CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000030677/1-1291 MAGPCPGAGVLERAGSCWQDPLAEALSRGRSSPAVTGRGCARSRPLSVVYVLTREPGLGV ENSRNOP00000012463/1-1292 MAGPCPGAGVLERAGSCWQDPLAEALSRGRSSPAVAGRGCARSRPLSVVYVLTREPGPGV ENSP00000419591/1-1288 MAGPCPRSGA-ERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGL ENSCPOP00000011121/1-1239 ------------------------------------------------------------ XP_004850759.1/1-1290 MAGLCPGSGTLERAGSCWQDPLAEALSRGRPIAGPPGRGCARSRPLSVVYVLTREPRPDL ENSMUSP00000030677/1-1291 EPGSGTEAEPLPLRCLREACAQLQGTRPPPQLRSLPFATLALGDTAALDSFYNADVVVLE ENSRNOP00000012463/1-1292 EPGSGTEAEPLPLRCLREACAQLQSTRPPPQLRSLPFATLALGDTAALDSFYNADVVVLE ENSP00000419591/1-1288 EPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLE ENSCPOP00000011121/1-1239 ------------LRCLREACAQLSGPRPPPQLRSLPFGTLALGDTTALDSFYTTDVVVLE XP_004850759.1/1-1290 EPGAGTEAEPLPLRCLREACAQLSGPRPPPQLRSLPFGTLTLGDTTALDSFYNADVVVLE **********: .***********.** ****:***:**.:****** ENSMUSP00000030677/1-1291 VSSSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQALREDVFQKNSDCVGSYTLIPY ENSRNOP00000012463/1-1292 VSNSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQALREDVFQKNSDCVGSYTLIPY ENSP00000419591/1-1288 VSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSYTLIPY ENSCPOP00000011121/1-1239 VSSSLAQPSLFYHLAVRESFSMTNNVLLCSQADLPDLQALREDIFQKNSDCAGSYTLIPY XP_004850759.1/1-1290 VSGSLAQPSLFYHLAVRESFSMTNNVLLCSQADLPDLQALREDIFQKNSDCAGSYTLIPY **.**.********.*****************:**********:*******.******** ENSMUSP00000030677/1-1291 VVTATGRVLCGDAGLLRGIADGLVQAGAGTEALLTPLVGRLVRLLEATPTDSCGYFRETI ENSRNOP00000012463/1-1292 VVTATGRVLCGDAGLLRGIADGLVQAGVGTEALLTPLVGRLVRLLEATPTDSCGYFRETI ENSP00000419591/1-1288 VVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETI ENSCPOP00000011121/1-1239 VVTATGRVLCGDAGLLKGLADGLVQAGVGTEALLTPLVGRLACLLETTSTDSCGYFRETI XP_004850759.1/1-1290 VVTATGRVLCGDVGLLRGLADGLVQAGVGTEALLSPLVGRLACLLEATPTDSCGYFRETI ************.***:*:********.******:******. ***:*.*********** ENSMUSP00000030677/1-1291 RQDIRQARERFSGQQLRQELARLQRRLDSVELLSPDIVMNLLLSYRDVQDYSAIIELVET ENSRNOP00000012463/1-1292 RQDIRKARERFSGQQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVET ENSP00000419591/1-1288 RRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVET ENSCPOP00000011121/1-1239 RQAIRQARERFSGQQLRQELARLQRRLDSVELLSPDIVMNLLLSYRDVQDYSAIIELVET XP_004850759.1/1-1290 RQAIRQARERFSGQRLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVET *: **:******* :**********************:********************** ENSMUSP00000030677/1-1291 LQALPTCDVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVKYEGPVAPDLYCMCGRI ENSRNOP00000012463/1-1292 LQALPTCDVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVKHEGPVAPDLYCMCGRI ENSP00000419591/1-1288 LQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRI ENSCPOP00000011121/1-1239 LQALPTCDVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVQLEGSVAPDLYCMCGRV XP_004850759.1/1-1290 LQALPTCDVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVQLEGSVAPDLYCMCGRI ******************************** ***:******: **.***********: ENSMUSP00000030677/1-1291 YKDMFFTSGFQNAGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSEELRLIG ENSRNOP00000012463/1-1292 YKDMFFSSSFQSTGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGKHFDDSEELQLIG ENSP00000419591/1-1288 YKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIG ENSCPOP00000011121/1-1239 YKDMFFSSGFQDTGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQQFEDSEELQLIG XP_004850759.1/1-1290 YKDMFFSSGFQDRGHLEQAYHWYRKAFDVEPSLHSGINAAVLLMAAGQQFEDSEELQLIG ******:*.**. ** ***************************:***::*:**:**:*** ENSMUSP00000030677/1-1291 MKLACLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVME ENSRNOP00000012463/1-1292 MKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVME ENSP00000419591/1-1288 MKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVME ENSCPOP00000011121/1-1239 MKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVME XP_004850759.1/1-1290 MKLGCLLARKGCVEKLQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVME ***.***********:******************* ************************ ENSMUSP00000030677/1-1291 TFLLYQHFRPTPEPSGGPPLRAHFWLHFLLQSCQPFKM-APPQEDQCLVLVLEINKVLLP ENSRNOP00000012463/1-1292 TFLLYQHFRPTPEPSGGPVLRAHFWLHFLLQSCQPFKA-TPPQEDQCLVLVLEINKVLLP ENSP00000419591/1-1288 TFLLYQHFRPTPEPPGGPPRRAHFWLHFLLQSCQPFKT-ACAQGDQCLVLVLEMNKVLLP ENSCPOP00000011121/1-1239 TFLLYQHFRPTPEPSGGPLLRAHFWLHFLLQSCQPFKT-ACPQ-----VLVLEMNKVLLP XP_004850759.1/1-1290 TFLLYQHFRPTPEPSGGPHLRAHFWLHFLLQSCKPLKTAACPQENQCLVLILEMNKVMLP **************.*** *************:*:* : .* **:**:***:** ENSMUSP00000030677/1-1291 ARLEIQGTDPVSTVTLSLLDPETQEDPSSWTFPVTSICGISTSKLDQRCCFLYALPPAQD ENSRNOP00000012463/1-1292 ARLEIQGADPMSAVTLSLLEPETQDDPSSWTFPVTSICGISASKLDQRCCFLYALPPAQD ENSP00000419591/1-1288 AKLEVRGTDPVSTVTLSLLEPETQDIPSSWTFPVASICGVSASKRDERCCFLYALPPAQD ENSCPOP00000011121/1-1239 AKLEVQGTNPVSAVSLGLLEEE----PSSWTFPVASICGVSASKRDERCCFLYALPPAQD XP_004850759.1/1-1290 ARLEVQGANPVRTVTLNLQEPETQEGPSSWTFPVPSICGVSASKRDERCCFLYALPPAQD *:**::*::*: :*:*.* : * ********.****:*:** *:************* ENSMUSP00000030677/1-1291 VQLCFPSVERCQRFCGLIQVLV-MNPDSSAPTEEAEG-AREVLEFDYEYSETGERLVLGR ENSRNOP00000012463/1-1292 VQLCFPSVERCRWFCSQIQVLV-MNPDSSAPTEEAEG-TREVLEFDYEYSETGERLVLGK ENSP00000419591/1-1288 VQLCFPSVGHCQWFCGLIQAWV-TNPDSTAPAEEAEG-AGEMLEFDYEYTETGERLVLGK ENSCPOP00000011121/1-1239 VQLCFPSVGHCQWFCGLIQALVKKNPDSIAPAEEAAGRVGEVLEFDYEYAENGERLVLGK XP_004850759.1/1-1290 VQLCFPSVGHCQWFCGLIQASV-KNPESTAPAEEAGG-VGEVLEFDYEYTENGERLVLGK ******** :*: **. **. * **:* **:*** * . *:*******:*.*******: ENSMUSP00000030677/1-1291 GTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGG ENSRNOP00000012463/1-1292 GTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGG ENSP00000419591/1-1288 GTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGG ENSCPOP00000011121/1-1239 GTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGG XP_004850759.1/1-1290 GTYGVVYAARDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLHHKNIVRYLGSASQGG ********.********************************:**:*************** ENSMUSP00000030677/1-1291 YLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDN ENSRNOP00000012463/1-1292 YLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDN ENSP00000419591/1-1288 YLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDN ENSCPOP00000011121/1-1239 YLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHDNRIVHRDIKGDN XP_004850759.1/1-1290 YLKIFMEEVPGGSLSSLLRSVWGPLKDNESTITFYTRQILQGLSYLHDNCIVHRDIKGDN ********************************:**********.***:* ********** ENSMUSP00000030677/1-1291 VLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLG ENSRNOP00000012463/1-1292 VLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLG ENSP00000419591/1-1288 VLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLG ENSCPOP00000011121/1-1239 VLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLG XP_004850759.1/1-1290 VLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLG ************************************************************ ENSMUSP00000030677/1-1291 CTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRAS ENSRNOP00000012463/1-1292 CTVIEMATGWPPFHELGSPQAAMFQVGMYKVHPPVPSSLSAEAQAFLLRTFEPDPRLRAS ENSP00000419591/1-1288 CTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRAS ENSCPOP00000011121/1-1239 CTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPNSLSAEAQAFLLRTFEPDPRLRAN XP_004850759.1/1-1290 CTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPNSLSAEAQAFLLRTFEPDPRLRAN ********* ************************:*.**********************. ENSMUSP00000030677/1-1291 AQELLGDPFLQPGKRSRSPGSPRHTPRPSGAPSGPSSPSADSATQSQTFPRPQAPSQHPP ENSRNOP00000012463/1-1292 AQELLGDPFLQPGKRSRSPGSPRHTPRPSGTPSSTSSPSADSATQSQTFPRPQAPSQHPP ENSP00000419591/1-1288 AQTLLGDPFLQPGKRSRSPSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPP ENSCPOP00000011121/1-1239 AQALLEDPFLQPGKRSRSPSSTRQAPQPSVSRHDHPVP--DIPSASGTLSAPTQPSKALP XP_004850759.1/1-1290 AQALLEDPFLQPGKRSRSPSSPRQAPQSSDAPSAGPTHSADMTTQSQTFPRPQAPSQQPP ** ** *************.*.*::*:.* : . : .: * *:. * **: * ENSMUSP00000030677/1-1291 -------------SPPKRCLSYGDTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAM ENSRNOP00000012463/1-1292 -------------SPPKRCLSYGDTSQLRVPEESAAEEPASPEESSGLSLLHQESKRRAM ENSP00000419591/1-1288 -------------SPPKRCLSYGGTSQLRVPEEPAAEEPASPEESSGLSLLHQESKRRAM ENSCPOP00000011121/1-1239 QLWRHLPAPVRAWGPREGSLCNLPSLLESVPEEPGVEEPTSPEESSGLSLLHQESKRRAM XP_004850759.1/1-1290 -------------SPPKRCLSYGDTSLLRVPEEGGVEEPASLEESSGLSLLHQESKRRAM .* : .*. : **** ..***:* ****************** ENSMUSP00000030677/1-1291 LAAVLEQEVPTLAENLLE---QEQDSRLSKIHVELLLRCLGAQIHTPNRRQLAQELRTLQ ENSRNOP00000012463/1-1292 LAAVLEQEVPILAENLLD---QEQDSRLSRNHVELLLRCLGAQIHTPNRRQLAQELRALQ ENSP00000419591/1-1288 LAAVLEQELPALAENLHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQ ENSCPOP00000011121/1-1239 LAEVLQQELSTLADNLRPE--QEQGSRLSRTHVEQLLRCLGAHIHTPNRRQLAQELRALQ XP_004850759.1/1-1290 LAEVLQQELPTLAENLLLE--REQGTRLNRTHVEQLLRCLGAHIHTPNRRQLAQELRVLQ ** **:**:. **:** :**.:**.: *** *******:**************.** ENSMUSP00000030677/1-1291 AQLRAQSLGPALLKGPLFAFPDAVKQILRRRQIRPHWMFVLDSLLSRAVRAAMAVLDA-- ENSRNOP00000012463/1-1292 AQLRAQSLSPALLKGPLFAFPDAVKQILRRRQIRPHWMFVLDSLLSRAVRAALAVLDA-- ENSP00000419591/1-1288 GRLRAQGLGPALLHRPLFAFPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGP-- ENSCPOP00000011121/1-1239 AQLQAQGLGPTLLSGPLFAFPDAVKQILRRRQIRPHWMFVLDSLLSRAVRAALAVLDPGR XP_004850759.1/1-1290 AQLQAQGLGPTLLSGPLFAFPDAVKQILRRRQIRPHWMFVLDSLLSRAVRAALAVLDP-- .:*:**.*.*:** **************:**********************:.**.. ENSMUSP00000030677/1-1291 -------------------ESEKKAVLPRSEESSKE-ESQQKP-QESQ-ALQSQLPPEQG ENSRNOP00000012463/1-1292 -------------------EAEKKAVSPKSEEWSQG-ESQQKP-LESQPPLQSQLPPEQE ENSP00000419591/1-1288 -------------------EVEKEAVSPRSEELSNEGDSQQSPGQQSPLPVE----PEQG ENSCPOP00000011121/1-1239 RGHRPAASGRGCGPEEGVAEVEKKTVSPKSEQLSKDAESEQKQ-QETRLPAE----TEQC XP_004850759.1/1-1290 -------------------EVEKKMVSPRSEELSKDWESQQKQ-QETSLLTE----PEQS * **: * *:**: *: :*:*. :: : .** ENSMUSP00000030677/1-1291 PPSLMVELGLLRAETDRLRDLLAEKERECQALVQQALHRVHAETRKYAPASETP------ ENSRNOP00000012463/1-1292 PPSLMIQLGLLRAETDRLRDILAEKERECQALVQQALHRVHAETRTYALASETP------ ENSP00000419591/1-1288 PAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPEPP------ ENSCPOP00000011121/1-1239 PLPLIVQLGLFRAETDRLRKVLMEKERECQALVLRALQGMNREARTYALASEPPASPDFL XP_004850759.1/1-1290 P-PLTVQLGLLRAETDRLRDVLEEKERECQALVHRALQRVNEEVQTYALASEPL------ * .* ::*.*:********.:* **** **** :**: :: *.:.*. *.*. ENSMUSP00000030677/1-1291 -ATLPKDQNLVRWLQELSVDPATIQTLLSHSFTLQTLLTCATQDDLVYTRIRGGMVCRIW ENSRNOP00000012463/1-1292 -ATLPKDQKLVQWLQDLSVDPTTIQTLLSHSFTLQTLLTCATQDDLVYTRIRGGMVCRIW ENSP00000419591/1-1288 -TALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIW ENSCPOP00000011121/1-1239 TASLTKDQNLVQWLQDLDVDSGTIQTLLNHSFTLQALLTCATRDDLLYTRIRGGMVCRIW XP_004850759.1/1-1290 -ACLPKDQSLVQWLQDLSVDSGTIQTLLNHSFTLQSLLTCATRDDLLYTRIRGGMVCRIW : *..** **:***:*.**. *** **.*****::*** **:***:************* ENSMUSP00000030677/1-1291 RAILAQRAGATSVTPVPRDAE ENSRNOP00000012463/1-1292 RAILAQRAGATSVTPGPRDAE ENSP00000419591/1-1288 RAILAQRAGSTPVTSGP---- ENSCPOP00000011121/1-1239 RAILAQRAGS----------- XP_004850759.1/1-1290 RAILAKRAGSISGTPGPREAE *****:***: