CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000002825/1-1479 MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQL ENSRNOP00000001975/1-1476 MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQL ENSP00000342434/1-1483 MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQL ENSCPOP00000010640/1-1433 ------------------------------------EYEARLERYSERIWTCKSTGSSQL XP_004840128.1/1-1473 MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQL ************************ ENSMUSP00000002825/1-1479 THKEAWEEEQEVAELLKEEFPNWYEKLVLEMVHHNTASLEKLVDSAWLEIMTKYAVGEEC ENSRNOP00000001975/1-1476 THKEAWEEEQEVAELLKEEFPNWYEKLVLEMVHHNTASLEKLVDSAWLEIMTKYAVGEEC ENSP00000342434/1-1483 THKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEEC ENSCPOP00000010640/1-1433 THKEAWEEEQEVAELLKEEFPTWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEEC XP_004840128.1/1-1473 THKEAWEEEQEVAELLKEEFPTWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEEC ********************* **********************:*************** ENSMUSP00000002825/1-1479 DFEVGKEKMLKVKIVKIHPLEKVDEEAVEKKSDGACDSPSSDKENSSQMAQDLQKKETVV ENSRNOP00000001975/1-1476 DFEVGKEKMLKVKIVKIHPLEKVDEEAAEKKSDGTCDSPSSDKENSSQMAQDHQ-KETVV ENSP00000342434/1-1483 DFEVGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVV ENSCPOP00000010640/1-1433 DFEVGKEKMLKVKIVKIHPLEKVDEEANEKKSDGACDSPSSDKENSSQMAQDHQKKEATV XP_004840128.1/1-1473 DFEVGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQMAQDHQKKEAVV *************************** ******:*************:*** * **:.* ENSMUSP00000002825/1-1479 KEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADS ENSRNOP00000001975/1-1476 KEDGGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQSEDKIISNVPADS ENSP00000342434/1-1483 KEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADS ENSCPOP00000010640/1-1433 KEDEGRREIINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISSVPADS XP_004840128.1/1-1473 KEDEGRREIINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADS *** **** **************************************.******.***** ENSMUSP00000002825/1-1479 LIRTERPPNKEILRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMT ENSRNOP00000001975/1-1476 LIRTERPPNKEILRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMT ENSP00000342434/1-1483 LIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMT ENSCPOP00000010640/1-1433 LIRTERPPNKEILRYFIRHNALRAGAGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMT XP_004840128.1/1-1473 LIRTERPPNKEILRYFIRHNALRAGAGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMT ************:************:********************************** ENSMUSP00000002825/1-1479 LNPSTKRRNTGSPDRKPSKKPKRDSSSLSSPLNPKLWCHVHLEKSLNGPPLKVKNSKNSK ENSRNOP00000001975/1-1476 LNPSTKRKNTGSPDRKPSKKPKRDNSSLSSPLNPKLWCHVHLEKSLNGPPLKVKNSKNSK ENSP00000342434/1-1483 LNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSK ENSCPOP00000010640/1-1433 LNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLNGSPLKLKNSKNSK XP_004840128.1/1-1473 LNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLNGSPLKMKNSKNSK *******:************.* *.*****************:***.*.***:******* ENSMUSP00000002825/1-1479 SPEEHLEGVMKIMSPNNNKLHS-FHIPKKGPAAKKPGKHSDKPLKAKGRGKGILNGQKST ENSRNOP00000001975/1-1476 SPEEHLEEVMKIMSP--NKLHS-FHIPKKGPSTKKPGKHSDKPLKAKGRGKGILNGQKST ENSP00000342434/1-1483 SPEEHLEEMMKMMSP--NKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQKST ENSCPOP00000010640/1-1433 SPEEHLEEVMKMMSP--NKLHANFHIPKKGPPAKKPGKHSDKPLKPKGRSKGILNGQKST XP_004840128.1/1-1473 SPEEHLEEVMKMMSP--NKLHANFHIPKRGPAAKKPGKHSDKPLKAKGRSKGILNGQKST ******* :**:*** ****: *****:**.:************.***.********** ENSMUSP00000002825/1-1479 GNSKSPSKCVKTPKTKMKQMTLLDMAKGTQKMTRTPRSSGGVPRSSGKPHKHLPPAALHL ENSRNOP00000001975/1-1476 GNSKSPSKCVKTPKTKMKQMTLLDMAKGTQKMTRTPRSSGGVPRSSGKPHKHLPPAALHL ENSP00000342434/1-1483 GNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHL ENSCPOP00000010640/1-1433 GNSKSPKKGLKTPKTKLKQMTLLDMAKGTQKMTRAPRNSGGTPRSSSKPHKHLPPAALHL XP_004840128.1/1-1473 GSSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMARAPRNSGGTPRSSSKPHKHLPPAALHL *.****.* :******:***************:*:**.***.**:*.************* ENSMUSP00000002825/1-1479 IAYYKENKDKEDKKSALSCVISKTARLLSNEDRARLPEELRALVQKRYELLEHKKRWASM ENSRNOP00000001975/1-1476 IAYYKENKDKEDKKSALSCVISKTARLLSSEDRARLPEELRALVQKRYELLEHKKRWASM ENSP00000342434/1-1483 IAYYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASM ENSCPOP00000010640/1-1433 IAYYKENKDREDKKSALSCVISKTARLLSSEDRARLPEELRTIVQKRYELLEHRKRWASM XP_004840128.1/1-1473 IAYYKENKDREDKKSALSCVISKTARLLSSEDRARLPEELRTIVQKRYELLEHRKRWASM *********:***:***************.***********::**********:****** ENSMUSP00000002825/1-1479 SEEQRKEYLKKKRQELKERLREKAKERREREMLERLEKQKRFEDQELGGRNLPAFRLVDT ENSRNOP00000001975/1-1476 SEEQRKEYLKKKRQELKERLREKAKERREKEMLERLEKQKRYEDQELGGRNLPTFRLVDT ENSP00000342434/1-1483 SEEQRKEYLKKKREELKKKLKEKAKERREKEMLERLEKQKRYEDQELTGKNLPAFRLVDT ENSCPOP00000010640/1-1433 SEEQRKEYLKKKRQELKEKLKEKAKERRQKEMLEKLEKQKRYEDQELAGKNLPAFRLVDT XP_004840128.1/1-1473 SEEQRKEYLKKKRQELKEKLKEKAKERRQKEMLEKLEKQKRYEDQELAGKNLPTFRLVDT *************:***::*:*******::****:******:***** *:***:****** ENSMUSP00000002825/1-1479 PEGLPNTLFGDVALVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVIL ENSRNOP00000001975/1-1476 PEGLPNTLFGDVALVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVIL ENSP00000342434/1-1483 PEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVIL ENSCPOP00000010640/1-1433 PEGLPNTLFGDVALVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVIL XP_004840128.1/1-1473 PEGLPNTLFGDVALVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVIL *************:********************************************** ENSMUSP00000002825/1-1479 LQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRCDVQEDSEGSETDDNKDSTP ENSRNOP00000001975/1-1476 LQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRCDVQEDSEGSDTDDNKDSTP ENSP00000342434/1-1483 LQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAA ENSCPOP00000010640/1-1433 LQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDAQEESEGSDTDDNKDSAP XP_004840128.1/1-1473 LQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDAQEESESSDTDD-KDSAP ****************************************.*.**:**.*:*** ***:. ENSMUSP00000002825/1-1479 FEDNEVQDEFLEKLETSEFFELTSEEKLRILTALCHRILMTYSVQDHMETRQQVSAELWK ENSRNOP00000001975/1-1476 FEDNEVQDEFLEKLETSEFFELTSEEKLRILTALCHRILMTYSVQDHMETRQQMSAELWK ENSP00000342434/1-1483 FEDNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWK ENSCPOP00000010640/1-1433 FEDNEVQDEFLEKLETSEFFELTSEEKLRILTALCHRILMTYSVQDHMETRQQMSAELWK XP_004840128.1/1-1473 FEDNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWK ****************************:************************:****** ENSMUSP00000002825/1-1479 ERLAVLKEENDKKRAEKQKRKEMEARNKENGKEENVLGKVDRKKEIVKIEQQVEVEADDM ENSRNOP00000001975/1-1476 ERLAVLKEENDKKRAEKQKRKEMEARNKENGKEENVLGKVDRKKEIVKIENQVEVEADDM ENSP00000342434/1-1483 ERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDM ENSCPOP00000010640/1-1433 ERLAVLKEENDKKRAEKQKRKEMEARNKENGREENGLGKTDRKKEIVKFEPQVDTEAEDM XP_004840128.1/1-1473 ERLAVLKEENDKKRAEKQKRKEMEARSKENGKEENGLGKTDRKKEIVKFEPQVDMEAEDM *************************:.****: ** ***.********:* **: **:** ENSMUSP00000002825/1-1479 ISAVKSRRLLSMQAKRKREIQERETKVRLEREAEEERMRKHKAAAEKAFQEGIAKAKLVL ENSRNOP00000001975/1-1476 ISAVKSRRLLSMQAKRKREIQERETKVRLEREAEEERVRKHKAAAEKAFQEGIAKAKLVL ENSP00000342434/1-1483 ISAVKSRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVM ENSCPOP00000010640/1-1433 ISAVKSRRLLALQAKRKREIQEREMKVKLEREAEEERIRKHKAAAEKAFQEGIARAKLVM XP_004840128.1/1-1473 ISAVKSRRLLALQAKREREIQEREMKVKLEREAEEERIRKHKAAAEKAFQEGIARAKLVM **********::***::******* **:***:*****:****************:****: ENSMUSP00000002825/1-1479 RRTPIGTDRNHNRYWLFSNEVPGLFIEKGWVHNSIDYRFKHHRKDHSNLPDDDYCPRSKK ENSRNOP00000001975/1-1476 RRTPIGTDRNHNRYWLFSNEVPGLFIEKGWVHNSIDYRFKHHRKDHNNLPDDDYCPRSKK ENSP00000342434/1-1483 RRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKK ENSCPOP00000010640/1-1433 RRTPIGTDRNHNRYWLFSDEVPGLFIEKGWAHDSIDYRFNHHRKDHVDSPDEDYCPRSKK XP_004840128.1/1-1473 RRTPIGTDRNHNRYWLFSDEVPGLFIEKGWAHDSIDYRFNHHRKDHADSS-------GKK ******************:***********.*:******:** *** .** ENSMUSP00000002825/1-1479 ANLGKNASVNAHHGPALE-AVETTVPKQGQNLWFLCDSQKELDELLSCLHPQGIRESQLK ENSRNOP00000001975/1-1476 ANLGKNASVNAHLGSALE-AVETTVPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLK ENSP00000342434/1-1483 ANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLK ENSCPOP00000010640/1-1433 ANLGKNASMNTHR-SALEIAVETTIPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLK XP_004840128.1/1-1473 ANLGKNASMNTHR-SALEIAVETTIPKQGQNLWFLCDSQKELDDLLNCLHPQGIRESQLK ********:*:: .* * ***** ******************:**.************* ENSMUSP00000002825/1-1479 ERLEKRYQEITHSIYLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYMEGTS ENSRNOP00000001975/1-1476 ERLEKRYQEITHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYMEGTS ENSP00000342434/1-1483 ERLEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETS ENSCPOP00000010640/1-1433 DRLEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETS XP_004840128.1/1-1473 ERLEKRYQDIIHSIHLARKPNLGLKCCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETS :*******:* ***:**********.*****************************:* ** ENSMUSP00000002825/1-1479 EFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKKRKLQSEDSTKSEEVDEEKK ENSRNOP00000001975/1-1476 EFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKKRKLQSEDSTKSEEVDEEKK ENSP00000342434/1-1483 EFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKK ENSCPOP00000010640/1-1433 EFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDLVKTEEVDEEKK XP_004840128.1/1-1473 EFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKVQSEDSAKTEEVDEEKK ****************************************:**:**** .*:******** ENSMUSP00000002825/1-1479 MVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDK ENSRNOP00000001975/1-1476 MVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDK ENSP00000342434/1-1483 MVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDK ENSCPOP00000010640/1-1433 IAEEEKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDK XP_004840128.1/1-1473 MAEEEKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDK :.** ******************************************************* ENSMUSP00000002825/1-1479 LILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPPTARRNSRGRNYTEESTSEGSEGDE ENSRNOP00000001975/1-1476 LILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPPTARRNSRGRNYTEESTSEDSEGDE ENSP00000342434/1-1483 LILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDE ENSCPOP00000010640/1-1433 LILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDTEEDE XP_004840128.1/1-1473 LILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDE ***********************************.***************:**.:* ** ENSMUSP00000002825/1-1479 SGEEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKQSVI-PAARPGRPPGKKSHPARRSRP ENSRNOP00000001975/1-1476 SGDEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKQSVI-PAARPGRPPGKKSHAARRSRP ENSP00000342434/1-1483 S-DEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQP ENSCPOP00000010640/1-1433 S--------------NYYEVAGLRLRPRKIIRGKQIVIPPASRPGRRPGKKPHPTRRSRQ XP_004840128.1/1-1473 S--DSEEEEEEEEEEEDYEVAGLRLRPRKIIRGKQIVIPPASRPGRRPGKKPHPPQRSQQ * : ************ ****: ** **:*.** ****.*..:**: ENSMUSP00000002825/1-1479 K----DDPEVDDLVLQTKRISRRQSLELQKCEDILHKLVKYRFSWPFREPVTRDEAEDYY ENSRNOP00000001975/1-1476 K----DDTEVDELVLQTKRSSRRQSLELQKCEEILHKLVKYRFSWPFREPVTRDEAEDYY ENSP00000342434/1-1483 KAPPVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYY ENSCPOP00000010640/1-1433 KASLVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIIKYRFSWPFREPVTRDEAEDYY XP_004840128.1/1-1473 KASPVDDVEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYY * ** ***:******* ************:****::********************* ENSMUSP00000002825/1-1479 DVIEHPMDFQTIQNKCSCGNYRSVQEFLTDMKQVFANAELYNCRGSHVLSCMEKTEQCLL ENSRNOP00000001975/1-1476 DVIDHPMDFQTMQNKCSCGNYRSVQEFLTDVKQVFANAELYNCRGSHVLSCMEKTEQCLL ENSP00000342434/1-1483 DVITHPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLV ENSCPOP00000010640/1-1433 DVISHPMDFQTMQNKCSCGNYRSVQEFLTDMKQVFTNAELYNCRGSHVLNCTVKTEQCLV XP_004840128.1/1-1473 DVITQPMDFQTMQNKCSCGNYRSVQEFLTDMKQVFTNAELYNCRGSHVLNCTVKTEQCLV *** :******:*******.**********:****:***:*********.* ******: ENSMUSP00000002825/1-1479 ALLQKHLPGHPYVRRKRRKFPDRLADDEGDSDSESVGQSRGRRQKK ENSRNOP00000001975/1-1476 ALLQKHLPGHPYVRRKRRKFPDRLADDEGDSDSESVGQSRGRRQKK ENSP00000342434/1-1483 ALLHKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEAVGQSRGRRQKK ENSCPOP00000010640/1-1433 ALLHKHLPGHPYVRRKRKKFPDQLADDEGDSDPEPVGQSRGRRQKK XP_004840128.1/1-1473 ALLHKHLPGHPYVRRKRKKFPDRLADDEVDSDPEPVGQSRGRRQKK ***:*************:****:**:** **:.*.***********