CLUSTAL W(1.81) multiple sequence alignment ENSP00000317985/1-1388 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP ENSMUSP00000020904/1-1388 MSRPPPTGKMPGAPETAPGDGAGAGRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP ENSRNOP00000006403/1-1318 ------------------------------------------------------------ ENSCPOP00000011391/1-1345 -----------------------------------------------DGLNSLVLDLDFP XP_004870002.1/1-1384 MSRAPPPGKMPGDPEEAGPGDGAADRRRKLDALLRDPRSPINVDSLLDGLNSLVLDLDFP ENSP00000317985/1-1388 ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM ENSMUSP00000020904/1-1388 ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM ENSRNOP00000006403/1-1318 ----------FLNRNEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM ENSCPOP00000011391/1-1345 ALRKNKNIDNFLNRYEKVVKKVRDLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM XP_004870002.1/1-1384 ALRKNKNIDNFLNRYEKVVKKVRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQNVYAM **** **:***:*.*******************************:**** ENSP00000317985/1-1388 KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL--FYAFQDDRYLYMVMEYMPGGDLV ENSMUSP00000020904/1-1388 KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL--FCAFQDDRYLYMVMEYMPGGDLV ENSRNOP00000006403/1-1318 KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL--FCAFQDDRYLYMVMEYMPGGDLV ENSCPOP00000011391/1-1345 KLLSKFEMIKRSDAAFFWEERDIMAFASSPWVVELYSFCAFQDDRYLYMVMEYMPGGDLV XP_004870002.1/1-1384 KLLSKFEMIKRSDAAFFWEERDIMAFANSPWVVEL--FCAFQDDKYLYMVMEYMPGGDLV *************:*************.*****:* * *****:*************** ENSP00000317985/1-1388 NLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMK ENSMUSP00000020904/1-1388 NLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMK ENSRNOP00000006403/1-1318 NLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMK ENSCPOP00000011391/1-1345 NLMSNYDVPEKWAKFYTAEVVLALDVIHSMGLIHRDVKPDNMLLDRHGHLKLADFGTCMK XP_004870002.1/1-1384 NLMSNYDVPEKWAKFYTAEVVLALDVIHSMGLIHRDVKPDNMLLDRHGHLKLADFGTCMK *************************.*******************:************** ENSP00000317985/1-1388 MDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADS ENSMUSP00000020904/1-1388 MDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADS ENSRNOP00000006403/1-1318 MDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADS ENSCPOP00000011391/1-1345 MDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADS XP_004870002.1/1-1384 MDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADS *******************************:**************:************* ENSP00000317985/1-1388 LVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQ ENSMUSP00000020904/1-1388 LVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQ ENSRNOP00000006403/1-1318 LVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQ ENSCPOP00000011391/1-1345 LVGTYSKIMDHKNSLSIPEDAEISKHAKNLICAFLTEREVRLGRNGVEEIKQHPFFKNDQ XP_004870002.1/1-1384 LVGTYSKIMDHKNSLSIPEDAEISKHAKNLICAFLTEREVRLGRNGVEEIKQHPFFKNDQ ***************.:***:***************:*************:********* ENSP00000317985/1-1388 WHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRE ENSMUSP00000020904/1-1388 WNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYFRE ENSRNOP00000006403/1-1318 WNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYFRE ENSCPOP00000011391/1-1345 WNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRD XP_004870002.1/1-1384 WNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRD *:*******************************************************:*: ENSP00000317985/1-1388 NLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLE ENSMUSP00000020904/1-1388 NLLLSDSPPCRENDAIQTRKSEESQEIQKKLYALEEHLSSEVQAKEELEQKCKSINTRLE ENSRNOP00000006403/1-1318 NLLLSDSPPCRENDAIQTRKSEKGGQIQKKLYALEEHLSSEVQAKEELEQKCKSINTRLE ENSCPOP00000011391/1-1345 NLLLSNSPPCRESDPVQSRKNEESQEIQKRLFTLEEHLSNELQAREELEQKCKSINTRLE XP_004870002.1/1-1384 DLLLSDSPPCRESDSVQSRKNE----IQKKLYSLEERFNSELQAKEELEQKCKSINTRLE :****:**.***.*.:*:**.* ***:*::***::..*:**:*********:***** ENSP00000317985/1-1388 KTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKD ENSMUSP00000020904/1-1388 KTAKELEEEITLRKSVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKD ENSRNOP00000006403/1-1318 KTAKELEEEITFRKNVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKD ENSCPOP00000011391/1-1345 KTAKELEEEITLRKTVESTLRQLEREKALLQHKNAEHQRRADHEADKKRNLENDVNSLKD XP_004870002.1/1-1384 KTAKELEEEITLRKNVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKD ***********:**.***:*****************:**:******************** ENSP00000317985/1-1388 QLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESN ENSMUSP00000020904/1-1388 QLEDLKKRNQSSQISTEKVNQLQKQLDEANALLRTESDTAARLRKTQAESSKQIQQLESN ENSRNOP00000006403/1-1318 QLEDLKKRNQSSQISTEKVNQLQKQLDEANALLRTESDTAARLRKTQAESSKQIQQLESN ENSCPOP00000011391/1-1345 QLEDLKKRNQNSQVSTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESN XP_004870002.1/1-1384 QLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESN **********.**:*********:****:******************************* ENSP00000317985/1-1388 NRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNG ENSMUSP00000020904/1-1388 NRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRISGLEEDLKTG ENSRNOP00000006403/1-1318 NRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRISGLEEDLKTG ENSCPOP00000011391/1-1345 NRDLQDKNCLLETARLKLEKEFINLQSALESERRDRTHGSEIINDLQGRISGLEEDLKNG XP_004870002.1/1-1384 NRDLQDKNCLLETARLKLEKEFINLQSALESERRDWTHRSEIISDLQGRISGLEEDLKNG **************:******************** ** ****.******.*******.* ENSP00000317985/1-1388 KILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADK ENSMUSP00000020904/1-1388 KALLAKVELEKRQLQEKLTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKTTKARLADK ENSRNOP00000006403/1-1318 KTLLAKVELEKRQLQEKLTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKTTKARLADK ENSCPOP00000011391/1-1345 KVLLAKVELEKRQLQEKLTDLEKEKSNLEIDMTYRLKVIQQSFEQEEAEHKATKARLADE XP_004870002.1/1-1384 KILLAKVELEKRQLQEKLTDLEKEKSNMEIDMTYQLKVIQQSFEQEEAEHKATKARLADK * **************::*********:******:*******:********:*******: ENSP00000317985/1-1388 NKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINEL ENSMUSP00000020904/1-1388 NKIYESIEEAKSEAMKEMEKKLLEERSLKQKVENLLLEAEKRCSILDCDLKQSQQKLNEL ENSRNOP00000006403/1-1318 NKIYESIEEAKSEAMKEMEKKLLEERSLKQKVENLLLEAEKRCSILDCDLKQSQQKLNEL ENSCPOP00000011391/1-1345 NKIYESIEEAKSEAMKEMEKKLLEERALKQKVENLLLESEKKCSLLDCDLKQSQQKLGEL XP_004870002.1/1-1384 NKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLESEKKCSMLDCDLKQSQQKLNEL **************************:***********:**:**:***********:.** ENSP00000317985/1-1388 LKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMK ENSMUSP00000020904/1-1388 LKQKDVLNEDVRNLTLKIEQETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQENNHLMEMK ENSRNOP00000006403/1-1318 LKQKDVLNEDVRNLTLKIEQETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQENNHLMEMK ENSCPOP00000011391/1-1345 RTQKEVLSEDVRNLTLKIEQETQKRCLTQNDLKLQAQQVNTLRMSEKQLKQENNHLVEMK XP_004870002.1/1-1384 LKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLVEMK .**:**.******************* *****:*:******:*****:*******:*** ENSP00000317985/1-1388 MNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQ ENSMUSP00000020904/1-1388 MNLEKQNTELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKELQ ENSRNOP00000006403/1-1318 MNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKELQ ENSCPOP00000011391/1-1345 LSLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKELQ XP_004870002.1/1-1384 LSLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKELQ :.*****:**************************************** ****** **** ENSP00000317985/1-1388 QKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHK ENSMUSP00000020904/1-1388 QKKQDLQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHK ENSRNOP00000006403/1-1318 QKKQDLQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHK ENSCPOP00000011391/1-1345 QKKQEFQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHK XP_004870002.1/1-1384 QKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHK ****::****************************************************** ENSP00000317985/1-1388 QELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKA ENSMUSP00000020904/1-1388 QELTEKDTTIASLEETNRTLTSDVANLANEKEELNNKLKDSQEQLSKLKDEEMSAAAIKA ENSRNOP00000006403/1-1318 QELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDTQEQLSKLKDEEISAAAIKA ENSCPOP00000011391/1-1345 QELAEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDAQEQLSRLKEEEISAVAIKA XP_004870002.1/1-1384 QELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDAQEQLSRLKDEELSATAVKA ***:***:******************************** *****:**:**:**.*:** ENSP00000317985/1-1388 QFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTD--VRRKEKENRKLHMELKSEREK ENSMUSP00000020904/1-1388 QFEKQLLNERTLKTQAVNKLAEIMNRKEPVKRGSDTD--VRRKEKENRKLHMELKSEREK ENSRNOP00000006403/1-1318 QFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGSDTD--VRRKEKENRKLHMELKSEREK ENSCPOP00000011391/1-1345 QFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGSDTEERVRRKEKENRKLHMELKSEREK XP_004870002.1/1-1384 QFEKQLLTERTLKTQAVNKLAEIMNRKEPIKRGSDTD--VRRKEKENRKLHMELKSEREK *******.*********************:***.**: ********************* ENSP00000317985/1-1388 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIG ENSMUSP00000020904/1-1388 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGMDSSSIG ENSRNOP00000006403/1-1318 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGMDSSSIG ENSCPOP00000011391/1-1345 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIG XP_004870002.1/1-1384 LTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIG *****************************************************:****** ENSP00000317985/1-1388 SGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNP ENSMUSP00000020904/1-1388 SGPGDAEPDDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNP ENSRNOP00000006403/1-1318 SGPGDAEPDDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNP ENSCPOP00000011391/1-1345 SGLGDAEAEDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNP XP_004870002.1/1-1384 SGPGDTEAEDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNP ** **:*.:*************************************************** ENSP00000317985/1-1388 YMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYI ENSMUSP00000020904/1-1388 YMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEPEFPVEPVGEKSNYI ENSRNOP00000006403/1-1318 YMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEPEFPVEPVGEKSNYI ENSCPOP00000011391/1-1345 YMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYI XP_004870002.1/1-1384 YMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYI ********************************************* ************** ENSP00000317985/1-1388 CHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCK ENSMUSP00000020904/1-1388 CHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCK ENSRNOP00000006403/1-1318 CHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCK ENSCPOP00000011391/1-1345 CYKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHLDRKEEIVAPCK XP_004870002.1/1-1384 CHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHLDRKEEIIAPCK *:**********************************************:*:****:**** ENSP00000317985/1-1388 VYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIR ENSMUSP00000020904/1-1388 VYYDISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIR ENSRNOP00000006403/1-1318 VYYDISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIR ENSCPOP00000011391/1-1345 VYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIPQNQSIR XP_004870002.1/1-1384 VYYDISTAKNLLLLANSTEEQQRWVSRLVKKIPKKPPAPDPFARSSPRTSMKIPQNQSVR ******:***************:****************************** ****:* ENSP00000317985/1-1388 RPSRQLAPNKPS ENSMUSP00000020904/1-1388 RPSRQLAPNKPS ENSRNOP00000006403/1-1318 RPSRQLAPNKPS ENSCPOP00000011391/1-1345 RPSRQLAPTMPL XP_004870002.1/1-1384 RPSRQLAPNKPR ********. *