CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000023747/1-1323 ----MDQPAGGTGKLRASAGEDDSMELSTCQELLHRLRELEAENSALAQANENQRETYER ENSRNOP00000022937/1-1325 ----MDQPAGGTGNLRPASGEDSSMELGTCQELLHRLRELEAENSALAQANENQRETYER ENSP00000337998/1-1334 MSEAMDQPAGGPGNPRPGEGDDGSMEPGTCQELLHRLRELEAENSALAQANENQRETYER ENSCPOP00000011763/1-1296 ----MDQTAGGPGYPALGEGADGNMEPSSCQELLHRLRELEAENSALAQANENQRETYER XP_004863070.1/1-1331 MAEAMDQTPGGPGYPVPGEGADGSMEPGSCQELLHRLRELEAENSALAQANENQRETYER ***..**.* . * *..** .:******************************* ENSMUSP00000023747/1-1323 CLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQVLSALLQQKLQLT-ANSLPQIP ENSRNOP00000022937/1-1325 CLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSTLLQQKLQLT-TSSLPQIP ENSP00000337998/1-1334 CLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLT-TGSLPQIP ENSCPOP00000011763/1-1296 CLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLT-VGSLPQIP XP_004863070.1/1-1331 CLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTAAGSLPQLP **************************************:**:*:******* ..****:* ENSMUSP00000023747/1-1323 LTPLQPPSERPTSPAPNVSEGPATSLPSGLCAGQREVCWEQQLRPGGPGPPATPPPALDA ENSRNOP00000022937/1-1325 LTPLQPPSERPASPSPNAAEGPATTLPLGHCAGPREVCWEQQLRPGGPGPPATPPPALDA ENSP00000337998/1-1334 LTPLQPPSEPPASPSLSSTEGPAAPLPLGHCAGQREVCWEQQLRPGGPGPPAAPPPALDA ENSCPOP00000011763/1-1296 LTPLQPPSEPPACPSLGTAEGPATSLPLGHCAGQREVCWEQQLRPGGPGPPAAPPPALDA XP_004863070.1/1-1331 LTPLQPPSEPPASPSLGTAEGPSTSLPLGHCAGQREVCWEQQLRPGGPGPPAAPPPALDA ********* *:.*: . :***::.** * *** ******************:******* ENSMUSP00000023747/1-1323 LSPFLRKKAQILEVLRALEETDPLLLCSPATPWRPTGQGPGSPEPINGEPCGPPQPEPSP ENSRNOP00000022937/1-1325 LSPFLRKKAQILEVLRALEETDPLLLCSPATPWRPTGQGPGSPEPINGELCGPPQPEPSP ENSP00000337998/1-1334 LSPFLRKKAQILEVLRALEETDPLLLCSPATPWRPPGQGPGSPEPINGELCGPPQPEPSP ENSCPOP00000011763/1-1296 LSPFLRKKAQILEVLRALEETDPLLLCSPATPWQPQGHGPGSPEPINGELCGPPQAEPSP XP_004863070.1/1-1331 LSPFLRKKAQILEVLRALEETDPLLLCSPATPWRPPGQGPGSPEPINGELCGPPKPEPSP *********************************:* *:*********** ****:.**** ENSMUSP00000023747/1-1323 WAPYLLLGPGSLGALLHWERVLGGPGEEEGIRQPWASSRAPPSAQGPSSGPHCAPGSSSS ENSRNOP00000022937/1-1325 WAPYLLLGPGSLGALLHWERALGGPGEEEGIRQPWASSRAPLPAQGPGAGPHCAPGSSSS ENSP00000337998/1-1334 WAPCLLLGPGNLGGLLHWERLLGGLGGEEDTGRPWGPSRGPPQAQGTSSGPNCAPGSSSS ENSCPOP00000011763/1-1296 WAPYLLVGPGSLGGLLHWERLLGGPGEEENTRRPWGPNRAPSQVQDT----HCTPGSSSS XP_004863070.1/1-1331 WAPYLLVGPGSLGGLVHWEHVLGGPGEEGSARRPY---RAPLQAQGTNPNPHCAPGSSSS *** **:***.**.*:***: *** * * . :*: *.* .*.. :*:****** ENSMUSP00000023747/1-1323 SSSDEAGDPNEAPSPDTLLGALARKQLNLGQLLGDTETYLQAFLAGATGPLSGDQPGP-- ENSRNOP00000022937/1-1325 SSSDEAGDPNEAPSPDTLLGVLARKQLNLGQLLGDTEISLPAFLAGATGPLSGDHPHPSA ENSP00000337998/1-1334 SSSDEAGDPNEAPSPDTLLGALARRQLNLGQLLEDTESYLQAFLAGAAGPLNGDHPGP-- ENSCPOP00000011763/1-1296 SSSDEAGDPNEAPSPDTLLGALTRKQLNLGQLLEDTETYLQAFLAGAAGPLSGDHPGP-- XP_004863070.1/1-1331 SSSDEAGDPNEAPSPDTLLGALARKQLNLGQLLEDTETYLQAFLAGAAGPLNGDHPGP-- ********************.*:*:******** *** * ******:***.**:* * ENSMUSP00000023747/1-1323 GKPNSPDPGPPQVSKSKGLPKSAWGASTPEATRLGFGATSEGQGPLPFLSMFMGAGDAPL ENSRNOP00000022937/1-1325 GKLSSPDPGAPQVSKSKGLPKSAWGGSAPEASRLGFGATSEGQGPLPFLSMFMGAGDAPL ENSP00000337998/1-1334 GQSSSPDQAPPQLSKSKGLPKSAWGGGTPEAHRPGFGATSEGQGPLPFLSMFMGAGDAPL ENSCPOP00000011763/1-1296 GQPLSSDQGSPQ--QSKGLLKSSWGGGTPEAHRLGFGATSEGQGPLPFLSVFAGTEDAPL XP_004863070.1/1-1331 RQPSSPDQGPLQLSKCKGLPKSAWGGGTPEAHRLGFGATSEGQGPLPFLSMFVGTEDAPL : *.* .. * :.*** **:**..:*** * ****************:* *: **** ENSMUSP00000023747/1-1323 GSRPGHPHSSSQVKSKLQIGPPSPGDAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLS ENSRNOP00000022937/1-1325 GSRPGHSHSSSQVKSKLQIGLPSPGDAQGPLLPSPARGLKFLKLPPASEKVPSPGGPQLS ENSP00000337998/1-1334 GSRPGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPTSEKSPSPGGPQLS ENSCPOP00000011763/1-1296 GSQPGHAH-SSQVKSKLQIGPASPGEAQGPLLPSPARSLKFLKLPPTSEKVPSPGSPQL- XP_004863070.1/1-1331 GSQPGHPHSSSQVKSKLQMGPPSPGEAQGPLLPSPAKSLKFLKLPPASEKVPSPGGPQLS **:***.* *********:* .***:**********:.********:*** ****.*** ENSMUSP00000023747/1-1323 PQLPRSSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPGSPLPCSAMPDSAQLRP ENSRNOP00000022937/1-1325 PQLPRSSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPSSPLPCSANPDSAQLRT ENSP00000337998/1-1334 PQLPRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCYTTPDSTQLRP ENSCPOP00000011763/1-1296 ---PRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGQQGLATSPSPCLTTPDSAQLRP XP_004863070.1/1-1331 PQLPRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCSTVLDSVQLRP **.******************************** ***. ** ** : **.***. ENSMUSP00000023747/1-1323 SQSTVSTALSPGPVVSPCFENILDLSRSTFRGSPPEPPPSPLQVPTYPQLTLEVPQTPEV ENSRNOP00000022937/1-1325 SQSAVSTTLSAGPVVSPCFENILDLSRGTFRGSSTEPPPSPLQVPTYPQLTLEVPQTHEV ENSP00000337998/1-1334 PQSALSTTLSPGPVVSPCYENILDLSRSTFRGPSPEPPPSPLQVPTYPQLTLEVPQAPEV ENSCPOP00000011763/1-1296 PQSTLSTTLSPGPVVSPCYENILDLSRSTFRGSSPEPPPSPLQVPTYPQLALEVPQASEG XP_004863070.1/1-1331 PQSAFSTTPSPGPVVSPCYENILDLSRSTFKGSSPEPPPSPLQVPTYPQLSLEVPQAPEV .**:.**: *.*******:********.**:*...***************:*****: * ENSMUSP00000023747/1-1323 LRSPGA-PSPGLPESCPYSGPQEKSMDRAGSESPHASRRTPGGSSKKPGQGSGRRPGDPS ENSRNOP00000022937/1-1325 LRSPGA-PSPGLPGPCPYSSPQEKSVDRAGSESPHLSRRTPCGSSKKPGQGSGRRPGDPS ENSP00000337998/1-1334 LRSPGVPPSPCLPESYPYGSPQEKSLDKAGSESPHPGRRTPGNSSKKPSQGSGRRPGDPG ENSCPOP00000011763/1-1296 LRSPRAPPSPCLSESCPYGTPQEKSSDKVGSESPHPGRRTPGSSSKKPAQGSGRRAGDPG XP_004863070.1/1-1331 LRSPRVPPTPCLSESCPYGAPQEKGSDKAGSESPHPGRRTPGSSSRKPGQGSGRRPGDPG **** . *:* *. . **. ****. *:.****** .**** .**:**.******.***. ENSMUSP00000023747/1-1323 HTPLRDRLAALGKLKTGPEGPLGPEKNGVPARSSAEKARALVRSGECAGD-VPPSARPLE ENSRNOP00000022937/1-1325 HTPLRDRLAALGKLKTGPEGPLGPEKNGVPARSNTEKAKAPVRSGECPGD-VSPSTRPLE ENSP00000337998/1-1334 STPLRDRLAALGKLKTGPEGALGSEKNGVPARPGTEKTRGPGKSGESAGDMVPSIHRPLE ENSCPOP00000011763/1-1296 YAPLRDRLAALGKLKTGPEGL---EKNGVPARPGTEKARGPGRSGESTGDVVPLTTRPLE XP_004863070.1/1-1331 FTALRDRLAALGKLKTGPEGPLGPEKSGVPARPGTEKARGPGRSGESTGDTVPPTTQPLE :.***************** **.*****..:**::. :***..** *. :*** ENSMUSP00000023747/1-1323 QPEAKGIFRGAVALGTSSLKQQEPGL-TDPGARVYSSHSMGARVDLEPISPRSCLTKVEL ENSRNOP00000022937/1-1325 QPEAKGIFRGAVALGTSSLKQQEPGL-TDLGARVYSSHSMGARVDLEPISPRSCLTKVEL ENSP00000337998/1-1334 QLEAKGGIRGAVALGTNSLKQQEPGLMGDPGARVYSSHSMGARVDLEPVSPRSCLTKVEL ENSCPOP00000011763/1-1296 QPEAKGALRGAVALGTSSLKQQDPGL-GDPGARVYSSHSMGARVDLDPVSPRSCLTKVEL XP_004863070.1/1-1331 QPEAKGPLQGVVALGTSSLKQQEPGL-GDPGARVYSSHSMGARVDLEPVSPRSCLTKVEL * **** ::*.*****.*****:*** * ****************:*:*********** ENSMUSP00000023747/1-1323 AKSRLAGALCPQMPRTPAKVPTSAPSLGKP-KSPHSSPTKLPSKSPTKVVPRPVVPLGTK ENSRNOP00000022937/1-1325 AKSRLAGALCPQMPRTPAKVPTSAPSLGKP-KSPHSSPTKLPSKSPTKVVPRPVAPLGTK ENSP00000337998/1-1334 AKSRLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHSSPTKLPSKSPTKVVPRPGAPLVTK ENSCPOP00000011763/1-1296 AKSRLAGSL------------------GKPSKSPHSSPTKLPSKSPTKVVPRPGASPVTK XP_004863070.1/1-1331 AKSRLAGALCPQVPRTPAKVPTSAPSLGKPSKSPHSSPTKLPSKSPTKVVPRPGPPPVPK *******:* *** ********************** . .* ENSMUSP00000023747/1-1323 EPPKPDKVKGPPWADCGSTVGQPTSPVAGPADPSQGSEGPAPHSAIEEKVMKGIEENVLR ENSRNOP00000022937/1-1325 EPPKPDKVKGPPWADCGTTVGQPTSPVPGPVDQSPGPEGPVPHSAIEEKVMKGIEENVLR ENSP00000337998/1-1334 ESPKPDKGKGPPWADCGSTTAQSTPLVPGPTDPSQGPEGLAPHSAIEEKVMKGIEENVLR ENSCPOP00000011763/1-1296 EPPKPEKGKGSSWADCSSSTGQPTSPIPGPPDPSQGPEGSAPHSAIEEKVMKGIEENVLR XP_004863070.1/1-1331 EPPKPDKGKGSSWADCSSVTGQPTSPIPGPPNPSQVPEGLAPHSAIEEKVMKGIEENVLR *.***:* **..****.: ..*.*. :.** : * .** .******************* ENSMUSP00000023747/1-1323 LQGQERTPGSEAKHRNTSSIASWFGLKKSKLPALNRRTEATKNKDGAGGGSPLRKEVKTE ENSRNOP00000022937/1-1325 LQGQERTPGSEAKHRNASSIASWFGLKKSKLPALNRRTEAAKNKEGAGGGSPLRKEVKTE ENSP00000337998/1-1334 LQGQERAPGAEVKHRNTSSIASWFGLKKSKLPALNRRTEATKNKEGAGGGSPLRREVKME ENSCPOP00000011763/1-1296 LQGQERAPASEAKHRGTSSIASWFGLKKSKLPALNRRTEA-KSKEGASGGSPLRKEVKVE XP_004863070.1/1-1331 LQGQERAPGSEAKHRSTSSIASWFGLKKSKLPALNRRTEATKSKDGPSGGSPLRKEGKVE ******:*.:*.***.:*********************** *.*:*..******:* * * ENSMUSP00000023747/1-1323 ARKLEAESLNISKLMAKAEDLRRALEEEKAYLS-RARPRPGGPATVPSPGLGQAQGQLAG ENSRNOP00000022937/1-1325 AWKLEAESLNISKLMAKAEDLRRALEEEKAYLS-RARPRPGGPATVPSPSVGQPQGQLTG ENSP00000337998/1-1334 ARKLEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPAPGPNTGLGQVQGQLAG ENSCPOP00000011763/1-1296 ARKLEAESLNISKLMAKAEDLRRALEEEKAYLSSRTRPRPGGPAAGPSQALGQVQGQLVG XP_004863070.1/1-1331 ARKLEPESLNISKLMAKAEDLRRALEEEKAYLSRGTRPRPGGSATGPSQGLGQVQGQLVG * ***.*************************** :******.*. *. .:** ****.* ENSMUSP00000023747/1-1323 MYQGADTFMQQLLNRVDGKELPPKSWREPKPEYGDFQPVSTDPKSPWPACGPRNGLVGPL ENSRNOP00000022937/1-1325 MYQGADTFMQQLLNRVDGKDLPPESWREPKPEYGDFQPVSSDPKSPWPACGPRNGLVGPL ENSP00000337998/1-1334 MYQGADTFMQQLLNRVDGKELPSKSWREPKPEYGDFQPVSSDPKSPWPACGPRNGLVGPL ENSCPOP00000011763/1-1296 MYQGADTFMQQLLNRVDGKELPPKSWREAKPEYGDFQPGSSDPKSPWPPCRPRNGLVGPL XP_004863070.1/1-1331 MYQGADTFMQQLLNRVDGKELPPKSWREAKPEYGDFQPVSSDPKSPWPACGPRNGLVGPP *******************:**.:****.********* *:*******.* ******** ENSMUSP00000023747/1-1323 QGCGK-PGKPSSEPGRREEMPSEDSLAEPVSTTHFTACGSLTRTLDSGIGTFPPPDHSSS ENSRNOP00000022937/1-1325 QGCGK-PGKPISEPGRREAMPPEDNLAEPVSTAHFTACGSLTRTLDSGIGTFPPPDHSSS ENSP00000337998/1-1334 QGCGKPPGKPSSEPGRREEMPSEDSLAEPVPTSHFTACGSLTRTLDSGIGTFPPPDHGSS ENSCPOP00000011763/1-1296 QGCGKSPGKASSEPGRQEEMPSEDSLAEPVPTSHFTACGSLTRTLDSGIGTFPPPDHGSN XP_004863070.1/1-1331 QGCRKSPGKPSSEPGRQEEMPLEDSLAEPVPTSHFTACGSLTRTLDSGIGTFPPPDHGSS *** * ***. *****:* ** **.*****.*:************************.*. ENSMUSP00000023747/1-1323 GTPSKNLPKTKSLRLDPPPGAPPARPPGLTKVPRRAHTLEREVPGIEELLVSGRHPSMPA ENSRNOP00000022937/1-1325 GTPSKNLPKTKSFRLDPPPGAPAARPPGLTKVPRRAHTLEREVPGIEELLVSGRHPSMPA ENSP00000337998/1-1334 GTPSKNLPKTKPPRLDPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPA ENSCPOP00000011763/1-1296 GTPSKNLPKAKPPRLDPQPGGPPARPPALTKVPRRAHTLEREVPGIEELLVSGRHPSVPA XP_004863070.1/1-1331 GTPSKNLPKAKPPRLEPPPGLPPARPPALTKVPRRAHTLEREVPGIEELLVSGRHPSMPA *********:*. **:* ** *.**** *****************************:** ENSMUSP00000023747/1-1323 FPGLLTAPPGHRSHQTCPDDPCEDPGPPPPVQLAKNWTFPNTRTAGSSSDPFLCPPRQLE ENSRNOP00000022937/1-1325 FPALLTAPPGHRSHQTCPDDPCEDPGPPPPVQLAKNWTFPNTRTSGSTSDPFLCPPRQLE ENSP00000337998/1-1334 FPALLPAAPGHRGHETCPDDPCEDPGPTPPVQLAKNWTFPNTRAAGSSSDPLMCPPRQLE ENSCPOP00000011763/1-1296 FPALLTTTPSHRGHLTCPDDPCEDPGPPPAVQLAKNWTFPNTRAASSSSDPFLCPPRQLE XP_004863070.1/1-1331 FPALLTSTPSHRGHPPCPDDPCEDPGPSPPVQLAKNWTFPNTRAASSSSDPFLCPPQQLE **.**.:.*.**.* .***********.*.*************::.*:***::***:*** ENSMUSP00000023747/1-1323 GLPRTPMALPVDRKQSVDPSR-TSTPQGPAFGGSRTPSTSDMGEEGRVASGGAPGLETSE ENSRNOP00000022937/1-1325 GLPRTAMALPVDRKQSLDPSR-TSMPQGPAFGGSRTPSTSDMGEEGRVASGGAPGLETSE ENSP00000337998/1-1334 GLPRTPMALPVDRKRSQEPSRPSPTPQGPPFGGSRTPSTSDMAEEGRVASGGPPGLETSE ENSCPOP00000011763/1-1296 GLPRTPMALPVDQKQSLEPSRPPPTPQGPVFGGSRTPSTSDMGEEGRVASGSAPGLETSE XP_004863070.1/1-1331 ELPRTPMALPVDQKRSLEPSRPPAAPQGPGFGGSRTPSTSDVGEEGRTASGGAPGLEASE ****.******:*:* :*** .. **** ***********:.****.***..****:** ENSMUSP00000023747/1-1323 SLSDSLYDSLSSCGSQG ENSRNOP00000022937/1-1325 SLSDSLYDSLSSCGSQG ENSP00000337998/1-1334 SLSDSLYDSLSSCGSQG ENSCPOP00000011763/1-1296 SLSDSLYDSLSSCGSQG XP_004863070.1/1-1331 SLSDSLYDSLSSCGSQG *****************