CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000080066/1-1216 -----------------------MEKKIGSRSFRDGVVKKPCSPKTLPLKKSSAFSGIQR ENSRNOP00000037698/1-1209 -----------------------MEKKIGFRSFRDGVVKKPCSPKALPLKKSSAFSGIQR ENSP00000383145/1-1242 MKNLLTEKCISSHNFHQKVIKQRMEKKVDSRYFKDGAVKKPYSAKTLSNKKSSASFGIRR ENSCPOP00000011110/1-1201 --------------------------SSNLRSFRDDEMKKYYSPKALPTKKSSAFSG--- XP_004843550.1/1-1198 -----------------------MEKKVVVRSFRDDEVKKPCSPKALPKKKSSALSG--- . * *:*. :** *.*:*. ***** * ENSMUSP00000080066/1-1216 EPSRSCHSIYYHASQNWTRY-RLQELRIRCVARKFLYLWIRVTFGRVTPSRARIFHEQKI ENSRNOP00000037698/1-1209 ELTRSCHSSYYQSSQSWTPQ-RLRELRVRCVARKFLYLWMRVTFGRVTPSRARFFHEQKI ENSP00000383145/1-1242 ELPSTSHLVQYRGTHTCTRQGRLRELRIRCVARKFLYLWIRMTFGRVFPSKARFYYEQRL ENSCPOP00000011110/1-1201 RVPRTNHPVKYGASYSGTRRDRLRELCIRCVARKFLYLWMRMTFGRIFPSKARFYYQQRI XP_004843550.1/1-1198 RVPRTTCPVKCGTSHTGTRRGRLRELHIRCMARKFLYLWIRMTFGRIFPSKARFYYEQKI . . : : . * **:** :**:********:*:****: **:**::::*:: ENSMUSP00000080066/1-1216 LQKVFGEWREEWWVSQREWKLCVRADCHYRYYLYNLIFQNWKTFVHQQREMRKRFRIAEH ENSRNOP00000037698/1-1209 LRKVFGEWREEWWVSQREWKLCVRADCHYRYYLYNLIFQNWKSFVYQQREMRKRFQRAEH ENSP00000383145/1-1242 LRKVFEEWKEEWWVFQHEWKLCVRADCHYRYYLYNLMFQTWKTYVRQQQEMRNKYIRAEV ENSCPOP00000011110/1-1201 LRKALEGWKEEWWVSHREWKLCVRADCHYRYYLYSLVFQSWKAYVQQQQEMRNKYMKAKD XP_004843550.1/1-1198 LQKVFEGWKEEWWVSHREWKLCVRADYHYRYYLYNLVFQSWKACMRWQQEMRSKYMKAKD *:*.: *:***** ::********* *******.*:**.**: : *:***.:: *: ENSMUSP00000080066/1-1216 HDTKQKMCQAWKSWLIYMVSRRTKLHMKTTALEFRRQSVLCFWWSKWRWRLGQAHAEHAL ENSRNOP00000037698/1-1209 HDMKQKMRHAWKSWLIYMVARRTKFRMKSTALEFRRRSVLCFWWNKWRWRLGRVHAEQAL ENSP00000383145/1-1242 HDAKQKMRQAWKSWLIYVVVRRTKLQMQTTALEFRQRIILRVWWSTWRQRLGQVRVSRAL ENSCPOP00000011110/1-1201 HGAKQKMRQAWKSWLIYVAVRRTKLQMQTTAVEFRQRSILCLWWSKWKQQLGQAHMNHAF XP_004843550.1/1-1198 HDAKQKMRQAWKAWLIYVAVRRTKLQMHTTALEFSQQSILWMWWSKWRQQLGQAHMNHAF *. **** :***:****:. ****::*::**:** :: :* .**..*: :**:.: .:*: ENSMUSP00000080066/1-1216 HAVAVKHRALSLQLQGWLRWQEQLLISQRDRRKEATAVQHYQHWQKQRSLKAWLKYLQIC ENSRNOP00000037698/1-1209 HAAAVKHRALSLQLQAWLRWQEQLLISQRERRKVATAVRHHQRWQKQRTLKAWLKYLRIC ENSP00000383145/1-1242 HASALKHRALSLQVQAWSQWREQLLYVQKEKQKVVSAVKHHQHWQKRRFLKAWLEYLQVR ENSCPOP00000011110/1-1201 YATAVKHRASSLQLQAWSQWKEQLLLSQREKWKVISAVQHLQWWQKRKSLRAWLEYLNVR XP_004843550.1/1-1198 CGTALKHRAFSLKLQAWSQWKEQLLLSQRERWKVVLAVQHHQWWQKRKSLRAWLEYLNMH . *:**** **::*.* :*:**** *::: * **:* * ***:: *:***:**.: ENSMUSP00000080066/1-1216 RVKRWQNEMAVQFHRATVLQIHFCDWQWAWEWRQSLSAHQALVVKLAGRMVLRRAFTHWK ENSRNOP00000037698/1-1209 RVKRWQNEMAVQFHRITVLQIHFCDWQWAWEWRQSLSAHQALVAKLARKMVLRRAFAHWK ENSP00000383145/1-1242 RVKRQQNEMAERFHHVTVLQIYFCDWQQAWERRESLYAHHAQVEKLARKMALRRAFTHWK ENSCPOP00000011110/1-1201 RVKRQQNEMAERLHRVTVLQIHFYDWRWAWEQRQSLYAHQALVEELARKMALRRVFSHWR XP_004843550.1/1-1198 RVKKQQNEMAEQLHRVTVLQIHFCDWRWAWEQRQSLYAHQALVEELARKMALRRAFLHWR ***: ***** ::*: *****:* **: *** *:** **:* * :** :*.***.* **: ENSMUSP00000080066/1-1216 HYMLLQAEEAAQREAAAEHRQHYLLYSCFRAFKDNVTQARLQQTRKKLAQQLRDTTLLHR ENSRNOP00000037698/1-1209 HYMLLQEEEAAQREAAAEHHQHCLLHSCFRAFKDNVTRARLKRMRKSLAHQLRDTTLLHR ENSP00000383145/1-1242 HYMLLCAEEAAQFEMAEEHHRHSQLYFCFRALKDNVTHAHLQQIRRNLAHQQHGVTLLHR ENSCPOP00000011110/1-1201 HYVLLCTEETAQRKVAERHHHCSLLKFCFRALKHNMSQVHLQQIRRNLAHQQHDMMLLHR XP_004843550.1/1-1198 RYVSLCTEEIAQREVGERHQQHSLLNFCFRALKDNVTQVHLKQIRKNLAHRQHDMMLLHR :*: * ** ** : . .*:: * ****:*.*:::.:*:: *:.**:: :. **** ENSMUSP00000080066/1-1216 FWNLWQSRIEQREERVQTPSLHAALSHYRVTVLHKCVRVWLRYVHKRQWQQLLRARADGH ENSRNOP00000037698/1-1209 FWNLWQSRVEQREERVQPPSLLAAQSHYRMTVLRKCVRVWLQYVHKRRCLQSLQARALGH ENSP00000383145/1-1242 FWNLWRSQIEQKKERELLPLLHAAWDHYRIALLCKCIELWLQYTQKRRYKQLLQARADGH ENSCPOP00000011110/1-1201 FWNLWHSRIEQREEKELLPLLSIAWGHYRVTLLHKSIKSWLLYTQKRRYKQQLQARADDY XP_004843550.1/1-1198 FWNIWQSRIEQRAEKEQLPSLNIAWAHYRITVLCKCIKLWLHYTQKRRYKQLLQARADGH ***:*:*::**: *: * * * ***:::* *.:. ** *.:**: * *:*** .: ENSMUSP00000080066/1-1216 FQQRALPAAFYTWYRGWLWHQQRRILHTKAVRFHRGTLEKQVFALWRQKMSQHRENCLAE ENSRNOP00000037698/1-1209 FQQRALPAAFYTWYRVWRWHQQRRTLHTRAVRFHREALEKQVFALWRQKVSQHREIRLAE ENSP00000383145/1-1242 FQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQKMFQHRENRLAE ENSCPOP00000011110/1-1201 FQQRALPAAFHMWSRLWRWYQRENVLNTRAACFHRETLEKQMFTVWWQKMFWHRENRLAE XP_004843550.1/1-1198 FQQRTLPAALHTWSRLWRWHQQESVLSARAACFHREVIEKQVFAVWWQKMFQHRENHLAE ****:****:: * * * * ::. * ::*. *** .:***:*::* **: *** *** ENSMUSP00000080066/1-1216 RMAILQAEQQLLRRFWFVWHQQAAVCQLERQQQAMAIAHHHSGLLRRAFCIWKESTQGFR ENSRNOP00000037698/1-1209 RMAMLQAEQQLLRRFWFVWHQRAAACHQERQRQAMAIAHHHSGLLRRAFCIWRESTQGFR ENSP00000383145/1-1242 RMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVACAHHRHGRLKKAFCLWRESAQGLR ENSCPOP00000011110/1-1201 RIAILQAEGQLLRRFWSMWHQRAAACHQEREWEAVACAQHHHRQLRNAFCVWKQSAHGLR XP_004843550.1/1-1198 RIAILQAERHLLRRFWLTWHQRVAARQQEREWEAVACAQHRERRLRNAFCIWKESAQQLR *:*:*:** :** * * ***:.*. : *:: :::* *:*: *:.***:*::*:: :* ENSMUSP00000080066/1-1216 IERMGRAQAAHFHSAQLLSRAWSMWRECLALRLEEQQKLKCAALHSQCILLRRALQKWLV ENSRNOP00000037698/1-1209 MERMGRAQASHFHSVRLLCWAWSKWREGLALRMEEQQKLKRAALHSQRTLLHRALQKWLV ENSP00000383145/1-1242 TERTGRVRAAEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVT ENSCPOP00000011110/1-1201 TERMSRVQAAQFYSGWLLRWAWSRWRESLALQAAEQQKLMQADLHSQHAMLRRALRKWLA XP_004843550.1/1-1198 TERISRVQAAQFHSGQLLRWAWSRWRERLALQAAEQQKLMQADLHSQRAMLRRALQKWLA ** .*.:*:.*: ** *** *** ***: *:*** * ** * :*:***: *:. ENSMUSP00000080066/1-1216 YQNRVRSVLREVAARERQHNRQLLWWALHLWRENTMARLDGAKKTSQARVHYSRTLCSKV ENSRNOP00000037698/1-1209 YQDRMRSVLQEVAARERQHNRQLLWWVLHRWRENTMARLDGAKKTSQARVHYNRTLCSKV ENSP00000383145/1-1242 YQGRVRSILREVAARESQHNRQLLRGALRRWKENTMARVDEAKKTFQASTHYRRTICSKV ENSCPOP00000011110/1-1201 YQSRVRSILQEAAVRESKHNRQLIRWALHCWRKNTEARADEARKSSQAFAHYRRTMCSKV XP_004843550.1/1-1198 YQGWVWSILQEVTVRESQHNRQLIRWALHRWRKNTMAHADEARRSSQARAHYRRTVCSKV **. : *:*:*.:.** :*****: .*: *::** *: * *::: ** .** **:**** ENSMUSP00000080066/1-1216 LVQWREVTSVQIYYRQKEAAALREARKALDRGRLQNWFQHWRFCSQRAAQQRFQLGQAAQ ENSRNOP00000037698/1-1209 LVQWREVTSVKIYYRQKEAAALREARKALDRGRLRTWLQRWQVCRQREAQQTFRLQQAAQ ENSP00000383145/1-1242 LVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSAQQRLQLERAVQ ENSCPOP00000011110/1-1201 LVQWQEVTSMQIYYRQQKACALREARKMLEKGCLRTWFQHWQDRSQRAAQQKAQLERAVQ XP_004843550.1/1-1198 LVQWREVASVQIYYRQWEACALREAQKVLERGCLCIWFRCWQDRSQRAAQQKAQLEGAAR ****:*..*:::**** : .*: **:* *::* * *:: * :* *** :* *.: ENSMUSP00000080066/1-1216 HHHWQLLMEAMARWKAHHLGCIRKKFLQRQAAQLLAQRLSRACFCQWRKQLAVRKQEQWG ENSRNOP00000037698/1-1209 HHRRQLLAGAMARWKAYHLCCVRKKFLQRQAAQLLAQRLGRACFCQWRKQLAVRKQEQWG ENSP00000383145/1-1242 HHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRA ENSCPOP00000011110/1-1201 HHHQQLLRETVAHWKMYHLGCVRKRILQQQGTQLLVQRLSWACFQQWKQQLVAKRLEQQS XP_004843550.1/1-1198 HHHQHLLREAVAQWKAYHLECVRKKILQRQGSQLLAQRLSQACFHQWRRQLVVKRQEQQS **: :** :*:** :** *:**::*::*.:***.***. :** **::**..:: ** . ENSMUSP00000080066/1-1216 TARALWLWAFSLQAKVWTAWLGFVLERRRKKARLERAMQAYQQQLLQEGATRLLRFTAGT ENSRNOP00000037698/1-1209 TARALWFWAFSLQAKVWAAWLGFVLEKRRKKARLEQAMQAYHQQLLQEGATRLLRFTAGM ENSP00000383145/1-1242 TVRALWFWAFSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASM ENSCPOP00000011110/1-1201 TAKALWFWAFSLQAKAWAAWLGFMQERKRKKVRLEQAVQAYHRQLLQEGTTRLLCFTSSM XP_004843550.1/1-1198 TARALWFWAFSLQAKAWAAWLGFALDRRRKKVRLEQAVQAYHQQLLQEGATRLLRFTASL *.:***:********.*::**.* :::***.**: *:***: ******:**** *::. ENSMUSP00000080066/1-1216 KAFRQQLQAQQQVQAAHSLHCAVRHCAELWKKKVLGPGKTSQPPAPTTFSKRVTFKDSFL ENSRNOP00000037698/1-1209 KALRQQLQAQQQVQAAHSLHCAVRHCAELWKKKVLGPDKTSQPPAPIAFSRRVTFKDFSL ENSP00000383145/1-1242 KASRQQLQAQQQVQAAHSLHRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEGPLL ENSCPOP00000011110/1-1201 KAFRQQLLAQQQVQATQSLHRIVRRCAEIWKQKVLGPGRESQPLASIAPGRRVTFEGPLL XP_004843550.1/1-1198 KAFRQQLQAQQQVQAAQSLHRAVCHCAELWKQKVLGPSRESQPLAPIASSRRVTFEGPLL ** **** *******::*** * :** :**:**** . .** *. : .::***:. * ENSMUSP00000080066/1-1216 SGHAAEAGDATQETKKLRAPPSQGVLGSLAGAAGEPCHLDLNAARSSRKQPRRPSFLLER ENSRNOP00000037698/1-1209 SGLAAEAGD---------APLSQGVLGSLAVAAGEPFIPELNEARPSRKQPRRPSFLLER ENSP00000383145/1-1242 NRIAAGAGDGTLETKRPQASRPLGALGRL--AAEEPHALELNTAHSARKQPRRPHFLLEP ENSCPOP00000011110/1-1201 DFVATGAGDATSEAKKLQAQQPRRAPGSLTLAAGEPQLLELSAARSARKQPRRPSFLLEP XP_004843550.1/1-1198 DFVAAGAGDATLETKRLQVQQPRAALGSLALAAGEPQLLEL------------------- . *: *** . . . * * ** ** :* ENSMUSP00000080066/1-1216 LGSQRSPEWYSLGEQQLEKPPEE-ESTALLGGSSLTRPF-------------LPGVLPNV ENSRNOP00000037698/1-1209 VQSQRSPERCTLGEQQLQKTPEKGQSMAPPGGSSLTRPF-------------LPVVRPNV ENSP00000383145/1-1242 AQSQRP-----------QKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSA ENSCPOP00000011110/1-1201 MQSQRP-----------EKLQEQGQGLAWPAGTSLTRPF-------------FTGALPSS XP_004843550.1/1-1198 -----P-----------EKPQEQGQGLAWPAGHSLTRSF-------------LTGALPNV . :* *. . * .. ****.* :. . .. ENSMUSP00000080066/1-1216 PGPKLPPTA--SPGLELLPPSSIMPHAAGGTARVSAKPSIPGPQPWGCPSLPRDLDPQLL ENSRNOP00000037698/1-1209 SGPKLPPTA--SPGLELLPPSSFMPHGVRDAARVSTKPSISGPQPWGCPSLTRDPDPHLL ENSP00000383145/1-1242 PGPKQPPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPRDKPPVPSSLASVPDPHLL ENSCPOP00000011110/1-1201 PGLKVPSEA--SPSPELLPPSSFMPLRTGAPARMLAQPTISRTKPQVPRTLACDPDPHLL XP_004843550.1/1-1198 PGPKLPSVASPSPSPELLPPSSFVPLRAGAPAWMSAQPTTPGPKPKVPPILTCGPDPHLL .* * *. * .* *** **::* . .* : :: : . :* *. **:** ENSMUSP00000080066/1-1216 -PGDSISTRTEPVYGSEATGHTELEAELEGIQQQLQHYQTTKQNLWSCQRQANSLRRWLE ENSRNOP00000037698/1-1209 LPGDSTSTRTGPGYGSETTGHTELEAELEGIQQQLQHYQTTKQNLWSCQRQANSLRRWLE ENSP00000383145/1-1242 LPGDFSATRAGPGLSTA--GSLDLEAELEEIQQQLLHYQTTKQNLWSCRRQASSLRRWLE ENSCPOP00000011110/1-1201 LPEDFTGSRARSSLVSEA-GHTDLEAELEGIQQQLQHYQTTRQNLWSCQRQASSLRKWLE XP_004843550.1/1-1198 LPEDFTGTRARPDLSSEAASHVDLEVELEGIQQQLQQYQTTRKDLWSCQRQASNLRKWLE * * .:*: . : . :**.*** ***** :****:::****:***..**:*** ENSMUSP00000080066/1-1216 LSQEEPKSEDLHLEEQVKTELEEVELQVQQLAKELEAQRQPVGTCI--------ARVRAL ENSRNOP00000037698/1-1209 LSQEEPSCEDLHLEEQVKTELEEVELQIQQLAKELEAQRQPVGTCI--------ARVRAL ENSP00000383145/1-1242 LNREEPGPEDQEVEQQVQKELEQVEMQIQLLAEELQAQRQPIGACV--------ARIQAL ENSCPOP00000011110/1-1201 LNQEEPRAEDHDAEQQIQKELEEVELQIQQLSGELQAQRQPIRSCI--------ARIQVL XP_004843550.1/1-1198 LSQEDPRAEDQDTERQIQKELEEV--RPQAIPRTAPSRVHPFHSACPSPTPRWNCRSSSW *.:*:* ** . *.*::.***:* : * :. :: :*. :. .* ENSMUSP00000080066/1-1216 RRALC--------- ENSRNOP00000037698/1-1209 RRALC--------- ENSP00000383145/1-1242 RQALC--------- ENSCPOP00000011110/1-1201 QQALR--------- XP_004843550.1/1-1198 PRIFRPSASPSIPA : :