CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000119370/1-1552 MPSDFISLLSADLDLESPKSLYSRDSLKLHPSQTFHRAGLLEESVYDLLPKELQLPPPRE ENSRNOP00000017005/1-1548 MPSDFISLLSADLDLESPKSLYSRDSLKLHPSQNFHRAGLLEESVYDLLPKELQLPPPRE ENSP00000396538/1-1549 MPSDFISLLSADLDLESPKSLYSRDSLKLHPSQNFHRAGLLEESVYDLLPKELQLPPSRE ENSCPOP00000011180/1-1485 ------------------------------------------ESVYDLLPKELQLPPSRE XP_004842997.1/1-1454 ------------------------------------------------------------ ENSMUSP00000119370/1-1552 TSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKA ENSRNOP00000017005/1-1548 TSAASMSQTSGGEAGSPPPAVVAADASSAP-SSSMGGACSSFTTSSSPTIYSTSVTDSKA ENSP00000396538/1-1549 TSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKA ENSCPOP00000011180/1-1485 TSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKA XP_004842997.1/1-1454 ----------------------------------MGGACSSFTTSSSPTIYSTSVTDSKA ************************** ENSMUSP00000119370/1-1552 MQVESCSSAVGVSNRGVSEKQLTGNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDE ENSRNOP00000017005/1-1548 MQVESCSSAVGVSNRGVSEKQLTGNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDE ENSP00000396538/1-1549 MQVESCSSAVGVSNRGVSEKQLTSNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDE ENSCPOP00000011180/1-1485 MQVESCSSAVGVSNRGVSEKQLTSNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDE XP_004842997.1/1-1454 MQVESCSSAVGVSNRGVSEKQLTSNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDE ***********************.************************************ ENSMUSP00000119370/1-1552 GCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNM ENSRNOP00000017005/1-1548 GCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNM ENSP00000396538/1-1549 GCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNM ENSCPOP00000011180/1-1485 GCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNM XP_004842997.1/1-1454 GCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNM ************************************************************ ENSMUSP00000119370/1-1552 DIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLDSQKGTGVKKSPMLCGQYPVKSEGKEL ENSRNOP00000017005/1-1548 DIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLDSQKGTGVKKSPMLCGQYPVKSEGKEL ENSP00000396538/1-1549 DIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLENQKGTGVKKSPMLCGQYPVKSEGKEL ENSCPOP00000011180/1-1485 DIFDADSAKAPHYVLSQLTTDSKNNSKAGNGTLDNQKGTGVKKSPMLCGQYPVKSEGKEL XP_004842997.1/1-1454 DIFDADSAKAPHYVLSQLTTDSKSNSKAGNGTLDNQKGTGVKKSPMLCGQYPVKSEGKEL *********************.*.*********:.************************* ENSMUSP00000119370/1-1552 KIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHG ENSRNOP00000017005/1-1548 KIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHG ENSP00000396538/1-1549 KIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHG ENSCPOP00000011180/1-1485 KIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHG XP_004842997.1/1-1454 KIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHG ************************************************************ ENSMUSP00000119370/1-1552 FYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIA ENSRNOP00000017005/1-1548 FYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSSNMTLAVDCVGILKLRNADVEARIGIA ENSP00000396538/1-1549 FYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIA ENSCPOP00000011180/1-1485 FYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIA XP_004842997.1/1-1454 FYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIA *********************************.************************** ENSMUSP00000119370/1-1552 GSKKKSTRARLVFRVNITRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEE ENSRNOP00000017005/1-1548 GSKKKSTRARLVFRVNITRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEE ENSP00000396538/1-1549 GSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEE ENSCPOP00000011180/1-1485 GSKKKSTRARLVFRVNITRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEE XP_004842997.1/1-1454 GSKKKSTRARLVFRVNITRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEE ***************** ****************************************** ENSMUSP00000119370/1-1552 VFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSV ENSRNOP00000017005/1-1548 VFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSV ENSP00000396538/1-1549 VFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSV ENSCPOP00000011180/1-1485 VFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSV XP_004842997.1/1-1454 VFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSV ************************************************************ ENSMUSP00000119370/1-1552 GIYVVTNAGRSHDVQPFTYTPDP-AAGALNVNVKKEISSPARPCSFEEAMKAMKTTGCNV ENSRNOP00000017005/1-1548 GIYVVTNAGRSHDVQPFTYTPDP-AAGALSVNVKKEISSPARPCSFEEALKAMKTTGCNV ENSP00000396538/1-1549 GIYVVTNAGRSHDVQPFTYTPDPAAAGALNVNVKKEISSPARPCSFEEAMKAMKTTGCNL ENSCPOP00000011180/1-1485 GIYVVTNAGRSHDVQPFTYTPDPAAAGALNVTVKKEISSPARPCSFEEAMKAIKTTGCNL XP_004842997.1/1-1454 GIYVVTNAGRSHDVQPFTYTPDPAAAGTLNVTVKKEMSSPARPCSFEEAMKAIKTTGCNL *********************** ***:*.*.****:************:**:******: ENSMUSP00000119370/1-1552 DKVTILPNALITPLISSSMIKTEDVTPMEVTSEKRSSPIFQTTKSIGSTQQTLETISNIA ENSRNOP00000017005/1-1548 DKVTILPNALITPLISSSMIKTEDVTPMEVTSEKRSSPIFQTTKTVGSTQQTLETISNIA ENSP00000396538/1-1549 DKVNIIPNALMTPLIPSSMIKSEDVTPMEVTAEKRSSTIFKTTKSVGSTQQTLENISNIA ENSCPOP00000011180/1-1485 DKVNILPNALITPLISSSMIKSEDVTPMEVTAEKRSSPIFKTTKTVGSTQQTLENISNIP XP_004842997.1/1-1454 DKVNILPSALITPLISSSMIKSEDVTPMEVTAEKRSSPIFKTTKTVGSTQQALENISNIP ***.*:*.**:****.*****:*********:*****.**:***::*****:**.****. ENSMUSP00000119370/1-1552 GGAPFSSPSSSSHLTPESENQQQLQPKAYNPETLTTIQTQDISQPGTFPAVSAASQLPSS ENSRNOP00000017005/1-1548 GNASFSSP-SSSHLSPENENQQQLQPKAYNPETLTTIQTQDISQPGTFPAVSASSQLPSS ENSP00000396538/1-1549 GNGSFSSP-SSSHLPSENEKQQQIQPKAYNPETLTTIQTQDISQPGTFPAVSASSQLPNS ENSCPOP00000011180/1-1485 GNGSFSSP-SSSHLPSENEKQQQLQSKAYNPETLTTIQTQDISQSGAFPAVSASNQLPGS XP_004842997.1/1-1454 GNGSFSSP-SSSHLPSENEKQQQLQSKAYNTETLTTIQTQDISQPGTFPAVSASSQLPGS *...**** *****..*.*:***:*.****.*************.*:******:.***.* ENSMUSP00000119370/1-1552 DALLQQATQFQTREAQSRDTIQSD-TVVNLSQLTEAS-QQQQSPLQEQAQTLQQQIPSNI ENSRNOP00000017005/1-1548 DALLQQAAQFQTRDAQSRDTMQSD-SVVNLSQLTEAP-QQQQSPLQEQA-----QIPSNI ENSP00000396538/1-1549 DALLQQATQFQTRETQSREILQSDGTVVNLSQLTEASQQQQQSPLQEQAQTLQQQISSNI ENSCPOP00000011180/1-1485 EALLQQATQFQTRETQSREVLQSDGTVVNLSQLTEAS-QQQQSPLQEQAQTLQQQISSNI XP_004842997.1/1-1454 EALLQQATQFQARETQSREVLQSDGTVVNLSQLTEASQQQQQSPLQEQAQTLQHQISSNI :******:***:*::***: :*** :**********. *********** **.*** ENSMUSP00000119370/1-1552 FPSPSSVSQLQSTIQQLQAGSFTGSAAGGRSGSVDLVQQVLEAQQQLSSVLFSTPDGNEN ENSRNOP00000017005/1-1548 FPSPNSVSQLQSTIQQLQAGSFTGSTASGSNGSVDLVQQVLEAQQQLSSVLFSTPDGNEN ENSP00000396538/1-1549 FPSPNSVSQLQNTIQQLQAGSFTGSTASGSSGSVDLVQQVLEAQQQLSSVLFSAPDGNEN ENSCPOP00000011180/1-1485 FPSPNSVSQLQNTIQQLQAGSFTGSAASSNSGSVDLVQQVLEAQQQLSSVLFSAPDGNEN XP_004842997.1/1-1454 FPSPSSVSQLQNTIQQLQAGSFTGSATSSNSGSVDLVQQVLEAQQQLSSVLFSAPDGNEN ****.******.*************::.. .**********************:****** ENSMUSP00000119370/1-1552 VQEQLNADIF-QVSQIQNSVSPGMFSSAESAVHTRPDNLLPGRADSVHQQTENTLSN--- ENSRNOP00000017005/1-1548 VQEQLNADIF-QVSQIQNSVSPGMFSSTESAVHTRPDNLLPGRADSVHQQTENTLSSQQQ ENSP00000396538/1-1549 VQEQLSADIFQQVSQIQSGVSPGMFSSTEPTVHTRPDNLLPGRAESVHPQSENTLSN--- ENSCPOP00000011180/1-1485 VQEQLSAGIFQQVSQIQNSVSPGIFSSTEPAVHPRQDNLIPGRAESVRPQTESTLSN--- XP_004842997.1/1-1454 VQEQLSADIFQQVSQIQNSVSPGMFSSTEPAVHTRQDNLIPGRAESVCPQTEGTLSN--- *****.*.** ******..****:***:*.:**.* ***:****:** *:*.***. ENSMUSP00000119370/1-1552 --QQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSAASASGSLQQSPVYQQPS ENSRNOP00000017005/1-1548 QQQQQQQQQQQQVIESSAAMVMEMQQSICQAAAQIQSELFPSAASANGSLQQSPVYQQPS ENSP00000396538/1-1549 --QQQQQQQQQQVMESSAAMVMEMQQSICQAAAQIQSELFPSTASANGNLQQSPVYQQTS ENSCPOP00000011180/1-1485 ---PQQQQQQQQVMEPSAAMVIEMQQSICQAAAQIQSELFPSTPSANGNLQQSPVYQQPS XP_004842997.1/1-1454 ---QQPQQQQQQVMEPSAAMVMEMQQSICQAAAQIQSELFPSTPSANGNLQQSPVYQQPS * *******:*.*****:********************:.**.*.*********.* ENSMUSP00000119370/1-1552 HMMSALPTNEDMQMQCELFSSPPAASGNETSTTTTPQVATPGSTMFQTPSSGDGEETGAQ ENSRNOP00000017005/1-1548 HMMSALPTSEDMQMQCELFSSPPAVSGNETSTTTTPQVATPGSTMFQPPNSGDGEETGAQ ENSP00000396538/1-1549 HMMSALSTNEDMQMQCELFSSPPAVSGNETSTTTTQQVATPGTTMFQTSSSGDGEETGTQ ENSCPOP00000011180/1-1485 HMINALSTNEDIQMQCELFSTPPAVSGNETSTTTTQQVATPGATMFQTPSSGDGEETGVQ XP_004842997.1/1-1454 HMMSALSANEDIQMQCELFSS-PAVSGNETSTTTTQQVATPGTTMFQTPSSGDGEETGAQ **:.**.:.**:********: **.********** ******:****...********.* ENSMUSP00000119370/1-1552 AKQIQNSVFQTMVQMQRSGDSQPQVNLFSSTKNIMSVQNNGTQQQGNSLFQQGSEMMSLQ ENSRNOP00000017005/1-1548 AKQIQSSVFQTMVQMQHSGDSQPQVNLFSSTKNIMSVQSNGTQQQGNSLFQQGSEMLSLQ ENSP00000396538/1-1549 AKQIQNSVFQTMVQMQHSGDNQPQVNLFSSTKSMMSVQNSGTQQQGNGLFQQGNEMMSLQ ENSCPOP00000011180/1-1485 TKQIQNNVFQTIVQMQHSGDSQPQVNLFSSTKSMMSVQNSGTQQQGNGLFQPGNDMMSLQ XP_004842997.1/1-1454 AKQIQNSVFQTMVQMQHSGDNQPQVNLFSSTKSMMSVQNSGTQQQGNGLFQQGNEMMSLQ :****..****:****:***.***********.:****..*******.*** *.:*:*** ENSMUSP00000119370/1-1552 SGNFLQQSSHSQAQLFHPQNPIADAQNLSQETQGSIFHSPNPIVHSQTSTASSEQLQPSM ENSRNOP00000017005/1-1548 SGSFLQQSSHSQAQLFHPQNPIADAQSLSQETQGPMFHSANPIVHSQTSTASSEQLQPSM ENSP00000396538/1-1549 SGNFLQQSSHSQAQLFHPQNPIADAQNLSQETQGSLFHSPNPIVHSQTSTTSSEQMQPPM ENSCPOP00000011180/1-1485 SGNFLPQSSHSQAQLFHPQNPIADAQNLTQETPGSIFHSPNPIVHSQTSTPSSEQMQPPM XP_004842997.1/1-1454 SGNFLPQSSHSQAQLFHPQNPIADPQNLTQETQGSIFHSPNPIVHSQTSTPSSEQMQPPM **.** ******************.*.*:*** *.:***.**********.****:**.* ENSMUSP00000119370/1-1552 FHSQNTIAVLQGSSVPQDQQSPNIFLSQSSINNLQTNTVAQEEQISFFAAQNSISPLQST ENSRNOP00000017005/1-1548 FHSQSTIAVLQGSSVPQDQQSPNIYLSQSSISNLQTNTVAQEEQISFFSAQNSISPLQST ENSP00000396538/1-1549 FHSQSTIAVLQGSSVPQDQQSTNIFLSQSPMNNLQTNTVAQE---AFFAAPNSISPLQST ENSCPOP00000011180/1-1485 FHSQSTIAVLQGSSVSQDQQSPNIFLSQSPMNNLQTNTVAQEEQISFF-AQNSIPPLQSA XP_004842997.1/1-1454 FHSQSTIAVLQGSSVPQDQQSPNIFLSQSPMNNLQTNTVAQEEQISFF-AQNSISSLQST ****.**********.*****.**:****.:.********** :** * ***..***: ENSMUSP00000119370/1-1552 SNTEQQAAFQQQPPISHIQTPILSQEQAQPSQQGLFQPQVALGSLPPNPMPQNQQGPIFQ ENSRNOP00000017005/1-1548 SNTEQQAAFQQQPPISHIQTPLLSQEQAQPSQQGLFQPQVALGSLPANPMPQNQQGPIFQ ENSP00000396538/1-1549 SNSEQQAAFQQQAPISHIQTPMLSQEQAQPPQQGLFQPQVALGSLPPNPMPQSQQGTMFQ ENSCPOP00000011180/1-1485 SNTEQPTAFQQQSPISHIQSPMLSQEQAQSSQQSLFQPQVSLGSLPPNPMPQNQQGAIFQ XP_004842997.1/1-1454 SNTEQQAAFQQQSPISHIQNPMLSQEQAQPSQQGLFQPQVSLGSLPPNPMPQNQQGAMFQ **:** :*****.******.*:*******..**.******:*****.*****.***.:** ENSMUSP00000119370/1-1552 TQRPIVGMQSNSPSQEQQQQQQQQQQQQQQQQQQQQSILFSNQNAMATMASQKQPPPNMM ENSRNOP00000017005/1-1548 TQRPIVGMQSNSPSQE--QQQQQQQQQQQQQQQQQQSILFSNQNAMATMASQKQPPPNMI ENSP00000396538/1-1549 SQHSIVAMQSNSPSQE---QQQQQQQQQQQQQQQQQSILFSNQNTMATMASPKQPPPNMI ENSCPOP00000011180/1-1485 AQHSIVAMQSNSP------------------------FLFSNQNTIASMASQKQPPPNMI XP_004842997.1/1-1454 AQHSIVAMQSNSPSQE----QQQQQQQQQQQQQQQQSILFSNQNTMATMASQKQPPPNMI :*:.**.****** :******::*:*** *******: ENSMUSP00000119370/1-1552 FSPNQNPMASQEQQNQSIFHQQSNMAPMNQEQQPMQFQNQPTVSSLQNPGPTQSESPQTS ENSRNOP00000017005/1-1548 FSPNQNPMASQEQQNQSIFHQQSNMAPMNQEQQPMQFQNQPTVSSLQNPGPTPSESPQTS ENSP00000396538/1-1549 FNPNQNPMANQEQQNQSIFHQQSNMAPMNQEQQPMQFQSQSTVSSLQNPGPTQSESSQTP ENSCPOP00000011180/1-1485 FSPNQNPMASQEQQNQSIFHQQSNMASMNQEQQPMQFQNQPTVSSLQNPGPTQSESSQTS XP_004842997.1/1-1454 FSPNQNPMASQEQQNQSIFHQQNNMASMNQEQQPMQFQNQPTVSSLQNPGPTPSESSQTS *.*******.************.***.***********.*.*********** ***.**. ENSMUSP00000119370/1-1552 LFHSSPQIQLVQGSPSSQDQQVTLFLSPASMSALQTSINQPDMQQSPLYSPQNNIPGIQG ENSRNOP00000017005/1-1548 LFHSSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSINQPDMQQSPLYSPQNNIPGIQG ENSP00000396538/1-1549 LFHSSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSINQQDMQQSPLYSPQNNMPGIQG ENSCPOP00000011180/1-1485 LFHSSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSISQQDMQQSPLYSSQNNLPGIQG XP_004842997.1/1-1454 LFHSSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSITQQDMQQSPLYSSQNNLPGIQG ******************:*******************.* *********.***:***** ENSMUSP00000119370/1-1552 STSSPQPQATLFHNTTGGTINQIQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQL ENSRNOP00000017005/1-1548 STSSPQPQAALFHNTTGGTINQLQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPEQL ENSP00000396538/1-1549 ATSSPQPQATLFHNTAGGTMNQLQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQL ENSCPOP00000011180/1-1485 ATSSPQPQSTLFHNTAGGTMNQLQNS-GSSQPTSGMFLFGIQNNCSQLLTPGPGALPEQL XP_004842997.1/1-1454 ATSSPQPQSTLFHNTAGGTMNQLQNSPGSSQPTSGMFLFGIQNNCSQLLTSGPGTLPEQL :*******::*****:***:**:*** **** ******************.**.:**:** ENSMUSP00000119370/1-1552 MAINQQGQPQNEGQSSVTTLLSQQMPETSPLASSVNSSQNMEKIDLLVSLQSQGNNLTGS ENSRNOP00000017005/1-1548 MAINQPGQPQNEGQSSVTTLLSQQMPESAPLASSVNNSQNMEKIDLLVSLQSQGNNLTGS ENSP00000396538/1-1549 MAISQPGQPQNEGQPPVTTLLSQQMPENSPLASSINTNQNIEKIDLLVSLQNQGNNLTGS ENSCPOP00000011180/1-1485 MAISQPGQPQNEGQSPVTTLLSQQMPENSPLASSINTNQNIEKIDLLVSLQNQGNNLTGS XP_004842997.1/1-1454 MAISQPGQPQNEGQSPVTTLLSQQMPENSPLASSINTNQNIEKIDLLVSLQNQGNSLTGS ***.* ********..***********.:*****:*..**:**********.***.**** ENSMUSP00000119370/1-1552 F ENSRNOP00000017005/1-1548 F ENSP00000396538/1-1549 F ENSCPOP00000011180/1-1485 F XP_004842997.1/1-1454 F *