CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000106137/1-1583 MEAQAH-SSTATERKKAENSIGKCPTRTDVSEKAVASSTTSNEDESPGQIYHRERRNAIT ENSRNOP00000019396/1-1582 MEAQSH-SSTTTERKKAESSIAKCPTRTDVSEKAVASSTTSNEDESAGQIYHRERRNAIT ENSP00000379258/1-1580 MEAQSH-SSTTTEKKKVENSIVKCSTRTDVSEKAVASSTTSNEDESPGQTYHRERRNAIT ENSCPOP00000011914/1-1216 MEAQSH-SSTTTEKKKVENSIVKCSSRTDVSEKAVASSTTSNEDESPGQIYHRERRNAIT XP_004840306.1/1-1576 MEAQSHNSSATTEKKKVENSIVKCSSRTDVSEKAVASSTTSNEDESPGQIYHRERRNAIT ****:* **::**:**.*.** **.:********************.** ********** ENSMUSP00000106137/1-1583 MQPQSVQGLNKISEEPSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTVFAMDPRNGYME ENSRNOP00000019396/1-1582 MQPQSVQGLSKISEEPSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTVFAMDPRNGYME ENSP00000379258/1-1580 MQPQNVQGLSKVSEEPSTSSDERASLIKKEIHGSLPHVAEPSVPYRGTVFAMDPRNGYME ENSCPOP00000011914/1-1216 MQPQSVQGLSKISEEPSTSSDERASLIKKEVHGSLPHLAEPSVPYRGTMFAMDPRNGYME XP_004840306.1/1-1576 MQPQSVQGLSKISEEPSTSSDERASLIKKEIHGSLPHLAEPSVPYRGTVFAMDPRNGYME ****.****.*:******************:******:****:*****:*********** ENSMUSP00000106137/1-1583 PHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHVPSALSSSPTYPDLPFIRISPH ENSRNOP00000019396/1-1582 PHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHVPSALSSSPTYPDLPFIRISPH ENSP00000379258/1-1580 PHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHMTSALSSSPTYPDLPFIRISPH ENSCPOP00000011914/1-1216 PHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHVPSALSSSPTYSDLPFIRISPH XP_004840306.1/1-1576 PHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHVPSALSSSPTYSDLPFIRISPH **************************************:.*********.********** ENSMUSP00000106137/1-1583 RNPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISAARGLSPTDAPHAGVSPAEYYH ENSRNOP00000019396/1-1582 RNPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISAARGLSPTDAPHAGVSPAEYYH ENSP00000379258/1-1580 RNPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISATRGLSPTDAPHAGVSPAEYYH ENSCPOP00000011914/1-1216 RNPAAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISAARGLSPTDAPHAGVSPAEYYH XP_004840306.1/1-1576 RNPAAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISAARGLSPTDAPHAGVSPAEYYH ***:***********************************:******************** ENSMUSP00000106137/1-1583 QMALLTGQRSPYADILPSAATAGAGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSISPL ENSRNOP00000019396/1-1582 QMALLTGQRSPYADILPSAATAGAGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSISPL ENSP00000379258/1-1580 QMALLTGQRSPYADIIPSAATAGTGAIHMEYLHAMDSTRFSSPRLSARPSRKRTLSISPL ENSCPOP00000011914/1-1216 QMALLAGQRSPYADILPSAAT-SAGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSISPL XP_004840306.1/1-1576 QMALLTGQRSPYADILPSAAT-GAGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSISPL *****:*********:***** .:****************.******************* ENSMUSP00000106137/1-1583 SDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSLHM ENSRNOP00000019396/1-1582 SDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSLHM ENSP00000379258/1-1580 SDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHM ENSCPOP00000011914/1-1216 SDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSLHM XP_004840306.1/1-1576 SDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSLHM ***************************************************.******** ENSMUSP00000106137/1-1583 HQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQSKPTS ENSRNOP00000019396/1-1582 HQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQSKPTS ENSP00000379258/1-1580 HQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTS ENSCPOP00000011914/1-1216 HQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTS XP_004840306.1/1-1576 HQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTS *******************************************************.**** ENSMUSP00000106137/1-1583 ESAVSSTGDPMHNKRSKIKPDEDLPSPGSRGQQEQPEGTTLVKEEADKDESKQEPEVIYE ENSRNOP00000019396/1-1582 ESAVSSTGDPMHNKRSKIKPDEDLPSPGSRGQQEQPEGTTLVKEEGDKDESKQEPEVIYE ENSP00000379258/1-1580 ESAVSSTGDPMHNKRSKIKPDEDLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYE ENSCPOP00000011914/1-1216 ESAVSSTGDPMHNKRSKIKPDEDLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYE XP_004840306.1/1-1576 ESAVSSTGDPMHNKRSKIKPDEDLPSPGARGQQEQPEGTTLVKEEGEKDESKQEPEVIYE ****************************:****************.:************* ENSMUSP00000106137/1-1583 TNCHWEGCTREFDTQDQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRR ENSRNOP00000019396/1-1582 TNCHWEGCTREFDTQDQLPQHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRR ENSP00000379258/1-1580 TNCHWEGCAREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRR ENSCPOP00000011914/1-1216 TNCHWEGCTREFDTQDQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRR XP_004840306.1/1-1576 TNCHWEGCTREFDTQDQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRR ********:******:** :**************************************** ENSMUSP00000106137/1-1583 HTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNR ENSRNOP00000019396/1-1582 HTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNR ENSP00000379258/1-1580 HTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNR ENSCPOP00000011914/1-1216 HTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNR XP_004840306.1/1-1576 HTGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNR ************************************************************ ENSMUSP00000106137/1-1583 THSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSH ENSRNOP00000019396/1-1582 THSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSH ENSP00000379258/1-1580 THSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSH ENSCPOP00000011914/1-1216 THSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSSSH XP_004840306.1/1-1576 THSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSH **********************************************:**********.** ENSMUSP00000106137/1-1583 SQSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSP ENSRNOP00000019396/1-1582 SQSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSP ENSP00000379258/1-1580 SQSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSP ENSCPOP00000011914/1-1216 SQSRSPGRPTQGALGEQKDLSTTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSP XP_004840306.1/1-1576 SQSRSPGRPTQGALGDQKDLSTPTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSEQSP *************:*:*::**..*********************************:*** ENSMUSP00000106137/1-1583 ISNYSNSGLELPLTDGGSVADLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHIK ENSRNOP00000019396/1-1582 ISNYSNSGLELPLTDGGSIADLSAIDETPIMDSTISTATTALALQGRRNPAGTKWMEHIK ENSP00000379258/1-1580 ISNYSNSGLELPLTDGGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVK ENSCPOP00000011914/1-1216 ISSYSNSGLELPLTDRGSVADLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVK XP_004840306.1/1-1576 ISSYSHSGLELPLTDGGSAADLSAIDETPIMDSTISTATTALALQTRRNPAGTKWMEHVK **.**:********* ** .************************* ************:* ENSMUSP00000106137/1-1583 LERLKQVNGMFPRLNPILPSKAPAVSPLIGNGTQSNNNYSSGGPGTLLPSRSDLSGVDFT ENSRNOP00000019396/1-1582 LERLKQVNGMFPRLNPILPSKAPAVSPLIGNGTQSNNNYSSGGPGTLLPSRSDLSGVDFT ENSP00000379258/1-1580 LERLKQVNGMFPRLNPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVT ENSCPOP00000011914/1-1216 LERLKQVNGMLPRLNPILPPKAPAVSPLIGNGTQSSNNCSSGGPVTLLPNRSDFSGVDLT XP_004840306.1/1-1576 LERLKQVNGMLPRLNPILPPKAPAVSPLIGNGTQSSNNCSSGGPVTLIPNRGDFSGVDLT **********:********.***************.*. * *** **:*.*.*:****.* ENSMUSP00000106137/1-1583 VLNTLNRRDSNTSTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPIS ENSRNOP00000019396/1-1582 VLNTLNRRDSNTSTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPIS ENSP00000379258/1-1580 MLNMLNRRDSSASTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPIS ENSCPOP00000011914/1-1216 MLNTLTRRDSNTSTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPIS XP_004840306.1/1-1576 MLNTLTRRDSNTSTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPIS :** *.****.:************************************************ ENSMUSP00000106137/1-1583 TDASRRSSEASQGDGLPSLLSLTPVQQYRLKAKYAAATGGPPPTPLPHMERLSLKTKMAL ENSRNOP00000019396/1-1582 TDASRRSSEASQGDGLPSLLSLTPVQQYRLKAKYAAATGGPPPTPLPHMEKLSLKTRMAL ENSP00000379258/1-1580 TDASRRSSEASQSDGLPSLLSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKTRLAL ENSCPOP00000011914/1-1216 TDASRRSSEASQSDGLPSLLSLTPAQQYRLKAKYAAATGGPPPTPLPHMERLSLKTRMAL XP_004840306.1/1-1576 TDASRRSSEASQGDGLPSLLSLTPAQQYRLKAKYAAATGGPPPTPLPHMERLSLKTRMAL ************.***********.**********************:**::****::** ENSMUSP00000106137/1-1583 LGEGRDSGVTLPPVHPPRRCSDGGGHTYRGRHLMPHDALANSVRRASDPVRTVSENMSLA ENSRNOP00000019396/1-1582 LGEGRDSGVTLPPVHPPRRCSDGGGHTYSRRHLLPHDALANSARRASDPVRTVSENMSLP ENSP00000379258/1-1580 LGDALEPGVALPPVHAPRRCSDGGAHGYGRRHLQPHDAPGHGVRRASDPVRTGSEGLALP ENSCPOP00000011914/1-1216 LGDSRESGVTLPPVHPPRRCSDGGAHGYSRRHLLPHDALGNSVRRASDPVRMASESLPPP XP_004840306.1/1-1576 LGDSRESGVTLPPVPPPRRCSDGGAHSYGRRHLLPHDALGNSVRRASDPVRTASDSLPPP **:. :.**:**** .********.* * *** **** .:..******** *:.:. . ENSMUSP00000106137/1-1583 RVQRFSSLNSFNPPNLPPSVEKRSLVLQNYTRQESSQPRYFQASPCPPSITENVALEALT ENSRNOP00000019396/1-1582 RVQRFSSLNSFNPPNLPPSVEKRSLVLQNYTRQESTHPRYFQASPCPPSITENVALEALT ENSP00000379258/1-1580 RVPRFSSLSSCNPPAMATSAEKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESLT ENSCPOP00000011914/1-1216 RVPRFSSLNSFSPP----STEKRNLVLQNYTRPEGSQPRPFHVSPCPPSITENITLESLT XP_004840306.1/1-1576 RVPRFSSLNSFSPP----SAEKRSLVLQNYTRPEGSQPHPFHASPCPPSITENVTLESLT ** *****.* .** *.***.******** *. :.: *: **********::**:** ENSMUSP00000106137/1-1583 MDADANLNDEDLLPDDVVQYLNSQNQTGYGQQLQSGISEDSKVAHEPEDLDLAGLPDSHV ENSRNOP00000019396/1-1582 MDADASLNDEDFLPDDVVQYLNSQNQTGYGQQLQSSISEDGKVAREPEDLDLPGLPDSHV ENSP00000379258/1-1580 MDADANLNDEDFLPDDVVQYLNSQNQAGYEQHFPSALPDDSKVPHGPGDFDAPGLPDSHA ENSCPOP00000011914/1-1216 MDADANLNDEDLLPDDVVQYLNSQNQAGYGQHLQSALSEDSKGPHGPADFDPSGLPDSHA XP_004840306.1/1-1576 VDADANLNDEDFLPDDVVQYLNSQNQAGYGQHLQSAISEDSKGPHRLGDFDPPGLPDN-- :****.*****:**************:** *:: *.:.:*.* .: *:* .****. ENSMUSP00000106137/1-1583 GQEYPALEQPCSEGSKTDLPIQWNEVSSGTSDLSSSKLKCGQQRPSAQQPRGFGLYNNMV ENSRNOP00000019396/1-1582 GQQYPALEQPCSEGSKTDLPIQWNEVSSGSSDLSSSKLKCG-QRPTVQQARGFGLYSNMV ENSP00000379258/1-1580 GQQFHALEQPCPEGSKTDLPIQWNEVSSGSADLSSSKLKCG-PRPAVPQTRAFGFCNGMV ENSCPOP00000011914/1-1216 GQQFHSLEQPGPEGSKSDLPIQWNEVSSGSADLPSSKLKCS-QRSTAQQARAFGLYSSIV XP_004840306.1/1-1576 --QFHSLEQTGTEGSKSDLPIQWNEVSSGSADLPSSKLKCG-QRSAGQQARGFGLYSSMV :: :***. .****:************::**.******. *.: *.*.**: ..:* ENSMUSP00000106137/1-1583 VHPHNLWKVGTGPAGGYQTLGENSSTY-NGPEHFAIHSGDGLGTNGNTFHEQPFKTQQYG ENSRNOP00000019396/1-1582 VHPQNLWKVGTGPAGGSQTLGENGSSY-SDPEHFAVHSGDGLGPSGDTFHEQAYKTQQYG ENSP00000379258/1-1580 VHPQNPLR--SGPAGGYQTLGENSNPY-GGPEHLMLHNSPGSGTSGNAFHEQPCKAPQYG ENSCPOP00000011914/1-1216 VPPQNPWRAGPGPATGYQDLGEN------------------------------------- XP_004840306.1/1-1576 VPPQNPWRAGLGLAGGYQGLTDNGSTFSSGPEHLAIPGDTSTSPGGNPFHAQPYKAQQYV * *:* : * * * * * :* ENSMUSP00000106137/1-1583 SQLNRQPLTSSALDHACGTGIQGSKLKGNSLQENGGLLDFSLSVAPNELAGNTVNGMQTQ ENSRNOP00000019396/1-1582 SQLSRQPLTSSVLDSACGAGIQGSKLKGNSLQENGGLLDFGLSMAPNELADNIVNGIQTQ ENSP00000379258/1-1580 NCLNRQPVAPGALDGACGAGIQASKLKSTPMQGSGGQLNFGLPVAPNESAGSMVNGMQNQ ENSCPOP00000011914/1-1216 ------------------------------------------------------------ XP_004840306.1/1-1576 NCLARQPAAPGSLDSASGTGVQGSKLKSATMQGNGGPLDFDVPVAPNESTRITVSGMQTP ENSMUSP00000106137/1-1583 DQMGQGYIAHQLLSGSM-QHQGPSRPGQQVLGQVGATSHINIYQGTESCLPGTQDNSSQP ENSRNOP00000019396/1-1582 EQMGQGYIAPQLLSGSM-QHQGPSRPGQQVLGQVGATSHINIYQGTESCLPGTQDKISQP ENSP00000379258/1-1580 DPVGQGYLAHQLLGDSM-QHPGAGRPGQQMLGQISATSHINIYQGPESCLPGAHGMGSQP ENSCPOP00000011914/1-1216 ------------------------------------------------------------ XP_004840306.1/1-1576 DPMGQGCLPHQLLGDGVQQHQGAGRAGQQVLQQVSATSHISSYQGPEGCLPGTHGVSCQP ENSMUSP00000106137/1-1583 SSMAAIRGYQPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSSRVNSIKMEAQGQSQQLCS ENSRNOP00000019396/1-1582 SSMAVIRGYQPCASYGGSRRQAMPRGSLTLQQGQLSDVSQTSRVNSIKMEAHGQSHQLCS ENSP00000379258/1-1580 SSLAVVRGYQPCASFGGSRRQAMPRDSLALQSGQLSDTSQTCRVNGIKMEMKGQPHPLCS ENSCPOP00000011914/1-1216 ------------------------------------------------------------ XP_004840306.1/1-1576 SGLVGVRGYQPCAGYGGSRRQAVPRASLTLQQGQLSDRSQTCRVNGIKTEMPGQPSQLCA ENSMUSP00000106137/1-1583 TVQNYSGQFYDQTMGFSQQDRKAGSFSLSDANCLLQGNGTENSELLSPGANQVTSTVDSF ENSRNOP00000019396/1-1582 SMQNYSGQFYDQTMGFSQQDRKAGSFSLSEANCLLQENGSENSELLSPGVNQVTSTVDSF ENSP00000379258/1-1580 NLQNYSGQFYDQTVGFSQQDTKAGSFSISDASCLLQGTSAKNSELLSPGANQVTSTVDSL ENSCPOP00000011914/1-1216 ------------------------------------------------------------ XP_004840306.1/1-1576 NVQNYSGQFYDQTMGFSLQDTKAGSFSMSGASCLLQEAGAENSELLSPGANQVTSTVDSL ENSMUSP00000106137/1-1583 ESHDLEGVQIDFDAIIDDGDHTSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPSLSMGT ENSRNOP00000019396/1-1582 ESHDLEGVQIDFDAIIDDGDHTSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPSLSMST ENSP00000379258/1-1580 DSHDLEGVQIDFDAIIDDGDHSSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPALSMST ENSCPOP00000011914/1-1216 ------------------------------------------------------------ XP_004840306.1/1-1576 DSHDLEGVQIDFDAIIDDGDHASLMSGALSPSIIQNLSHSSSRLTTPRASLPFPALPVST ENSMUSP00000106137/1-1583 TNMAIGDMSSLLTSLAEESKFLAVMQ ENSRNOP00000019396/1-1582 TNMAIGDMSSLLTSLAEESKFLAVMQ ENSP00000379258/1-1580 TNMAIGDMSSLLTSLAEESKFLAVMQ ENSCPOP00000011914/1-1216 -------------------------- XP_004840306.1/1-1576 TNMAIGDMSSLLTSLAEESKFLAVMQ