CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000105413/1-1514 MKDKQKRKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAML ENSRNOP00000049815/1-1494 -------------------VLENYSDAPMTPKQILQVIEAEGLKEM-SGTSPLACLNAML ENSP00000364839/1-1541 MKDKQKKKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAML ENSCPOP00000011566/1-1430 ------------------------------------------------------------ XP_004840635.1/1-1505 ----------------------------MTPKQILQVIETEGLKEMRSGTSPLACLNAML ENSMUSP00000105413/1-1514 HSNSRGGEGLFYKLPGRISLFTLKKDAVQWSRNAATVDGDEPEDSADVESCGSNEASTVS ENSRNOP00000049815/1-1494 HSNSRGGEGLFYKLPGRISLFTLKKDAVQWSRNVATLDGEEPEDSADVESCGSNEASTVS ENSP00000364839/1-1541 HSNSRGGEGLFYKLPGRISLFTLKKDALQWSRHPATVEGEEPEDTADVESCGSNEASTVS ENSCPOP00000011566/1-1430 --------------------FLSQKDALQWSRNTAAVEGEEPEDSADVESCGSNEASTVS XP_004840635.1/1-1505 HSNSRGGEGLFYKLPGRISLFTLKKDALQWSRNTAAMEGEEPEDSADVESCGSNEASTVS * :***:****: *:::*:****:*************** ENSMUSP00000105413/1-1514 GENDVSLDETSSNASCSTESQSRPLSNPRDSHRASSQANKQKKRTGVMLPRVVLTPLKVN ENSRNOP00000049815/1-1494 GENDVSLDETSSNASCATEPQGRSLSNPRDGHRASSQANKQKKRTGVMLPRVVLTPLKVN ENSP00000364839/1-1541 GENDVSLDETSSNASCSTESQSRPLSNPRDSYRASSQANKQKKKTGVMLPRVVLTPLKVN ENSCPOP00000011566/1-1430 GENDVSLDETSSNASCSTESQNRPLSSPRDSYRTSSQANKQKKKTGVMLPRVVLTPLKVN XP_004840635.1/1-1505 GENDVSLDETSSNASCSTESQNRPLSSPRDNYRASSQANKQKKKTGVMLPRVVLTPLKVN ****************:**.*.*.**.***.:*:*********:**************** ENSMUSP00000105413/1-1514 GAHVEPASGFSGRHADGESGSPSSSSSGSLALGNSAIRGQAEVTRDPAPLLRGFRKPATG ENSRNOP00000049815/1-1494 GAHVEPASGFSGRHADGESGSPSSSSSGSLALGNSTIRSQAEVTRDPAPLLRGFRKPATG ENSP00000364839/1-1541 GAHVESASGFSGCHADGESGSPSSSSSGSLALGSAAIRGQAEVTQDPAPLLRGFRKPATG ENSCPOP00000011566/1-1430 GAHVESAAGFSGRHADGESGSPSSSSSGSLALGSAAIRGQAEVARDPAPLLRGFRKPATG XP_004840635.1/1-1505 GAHMESAAGFSGRHADGESGSPSSSSSGSLALGSAAIRGQAEVTRDPAPLLKGFRKPATG ***:*.*:**** ********************.::**.****::******:******** ENSMUSP00000105413/1-1514 QMKRNRGEEVDFETPGSILVNTNLRALINSRTFHALPLHFQQQLLLLLPEVDRQVGTDGL ENSRNOP00000049815/1-1494 QMKRNRGEEVDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGL ENSP00000364839/1-1541 QMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGL ENSCPOP00000011566/1-1430 QVKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQMGTDGL XP_004840635.1/1-1505 QMKRNRGEEIDFETPGSILVNTNLRALINSRTFHALPSHFQQQLLFLLPEVDRQVGTDGL *:*******:*************************** *******:********:***** ENSMUSP00000105413/1-1514 LRLSGSALNNEFFTHAAQSWRERLADGEFTHEMQVRLRQEMEKEKKVEQWKEKFFEDYYG ENSRNOP00000049815/1-1494 LRLSSSALNNEFFTHAAQSWRERLAEGEFTHEMQVRLRQEMEKEKKVEQWKEKFFEDYYG ENSP00000364839/1-1541 LRLSSSALNNEFFTHAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYG ENSCPOP00000011566/1-1430 LRLSNSALNNEFFTHAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEEYYG XP_004840635.1/1-1505 LRLSSSALNNEFFTHAAQSWRERLADGEFTHEMQVRIRQEMEKEKKVEQWKEKFFEDYYG ****.********************:**********:*******************:*** ENSMUSP00000105413/1-1514 QKLGLTKEESLQQKEVQEEAKVKSGLCVSGESVRPQRGPNTRQRDGHFKKRS----RPDL ENSRNOP00000049815/1-1494 QKLGLTKEESLQQKEDQEEAKIKSGFCVSGESVRPQRGPNTRLQRHHPANESLFFVKIIS ENSP00000364839/1-1541 QKLGLTKEESLQQNVGQEEAEIKSGLCVPGESVRIQRGPATRQRDGHFKKRS----RPDL ENSCPOP00000011566/1-1430 QRLGLTKEES--QNVSQEETEIKSGLCVSGESPRPQRGPVTRQRDGHFKKRS----RPDL XP_004840635.1/1-1505 QRLGLTKEESLQQNVSQEVTEVMSGLHVPGESAQPQHGPAARQRDGHFKKRS----RPDL *:******** *: ** ::: **: *.*** : *:** :* : * :.* : ENSMUSP00000105413/1-1514 RTRSRRNIYKKQEPEQAGVAKDA-SAAPDVSLSKD--TKTDLAGVNSTPGPDVSSATSGQ ENSRNOP00000049815/1-1494 RSKSWGFMFLLLDCRRRIANVKPVSVTKELAAKSNGDFLDGLREWTPTSWPKTCTCVLWH ENSP00000364839/1-1541 RTRARRNLYKKQESEQAGVAKDAKSVASDVPLYKDGEAKTDPAGLSSPHLPGTSSAAPDL ENSCPOP00000011566/1-1430 RTRARRNLCKKQEPEQAGVAKDANSVAPDIPLSEDGEAKTGSARMSSTPMPSISSTESGP XP_004840635.1/1-1505 QTRGRRSLCKKQEPEQAGVAKEANSVAPDILLSEDGEAKTGSARVSSPPLPSVSSAASGQ :::. : : .: . .. *.: :: .: . ... * .: ENSMUSP00000105413/1-1514 EGPKCPSEPVASQIQAERDNLACASASPDRIPT----LPQDTVDQETKDQKRKSFEQEAS ENSRNOP00000049815/1-1494 VCIQVYDEDSKNEILKSGETFHVAKMTLDTMGSHFTVIVKKMIPRSGHPVKKKXFYFF-- ENSP00000364839/1-1541 EGPEFPVESVASRIQAEPDNLARASASPDRIPS----LPQETVDQEPKDQKRKSFEQAAS ENSCPOP00000011566/1-1430 GVPHCADELVASHIQTEPDNSVRASASPDRIPS----LSQDTVDQEPKDQKRKSFEQAAS XP_004840635.1/1-1505 GVPECPGELVASHIQTEADNLAHASASPDRIPC----LSQDTVDQEPKDQKRKSFEQAAS . * ..* . :. *. : * : : :. : :. : *:* * ENSMUSP00000105413/1-1514 ASFPE--KKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPWVAKGRPT ENSRNOP00000049815/1-1494 --FSELGTEPRVLRLLGKRSTTEPI----PNPP----------IQLSRIKPPWVAKGRPT ENSP00000364839/1-1541 ASFPE--KKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPWVVKGQPT ENSCPOP00000011566/1-1430 ASFPE--KKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPWVVKGQPT XP_004840635.1/1-1505 ASFPE--KKPRLEDRQSFRNTIESVHTEKPQPTKEEPKVPPIRIQLSRIKPPWVVKGQPT *.* .:**: . *.* *.: *:*. ***********.**:** ENSMUSP00000105413/1-1514 YQICPRIVPITESSCRGWTGARTLADIKARALQARGARGYHCNRETATTAIGGGGGPGGG ENSRNOP00000049815/1-1494 YQICPRIVPITESSCRGWTGARTLADIKARALQARGARGYHCNREAAATAIGGGGGPGGG ENSP00000364839/1-1541 YQICPRIIPTTESSCRGWTGARTLADIKARALQVRGARGHHCHREAATTAIGGGGGPGGG ENSCPOP00000011566/1-1430 YQICPRIVPVTESSCRGWTSARTLADIKARALQARG-------------------GPGGG XP_004840635.1/1-1505 YQICPRIIPITESSCRGWTGARTLADIKARALQARGTRGHHCHRETATTAIGGGGGPGGG *******:* *********.*************.** ***** ENSMUSP00000105413/1-1514 GSGAIDEGGGRDSSSGDGSEACGHPEPRGAPSTSGESASDLQRTQLLPPCPLNGEHTPAE ENSRNOP00000049815/1-1494 GSGAIDEGGGRDGSSGDGSEACGHSEPRGASSNPGESASDLQRTQLLPSCPLNGEHTQAD ENSP00000364839/1-1541 GGGATDEGGGRGSSSGDGGEACGHPEPRGGPSTPGKCTSDLQRTQLLPPYPLNGEHTQAG ENSCPOP00000011566/1-1430 GGGATDEGGGRGSSSGNGGEACGHPEPRGAPSTPRECASDLQRAQLLPPCPLNGEHTQAG XP_004840635.1/1-1505 GSGATDEGGGRGGSSSDGGEACGHSEPRGASSTPRECTSDLQRTQLLPPCPLNEEHTQAG *.** ******..**.:*.*****.****..*.. :.:*****:****. *** *** * ENSMUSP00000105413/1-1514 AAMPRARREDSASLRKEESCLLKRVPGVLTSGLEDASQPPIAPTGDQPCQALPPLSSQTP ENSRNOP00000049815/1-1494 AAMVRAKGEDSASLRKEENGLLTRAPGVLTSGLEDASQPPVAPTGDQPCQALPPLSSQTP ENSP00000364839/1-1541 TAMSRARREDLPSLRKEESCLLQRATVGLTDGLGDASQLPVAPTGDQPCQALPLLSSQTS ENSCPOP00000011566/1-1430 TAMARARREDLASHRKEENCPLQRIPGVFTSGLDDSSQPPIAPTGDQPCQALPSLSSQTP XP_004840635.1/1-1505 TAMSRAKREELASHRKEENCPLQRVPGILTSGLDDASQPPIAPTGDQPCQALPLLSSQTP :** **: *: .* ****. * * . :*.** *:** *:************ *****. ENSMUSP00000105413/1-1514 VAEMLTEQPKLLLDDRTECESS-------REDQGPTIPSESSSGRFPLG-DLLGGGSDQA ENSRNOP00000049815/1-1494 VAEMLAEQAKLLPDDRTECEP--------REDQGPTVPSEGSSGQSPLG-DILGGGNDQI ENSP00000364839/1-1541 VAERLVEQPQLHPDVRTECESGTTSWESDDEEQGPTVPADNGPILSLVGDDTLEKGTGQA ENSCPOP00000011566/1-1430 VTEKLAKQPELHQDTRTECESGTISRDMDNKKQGAIVPLENAPVQSLGG-DTLAEGTGQT XP_004840635.1/1-1505 VAEKLAEQPELYQDTRTQCESGTTSWEVGNEEQGATVPLENGPVQSLLL-DTLAKGTDQT *:* *.:*.:* * **:**. :.**. :* :... * * *..* ENSMUSP00000105413/1-1514 FDN---MKEPVSMTPTFISELSLANYLQDRPDDDGLGLGATGLLIRES-SRQEAL-TEAF ENSRNOP00000049815/1-1494 FDN---MKEPVNMTPAFISELSLANSLQDRPSDDELGVGATGPHIRES--RQETLKTEAF ENSP00000364839/1-1541 LDSHPTMKDPVNVTPSSTPESSPTDCLQNRAFDDELGLGGSCPPMRESDTRQENLKTKAL ENSCPOP00000011566/1-1430 VNRNPTMKDPVNMTPSSTPESSLIGSLQDRPFDDKLGLCSSGP-MKESYSRQETLRSEAL XP_004840635.1/1-1505 LNSNPTMKDPINVTPSSTPELSLTAFLQDRPFDDKLGLGDSGLPMRESYSRQESLRTEAL .: **:*:.:**: .* * **:*. ** **: : ::** *** * ::*: ENSMUSP00000105413/1-1514 ASGSPTSWVPILSNYEVIKTSDPESRENIPCPEPQDEKEWERAVPLIAAT-------ESV ENSRNOP00000049815/1-1494 VSGSPGSWVPILSNYEVIKESYPEARENAPCLEPQDGKGWERTVPLVAAMPGGHA--EVL ENSP00000364839/1-1541 VSNSSLHWIPIPSNDEVVKQPKPESREHIPSVEPQVGEEWEKAAPTPPALPGDLTAEEGL ENSCPOP00000011566/1-1430 VSNNADLWSPILSNDKVVNRSEPKYRENVPSVEPQVGEEWEKAAPLISMLSGGLAAEEGV XP_004840635.1/1-1505 SSNNAALWTPILLNDRVVNQSEPESRENFPSVEPQVGEEWEKAAPLIALLSGSLAAEEGV *... * ** * .*:: . *: **: *. *** : **::.* . * : ENSMUSP00000105413/1-1514 PQPESCISHWT-PPPAAVGSTGSDSEQVDLERLEMNGISEAPSPHSESTDTASDSEGHLS ENSRNOP00000049815/1-1494 PYHESCASHWTAPPPGVLGSTCSDSQQVDLERLEMNGISDILSPHNESTDTASDSEGHFS ENSP00000364839/1-1541 DPLDSLTSLWTVPSRGGSDSNGSYCQQVDIEKLKINGDSEALSPHGESTDTASDFEGHLT ENSCPOP00000011566/1-1430 APPDSCTSHWTVLPRGAMDGTDTEGKQVNVEKLKTSIDAETLSPHSESTDTASDFEGHLT XP_004840635.1/1-1505 APPDKCTSLWTLPPQGGIGDRDTEDKQVDIEKLKINEDSEALSPHSESTDTVSDFEGHLT :. * ** . . .. : :**::*:*: . :: ***.*****.** ***:: ENSMUSP00000105413/1-1514 EDSSEVDASEVTVVKGSL-GGDEKQDWDPSASLSKVNNDLSVLTRTGGVAASQSWVSRVC ENSRNOP00000049815/1-1494 EDSSEVDACEITVVKGLL-GGSEKQDWDPSASLSKASTDLSVLTRTEGVATPQSWVSRVC ENSP00000364839/1-1541 EDSSEADTREAAVTKGSSVDKDEKPNWNQSAPLSKVNGDMRLVTRTDGMVAPQSWVSRVC ENSCPOP00000011566/1-1430 EDSSEADTREAVVQKRSLVEKDTKHDWNQSASLSKVHSDLSLVTRTEGVVTSQSWVSRVC XP_004840635.1/1-1505 EDSSEPAASEATMKKESLMEKDTKHDWNQSASLSKVHSDLSLVTRTEGVVTSQSWVSRVC ***** : * .: * . * :*: **.***. *: ::*** *:.:.******** ENSMUSP00000105413/1-1514 SVPHKIPDSLLLSSTECQPRSVCPLRPGSSVEVTNPLVMHLLHGNLPLEKVLPPGHRSSR ENSRNOP00000049815/1-1494 AVPHKIPDSLLLSSTECQPRSVCPPKPGSSAEVTNPLVMHLLHGNLPLEKVLAPGHRSNQ ENSP00000364839/1-1541 AVRQKIPDSLLLASTEYQPRAVCLSMPGSSVEATNPLVMQLLQGSLPLEKVLPPAHDDSM ENSCPOP00000011566/1-1430 AVPQKIPDSLLLASSEYPARPTCFARPGATVEANNPLVMQLLQGTLPLEKILPPVHGGSK XP_004840635.1/1-1505 AVPQKIPDSLLLASSEYQPRPMWLARPVSAVEANNPLVMQLLQGNLPLEKVLPPAHGGSK :* :********:*:* .*. * ::.*..*****:**:*.*****:*.* * .. ENSMUSP00000105413/1-1514 LESSQLPL-REQSQ----DRGTLQGTGENNRLAARINPGSAQTLKESILAQSYGASAGLV ENSRNOP00000049815/1-1494 PESPHLPL-REQNQ----DRGTLQGTGGDNHLVARSNPGSVQTLKESILAQSYGASAGLV ENSP00000364839/1-1541 SESPQVPLTKDQSH-GSLRMGSLHGLGKNSGMVDGSSPSSLRALKEPLLPDSCETGTGLA ENSCPOP00000011566/1-1430 PESPQLPLTKEQSHGGPLAIGSLHNPGENGHLISKNSPGCLRMLKEPLTPKRCEANS-LG XP_004840635.1/1-1505 PESPQLPLTKGQSHGGPLGIGSLHNPGENSHTIGKISPGSLRVLKGPLQSESCEANS-LG **.::** : *.: *:*:. * :. .*.. : ** .: .. :.: * ENSMUSP00000105413/1-1514 RAMASKAPAMSQKIAKMVTSLDSQHPETELTPSSGNLEEIDSKEHLSSFLCEEQKEGHSL ENSRNOP00000049815/1-1494 RAKASKAPGMSQKIARLVPSSDSQHPVTELTPSSSNLEEIDSKEHLSSFLCEEQKEAHSL ENSP00000364839/1-1541 RIEATQAPGAPQKNCKAVPSFDSLHPVTNPITSSRKLEEMDSKEQFSSFSCEDQKEVRAM ENSCPOP00000011566/1-1430 RVEATQAPGTPQ-ISKLAPSLDPQQPVTNLMTSSGKLEEVDSKELLSSLSYEGKKDVWDA XP_004840635.1/1-1505 RVEATQTPGAPQ-ISKLVPSLDSPQPVTNLMTCSGKLEEVDSKEQLSSFNFED-KGVQDA * *:::*. .* .: ..* *. :* *: ..* :***:**** :**: * * ENSMUSP00000105413/1-1514 SQGSDPGAAPGQCLGDHTTSKVPCFSSTNVSLSFGSEQTDGTLSDQNNAGGHEKKLFGPG ENSRNOP00000049815/1-1494 SQGSDPGAAPGQFLGDHTTSKVPCFSSTNVSLSFGSEQTDGTLSDQNDVGGREKKLFGPR ENSP00000364839/1-1541 SQDSNSNAAPGKSPGDLTTSRTPRFSSPNV-ISFGPEQTGRALGDQSNVTGQGKKLFGSG ENSCPOP00000011566/1-1430 SQGSNLNAAS--SQGDLTTSRAPCFSSPNV-ISFGTKQTFGALG---SVGGQGKKLFGPR XP_004840635.1/1-1505 SRCSNSHAAS--SPGDLTTSRAPCFSSPNV-ISFGPKQPVGALS---NVGGQGKKLFGPR *: *: **. ** ***:.* ***.** :***.:*. :*. .. *: *****. ENSMUSP00000105413/1-1514 NTVTTLQCPRSEEQTPLPAEVPPVFPSRKIEPSKNSVSGGVQTTRENRMPKPPPVSADSI ENSRNOP00000049815/1-1494 NTVATLQYPRSEEQIPLPAEVPPVFPSRKIEPSKNSVPDGVQTARENRTPKPPAVSAGSI ENSP00000364839/1-1541 NVAATLQRPRPADPMPLPAEIPPVFPSGKLGPSTNSMSGGVQTPREDWAPK-PHAFVGSV ENSCPOP00000011566/1-1430 NMIA-VQCPRPADPTLLPSEVPPVFPSRKFGPSKNSVSDGVQTAKEDWVPKPPPASVSNI XP_004840635.1/1-1505 NMAATIQCPRPADSTPLPADVPPVFPSRKLGPSKNSLSDGVQTAKEDWVPKPPPASV-SI * : :* **. : **:::****** *: **.**:..****.:*: ** * . . .: ENSMUSP00000105413/1-1514 KTEQTFLRDPIKADAENRKAAGYSSLELVGHLQGMPFVVDLPFWKLPREPGKGFSQPLEP ENSRNOP00000049815/1-1494 KTEQTFLRDPIKADAENRKAAGYSSLELVGHLQGMPFVVDLPFWKLPREPGKGFSQPLEP ENSP00000364839/1-1541 KNEKTFVGGPLKANAENRKATGHSPLELVGHLEGMPFVMDLPFWKLPREPGKGLSEPLEP ENSCPOP00000011566/1-1430 KNEKA-VGSPLKADAENRKAE-HSPLELVGHLQGMPFVMDLPFWKLPREPGKGLSQPLEP XP_004840635.1/1-1505 KNEKTSVGAPLKADAENRKAAGHSPLELVGHLQGMPFVMDLPFWKLPREPGKGLSQPLEP *.*:: : *:**:****** :*.*******:*****:**************:*:**** ENSMUSP00000105413/1-1514 SSIPSQLNIKQALYGKLSKLQLSPTSFNYSSSSATFPKGLAGGVVQLSHKASFGTGHTAS ENSRNOP00000049815/1-1494 PSIPSQLSIKQALYGKFSKLQLSPSSFNYSSSSAAFPRGLAGGVVQLSHKASFGTGHTAS ENSP00000364839/1-1541 SSLPSQLSIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKGLAGSVVQLSHKANFGASHSAS ENSCPOP00000011566/1-1430 SSIPSQLNIKQAFYGKLSKLQLSSTSFNYSSSSPAFPKGLAGSVVQLSHKANFGANHSAS XP_004840635.1/1-1505 SSIPSQLNIKQAFYGKLSKLQLSSTSFNYSSSSPTFPKSLAGSVVQLSHKANFGASHSTS .*:****.****:***:******.:********.:**:.***.********.**:.*::* ENSMUSP00000105413/1-1514 LSLQMFADSSAVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR ENSRNOP00000049815/1-1494 LSLQMFTDSSAVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR ENSP00000364839/1-1541 LSLQMFTDSSTVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR ENSCPOP00000011566/1-1430 LSLQMFTDSSTVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR XP_004840635.1/1-1505 LSLQMFTDSSTVESISLQCACSLKAMIMCQGCGAFCHDDCIGPSKLCVLCLVVR ******:***:*******************************************