CLUSTAL W(1.81) multiple sequence alignment ENSP00000388093/1-1142 MATLLSHPQQRPPFLRQAIKIRRRRVRDLQDPPPQMAPEIQPPSHHFSPEQRALLYEDAL ENSMUSP00000102058/1-1085 MATHLSHPQRR-PLLRQAIKIRRRRVRDLQDPPPQATQEVQVQSHHFSPEERDLLYEEAL ENSRNOP00000010466/1-1088 MATHLSHPQRRPPLLRQAVKIRRRRVRDLQDPPPQATPEVQVQSHHFSPEERDLLYEEAL ENSCPOP00000011410/1-1090 MATRLSRPQQRPPLLRQAIKIRRRKVQDLQDPLAQMTQEVNPASYHFSPKERDLLYEEVL XP_004860771.1/1-1090 MATRLSCPQRRPPLLRQAIKIRRRKVQDLPDPLAQMTQEVKPASHHLSPKERDLLYEEAL *** ** **:* *:****:*****:*:** ** .* : *:: *:*:**::* ****:.* ENSP00000388093/1-1142 YTVLHRLGHPEPNHVTEASELLRYLQEAFHVEPEEHQQTLQRVRELEKPIFCLKATVKQA ENSMUSP00000102058/1-1085 YTVLHRLGQPEPNHVKEASELLSYLQEAFQVQPEEHQQMLRRVRELEKPVFCLKATVKQA ENSRNOP00000010466/1-1088 YTILHRLGQPEPNHVKEASELLCYLQEAFQVQPEEHQQMLQRVRELEKPIFCLKATVKQA ENSCPOP00000011410/1-1090 YTVLYRLGQPEPNHVVEASELLQYLQEAFQVQPEEHKRMLQQAKELEKPIFCLKATIKQA XP_004860771.1/1-1090 YTVLHRLGQPEPSHVVEASELLRYLQEAFQMQPEEHQRMLQQARELKKPIFCLKATVKQA **:*:***:***.** ****** ******:::****:: *::.:**:**:******:*** ENSP00000388093/1-1142 KGILGKDVSGFSDPYCLLGIEQGVGVPGGSPGSRHRQKAVVRHTIPEEETHRTQVITQTL ENSMUSP00000102058/1-1085 KGILGKDVSGFSDPYCLLGIEQKVGVAEGSPVSRRRQKAVVKHTIPEEETHRTQVKSQTL ENSRNOP00000010466/1-1088 KGILGKDVSGFSDPYCLLGIEQKVGVPEGSPVSRRRQKAVVRHTIPEEETHRTQVKTQTL ENSCPOP00000011410/1-1090 KGILGKDVSGLSDPYCLLGIEQGVSMPGGSPGSRRRQKAVVRYTIPEEQTHRTQVISQTL XP_004860771.1/1-1090 KGILGKDVSGFSDPYCLLGIEQGVGMPGGSPGSRRRQKAVVRHTIPEEQTHRTQVISQTL **********:*********** *.:. *** **:******::*****:****** :*** ENSP00000388093/1-1142 NPVWDETFILEFEDITNASFHLDMWDLDTVESVRQKLGELTDLHGLRRIFKEARKDKGQD ENSMUSP00000102058/1-1085 NPVWDETFILEFEDIANASFHLDMWDLDTVESVRQKLGELTDLHGLRRIFKEARKDKGQD ENSRNOP00000010466/1-1088 NPVWDETFILEFEDITNASFHLDMWDLDTVESVRHKLGELTDLHGLRRIFKEARKDKGQD ENSCPOP00000011410/1-1090 NPVWDETFILEFEDITNASFHLDMWDMDTVESVRQKLGELTDLHGLRRIFKEARKDKGQD XP_004860771.1/1-1090 NPVWDETFILEFEDIANASFHLDMWDMDTVESVRQKLGELTDLHGLRRIFKEARKDRGQD ***************:**********:*******:*********************:*** ENSP00000388093/1-1142 DFLGNVVLRLQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRRATSASRSQPSYTV ENSMUSP00000102058/1-1085 DFLGNVVLRLQDLRCREDQWFPLEPCTETYPDRGQCHLQFQFIHKRRATAASRSQPSYTV ENSRNOP00000010466/1-1088 DFLGNVMLRLQDLRCREDQWFPLEPCTETYPDRGQCHLQFQFIHKRRATVASRSQPSYTV ENSCPOP00000011410/1-1090 DFLGNVVLRLQDLHCREDQWYPLEPRTETYPDRGWCHLQFQLIHKRRATAASRSQPSYTV XP_004860771.1/1-1090 DFLGNVVLRLQDLRCREDQWYPLEPRTETYPDRGQCHLQFQLIHKRRATAASRSQPSYTM ******:******:******:**** ******** ******:******* *********: ENSP00000388093/1-1142 HLHLLQQLVSHEVTQHEAGSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMAQWLAYSRL ENSMUSP00000102058/1-1085 HFHLLQQLVSHEVTQHQAGSTSWDASLSPQAVTILFLHATQKDLSDFHQSMAQWLAYSRL ENSRNOP00000010466/1-1088 HFHLLQQLVSHEVTQHQAGGTSWDASLSPQAVTILFLHATQKDLSDFHQSMAQWLAYSRL ENSCPOP00000011410/1-1090 HLHLLQQLVSHEVTQHKVGSTSWDGSLSPQATTILFLHAMQKDLSDFHQSLAQWLAYSHL XP_004860771.1/1-1090 HLHLLQQLVSHEVTQHKVGSTSWDGSLSPQATTILFLHAMQKDLSDFHQSLAHWLAYSHL *:**************:.*.****.******.*:***** **********:*:*****:* ENSP00000388093/1-1142 YQSLEFPSSCLLHPITSIEYQWIQGRLKAEQQEELAASFSSLLTYGLSLIRRFRSVFPLS ENSMUSP00000102058/1-1085 YQSLEFPSSCLLHPITSIEYQWIQGRLKAEQREELATSFTSLLAYGLSLIRKFRSVFPLS ENSRNOP00000010466/1-1088 YQSLEFPSSCLLHPITSIEYQWIQGRLKAEQREELATSFTSLLAYGLSLIRKFRSVFPLS ENSCPOP00000011410/1-1090 YQKLEFPSSCLLHPITSIEYQWIQGRLKTEQLEELTLSFTSLLAYGLSLIRKFRSVFPLS XP_004860771.1/1-1090 YQSLEFPSSCLLHPITSIEYQWIQGRLKPEQLEELTTSFTSLLAYGLSLIRRFRSVFPLS **.*************************.** ***: **:***:*******:******** ENSP00000388093/1-1142 VSDSPARLQSLLRVLVQMCKMKAFGELCPNTAPLPQLVTEALQTGTTEWFHLKQQHHQPM ENSMUSP00000102058/1-1085 VSDSPSRLQSLLRVLVQMCKMKAFGELCPDSAPLSQLVSEALRMGTVEWFHLMQQHHQPM ENSRNOP00000010466/1-1088 VSDSPSRLQSLLRVLVQMCKMKAFGELCPDSAPLPQLVSEALRMGTVEWFHLMQQHHQPM ENSCPOP00000011410/1-1090 VSDSPARLQSLLRVLVQMCKMKAFGELCQDTAPLPQLVTEALQTGTVEWFHLKQQHHQPM XP_004860771.1/1-1090 VSDSPARLQSLLRVLVQMCKMKAFGELCQNSTPLPQLVTEALRTGTVEWFHLKQQHHQPM *****:********************** :::**.***:***: **.***** ******* ENSP00000388093/1-1142 VQGIPEAGKALLGLVQDVIGDLHQCQRTWDKIFHNTLKIHLFSMAFRELQWLVAKRVQDH ENSMUSP00000102058/1-1085 VQGILEAGKALLNLVQDVMGDLYQCRRTWNKIFHNVLKIDLFSMAFLELQWLVAKRVQDH ENSRNOP00000010466/1-1088 VQGILEAGKALLSLVQDVMGDLYQCRRTWNKIFHNVLKIDLFTMAFLELQWLVAKRVQDH ENSCPOP00000011410/1-1090 VQGMLEAGKALLSLVQDVLGDLHQCQRTWNKIFYNALKIDLFSTAFLKLQWLVAKRVQDH XP_004860771.1/1-1090 VQGMLEAGKALLSLVQDVLGDLHQCQRTWNKIFHNSLKIDLFSMVFLELQWLVAKRVQDH ***: *******.*****:***:**:***:***:* ***.**: .* :************ ENSP00000388093/1-1142 TTVVGDVVSPEMGESLFQLYISLKELCQLRMSSSERDGVLALDNFHRWFQPAIPSWLQKT ENSMUSP00000102058/1-1085 TVAAGNLVSPDIGESLFQLYVSLKELCQLGPVPSDSREVLALDGFHRWFQPAIPSWLQKT ENSRNOP00000010466/1-1088 TAAVGDLVSPDVGESLFQLYVSLREFCQLG--PSDSHEVLALDGFHRWFQSAIPSWLQRT ENSCPOP00000011410/1-1090 TSAVGSPVSPEMGENLFQLYISLKELYQLGSASLDRDGVLALDGFHHWFQPAIPSWLQKT XP_004860771.1/1-1090 TSAVGSPVSPEMAESLFQLYVSLKELCQLGPVPADRDGVLALDGFHRWFQPAIPSWLQKT * ..*. ***::.*.*****:**:*: ** . : *****.**:***.*******:* ENSP00000388093/1-1142 YNEALARVQRAVQMDELVPLGELTKHSTSAVDLSTCFAQISHTARQLDWPDPEEAFMITV ENSMUSP00000102058/1-1085 YSVALERVQRAVQMDTLVPLGELTKHSTSAVDLSTCFAQISHTARQLDWPDPEEAFMITV ENSRNOP00000010466/1-1088 YSVALERVQRAVQMDSLVPLGELTKHSTSAVDLSTCFAQISHTARQLDWPDPEEAFMITV ENSCPOP00000011410/1-1090 YSVALERVQRAVQMDKLVPLGELTKHSTSAVDLSTCFAQISHTARQLDWPDPEVAFMITV XP_004860771.1/1-1090 YSVALERVQRAVQMDKLVPLGELTKHSTSAVDLSTCFAQISHTAQQLDWPDPEEAFMITV *. ** ********* ****************************:******** ****** ENSP00000388093/1-1142 KFVEDTCRLALVYCSLIKARARELSSGQKDQGQAANMLCVVVNDMEQLRLVIGKLPAQLA ENSMUSP00000102058/1-1085 KFVEDTCRLALVYCSLIKARARELSAVQKDQSQAADMLCVVVNNMEQLRLIIDKLPTQLA ENSRNOP00000010466/1-1088 KFVEDTCRLALVYCSLIKARARELSAVQKDQSQAADMLCVVVNNVERLRLIIDKLPTQLA ENSCPOP00000011410/1-1090 KFVEDTCRLALVYCSLIKARARTLSAGQKDQGQAADMLCVVVNDMEQLRLVIGKLPSQLA XP_004860771.1/1-1090 KFVEDTCRLALVYCSLIKARARALSAGQKDQGQAADMLCVVVNDMEQLRLVIGKLPTQLA ********************** **: ****.***:*******::*:***:*.***:*** ENSP00000388093/1-1142 WEALEQRVGAVLEQGQLQNTLHAQLQSALAGLGHEIRTGVRTLAEQLEVGIAKHIQKLVG ENSMUSP00000102058/1-1085 WEALEQRVGAVLEEGQLQNTLHAQLQGALAGLGHEIRTGVRTLAEQLEVGIATHIQKLIG ENSRNOP00000010466/1-1088 WEALEQRVGAVLEQGQLQNTLHTQLQGALAGLGHEIRTGVRTLAEQLEVGIATHIQKLID ENSCPOP00000011410/1-1090 WEALERRVGTVLDQGQLQNTLHTQLQSALAGLGHEIRTGVQTLAEQLEVGIAKHIQKLVD XP_004860771.1/1-1090 WQALEQRVGTVLEQGQLQNTLHTQLQSALAGLGHEIRTGVQTLAEQLEVGIARHIQKLVD *:***:***:**::********:***.*************:*********** *****:. ENSP00000388093/1-1142 VRESVLPEDAILPLMKFLEVELCYMNTNLVQENFSSLLTLLWTHTLTVLVEAAASQRSSS ENSMUSP00000102058/1-1085 VKESVLPEDAILPLMKFLEVKLCYMNTNLVQENFSSLLTLLWTHTLTVLVEVASSQRSSS ENSRNOP00000010466/1-1088 AKGSILPEDAILPLMKFLEVKLCYMNTNLVQENFSSLLTLLWTHTLTVLVEAAASHRNSS ENSCPOP00000011410/1-1090 VKESVLPEDAILPLMKFLEVKLCYMNTNLVQENFSSLLTLLWTHTLTVLVEVTASQRSST XP_004860771.1/1-1090 VKESVLPEDAILPLMKFLEVKLCYMNTNLVQENFSSLLTLLWTHTLTVLVEAAASQRSST .: *:***************:******************************.::*:*.*: ENSP00000388093/1-1142 LASNRLKIALQNLEICFHAEGCGLPPKALHTATFQALQRDLELQAASSRELIRKYFCSRI ENSMUSP00000102058/1-1085 LASGRLKVALQNLEVCFHAEGCGLPPEALHTDTFQALQNDLELQAASSRELIQKYFCSRI ENSRNOP00000010466/1-1088 LASSRLKVALQNLEICFHAEGCGLPPEALHTDTFLALQSDLELQAASSRELIQKYFRSRI ENSCPOP00000011410/1-1090 LASGRLKVALENLEICFHAEGCGLPFEALHTATFQALQRDLELQAASSQELIRKYFCSRI XP_004860771.1/1-1090 LASGRLKVALQNLEICFHAEGCGLPPEALHTATFQALQRDLELQAASSRELIRKYFCSRI ***.***:**:***:********** :**** ** *** *********:***:*** *** ENSP00000388093/1-1142 QQQAETTSEELGAVTVKASYRASEQKLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEF ENSMUSP00000102058/1-1085 QQQAETTSERLGAVTVKVSYRASEQRLRVELLSASSLLPLDSNGSSDPFVQLTLEPRHEF ENSRNOP00000010466/1-1088 QQQAETTSERLGAVTVKASYRASEQKLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEF ENSCPOP00000011410/1-1090 QQQAETTSEQLGAVTVKASYHSSEQKLYVELLSASNLLPMDSNGSSDPFVQLTLEPRHEF XP_004860771.1/1-1090 QQQAETTSEWLGAVTVKASYRSSEQKLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEF ********* *******.**::***:* *******.***:******************** ENSP00000388093/1-1142 PELAARETQKHKKDLHPLFDETFEFLVPAEPCRKAGACLLLTVLDYDTLGADDLEGEAFL ENSMUSP00000102058/1-1085 PEVAPRETQKHKKELHPLFDETFEFLVPAEPCQKAWACLLLTVLDHDRLGADDLEGEAFL ENSRNOP00000010466/1-1088 PELAPRETQKHKKELHPLFDETFEFLVPAEPCQKDGACLLLTVLDHDRLGADDLEGEAFL ENSCPOP00000011410/1-1090 PELAPRETQKHKKDLHPLFDETFEFLVPAEPCQKDGACLLLTVLDHDTLGANDLEGEAFL XP_004860771.1/1-1090 PELAPRETQKHKKDLHPLFDETFEFLVAAEPCRKDGACLLLTVLDHDTLGANDLEGEAFL **:*.********:*************.****:* *********:* ***:******** ENSP00000388093/1-1142 PLREVPGLSGSEEPGEVPQTRLPLTYPAPNGDPILQLLEGRKGDREAQVFVRLRRHRAKQ ENSMUSP00000102058/1-1085 PLCRVPGLTDCAEPGEAPQMRLPLTYPAPNGDPILRLLESRKGDREAQAFVKLRRQRAKQ ENSRNOP00000010466/1-1088 PLCRVPGLTGCVEPGEAPQMRLPLTYPAPNGDPILRLLESRKGDREAQAFVKLRRQRAKQ ENSCPOP00000011410/1-1090 PLCTVPGLSGCEEPSEAPQTRLPLTYPVPDGDPILQLLESRKGDREAQAFVRLRRQRAKQ XP_004860771.1/1-1090 PLCAVPGLTGCEEPGEAPQTRLPLTYPMPNGDPILQLLEGRKGDREAQAFVRLRRQRAKQ ** ****:.. **.*.** ******* *:*****:***.********.**:***:**** ENSP00000388093/1-1142 GIGPSVSWPWPICLLAFLFQPLGWGPGSLGPGLQAQSLLEKGEGTLPKMRLQLPWGEGGG ENSMUSP00000102058/1-1085 A---------------------------------SQHAP--------------------- ENSRNOP00000010466/1-1088 A---------------------------------SQHAPATEP----------------- ENSCPOP00000011410/1-1090 A---------------------------------SQHAPRPGQ----------------- XP_004860771.1/1-1090 A---------------------------------SQHPPRPGQ----------------- . :* ENSP00000388093/1-1142 HY ENSMUSP00000102058/1-1085 -- ENSRNOP00000010466/1-1088 -- ENSCPOP00000011410/1-1090 -- XP_004860771.1/1-1090 --