CLUSTAL W(1.81) multiple sequence alignment ENSP00000314499/1-1311 MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEG-GFAFVYEAQD ENSMUSP00000036705/1-1305 MSLLQSALDFLAGPGSLGGAAGRDQSDFVGQTVELGELRLRVRRVLAEG-GFAFVYEAQD ENSRNOP00000000064/1-1305 MSLLQSALDFLAGPGSLGGAAGRDQSDFVGQTVELGELRLRVRRVLAEG-GFAFVYEAQD ENSCPOP00000011834/1-1315 MSLLQSALDFLAGPGSLSGATGRDQSDFVGQTVELGELRLRVRRVLAEGGGFAFVYEAQD XP_004847538.1/1-1299 MSLLQSALDFLAGPGSLGGAAGRDQSDFVGQTVELGELRLRVRRVLAEG-GFAFVYEAQD *****************.**:**************************** ********** ENSP00000314499/1-1311 VGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEF ENSMUSP00000036705/1-1305 LGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEF ENSRNOP00000000064/1-1305 LGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEF ENSCPOP00000011834/1-1315 LGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEF XP_004847538.1/1-1299 LGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEF :****************************:****************************** ENSP00000314499/1-1311 LLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENL ENSMUSP00000036705/1-1305 LLLTELCKGQLVEFLKRVECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENL ENSRNOP00000000064/1-1305 LLLTELCKGQLVEFLRRVECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENL ENSCPOP00000011834/1-1315 LLLTELCRGQLVEFLKKIEAKGPLPCDTVLKIFYQTCKAVQHMHRQKPPIIHRDLKVENL XP_004847538.1/1-1299 LLLTELCRGQLVEFLKKIEAKGPLPCDTILKIFYQTCRAVQHMHRQKPPIIHRDLKVENL *******:*******:::*.:***.**::********:********************** ENSP00000314499/1-1311 LLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFP ENSMUSP00000036705/1-1305 LLSNQGTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDLYSNFP ENSRNOP00000000064/1-1305 LLSNQGTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDLYSNFP ENSCPOP00000011834/1-1315 LLSSQGTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDLYSNFP XP_004847538.1/1-1299 LLSSQGTIKLCDFGSATTISHCPDYSWSAQRRAVVEEEITRNTTPMYRTPEIVDLYSNFP ***.***************** ********:**:******************:******* ENSP00000314499/1-1311 IGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVN ENSMUSP00000036705/1-1305 IGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPVNDTRYTVFHDLIRAMLKVN ENSRNOP00000000064/1-1305 IGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPVNDTRYTVFHDLIRGMLKVN ENSCPOP00000011834/1-1315 IGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPANDTQYCVFHDLIRAMLKVN XP_004847538.1/1-1299 IGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPANDTRYTVFHDLIRAMLKVN **************************************** :**:* ***.***.**:** ENSP00000314499/1-1311 PEERLSIAEVVHQLQEIAAARNVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYS ENSMUSP00000036705/1-1305 PEERLSIAEVVRQLQEIAAARNVNPKAPITELLEQNGGYGNSGPSRAQPPCGGTVNS--S ENSRNOP00000000064/1-1305 PEERLSIAEVVRQLQEIAAARNVNPKAPITELLEQNGGYGNSGPSRAQPPSGGPVNS--S ENSCPOP00000011834/1-1315 PEERLSIAEAVRQLQEIAAARNVNPKAPITELLEQNGGYGNPGPSRAPPTPGGPSSSSNS XP_004847538.1/1-1299 PEERLSIAEAVRQLQEIAAARNVNPKAPITELLEQNGGYGNPGPSRAPPTPGGPSSSSYS *********.*:**************:*************.. **. *. *. .* * ENSP00000314499/1-1311 GGLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAV ENSMUSP00000036705/1-1305 GVLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAV ENSRNOP00000000064/1-1305 GVLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAV ENSCPOP00000011834/1-1315 GALALAEYDQPYGGFFDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAV XP_004847538.1/1-1299 AVLALAEYDQPYGGFFDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAV . *************:******************************************** ENSP00000314499/1-1311 MSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRA ENSMUSP00000036705/1-1305 MSFPAEGVESAIKNNIEDVRMFLDAKHPGHYAVYNLSPRIYRASKFHNRVTECGWAVRRA ENSRNOP00000000064/1-1305 MSFPAEGVESAIKNNIEDVRLFLDAKHPGHYAVYNLSPRIYRASKFHNRVTECGWAVRRA ENSCPOP00000011834/1-1315 MSFPAEGMESAIKNNIEDVRLFLDAKHPGHYAVYNLSPRTYRASKFHNRVTECGWAARRT XP_004847538.1/1-1299 MSFPAEGVESAIKNNIEDVRLFLDAKHPGHYAVYNLSPRTYRASKFHNRVSECGWAARRA *******:***:********:***:************** **.*:*****:*****.**: ENSP00000314499/1-1311 PHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMF ENSMUSP00000036705/1-1305 PHLHSLYTLCRSMHAWLREDHRNVCVVHCMDGRAASAVAVCAFLCFCRLFSTAEAAVYMF ENSRNOP00000000064/1-1305 PHLHSLYTLCRSMHAWLREDHRNVCVVHCMDGRAASAVAVCAFLCFCRLFSTAEAAVYMF ENSCPOP00000011834/1-1315 PNLHSLYTICRNMHAWLRQDHRNICVVHCMDGRAASAVVVCAFLCFCRLFSTAEAAVYMF XP_004847538.1/1-1299 PNLHSLHTICRSMHSWLRQDHRNVCVVHCMDGRAASAVVVCAFLCFCRLFSTAEAAVYMF *:**:*:.:**.**:***:**:*:**************.**:****************** ENSP00000314499/1-1311 SMKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFC ENSMUSP00000036705/1-1305 SMKRCPPGIWPSHKRYIEYVCDMVAEEPITPHSKPMLVKSVVMTPVPLFSKQRNGCRPFC ENSRNOP00000000064/1-1305 SMKRCPPGIWPSHKRYIEYVCDMVAEEPITPHSKPMLVKSVVMTPVPLFSKQRNGCRPFC ENSCPOP00000011834/1-1315 SMKRCPPGIWPSHKRYIEYVCDMVAEEPITPHSKPMLVKAVIMTPVPLFSKQRNGCRPFC XP_004847538.1/1-1299 SMKRCPPGIWPSHKRYIEYVCDMVAEEAITPHSKPLLVKAVVMSPVPLFSKQRSGCRPFC *******************:*******.*******:**::*:*:*********.****** ENSP00000314499/1-1311 EVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKM ENSMUSP00000036705/1-1305 EVYVGEERVTTTSQEYDRMKEFKIEDGKAVIPLGVTVQGDVLIIIYHARATLGGRLQAKM ENSRNOP00000000064/1-1305 EVYVGEERVTTTSQEYDRMKEFKIEDGKAVIPLGITVQGDVLIIIYHARSTLGGRLQAKM ENSCPOP00000011834/1-1315 EVYVRDERVTTTSQEYDRMKEFKIEDGKAVIPLGITVQGDVLIVIYHARSTLGGRLQAKM XP_004847538.1/1-1299 EVYVADERVTTTSQEYDRMKEFKIEDGKAVIPLGITVQGDVLIVIYHARSTLGGRLQAKM **** :***::******:*::*************:********:*****:********** ENSP00000314499/1-1311 ASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREA ENSMUSP00000036705/1-1305 ASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREA ENSRNOP00000000064/1-1305 ASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSRDV ENSCPOP00000011834/1-1315 ASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRSCQEA XP_004847538.1/1-1299 ASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEARDRPCREA ***************************************************.***..::. ENSP00000314499/1-1311 PPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSD ENSMUSP00000036705/1-1305 PPWENTSLRGLNPKILFSNREEQQDILSKFGKPELPRQPGSTAQYDAEAGSPEAEITESD ENSRNOP00000000064/1-1305 PPWENTSLRGLNPKILFSNREEQQDILSKFGKPELPRQPGSTAQYDAEAGSPEAEITESD ENSCPOP00000011834/1-1315 QPWENTSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAEVVSPEAEPTDSD XP_004847538.1/1-1299 PPWENASMRGLNPKILFSSREEQQEILSKFGKPELPRQPGSTAQYDAEAESPEAEPTNSD ****:*:**********.*****:********************** . ***** *:** ENSP00000314499/1-1311 SPPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSE ENSMUSP00000036705/1-1305 SPQSSSTDTNHFLHTLDWQEEKEPETGLDNTSPKESQSVLIADGDGSEVSDEEEASFPSE ENSRNOP00000000064/1-1305 SPQSSSTDTNHFLHTLDWQEEKDPETGVDNTSPKESQSNLIADGDGSEVSDEEEASCPSE ENSCPOP00000011834/1-1315 SPQSSSADVKHFLHMLDWQGEKETETGMEGSSSKESQAVLITDRDESEASDEEAASVPNR XP_004847538.1/1-1299 SLQSSSTDANHFLHTLDWQEEKKAETVVEGSS-KQSQAVLVADRDGSETSDEEASPFPGG * ***:*..:*** **** **..** :.:* *:*:: *: * * **.*** :. .. ENSP00000314499/1-1311 GQEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQ ENSMUSP00000036705/1-1305 ERKPGAGEDTPRLAAGTKQQDLIFDVGMLAAPQEPVQPEEGVDLLGLHSEGDLRPAAPLQ ENSRNOP00000000064/1-1305 ERKPGAGEDTPRLAAGTRQQDLIFDVGMLAAPQEPVQPEEGVDLLGLHSEGDLRPAAPLQ ENSCPOP00000011834/1-1315 DSQPGASEDLPGPIAGSWQQDLMLDTATPASPQESRPQEDGIDLLGLHLEAAPGPAASAY XP_004847538.1/1-1299 DRQPGVSEDPPGPMAGTQHQDLILDAATPAFPQEARLKDDGVDLLGLHSQASPVPAASAE :* .. : * ** :***:::. * *. ::*:****** : **.. ENSP00000314499/1-1311 ACKAPSSNTDLLSCLLGPPEAASQGPPEDLL-SEDPLLLASPAPPLSVQSTPRGGPPAAA ENSMUSP00000036705/1-1305 ACGVPSSNTDLLSCLLEPSDAAQVGPPGDLLGGEAPLLLASPVSPLGLQNNLQGKVPDTV ENSRNOP00000000064/1-1305 ASGVQSSNTDLLSSLLEPSDASQVGPPGDLLGGETPLLLASPVSLLGVQSNLQGKVPDTV ENSCPOP00000011834/1-1315 TSPAPSSNTALLSCLLGPPESTLQGLPNDLLGSEAP-LLESPAPPLSVQSNPQGGPPATA XP_004847538.1/1-1299 TCRAPSSNTDLLSCLLGP--------PNDLLGGEAPLLLASPELPLSAQSTPQGAPPATD :. . **** ***.** * * *** .* * ** ** *. *.. :* * : ENSP00000314499/1-1311 DPFGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFP--SAHSAPPPSCSADFLHLGD ENSMUSP00000036705/1-1305 DPFDQFLLSSNSDTQPCSKPDLFGEFLNSDSVASSTAFP--STHSAPPPSCSTAFLHLGD ENSRNOP00000000064/1-1305 DPFDQFLLPSSSDTQPCSKPDLFGEFLNSDSVASSTAFP--STHSAPPPSCSTAFLHLGD ENSCPOP00000011834/1-1315 DPFDPLLLAPDADSQPCSQPDLFGEFLHADPVAAPATFPEVPTSSAPLPSSAT-FLPLGN XP_004847538.1/1-1299 DPFDPLLLAPDAKPQPCSQPDLFGEFLHADPVAAPAPFP--YTNSAPPPSCTA-FLPLGD ***. :* ... ..****:********::*.*: ...** : *** **.:: ** **: ENSP00000314499/1-1311 LPGEPSKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTK ENSMUSP00000036705/1-1305 LPAEPSKVIASSSHPDLLGGWDTWADTATPGPASIPVPEGTLFSSAGHPAPPGPNPSQTK ENSRNOP00000000064/1-1305 LPAEPNKVIASSSHPDLLGGWDTWAETALPGPASMPVPEGTLFSSAGHPAPPGPNPSQTK ENSCPOP00000011834/1-1315 LPAEPSKVTASSSHQDLLGGWDAWAEAAVPELASEVYPERSLFPSGAQLTPAGPHPSQTK XP_004847538.1/1-1299 LPAEPGQVTASSSHLDLLGGWDAWAEAAVPGPAS----GGPLFPPGAQPVPAGPQPSQTK **.**.:: ****: ****** :*:::* . *. .**....: .* *.:.* ** ENSP00000314499/1-1311 SQNPDPFADLG---DLSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQGASWPP ENSMUSP00000036705/1-1305 SQNLDPFADLS---DLSSSLQGLPAGLPAGGFVGAPAPTQKSNSPWQANRPTAPGTSWTP ENSRNOP00000000064/1-1305 SQNPDPFADLS---DLSSSLQGLPAGLPAGSFVGTSATTHKSNSSWQTTRPTAPGTSWPP ENSCPOP00000011834/1-1315 SQSLDPFADLGALCDLGCSLPGLAAGPPLGGFVPKAAPSPKGGSSWQTSRPPVQGTSWSP XP_004847538.1/1-1299 SQSLDPFADLGDLRGLSSSLPGPAAGPPPGGFVPKTAPSPKGGSSWQTNRP-AQGTSWPP **. ******. .*...* * .** * *.*: .*.: *..*.**:.** . *:**.* ENSP00000314499/1-1311 QAKPPPKACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRS ENSMUSP00000036705/1-1305 QAKPAPRASEQLR----SHFSVIGAREERGVRVPSFAQKPKVSENDFEDLLPNQGF-SKS ENSRNOP00000000064/1-1305 QAKPAPRASEQLR----SHFSVIGAREERGVRAPSFAQKPKVSENDFEDLLPNQGF-SKS ENSCPOP00000011834/1-1315 QPKIPAKTCVPPRPNYSMNFSVIGDREERGVRMPSFTQKPKVSENDFEDLLPNQGF-SRS XP_004847538.1/1-1299 QIKVPPKTGAPQRPNYAMSFSVIGDREDRGARVASFAPKPKVSENDFEDLLPNQGF-SKS * * ..:: * ***** **:**.* .**: *************.**** *:* ENSP00000314499/1-1311 DKKGPKTIAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVG ENSMUSP00000036705/1-1305 DKKGPKTMAEMRKQELARDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVS ENSRNOP00000000064/1-1305 DKKGPKTMAEMRKQELARDTDPFKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVS ENSCPOP00000011834/1-1315 DKKGPKTMAEMRKQDLARDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGEHRWTPVS XP_004847538.1/1-1299 DKRGPKTMAEMRKQDLARDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWAGEHRWTPVS **:****:******:**:****:*************************** ** *****. ENSP00000314499/1-1311 MADLVAPEQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF ENSMUSP00000036705/1-1305 MADLVTPEQVKKQYRRAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFENQGSRPLF ENSRNOP00000000064/1-1305 MADLVTPEQVKKQYRRAVLVVHPDKATGQPYEQSAKMIFMELNDAWSEFENQGSRPLF ENSCPOP00000011834/1-1315 MADLVTPGQVKKQYRRAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFENQGSRPLF XP_004847538.1/1-1299 MADLVTPGQVKRQYRRAVLVVHPDKATGQPYEQYAKMIFMELSDAWSEFENQGSRPLF *****:* ***::******.******:****** ********.***************