKEEQTRKLAILAEQYDQSIS------EMLSSQALRLDETQE XP_004856172.1/1-1049 SLLK-------------RLKEEQTRKLAILAEQYDQSIS------EMLSSQALRLDETQE ENSP00000310094/1-1235 SLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQG ENSMUSP00000112963/1-1240 SLANEEDWDISEEMKEIRVPSLASQERNIIGQEEAAAWSLWEKEGGNLVDVEFKLGWVQG ** . *: . .:: *:.:: : * * . :.*. .* ENSRNOP00000061854/1-1054 AEFQALRQSNRNWSSLM--LTRARKIRTESQHERELRELEQRVALRR-------ALLEQR ENSCPOP00000011921/1-1011 AEFQALRQQLQQELELLNAYQSKIKIRTESQHERELRELEQRVALRR-------ALLEQR XP_004856172.1/1-1049 AEFQALRQQLQQELELLNAYQSKIKIRTESQHERELREREQRVTLRR-------ALLEQR ENSP00000310094/1-1235 PALTPVPEEEEEEEE--GAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHG ENSMUSP00000112963/1-1240 PVLTPVPEEEEEEEEEGGAPIGTHRDPGDGCPSPDIPPEPPPSHLRQYPTSQLPGLLSHG . : .: :. .: . : :. . :: ** .**.: ENSRNOP00000061854/1-1054 VEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSSMALGGIPAEAA----AQGY ENSCPOP00000011921/1-1011 VEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSSMALGGIPAEAA-------- XP_004856172.1/1-1049 VEEELLALQTGRSERIRSLLERQAREIEAFDAESMRLGFSSMALGGIPAEAA----AQGY ENSP00000310094/1-1235 LLAGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTAL ENSMUSP00000112963/1-1240 LLAGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLFLCTAL : * . * : ** : * .. .:: .: :: :* : *: ENSRNOP00000061854/1-1054 PAPPPAPAWPSRPVPRS---GAHWSHG--PPPPGMPPP---AWRQPA--LLAPPGPPNWL ENSCPOP00000011921/1-1011 ----------AQGCS-----GAHWSHG--PPPPGMPPP---AWRQPS--LLAPPGPPNWL XP_004856172.1/1-1049 PAPPPAPAWPSRPVPRS---GAHWSHG--PPPPGMPPP---AWRQPA--LLAPPGPPNWL ENSP00000310094/1-1235 HLPSSLFLLLAQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWV ENSMUSP00000112963/1-1240 HLPPGLFLLLAQGTALLAVLSLSWRRGLMGVPLGLGAAWLLAWPSLALPLAAMAAGGKWV :: . . * :* * *: .. ** : * * .. .*: ENSRNOP00000061854/1-1054 ---GPPTQSGTPRGGALLLLRNSPQPLRRAASGGSSGEN----VGPPAA---------VP ENSCPOP00000011921/1-1011 ---GPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSEN----VGPPAA--------SVP XP_004856172.1/1-1049 ---GPPTQSGTPRGGALLLLRNSPQPLRRAASGGSGSEN----VGPPAA--------AVP ENSP00000310094/1-1235 RQQGPRVRRGISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVP ENSMUSP00000112963/1-1240 RQQGPQMRRGISRLWLRILLRLSPMVFRALQGCGAVGDRGLFALYPKTNKNGFRSRLPVP ** : * .* :*** ** :* . *: .:. : * : ** ENSRNOP00000061854/1-1054 GPLSRSTSVASHILNGSSHFYS-------------------------------------- ENSCPOP00000011921/1-1011 GPLSRSTSVASHILNGSSHFYS-------------------------------------- XP_004856172.1/1-1049 GPLSRSTSVASHILNGSSHFYS-------------------------------------- ENSP00000310094/1-1235 GPRRRNPRTTQHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGER ENSMUSP00000112963/1-1240 WPRQGNPRTTQHPLAQLTRVWAVCKGWNWRLARASHRLASCLPPWAVHILASWGLLKGER * .. .:.* * ::.: ENSRNOP00000061854/1-1054 --------------------------------------------- ENSCPOP00000011921/1-1011 --------------------------------------------- XP_004856172.1/1-1049 --------------------------------------------- ENSP00000310094/1-1235 PTRIPRLLPRSQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR ENSMUSP00000112963/1-1240 PSRIPRLLPRSQRRLGLSASRQLPPGTVAGRRSQTR--RTLPPWR