CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000027251/1-1249 MRRGGWRKRTENDGWEKWGGYMAAKVQKLEEQFRTDAANQKDGTASAIFSGVAIYVNGYT ENSRNOP00000059807/1-1119 MRRGGWRKRAEEDGWEKWGGYMAAKVQKLEEQFRSDAAKQKDGTASAIFSGVAIYVNGYT ENSP00000258428/1-1251 MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYT ENSCPOP00000010779/1-1228 MRRGGWRKRAEND-WEKWGGYMAAKVQKLEQQFRSDAALQKDGTSSTIFSGVAIYVNGYT XP_004844488.1/1-1251 MRRGGWRKRAEND-WEKWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYT *********:*:* **.*************:***:*** *****:*:************* ENSMUSP00000027251/1-1249 DPSAEELRNLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKA ENSRNOP00000059807/1-1119 DPSAEELRNLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKA ENSP00000258428/1-1251 DPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKA ENSCPOP00000010779/1-1228 DPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPTAKIKELKGEKVIRPEWIVESIKA XP_004844488.1/1-1251 DPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPTAKIKELKGEKVIRPEWIVESIKA ********:***************************.*********************** ENSMUSP00000027251/1-1249 GRLLSSAPYQLYTKPSAAQKSLNFNPVCKPEDPGPGPSNRAKQLNNRVNHIIKKIETESE ENSRNOP00000059807/1-1119 GRLLSSVPYQLYTKPSTAQKSLNFTPVCKPEEPVPGPSEIAKQLTNRVNHIIKKIETENE ENSP00000258428/1-1251 GRLLSYIPYQLYTKQSSVQKGLSFNPVCRPEDPLPGPSNIAKQLNNRVNHIVKKIETENE ENSCPOP00000010779/1-1228 GRLLSYIPYQLYTKQSNAQRSLNFNPVCKPEDPVPGPSHVAKQPNNKVNHVIKKIEAENE XP_004844488.1/1-1251 GRLLSYIPYQLYTKQSTAQKSLNFNPICKPEDPVPGPSNVAKQLNNKVNHIIKKIETENE ***** ******* * .*:.*.*.*:*:**:* ****. *** .*:***::****:*.* ENSMUSP00000027251/1-1249 VKANGLSSWNEDGVNDDFSFEDLEHTFPGRKQNGVMHPRDTAVIFNGHTHSSNGALKTQD ENSRNOP00000059807/1-1119 VKANGVSSWNEDSADDGFSSEGLGQTFPGRKQNGVMHPRDTAVIFNGHAHSSNGALKTQD ENSP00000258428/1-1251 VKVNGMNSWNEEDENNDFSFVDLEQTSPGRKQNGIPHPRGSTAIFNGHTPSSNGALKTQD ENSCPOP00000010779/1-1228 VKVNGMNSWNEQDANSDFSFVDLEHMLPGRKQNGIPHPRSSSALFNGHTPCSNGALKTQD XP_004844488.1/1-1251 VRVNGINTWNEEDANHNFSFVDLETPLPGRKQNVIPHPRGSAAILNGHSLSSNGALKTQD *:.**:.:***:. : .** .* ****** : ***.::.::***: .********* ENSMUSP00000027251/1-1249 CLVPVGNSVASRLSLDSTQEEKRAEKSNADFRDCTVQHLQHSTRSADALRSPHRTNSLSP ENSRNOP00000059807/1-1119 CLVPVDHSVASRLSLDSTQEEKRAEKSSTDFRDCSRQHLQHSTTNADTLCSPHRTSSLSP ENSP00000258428/1-1251 CLVPMVNSVASRLSPAFSQEEDKAEKSSTDFRDCTLQQLQQSTRNTDALRNPHRTNSFSL ENSCPOP00000010779/1-1228 CLVPEGNSVASRLSPDSAQDEEKVEKSSTDFRDCALQQLQQSSGNADTLQNPHRTNSLSP XP_004844488.1/1-1251 CLVPGGNSIASRLSPPDSAQEKNAEKSNTDFRDCTPQQLQQSTRNSETLRNPHRTNSLSP **** :*:***** : :*...***.:*****: *:**:*: .:::* .****.*:* ENSMUSP00000027251/1-1249 S-LHSNTKINGAHHSTVQGPSSTKSTSVL-TLSKVAPSVPSKPSDCNFISDFYSRSRLHH ENSRNOP00000059807/1-1119 S-LHSNTKINGAHHSTVQGPSSTKSTSAL-TLSKVAPSVPSKPSDCSFISDFYSRSRLHH ENSP00000258428/1-1251 SPLHSNTKINGAHHSTVQGPSSTKSTSSVSTFSKAAPSVPSKPSDCNFISNFYSHSRLHH ENSCPOP00000010779/1-1228 S-LHSSAKINGAHHSTVQGPSSTKSTSLLPAFSKAAPSVPFKPSDSSFISDFYSHSRLHH XP_004844488.1/1-1251 S-LHSNAKINGAHHSTVQGPSSTKSTSSLPALSKVAPSVPSKPSDCSFISDFYSHSRLHH * ***.:******************** : ::**.***** ****..***:***:***** ENSMUSP00000027251/1-1249 ISTWKCELTEFVNTLQRQSSGIFPGREKLKKVKTGRSSLVVTDTGTMSVLSSPRHQSCVM ENSRNOP00000059807/1-1119 ISTWKCELTEFVSALQRQRSGVFPGREKLKKVKTGRSSLVVTDTGDMSVLSSPRPQSCVM ENSP00000258428/1-1251 ISMWKCELTEFVNTLQRQSNGIFPGREKLKKMKTGRSALVVTDTGDMSVLNSPRHQSCIM ENSCPOP00000010779/1-1228 ISTWKCELTEFVNTLQRHSSGVFPGRE-----KTGRSALVVTDTGNMSVLSSPRHQSCIM XP_004844488.1/1-1251 ISTWKCELTEFVNTLQRQSSGVFPGREKLKKMKTGRSALVVTDTGNMSVLSSPRPQSCIM ** *********.:***: .*:***** *****:******* ****.*** ***:* ENSMUSP00000027251/1-1249 HVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGTAPLRPGANPQLEWQYYQNRALRGKAA ENSRNOP00000059807/1-1119 HVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLEWQYYQNKLLKGKAA ENSP00000258428/1-1251 HVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLEWQYYQNKILKGKAA ENSCPOP00000010779/1-1228 HVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLEWQYYQNKLVKGKAA XP_004844488.1/1-1251 HVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGSGRAPLRPGANPQLEWQYYQNKILKGK-A *******************************:* ******************: ::** * ENSMUSP00000027251/1-1249 DIPDSSVWENQDSTQTNGIDSVLSKAEIASCSYEARQVGIKNGMFFGYAKQLCPNLQAVP ENSRNOP00000059807/1-1119 DIPDSSVWENQDSAQTNGIDSVLSKAEIASCSYEARQVGIKNGMFFGHAKQLCPNLQAVP ENSP00000258428/1-1251 DIPDSSLWENPDSAQANGIDSVLSRAEIASCSYEARQLGIKNGMFFGHAKQLCPNLQAVP ENSCPOP00000010779/1-1228 DTLDSSVWENQDSTQTNGIDSVLSKAEIASCSYEARQVGIKNGMFFGHAKQLCPSLQAVP XP_004844488.1/1-1251 DIPDSSLWENQDSAQINGIDSVLSKAEIASCSYEARQVGIKNGMFFGHAKQLCPNLQAVP * ***:*** **:* ********:************:*********:******.***** ENSMUSP00000027251/1-1249 YDFHACREVAQAMYETLASYTHSIEAVSCDEALIDVTDILAETKLSPEEFAAALRIEIKD ENSRNOP00000059807/1-1119 YDFHACREVAQALYETLASYTHSIEAVSCDEALIDVTDILAETKLSPEEFAAALRMEIKN ENSP00000258428/1-1251 YDFHAYKEVAQTLYETLASYTHNIEAVSCDEALVDITEILAETKLTPDEFANAVRMEIKD ENSCPOP00000010779/1-1228 YDFHAYKEVARTMYETLASYTHSIEAVSCDEALVDITEILAETKLTPDEFANAVRMEIKD XP_004844488.1/1-1251 YDFHAYKEVARMMYETLASYTHNIEAVSCDEALVDITEILAETKLTPDEFANAVRVEIKD ***** :***: :*********.**********:*:*:*******:*:*** *:*:***: ENSMUSP00000027251/1-1249 KTKCAASVGIGSNILLARMATKKAKPDGQYHLQPDEVDDFIRGQLVTNLPGVGRSMESKL ENSRNOP00000059807/1-1119 KTQCAASVGIGSNILLARMATKKAKPDGQYHLQPDEVDDFIRGQLVTSLPGVGRSMESKL ENSP00000258428/1-1251 QTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVDDFIRGQLVTNLPGVGHSMESKL ENSCPOP00000010779/1-1228 RTKCAASVGIGSNILLAKMATKKAKPDGQYHLKPEEVDDFIRGQLVANLPGVGRSMEYKL XP_004844488.1/1-1251 KTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVDDFIRGQLVANLPGVGRSMESKL :*:**************:***:**********:*:***********:.*****:*** ** ENSMUSP00000027251/1-1249 ASLGIKTCGDLQCLTMAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGI ENSRNOP00000059807/1-1119 ASLGIKTCGDLQCLTMAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGI ENSP00000258428/1-1251 ASLGIKTCGDLQYMTMAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGI ENSCPOP00000010779/1-1228 TSLGIKTCGDLQHMTMAKLQKEFGPKIGQTLYRFCRGLDDRPVRTEKERKSISAEINYGI XP_004844488.1/1-1251 TSLGIKTCGDLQHMTMAKLQKEFGPKIGQMLYRFCRGLDDRPVRTEKERKSISAEINYGI :*********** :************ ** *********************:******** ENSMUSP00000027251/1-1249 RFTQPKEAEAFLLSLSEEIQRRLEAAGMKGKRLTLKIMVRKPGAPIETAKFGGHGICDNI ENSRNOP00000059807/1-1119 RFTQPREAEAFLLSLSGEIQSRLEAAGMKGKRLTLKIMVRKPGAPIETAKFGGHGICDNI ENSP00000258428/1-1251 RFTQPKEAEAFLLSLSEEIQRRLEATGMKGKRLTLKIMVRKPGAPVETAKFGGHGICDNI ENSCPOP00000010779/1-1228 RFTQPKEAEAFLLNFSEEIQRRLEAAGMKGKRLTLKIMVRKPGAPIETAKFGGHGICDNI XP_004844488.1/1-1251 RFTQPKEAEAFLLKLSEEIQRRLEAAGMKGKRLTLKIMVRKPGAPVETAKYGGHGICDNI *****:*******.:* *** ****:*******************:****:********* ENSMUSP00000027251/1-1249 ARTVTLDQATDSAKIIGKATLNMFHTMKLNISDMRGVGIQVNQLVPANSNLSTCSSRPSA ENSRNOP00000059807/1-1119 ARTVTLDQATDSAKIIGKATLNMFHTMKLNISDMRGVGIQVHQLVPANLHPSTCSSRPSA ENSP00000258428/1-1251 ARTVTLDQATDNAKIIGKAMLNMFHTMKLNISDMRGVGIHVNQLVPTNLNPSTCPSRPSV ENSCPOP00000010779/1-1228 ARTVTLDQATDSAKIIGKAILNMFHTMKLNISDMRGVGIHVNQLVPTNPNPSACSSRASA XP_004844488.1/1-1251 ARTVTLDQATDSAKIIGKATLNMFHTMKLNISDMRGVGIQVNQLVPTNPNPSTCSSRASA ***********.******* *******************:*:****:* : *:*.**.*. ENSMUSP00000027251/1-1249 QSSLFSGRPHSVRDLFQLQKAKKPTEEEHKEVFLAAVDLEVSSTSRACGLLSPLSAHLAA ENSRNOP00000059807/1-1119 QSSLFSGLPHSVRDLFQLQKAKKPTEEEHNEG-LAAVDLEVSSNSRACGLLSPPSAHL-A ENSP00000258428/1-1251 QSSHFPSGSYSVRDVFQVQKAKKSTEEEHKEVFRAAVDLEISSASRTCTFLPPFPAHLPT ENSCPOP00000010779/1-1228 QPGHFPGGSHSVRDLLQVHKAKRPTEEESKEGFLAAVDMDTSSAPRTCTLLPPCSPHLPA XP_004844488.1/1-1251 QSSHFPGGSHSVRDLLQVQKAKKPTEEDSKEVSLAAVDLEASSARRTCTFLPSFSAHLPA *.. *.. .:****::*::***:.***: :* ****:: ** *:* :*.. ..** : ENSMUSP00000027251/1-1249 SVSPDTNSGECSRKWNGLHSPVSGQSRLNLSIEVPSPSQIDQSVLEALPLDLREQIEQVC ENSRNOP00000059807/1-1119 TVSPDANRGECSRKWNGLHSPIGGQSRLNLSIEVPSPSQIDQSVLEALPPDIREQVEQAY ENSP00000258428/1-1251 --SPDTNKAESSGKWNGLHTPVSVQSRLNLSIEVPSPSQLDQSVLEALPPDLREQVEQVC ENSCPOP00000010779/1-1228 TVSADTVKGSSSRKWNGLHCPVTAQSRLNLSIEIPSPSQLDQSVLEALPCDLREQIEQAC XP_004844488.1/1-1251 TISADTNKAESSGKWNGLHSPISVQSRLNLSIEVPSSSQLDQSVLEALPSDLREQIEQVC *.*: ...* ****** *: *********:**.**:********* *:***:**. ENSMUSP00000027251/1-1249 AAQQGEPRG-KKKEPVNGCSSGVLPHPVGTVLLQIPEPQEPCNSDSKISVIALPAFSQVD ENSRNOP00000059807/1-1119 AAQQGEPRGSKKKEPVNGCSSGVLPHPVGTVLLQIPEPQEPNNSDTRISVIALPAFSQVD ENSP00000258428/1-1251 AVQQAESHGDKKKEPVNGCNTGILPQPVGTVLLQIPEPQE-SNSDAGINLIALPAFSQVD ENSCPOP00000010779/1-1228 ALQQGESRGDRKKEPVNGCNTGILPQVVGTVLLQIPEPQE-SNSDTGINIIALPAFSQVD XP_004844488.1/1-1251 AIQQGEPSGDKKKEPVNGCNTGILPQPVGTVLLQIPEPQE-SNSDIGISIIALPAFSQVD * **.*. * :********.:*:**: ************* *** *.:********** ENSMUSP00000027251/1-1249 PDVFAALPAELQKELKAAYDQRQRQGEDTTHQQPTSTSVPKNPLLQLKPPAMKD-KRNKR ENSRNOP00000059807/1-1119 PDVFAALPAELQKELKAAYDQRQRQGEDTTQQQPASTSVPKNPLLQLKPPAMKD-KRNKR ENSP00000258428/1-1251 PEVFAALPAELQRELKAAYDQRQRQGENSTHQQSASASVPKNPLLHLK-AAVKEKKRNKK ENSCPOP00000010779/1-1228 PEVFAALPAELQKELKAAYDQRQRQGEDTTHQPPASVSVPKNPSLQLKPVA--------- XP_004844488.1/1-1251 PEVFAALPAELQKELKAAYDQRQRQGEDPTHQQPASASEPKNPSLQLKPVAVKDKKKSKK *:**********:**************:.*:* .:*.* **** *:** * ENSMUSP00000027251/1-1249 KNLIGSPRK--SPLKNKLLSSPAKTLPGAYGSPQKLMDGFLQHEGMASERPLEEVSASTP ENSRNOP00000059807/1-1119 KNPIGSPRKIQS-------------LPGTSGSPQKLMDGFLQHE----ERPL-------- ENSP00000258428/1-1251 KKTIGSPKRIQSPLNNKLLNSPAKTLPGACGSPQKLIDGFLKHEGPPAEKPLEELSASTS ENSCPOP00000010779/1-1228 ---------IQSPLKNK-LNSPAKTLPGACMSPQKLMDGFLKPGGPAAEKLQEELSASTS XP_004844488.1/1-1251 KTPISPPKKIQNPLKNMLLNSPAKTLPGACGSPQKLMDGFLKHEGPAAEKPLEELSASTS . ***: *****:****: *: ENSMUSP00000027251/1-1249 GAQDLSSLLPGQSSCFRPAAPNLAGAVEFSDVKTLLKEWITTISDPMEEDILQVVRYCTD ENSRNOP00000059807/1-1119 -------VTGTKTDCY-------------------------------------------- ENSP00000258428/1-1251 GVPGLSSLQSDPAGCVRPPAPNLAGAVEFNDVKTLLREWITTISDPMEEDILQVVKYCTD ENSCPOP00000010779/1-1228 GVPGQSTLQPDQPSCARPAAPNLAGAIEFNDVKTLLREWITTISDPMEEDILQVVKYCTD XP_004844488.1/1-1251 GVQGLFSLQPAQHSCVRPVAPNLAGAVEFSDVKTLLREWITTISDPMEEDILQVVKYCTD : .* ENSMUSP00000027251/1-1249 LIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT ENSRNOP00000059807/1-1119 ------------------------------------------------------- ENSP00000258428/1-1251 LIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT ENSCPOP00000010779/1-1228 LIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT XP_004844488.1/1-1251 LIEEKDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT