CLUSTAL W(1.81) multiple sequence alignment ENSP00000239462/1-1299 MSLQEMFRFPMGLLLGSVLLVASAPATLEPPGCSNKEQQVTVSHTYKIDVPKSALVQVDA ENSMUSP00000039452/1-1560 MGLWGMLAFPLGFLLASVLLVASAPATPESPGCSNKEQQVTVSHTYKIDVPKSALVQVET ENSRNOP00000003452/1-1562 MGLWGMLAFPLGFLLASALLVASAPANPETPGCSHKDQQVTVSHTYKIDVPKSALVQVET ENSCPOP00000011015/1-1542 MGLQGTFSFLLGLLLGSVLPVTSAPATPELRNCSHKDQQVTISHNLNIEVNKSPLVQVEV XP_004853454.1/1-1561 MGLQGTFGFPLGLLLGSVLLVTSAPATPEPPGCSNKDQQVTVSHTYKIEVPKSTLVQVEA *.* : * :*:**.*.* *:****. * .**:*:****:**. :*:* **.****:. ENSP00000239462/1-1299 DPQPLSDDGASLLALGEAREEQNIIFRHNIRLQTPQKDCELAGSVQDLLARVKKLEEEMV ENSMUSP00000039452/1-1560 DPQSLSDDGTSLLAPGEDGEEQNIIFRHNIRLQTPQKNCDLADSVQDLLARMKKLEEEMA ENSRNOP00000003452/1-1562 DPQSLSDDGTSLLVPGEDGEEQNIIFRHNIRLQTPQKNCELADSVQDLLARVKKLEEEMA ENSCPOP00000011015/1-1542 DPKLLSGNGTSLLATGEEAEGQNFVFRHNIRLQTPQKDCDLSDSFQDLLARVKKLEEEMA XP_004853454.1/1-1561 DPQSLSDDGTSLLAMAEEGEEQNLIFRHNIRLQTPQKGCDLSDSVQDLLARVKKLEEEMA **: **.:*:***. .* * **::************.*:*:.*.******:*******. ENSP00000239462/1-1299 EMKEQCSAQRCCQGVTDLSRHCSGHGTFSLETCSCHCEEGREGPACERLACPGACSGHGR ENSMUSP00000039452/1-1560 ELKEQCNTNRCCQGAADLSRHCSGHGTFLPETCSCHCDQGWEGADCDQPTCPGACNGHGR ENSRNOP00000003452/1-1562 ELKEQCSTSRCCQGAADLSRHCSGHGTFFAETCSCHCDQGWEGADCEQPTCPGACSGHGR ENSCPOP00000011015/1-1542 EMKEQCNVQRCCQGATDPSRHCSGHGTFSPDTCSCHCEQGWEGAACELPTCPGACSGHGR XP_004853454.1/1-1561 ELKEQCNVQRCCQGAADLSRHCSGHGTFSPDTCSCHCEQGWEGADCELPSCPGACSGHGR *:****...*****.:* ********** :******::* **. *: :*****.**** ENSP00000239462/1-1299 CVDGRCLCHEPYVGADCGYPACPENCSGHGECVRGVCQCHEDFMSEDCSEKRCPGDCSGH ENSMUSP00000039452/1-1560 CVDGQCVCDAPYVGVDCAYAACPQDCSGHGVCVQGVCQCHEDFTAEDCSEQRCPGDCSGN ENSRNOP00000003452/1-1562 CVDGQCVCDQPYVGVDCAYAACPQDCSGHGVCVRGVCQCHKDFTAEDCSEQRCPGDCSGN ENSCPOP00000011015/1-1542 CVDGRCLCDEPYVGADCAYPPCPQNCSGHGVCVGGVCHCHEDFTSEDCSEQRCPGDCSGH XP_004853454.1/1-1561 CVDGRCVCDAPYVGPDCAYPACPQDCSGHGVCVRGVCQCQEDFTSEDCSEQRCPGDCSGH ****:*:*. **** **.*..**::***** ** ***:*::** :*****:********: ENSP00000239462/1-1299 GFCDTGECYCEEGFTGLDCAQVVTPQGLQLLKNTEDSLLVSWEPSSQVDHYLLSYYPLGK ENSMUSP00000039452/1-1560 GFCDTGECYCEMGFTGPDCSQVVAPQGLQLLKSTENSLLVSWEPSSEVDYYLLSYYPLGK ENSRNOP00000003452/1-1562 GFCDTGECYCEMGFTGPDCSQVVAPQGLQLLKSTENSLLVSWEPSSEVDHYLLSYYPLGK ENSCPOP00000011015/1-1542 GFCDTGECYCELGFTGLDCSQVIPPQGLQLLKSTENSLLVGWEPSSDVDHYLLSYYPLGS XP_004853454.1/1-1561 GFCDTGECYCELGFTGPDCSQVIPPQGLQLLKSTENSLLVGWEPSSDVDHYLLSYYPMGK *********** **** **:**:.********.**:****.*****:**:*******:*. ENSP00000239462/1-1299 ELSGKQIQVPKEQHSYEILGLLPGTKYIVTLRNVKNEVSSSPQHLLATTDLAVLGTAWVT ENSMUSP00000039452/1-1560 EQATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDISSSPQHLLATTDLAVVGTAWVN ENSRNOP00000003452/1-1562 EQATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDISSSPQHLLATTDLAVVGTAWVN ENSCPOP00000011015/1-1542 ELSGRQIRVPKEQHTYEIPDLLPGTKYIVTLRNVKKDISSSPQHLLATTDVAVVGTAWVT XP_004853454.1/1-1561 ERSSKQIQVPKEQHTYEIPGLLPGTKYVVTLRNVKKDIHSSPQHLVATTDLAVVGTAWVT * : :*::******:*:* .*******:*******::: ******:****:**:*****. ENSP00000239462/1-1299 DETENSLDVEWENPSTEVDYYKLRYGPMTGQEVAEVTVPKSSDPKSRYDITGLHPGTEYK ENSMUSP00000039452/1-1560 EETETSLDVEWENPLTEVDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLQPGTEYK ENSRNOP00000003452/1-1562 EETETSLDVEWENPLTEVDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLQPGTEYK ENSCPOP00000011015/1-1542 EETENSLDVEWENPPTEVDYYKLQYGPLTGHEVAEVTVPKSHEPKSRYDITGLQPGTDYK XP_004853454.1/1-1561 EETENSLDVEWENPPTEVDYYKLRYGPLTGHEVAEVTVPRSREPKSRYDITGLQPGTDYK :***.********* ********:***:**:**:*****:* :**********:***:** ENSP00000239462/1-1299 ITVVPMRGELEGKPILLNGRTEIDSPTNVVTDRVTEDTATVSWDPVQAVIDKYVVRYTSA ENSMUSP00000039452/1-1560 ITVVPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDPVRADIDKYVVRYIAP ENSRNOP00000003452/1-1562 ITVVPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDPVRADIDKYVVRYISH ENSCPOP00000011015/1-1542 ITVVPIRGDLAGTPIHLNGRTEIDGPTNVVTNQVTEDTAVVSWNPVKAEIDKYVVRHISP XP_004853454.1/1-1561 ITVVPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTAVVSWNPVKADIDKYVVRYISP *****:**:* *.** ********.******::****** ***:**:* *******: : ENSP00000239462/1-1299 DGDTKEMAVHKDESSTVLTGLKPGEAYKVYVWAERGNQGSKKADTNALTEIDSPANLVTD ENSMUSP00000039452/1-1560 DGETKEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGNQGSKKADTKALTEIDSPENLVTD ENSRNOP00000003452/1-1562 DGETKEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGNQGSKKADTKALTEIDSPENLVTD ENSCPOP00000011015/1-1542 DGDSKDTAVPKDRSSTTLTGLKPGEAYEVYVWAERGTQGSKKADAKALTEIDSPANLVTD XP_004853454.1/1-1561 DGETKERAVPRDQSSTTLTGLKPGETYKVYVWAERGNQGSKKADTKALTEIDSPANLVTD **::*: ** :*.***.********:*:*:******.*******::******** ***** ENSP00000239462/1-1299 RVTENTATISWDPVQATIDKYVVRYTSADDQETREVLVGKEQSSTVLTGLRPGVEYTVHV ENSMUSP00000039452/1-1560 RVTENSLSVSWDPVEADIDRYVVSYTSVDG-ETKQVPVKKDQRSTVLTGLSPGVEYKVYV ENSRNOP00000003452/1-1562 RVTENSLSVSWDPVEAEIDRYVVSYTSVDG-ETKQVPVRKDQSSTVLTGLSPGVEYKVYV ENSCPOP00000011015/1-1542 RVTENTLTVSWDPVEAEIDKYMVRYTSANG-ETREIPVAKEQTSTDLTGLSPGVEYKVYV XP_004853454.1/1-1561 RVTENTLTVSWDPVEAEIDRYVVSYTSADG-ETREIPVAKEQTSTDLIGLSPGVEYKVYV *****: ::*****:* **:*:* ***.:. **::: * *:* ** * ** *****.*:* ENSP00000239462/1-1299 WAQKGDRESKKADTNAPTDIDSPKNLVTDRVTENMATVSWDPVQAAIDKYVVRYTSAGGE ENSMUSP00000039452/1-1560 WAEKGDRESKKANTKAPTDIDSPKNLVTDQVTENTLSVSWDPVQANIDRYMVSYTSADGE ENSRNOP00000003452/1-1562 WAEKGDRESKKANTKAPTDIDSPKNLVTDQVTENTLSVSWDPVQANIDRYMVSYTSADGE ENSCPOP00000011015/1-1542 WAQKGDRESKKANTQAPTDIDSPKNLVTDQVTENMVTVSWDPVQAPIDRYMVSYTSADGE XP_004853454.1/1-1561 WAQKGDRESKKANTQAPTDIDSPKNLVTDKVTENMVTVSWDPVQAPIDRYVVSYTSADGV **:*********:*:**************:**** :******** **:*:* ****.* ENSP00000239462/1-1299 TREVPVGKEQSSTVLTGLRPGMEYMVHVWAQKGDQESKKADTKAQTDIDSPQNLVTDRVT ENSMUSP00000039452/1-1560 TREVPVPKEKSSTVLTGLRPGVEYKVHVWAQKGTQESRKANTKAPTDIDGPKNLVTDQVT ENSRNOP00000003452/1-1562 TREVPVPKEKSSTVLTGLRPGMEYKVHVWAQKGTQESRKANTKAPTDIDGPKNLVTDQVT ENSCPOP00000011015/1-1542 TKEVPVGKEQRSTILKGLKPGTEYKFHVWAQKGTQESRKADAQAPTDIDSPKNLVTDQVT XP_004853454.1/1-1561 TKEIPVGKDQRSTVLTGLKPGMEYKFHVWAQKGTQESRKADTKAPTDIDSPKNLVTDQVT *:*:** *:: **:*.**:** ** .******* ***:**:::* ****.*:*****:** ENSP00000239462/1-1299 ENMATVSWDPVRATIDRYVVRYTSAKDGETREVPVGKEQSSTVLTGLRPGVEYTVHVWAQ ENSMUSP00000039452/1-1560 ETTLSVSWDPVEADIDRYMVRYTSP-DGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQ ENSRNOP00000003452/1-1562 ETTLSVSWDPVEADIDRYMVRYTSP-DGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQ ENSCPOP00000011015/1-1542 ENTATVSWKPVKADIDRYVVRYTSA-DGETREVPVRKDRNRTILTGLKPGVEYEVDVWAQ XP_004853454.1/1-1561 ENTATVSWDPVEADIDRYMVRYTSA-DGETKEVPVRKDQRSTILRGLRPGVEYKVDVWAQ *. :***.**.* ****:*****. ****:**** *:: *:* **:***** *.**** ENSP00000239462/1-1299 KGAQESKKADTKAQTDIDSPQNLVTDWVTENTATVSWDPVQATIDRYVVHYTSANGETRE ENSMUSP00000039452/1-1560 KGAQDSRKANTKAPTDIDSPKNLVTEQVTESTATVSWDPVEADIDRYVVRYTSVDGETRE ENSRNOP00000003452/1-1562 KGAQDSRKANTKAPTDIDSPKNLVTEQVTESTATVSWDPVEADIDRYVVRYTSVDGETRE ENSCPOP00000011015/1-1542 KGARESRKANTKAPTDIDSPKNLVTDQVTENTATVSWDPVEADIDRYVVRYTSADGETRE XP_004853454.1/1-1561 KGARESRKANTKAPTDIDSPKNLVTDQVTENTATVSWDPVEADIDRYVVRYTSADGETRE ***::*:**:*** ******:****: ***.*********:* ******:***.:***** ENSP00000239462/1-1299 VPVGKEQSSTVLTGLRPGMEYTVHVWAQKGNQESKKADTKAQTEIDGPKNLVTDWVTENM ENSMUSP00000039452/1-1560 FLVGKDQTSTVLTGMRPGVEYQVDVWAQKGTQESRKTSTKAPTDIDGPKNLVTDQVTETT ENSRNOP00000003452/1-1562 FLVGKDQTSTILTGMKPGVEYQVDVWAQKGTRESRKTSTKAPTDIDGPKNLVTDQVTETT ENSCPOP00000011015/1-1542 FLVGKDQSSTILTGLRPGVEYEVDVWAQKGTRESRKVNSKAPTDIDSPKNLVTDQVTENT XP_004853454.1/1-1561 FLVGKDQSSTVLTGLRPGVEYEVDVWAQKGARESRKANSKAPTDIDSPQNLVTDQVTENT . ***:*:**:***::**:** *.****** :**:*..:** *:**.*:***** ***. ENSP00000239462/1-1299 ATVSWDPVQATIDKYMVRYTSADGETREVPVGKEHSSTVLTGLRPGMEYMVHVWAQKGAQ ENSMUSP00000039452/1-1560 LSVSWDPVEADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQ ENSRNOP00000003452/1-1562 LSVSWDPVEADIDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQ ENSCPOP00000011015/1-1542 ATVSWDPVEADIDQYVVRYISADGDTREIPVGKEHRSTLLTGLRPGVEYRVDVWAQKGTQ XP_004853454.1/1-1561 ATVSWDPVEAEIDRYVVRYTSADGETREIPVRKEQRSTVLTGLRPGVEYKVDVWARKGTQ :******:* **:*:*** *.**:*:*:** *:: **:* *****:** *.***:**:* ENSP00000239462/1-1299 ESKKADTKAQT------------------------------------------------- ENSMUSP00000039452/1-1560 DSRKANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRYTSADGESKEFLIG ENSRNOP00000003452/1-1562 DSRKANTKAPTDIDSPKNLAINQVTETTLSVSWDPVQADIDRYVVRYTSADGESKEFLIG ENSCPOP00000011015/1-1542 ESRKVTTKAPTDIDSPKNLVTDQVTENTATVSWDPVEADIDRYVVRYTSADGETKEFLVG XP_004853454.1/1-1561 ESRKANTKAPTDIDSPKNLVTDQVTENTATVSWDPVKADIDRYVVRYTSADGETKEFLLG :*:*. *** * ENSP00000239462/1-1299 ------------------------------------------------------------ ENSMUSP00000039452/1-1560 KEQRSTVLTGLRPGVEYKVEVWAQKGARESKKANTEGHTDIDSPKNLVTNQVTENTATIS ENSRNOP00000003452/1-1562 KEQRSTVLTGLRPGVEYKVEVWAQKGARESKKANTKGHTDIDSPKNLVTNQVTENTATIS ENSCPOP00000011015/1-1542 KEHKSTVLTDLRPGVEYKVDVWAQKGARESKKANTEAPTEIDSPKNLVTNQVTENTATIS XP_004853454.1/1-1561 KDQSSTVLTGLRPGVEYKVDVWAQKGARESRKANTKAPTDIDSPKNLVTNQVTENTATVS ENSP00000239462/1-1299 ------------------------------------------------------------ ENSMUSP00000039452/1-1560 WDPVQADIDRYMVRYTSADGETREIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGARESKK ENSRNOP00000003452/1-1562 WDPVQADIDRYMVRYTSADGETREVPVRKEKSSTVLTGLRPGVEYTVQVWAQKGARESRK ENSCPOP00000011015/1-1542 WDPVQANIDRYVVRYTSADGEIREIPVKKEKTSTVLTGLRPGVDYTVQVWAQKGNRQSKK XP_004853454.1/1-1561 WDPVQADIDRYVVRYTSADGETREIPVRKGKTSTVLTGLRPGVDYTIHVWAQKGTRESKK ENSP00000239462/1-1299 ------------------------------------------------------------ ENSMUSP00000039452/1-1560 AKTKAPTEIDSPKNLVTNRVTENTATISWDPVRANIDRYMVRYTSADGETKEIPVSKDQS ENSRNOP00000003452/1-1562 AKTKAPTEIDSPKNLVTNRVTENTATISWDPVRATIDRYMVRYTSADGETKEVPVSKDQS ENSCPOP00000011015/1-1542 AKTKAPTALPSRRTRVLSRL--HRAQISWESARQG------------ARVPSLSVSSVSH XP_004853454.1/1-1561 ANTKAPTEIDSPKNLVTNRVTETTATISWDPVRAAIDRYMVRYTSADGETKEIPVSKEQS ENSP00000239462/1-1299 -----------------------------------ELDPPRNLRPSAVTQSGGILTWTPP ENSMUSP00000039452/1-1560 STILTGLKPGMEYTIHVWAQKGARESKKADTKALTEIDPPRNLRPFGVTHSGGVLTWLPP ENSRNOP00000003452/1-1562 STILTGLKPGMEYTIHVWAQKGARESKKADTKALTEIDPPKNFRPFGVTHSSGVLTWMPP ENSCPOP00000011015/1-1542 SLIFLSLEQGRTDLLPVW-----REEQEWEYEGIIELDPPTNFRPFGITHSGGVLTWMPP XP_004853454.1/1-1561 STILTGLKPGVAYTVQVWAVKGARESKKVSTKALTEIDPPKNFRPFGVTHSGGALTWMPP *:*** *:** .:*:*.* *** ** ENSP00000239462/1-1299 SAQIHGYILTYQFPDGTVKEMQLGREDQRFALQGLEQGATYPVSLVAFKGGRRSRNVSTT ENSMUSP00000039452/1-1560 SAQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGNQRSRTVSTT ENSRNOP00000003452/1-1562 SAQIDGYILTYQLPNGILKEVELQRGQQRFELQDLEQGVTYPVSLVAFKGNQRSRSVSTT ENSCPOP00000011015/1-1542 SAQIDGYILTYQFPNGTLKEVKLGRGQERFELQGLSQGITYPASLVAFKGDQQSRSVSTS XP_004853454.1/1-1561 SAQIDGYILTYQFPNGTVKEVRLGRGEQRFELQGLEQGITYPASLVAFKGDHRSRSVSTS ****.*******:*:* :**:.* * ::** **.*.** ***.*******.::**.***: ENSP00000239462/1-1299 LSTVGARFPHPSDCSQVQQNSN-AASGLYTIYLHGDASRPLQVYCDMETDGGGWIVFQRR ENSMUSP00000039452/1-1560 LSTVDARFPHPSDCSQVQQNTN-AASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQRR ENSRNOP00000003452/1-1562 LSTVDARFPHPSDCSQVQQNTNAAASGLYTIYLNGDASRPMQVYCDMDTDGGGWIVFQRR ENSCPOP00000011015/1-1542 LSTVDARFPHPSDCSQVQQNSD-AASGLYTIYLNGDVSRPLEVYCDMDTDGGGWIVFQRR XP_004853454.1/1-1561 LSTVDARFPHPSDCSQIQQNSD-AASGLYTIYLNGDVNRPLKVYCDMDTDGGGWIVFQRR ****.***********:***:: **********:**..**::*****:************ ENSP00000239462/1-1299 NTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTPARYEVRVDLQTANESAYAIY ENSMUSP00000039452/1-1560 NTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQTFNESAYAVY ENSRNOP00000003452/1-1562 NTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQTANESAYAVY ENSCPOP00000011015/1-1542 NTGQLDFFKRWRSYVEGFGDLKQEFWLGLDKLHNLTSSTPTRYEVRVDLQTSNESAYAVY XP_004853454.1/1-1561 NTGQLDFFKRWRSYVEGFGDPMQEFWLGLDKLHNLTSGTPTRYEVRVDLQTSNESAYAVY ******************** :*************:.*.:*****.**** ******:* ENSP00000239462/1-1299 DFFQVASSKERYKLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYK ENSMUSP00000039452/1-1560 DFFQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYK ENSRNOP00000003452/1-1562 DFFQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYK ENSCPOP00000011015/1-1542 DFFQVASPKERYKLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYK XP_004853454.1/1-1561 DLFQVASPKERYKLTVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSNCALTHHGGWWYK *:*****.******:********************************************* ENSP00000239462/1-1299 NCHLANPNGRYGETKHSEGVNWEPWKGHEFSIPYVELKIRPHGYSREPVLGRKKRTLRGR ENSMUSP00000039452/1-1560 NCHLANPNGKYGETKHSEGVNWEPWKGHEFSIPYVELKIRPFGYSRDRFSGRKKRSI-GK ENSRNOP00000003452/1-1562 NCHLANPNGKYGETKHSEGVNWEPWKGHEFSIPYVELKIRPFGYSRDRFSGRKKRSIGGK ENSCPOP00000011015/1-1542 NCHLANPNGKYGETKHSEGVNWKPWKGHEFSIPYVEMKIRPHGYGSERFRGRKKRTLGGK XP_004853454.1/1-1561 NCHLANPNGKYGETKHSEGVNWKPWKGHEFSIPYVELKIRPNGYSRERFHGRKKRTLGGK *********:************:*************:**** **. : . *****:: *: ENSP00000239462/1-1299 LRTF ENSMUSP00000039452/1-1560 ARMF ENSRNOP00000003452/1-1562 ARVF ENSCPOP00000011015/1-1542 PRMF XP_004853454.1/1-1561 TRMF * *