CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000011844/1-1380 ---ADSPKPPVAPKPKTT------AFKFPASPRAEGPHSPSPMSRGPKPPLAPKPRLAGP XP_004870537.1/1-1432 MNGADSPKPPVAPKPKTA------VPKFPASPRPEGLHSPGPMSRGPKPPLAPKPRLAGP ENSP00000285046/1-1462 ------------------------------------------MFRGPKPPIAPKPRLTAP ENSMUSP00000086748/1-1514 MHRADSPKPPLAPKPKVATNPYAPAAKFPPSQRPDSFPSPNSMSRGPKPPIAPKPRLTGP ENSRNOP00000040013/1-1356 ------------------------------------------------------------ ENSCPOP00000011844/1-1380 AGCRPGAHVNHQLFKCSNGQLPCGARD-----SPNPECSGSETDEDIFTGPWAAPEEDTA XP_004870537.1/1-1432 MECRPGAHMNHRLSKCSNGQLPCEARG-----SPNPECSGYETDEDSFPGPQAAPGEDAA ENSP00000285046/1-1462 NEWRASVYLNDSLNKCSNGRLPCVDRGLDEGPRSIPKCSESETDEDYIVVPRVPLREDEP ENSMUSP00000086748/1-1514 SE-----YLNNSLGKCSNGRLLCEDRGLYDGHHSTLNCLELEPDEQYIMVPRAPQKEDTP ENSRNOP00000040013/1-1356 --------VDHAL----------------------------------------------- ::. * ENSCPOP00000011844/1-1380 KD----------------------MGS--------------------AGEEACVDGGIEE XP_004870537.1/1-1432 ED----------------------TGS--------------------AGEEACVDGGTED ENSP00000285046/1-1462 KD----------------------EGSVGNKALVSPESSAEEEEEREEGGEAC---GLEG ENSMUSP00000086748/1-1514 VDGATEEPGFEGEVQEHGTEQTGTEGDLEAPDEEAPSRDSEEGMVHALEDEDC-DHDPET ENSRNOP00000040013/1-1356 -----------------------------------------------EDEEDC-DHDLET * * . * ENSCPOP00000011844/1-1380 AGDTQDLILPA--GEEGPEDEQEE----------EDGSHGSGTGELLPVGEEEEEPGGRP XP_004870537.1/1-1432 TGDSWDLTPPAGEGKEGPGDEE------------EDGSHNSGSGALLPTGEEEEEPEGRL ENSP00000285046/1-1462 TGAGEDSVAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPH ENSMUSP00000086748/1-1514 DGT------PTSPDEGAPSRDSEEGE--------EDCDQGPGMEEHPMSEEEGEEEEVKE ENSRNOP00000040013/1-1356 DGT------PTAPGEGAPSRDGEKGE--------EDCGQDPGVEEHPMSEEEGEEEEAKE * *: . . : *. . .* ** *: ENSCPOP00000011844/1-1380 GPCDLEDS---------------QHEASWTHEVPREEPGLPGDTTEVEEDGEEGHCHSEP XP_004870537.1/1-1432 GLCDLEDG---------------QHEAPGTHKDPCEEPGLPGDTAEVEEDGEESRGHAEL ENSP00000285046/1-1462 RECSLEDSGPWAGEGVFQSDLLLPHIHGEDQEP-------PDTPGEAEEDDEEGCASTDP ENSMUSP00000086748/1-1514 HVYNSDNRAPWDGEEPFPNEVILTHVRSQSPEVPCWEPGPPETPGEAEEDCEDICNNTEP ENSRNOP00000040013/1-1356 CVHNRDDRAPWDGGEPFLNEVVLTHVCSQSPEVPCWEPGLPETPGEVDEDSEDICNNTEL . :: * : * . *.:** *: :: ENSCPOP00000011844/1-1380 --------------DSGQEVGKASEEPASFEEPECKEPSCEDEETPELTPCAQESVPVPE XP_004870537.1/1-1432 --------------DSGQDEDKASEELPESEEP----PECEEPPESEEPPESEES---PE ENSP00000285046/1-1462 AGADEGSGPDRPTEDMGQDAEDTSEEPPEKEEL----AGVQEAETATDCPEVLEE----G ENSMUSP00000086748/1-1514 G---------KPNQDTGQDTEDAGMGSPESEVS----PDVQEQEAATDNPEVFEE----D ENSRNOP00000040013/1-1356 G---------KPNQDTGQDTEDASMGSPESEVS----PDVQEQEAATDSPEVFEE----D * **: .:. .. * . :: . * *. ENSCPOP00000011844/1-1380 CFGSP---QEQSMDI--QPDQDE------------------------------------- XP_004870537.1/1-1432 CEESP--ECEESPEYEEPSDHEELPECEELPKNEEPSECEELTTGSQEPMPAAEELAVPE ENSP00000285046/1-1462 CEEATGVTGGEQVDLSEPPDHEK------------------------------------- ENSMUSP00000086748/1-1514 SADAA--EGEDQIEQEEPPNCDE------------------------------------- ENSRNOP00000040013/1-1356 SVDAA--EGEDQIARDEPPNCEE------------------------------------- . :. :. .: :: ENSCPOP00000011844/1-1380 ------PS---EPDGKDTQDGRGPGAAEDLMPTEPPEESCQIIPFESSSV-EDLVVALEG XP_004870537.1/1-1432 EQRKDIQADQDEPDGMAAQDGEGPGASKDPVPAEAPEDSCQIIPFESTSV-EDLVASLPG ENSP00000285046/1-1462 ------KT-NQEVAAATLE---------DHAQDESAEESCQIVPFENDCM-EDFVTSLTG ENSMUSP00000086748/1-1514 ------EAYNRDAAAATMQVGEDLGEEGDHVQEDPAEESCQIIPFESDSVEEDFSPTLTE ENSRNOP00000040013/1-1356 ------DTNNRETAAATMQAGEDHGEDGDRVQEDPAEENCQIIPFESDSVEEDCSPTLTE : : . : * :..*:.***:***. .: ** :* ENSCPOP00000011844/1-1380 SAYELFPSESTSFCGDSCAPVM-LAGSMESEPGPKWDV---------PSTGTAGDKKAEA XP_004870537.1/1-1432 SPYKLFPTESTSFCGDSCLPVM-PEGGLELEPQPEWGI---------PSTGTASGQRGGA ENSP00000285046/1-1462 SPYEFFPTESTSFCSESCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGA ENSMUSP00000086748/1-1514 NPYEIFPTESTSFCNNTYS-LDESANGHE----PVCEICVEEVPGVGPPLNQHDSLPDGS ENSRNOP00000040013/1-1356 NPYELFPTESTSFCNNSGS-LAESDKGQE----SVCKICVEEVPGIGPSLSQGDSLQDGS ..*::**:******.:: : . * . : . . .. : ENSCPOP00000011844/1-1380 GA-APPVPNVVVLPEDEGTTDVACNDPCMT----------------------------ES XP_004870537.1/1-1432 GE-VPAVPDVGVLPEDKD-------DPCMT----------------------------EL ENSP00000285046/1-1462 AE-GPAAPDVVVVLE-EEALDDALANPYVMGVGLPGQAAPGEGG----QAASDALGGYGS ENSMUSP00000086748/1-1514 GEDSPVVPDVVVVPENEGPVDDALSSPYVMGVGL---LSLGEGAQSDTQAASGTLSGYST ENSRNOP00000040013/1-1356 GEEAP-VPEVVVVPENEDPMDDALSSPYVMGVGL---LSLGEGAQSDTQAASGTLSGYST . * .*:* *: * : .* : ENSCPOP00000011844/1-1380 KEDTACDTEGGLVPGDKRNVVPWAWPHSGKVAGCVPETVPEESGPEAGSSAVGIAKEA-- XP_004870537.1/1-1432 EEDAACDSEGGLVPGDRRNVVPWAWPHSGKVAGCVPETVPEESGPEAGSLAMGVAKEA-- ENSP00000285046/1-1462 KEELNCEAEGGLVPADRKNTSTRVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAEE ENSMUSP00000086748/1-1514 WEE--GDSEGGQVPVDRKNIATRARPHSGKVAGHVPETVLEETGPETCSSGMGIRDTSDE ENSRNOP00000040013/1-1356 WEE--GDSDGGQVPVDRKNIATRARPHSGKVAGHVPETVLEETGPEACSSAMGIRDTGDE *: :::** ** *::* . . ******** ***** **:***: * . *: . ENSCPOP00000011844/1-1380 ---------GRP-----VLPLEAG-WALHPRSFSVEGREPPGVANREPQGTGLDLHRMKR XP_004870537.1/1-1432 ---------GRP-----VLPSEAS-WALQPRSFSVEGREPPGAVSREPQGTGLDLRRMKR ENSP00000285046/1-1462 VGKTLLSLEGKPLEASRALPAKPRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKR ENSMUSP00000086748/1-1514 VRKIGILPEGKPPECVRALPAKPRAFTLYPRSFSVEGRESPLSMFREPEGAGLDSHRVRR ENSRNOP00000040013/1-1356 VRKIGILPEGKPSESLRALPAKPRAFTLYPRSFSVEGRESPLSMFREPEGAGLDMHRVRR *:* .** :. ::* ********** * :**:*:*** :*::* ENSCPOP00000011844/1-1380 KEDNLSLPCVIGSSGSFSQSKHLPSSGTSTPCSLVDIPPPFDLACVTKRPVTKSFPSLLL XP_004870537.1/1-1432 KEDNLSLPCVISSSGSFSQSKCLPSSGTSTPCSLVDIPPPFDLACVTKRPVTKSFPSLLL ENSP00000285046/1-1462 KEDNLSLSCVIGSSGSFSQRNHLPSSGTSTPSSMVDIPPPFDLACITKKPITKSSPSLLI ENSMUSP00000086748/1-1514 KEDNLSLPGAIGSSGSFSQRSHLPSSGTSTPSSVVDIPPPFDLACITKKPITKSSPSLLI ENSRNOP00000040013/1-1356 KEDNLSLPGAIGSSGSFSQRSHLPSSGTSTPSSVVDIPPPFDLACITKRPITKSSPSLLI *******. .*.******* . *********.*:***********:**:*:*** ****: ENSCPOP00000011844/1-1380 DSEAPDKTTKKKKSSFKRFLALTFRRKTDSKAHVDTGLASSRSSSESSYHGPCRLLDGDR XP_004870537.1/1-1432 DSEAPDKATKKKKSSFKRFLALTFRRKADSKVHGDAGLTSSRSSSESSYHGPCRLLDGDR ENSP00000285046/1-1462 ESDSPDK-YKKKKSSFKRFLALTFKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDR ENSMUSP00000086748/1-1514 DGDTLEKASKKKKSSFKRFLELTFRKKTESKVHVDMNLSSSRSSSESSYHGPARVLELDR ENSRNOP00000040013/1-1356 DGDTLEKASKKKKSSFKRFLELTFRKKTESKVHVDMSLSSSRSSSESSYHGPARVLELDR :.:: :* *********** ***::*::.* * * .::*************.*:*: ** ENSCPOP00000011844/1-1380 RSLGSSPQLRAQVGKPRAPESPASLLFSKDGRRRGVPFSRTVSRVESFEDRSRPPFLPLP XP_004870537.1/1-1432 RSLGSSPQLRARVGNLRAPESPVSLLFSRDGKRRGIPFSRTVSRVESFEDRSRPPFLPLP ENSP00000285046/1-1462 RSLSNSPQLKSRTGKLRASESPSSLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLP ENSMUSP00000086748/1-1514 RSLSNSPQLKCRTGKLRASDSPAALIFYRDSKRKGVPFSRTVSRVESFEDRSRPPFLPLP ENSRNOP00000040013/1-1356 RSLSNSPQLKCHTGKLRASDSPASLIFYRDSKRKGVPFSRTVSRVESFEDRSRPPFLPLP ***..****:.:.*: **.:** :*:* :*.:*:*:************************ ENSCPOP00000011844/1-1380 LTKPRSISFPNADTSDYENIPALSSDYENIQLPPRRPARPGTFTKLFEEQSRALSAANEN XP_004870537.1/1-1432 LTKPRSISFPNADTSDYENIPALSSDYENIQLPPRRLARPGTFTKLFEEQSRALSAANEN ENSP00000285046/1-1462 LTKPRSISFPSADTSDYENIPAMNSDYENIQIPPRRPARAGAFTKLFEDQSRALSTANEN ENSMUSP00000086748/1-1514 LTKPRSISFPNADTSDYENIPAMNSDYENIQIPPRRPVRTGTFTKLFEEQSRALSTANEN ENSRNOP00000040013/1-1356 LTKPRSISFPNADTSDYENIPAMNSDYENIQIPPRRPARTGTFTKLFEEQSRALSTANEN **********.***********:.*******:**** .*.*:******:******:**** ENSCPOP00000011844/1-1380 DGYVDMSSFSAFDSRVQSTEPEAESAYTEPYKVCPISAMTPRENLGSEEEQSSSEEEDGT XP_004870537.1/1-1432 DGYVDMSSFSAFDIRPQGTEPEAESAYTEPYKVCPVSATVPRGDLASEEEQGSSEEEDDT ENSP00000285046/1-1462 DGYVDMSSFNAFESKQQSADQDAESAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSA ENSMUSP00000086748/1-1514 DGYVDMSSFNAFESKQQSSEQEAESAYTEPYKVCPISA-APREDLTSDEEQGSSEEEDSA ENSRNOP00000040013/1-1356 DGYVDMSSFNAFESKQQSSEQEAESAYTEPYKVCPIST-TPKEDLTSDEEQGSSEEEDNA *********.**: : *.:: :*************:*: .*: :* *:*** ******.: ENSCPOP00000011844/1-1380 LRDPSITNKVEGPSRALVIAQELLSSERVFLQTLGPVCLDFHAAVMRALDNVE----DT- XP_004870537.1/1-1432 PRDPSVTHKVQGPSRALVIAQELLSSERAFLQTLGLVCLDFHSAVTKALDDVE----DVR ENSP00000285046/1-1462 SRDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTL ENSMUSP00000086748/1-1514 SRDPSLSHKGEGQSRALVIAQELLSSEKAYVQMLQHLSLDFHGAVLRALENVEQEGREPL ENSRNOP00000040013/1-1356 SRDPSLSHKGEGQSRAFVIAQELLSSEKAYVQMLQHLSLDFHGAVLRALENVEQEGREPL ****:::* :* ***:**********:.::: * : ****.** :**:::: : ENSCPOP00000011844/1-1380 -------------AIHALHQGILQELEQRLGD-GEGPSQVADIFLAREQEFEHHAVLILH XP_004870537.1/1-1432 AQEELRRGLDELPAIHTLHQGILQELEQRLGD-GEGPFRVASTFLAREQEFEHHAALVLH ENSP00000285046/1-1462 AREELRQGLSELPAIHDLHQGILEELEERLSN-WESQQKVADVFLAREQGFDHHATHILQ ENSMUSP00000086748/1-1514 AQEELRQGLRELPAICDLHQGILESLEQRLGDCGEGQPQVADIFLAQEQEFEHHAAHILQ ENSRNOP00000040013/1-1356 AQEELRQGLRELPAICDLHQGILESLEQRLGDCGEGQQQVADIFLAREQEFEHHAAHILQ ** ******:.**:**.: *. :**. ***:** *:***. :*: ENSCPOP00000011844/1-1380 FDRSLALLAQTCTRCPHLAATIRDFEQQ---GGQRVKQQLLAVVRRPFQYHVLLTDYLNN XP_004870537.1/1-1432 FDRSLALLAQTCARCPHLAAAVHDFEQR---GGRQVKQQLLAVVRRPLQYHALLTDYLNN ENSP00000285046/1-1462 FDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNN ENSMUSP00000086748/1-1514 FDRYLGLLAESCLLSPRLATTVREFEQSSQGGGQSMKHRMLRVVQRLFQYQVLLTDYLNN ENSRNOP00000040013/1-1356 FDRYLGLLAESCLLSPRLATTVREFEQSSQGGGQSMKHRMLRVVQRLFQYQVLLTDYLNN *** *.**::.* .*:**:::::*** *.: *:::* **:* :**:.******** ENSCPOP00000011844/1-1380 LCPDSAEYDNTQGALTLISTITDRAHDSMEQGENLQKLVHIEHSVSGQGDLLQPGREFLK XP_004870537.1/1-1432 LCPDSAEYNDTQGALTLISTVTDRAHDGMEQGENLQKLVHIEHSIHGQGDLLQPGREFLK ENSP00000285046/1-1462 LCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLK ENSMUSP00000086748/1-1514 LCPDSAEYDNTQSALTLISKVTDRANESMEQGENLQKLVHIEYSVRGQGDLLQPGREFLK ENSRNOP00000040013/1-1356 LCPDSAEYDNTQSALNLISKVTDRANESMEQGENLQKLVHIEYSVRGQGDLLQPGREFLK ********::**.**.***.:****::.**************:*: ************** ENSCPOP00000011844/1-1380 EGTLMKVRGKDRHPRHLFLMSDVLLYTHPQKDGKYRLKRSLPVAGMKVSRPVMENVPYAL XP_004870537.1/1-1432 EGTLMKVRGKDRHPRHLFLMSDVLLYTHPEKDGKYRLKSSLPVAGMKVSRPVMENIPYAL ENSP00000285046/1-1462 EGTLMKVTGKNRRPRHLFLMNDVLLYTYPQKDGKYRLKNTLAVANMKVSRPVMEKVPYAL ENSMUSP00000086748/1-1514 EGTLMRVRGKSRHPRHLFLMNDTLLYTHPQKDGKYRLKSSLPVANMKVSRPVMDKVPYAL ENSRNOP00000040013/1-1356 EGTLMRVRGKSRHPRHLFLMNDTLLYTHPQKDGKYRLKSSLPVANMKVSRPVMDKVPYAL *****:* **.*:*******.*.****:*:******** :*.**.********:::**** ENSCPOP00000011844/1-1380 RIETAQSCLTLSASSCAERDEWHSCLSRAVPEDHEAQALAAFHYSAELRERLGVSLGERP XP_004870537.1/1-1432 RIETAQCCLMLSASSCTERDEWHSCLSRAVPEDHEAQALAAFHHSAELRERLGVSLGERP ENSP00000285046/1-1462 KIETSESCLMLSASSCAERDEWYGCLSRALPEDYKAQALAAFHHSVEIRERLGVSLGERP ENSMUSP00000086748/1-1514 KIETPESCLTLSASSCAERDEWHYCLSRALPEDYKTQALAAFHHSVEIRERLGISLGERL ENSRNOP00000040013/1-1356 KIETPESCLTLSASSCAERDEWHYCLSRALPEDYKTQALAAFHHSVEIRERLGISLGERL :***.:.** ******:*****: *****:***:::*******:*.*:*****:***** ENSCPOP00000011844/1-1380 PTLVPVTHAVMCMNCGCDFSLTLRRHHCHACGKIVCRNCSRNKYPLKYLRDRMAKVCDGC XP_004870537.1/1-1432 PTLVPVTHAMMCMNCGCDFSLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGC ENSP00000285046/1-1462 PTLVPVTHVMMCMNCGCDFSLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGC ENSMUSP00000086748/1-1514 PTLVPVTHAMMCMNCGCDFSLTVRRHHCHACGKIVCRNCSRNKYPLKCLKNRMAKVCDGC ENSRNOP00000040013/1-1356 PTLVPVTHAMMCMNCGCDFSLTVRRHHCHACGKIVCRNCSRNKYPLKCLKNRMAKVCDGC ********.:************:************************ *::********* ENSCPOP00000011844/1-1380 FGELRKRGGTPPATLRERPVTMSFPLSSPRFSSGSALSSVFHSINPSNFKKQKKVPSALA XP_004870537.1/1-1432 FGELRKRGGAAPGPLRERPVTMSFPLSSPLFSSGSALSSVFHSINPSNFKKQKKVPSALA ENSP00000285046/1-1462 FGELKKRGRAVPGLMRERPVSMSFPLSSPRF-SGSAFSSVFQSINPSTFKKQKKVPSALT ENSMUSP00000086748/1-1514 FRELKLRNGPVPGSMRERPVSMSFPLSSSRFSSGSALSSVFQSISPSTFKKQKKVPSALS ENSRNOP00000040013/1-1356 FRELKLRNGPVPGPIRERPVSMSFPLSSSRFSSGSTFSSVFQSISPSTFKKQKKVPSALA * **: *. . *. :*****:*******. * ***::****:**.**.***********: ENSCPOP00000011844/1-1380 EVAASGEGLAISGYLSRCKRGKRPWKRLWFVIKGKVLYTYTAHEDKVATESIPLLGFTIA XP_004870537.1/1-1432 EVAASGEGLAISGYLSRCKRGKRPWKRLWFAIKGKVLYTYTAREDKVAMESIPLLGFTIA ENSP00000285046/1-1462 EVAASGEGSAISGYLSRCKRGKRHWKKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIA ENSMUSP00000086748/1-1514 EVAASGEGSAISGYLSRCKSGKRRWKKLWLVIKGKVLYTYLASEDKVAMESIPLLGFTIA ENSRNOP00000040013/1-1356 EVAASGEGSAISGYLSRCKSGKRRWKKLWLVIKGKVLYTYLASEDKVAMESIPLLGFTIA ******** ********** *** **:**:.********* * ***** **:******** ENSCPOP00000011844/1-1380 PGREEGNSDPSPVFHLYHKKTLFYSFKAEDTSAAQRWMEAMEDASVL XP_004870537.1/1-1432 PGREEGSSDPGPIFHLYHKKTLFYSFKAEDASAAQRWMEAMEDASVL ENSP00000285046/1-1462 PEKEEGSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDASVL ENSMUSP00000086748/1-1514 PEKEEGSSEVGPVFHLYHKKTLFYSFKAEDSNSAQRWMEAMEDASVL ENSRNOP00000040013/1-1356 PEKEEGSSEVGPVFHLYHKKTLFYSFKAEDSSSAQRWMEAMEDASVL * :***.*: .*:*****************:.:****:*********