CLUSTAL W(1.81) multiple sequence alignment ENSRNOP00000052402/1-1544 MSLSFCGNNISSYNIYHGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH ENSMUSP00000084805/1-1546 MSLSFCGNNISSYNIYYGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH ENSCPOP00000010378/1-1553 MSLSFCGNNISSYNIYNGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH ENSP00000261200/1-1549 MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH XP_004845826.1/1-1548 MSLSFCGNNISSYNIYGGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH *************** *****.************************************* ENSRNOP00000052402/1-1544 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSQRASRHLHLFMPAVMGFVATTTSIV ENSMUSP00000084805/1-1546 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSHRASRHLHLFMPAVMGFVATTTSIV ENSCPOP00000010378/1-1553 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV ENSP00000261200/1-1549 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV XP_004845826.1/1-1548 NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV ***********************************:* ********************** ENSRNOP00000052402/1-1544 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQLGWGMSDLRFCITGVMVILNGLL ENSMUSP00000084805/1-1546 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQLGWGVSDLRFCITGVMVILNGLL ENSCPOP00000010378/1-1553 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQLGLGVSDLRFCITGMMVILNGLL ENSP00000261200/1-1549 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL XP_004845826.1/1-1548 YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQLGLDISNLRFCITGMMVILNGLL *********************************** * * .:*:*******:******** ENSRNOP00000052402/1-1544 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHR ENSMUSP00000084805/1-1546 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHR ENSCPOP00000010378/1-1553 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHR ENSP00000261200/1-1549 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK XP_004845826.1/1-1548 MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHR ***********************************************************: ENSRNOP00000052402/1-1544 KPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSIWLAMYR-FGRPILLS ENSMUSP00000084805/1-1546 KPIDLKAIGKLPIAMRAVTNYVCLKEAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLS ENSCPOP00000010378/1-1553 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS ENSP00000261200/1-1549 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS XP_004845826.1/1-1548 KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLS *************************:********.**************** ******** ENSRNOP00000052402/1-1544 STIRYLADLLGFAGPLCISGIVQRVNEP---KNNTTRF-SETLSSKEFLENAHVLAVLLF ENSMUSP00000084805/1-1546 STFRYLADLLGFAGPLCISGIVQRVNEK---TNTTREMFPETLSSKEFLENAHVLAVLLF ENSCPOP00000010378/1-1553 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGKRPETLSSKEFLENAYVLAVLLF ENSP00000261200/1-1549 STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGI-SETLSSKEFLENAYVLAVLLF XP_004845826.1/1-1548 STFRYLADLLGFAGPLCISGIVQRVNETQNGANKTTGI-SETLSSKEFLENAYVLAVLLF **:************************ *.* .************:******* ENSRNOP00000052402/1-1544 LALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAI ENSMUSP00000084805/1-1546 LALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAI ENSCPOP00000010378/1-1553 LALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAI ENSP00000261200/1-1549 LALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAI XP_004845826.1/1-1548 LALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAI ************************************************************ ENSRNOP00000052402/1-1544 ETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAE ENSMUSP00000084805/1-1546 ETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAE ENSCPOP00000010378/1-1553 ETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAE ENSP00000261200/1-1549 ETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAE XP_004845826.1/1-1548 ETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAE ************************************************************ ENSRNOP00000052402/1-1544 AQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLS ENSMUSP00000084805/1-1546 AQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLS ENSCPOP00000010378/1-1553 AQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKSFALYTSLS ENSP00000261200/1-1549 AQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLS XP_004845826.1/1-1548 AQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLS ***************************************************:******** ENSRNOP00000052402/1-1544 IFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAI ENSMUSP00000084805/1-1546 IFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAI ENSCPOP00000010378/1-1553 IFMNAAIPIAAVLATFVTHAYASGHNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAI ENSP00000261200/1-1549 IFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAI XP_004845826.1/1-1548 IFMNAAIPIAAVLATFVTHAYASGHHLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAI ************************::********************************** ENSRNOP00000052402/1-1544 ISVQKLNEFLLSDEIGEDSWRTGEGTLPFESCKKHTGVQSKPINRKQPGRYHLDNYEQ-A ENSMUSP00000084805/1-1546 ISVQKLNEFLLSDEIGEDSWRAGEGTLPFESCKKHTGVQSKPINRKQPGRYHLDSYEQ-A ENSCPOP00000010378/1-1553 ISVQKLNEFLLSDEIGDDSWRTGEGSLPFESCKKHTGVEPKTINRKQPGRYHLDSYEQSA ENSP00000261200/1-1549 ISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQST XP_004845826.1/1-1548 VSVQKLNEFLLSDEIGDDSWRTGDGSLPFESCKKHSGV-PKTINRKQPGRYHLDSYEQST :***************:****:*:.:*********:** .*.************.*** : ENSRNOP00000052402/1-1544 RRLRPAETEDVAIKVVVLLFSFETGFLVFGNISVCIPSGQLTMIVGQVGCGKSSLLLAIL ENSMUSP00000084805/1-1546 RRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAIL ENSCPOP00000010378/1-1553 RRLRPTESEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAIL ENSP00000261200/1-1549 RRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAIL XP_004845826.1/1-1548 RRLRPTETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAIL *****:*:**:****. **: :*: .:.**.: **:********************** ENSRNOP00000052402/1-1544 GEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSSFNRQ ENSMUSP00000084805/1-1546 GEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSPFNRQ ENSCPOP00000010378/1-1553 GEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNRQ ENSP00000261200/1-1549 GEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQ XP_004845826.1/1-1548 GEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNRQ **********:*.***************.**************************.**:* ENSRNOP00000052402/1-1544 RYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPF ENSMUSP00000084805/1-1546 RYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPF ENSCPOP00000010378/1-1553 RYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPF ENSP00000261200/1-1549 RYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPF XP_004845826.1/1-1548 RYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPF ************************************************************ ENSRNOP00000052402/1-1544 SALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDI ENSMUSP00000084805/1-1546 SALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDI ENSCPOP00000010378/1-1553 SALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDI ENSP00000261200/1-1549 SALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDI XP_004845826.1/1-1548 SALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDI **************************:********************************* ENSRNOP00000052402/1-1544 QTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDE-EEE ENSMUSP00000084805/1-1546 QTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDE-EEE ENSCPOP00000010378/1-1553 QTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEVEEE ENSP00000261200/1-1549 QTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDE-EEE XP_004845826.1/1-1548 QTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDE-EEE ******************************************************** *** ENSRNOP00000052402/1-1544 EEEDEDDNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATW ENSMUSP00000084805/1-1546 EEEDEEDNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATW ENSCPOP00000010378/1-1553 EEEDEDDNMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATW ENSP00000261200/1-1549 EEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW XP_004845826.1/1-1548 EEEDEDDDMSTVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAIDYWLATW *****:*:***************** **********:*********************** ENSRNOP00000052402/1-1544 TSEYSINDPGKADQTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIIL ENSMUSP00000084805/1-1546 TSEYSINHPGKADQTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIIL ENSCPOP00000010378/1-1553 TSEYSINNTGKTDQTFYVAGFSILCGGGIFLCLVTSLTVEWMGLTAAKNLHHNLLKKIIL ENSP00000261200/1-1549 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIIL XP_004845826.1/1-1548 TSEYSINNTGKTDQTFYVAVFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLKKIIL *******..**:***:*** ******.****************************:**** ENSRNOP00000052402/1-1544 GPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLIA ENSMUSP00000084805/1-1546 GPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVA ENSCPOP00000010378/1-1553 GPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVA ENSP00000261200/1-1549 GPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVA XP_004845826.1/1-1548 GPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAVGMISYATPVFLVA **********************************************:***********:* ENSRNOP00000052402/1-1544 LAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRM ENSMUSP00000084805/1-1546 LAPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRM ENSCPOP00000010378/1-1553 LVPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETVIKDFL ENSP00000261200/1-1549 LLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRM XP_004845826.1/1-1548 LVPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRM * **************************************************** :*: : ENSRNOP00000052402/1-1544 LELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTI ENSMUSP00000084805/1-1546 LELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTI ENSCPOP00000010378/1-1553 LHLPDRRKTQYMFYEAVNLLLPIKEDYLGACIVLTASIASISGSSNSGLVGLGLLYALTI ENSP00000261200/1-1549 LELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTI XP_004845826.1/1-1548 LELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTI *.*.* .: *:* .*.* * :: *********************************** ENSRNOP00000052402/1-1544 TNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMVPSFLPSFLPSHGSVYVAQAG ENSMUSP00000084805/1-1546 TNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLC ENSCPOP00000010378/1-1553 TNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTIDPSQVPEHWPQEGEIKIHDLC ENSP00000261200/1-1549 TNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLC XP_004845826.1/1-1548 TNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTIDPSQVPEHWPQEGEIKIHDLC **************************************: ** :*.. *..*.: : : ENSRNOP00000052402/1-1544 LKLRFNCLGPLSGPHGQVKVGEGYNFNSLMNEKVSHEFAACLWCLFSI-TGKIVIDGIDI ENSMUSP00000084805/1-1546 VRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKS-SLSLAFFRMVDIFDGKIVIDGIDI ENSCPOP00000010378/1-1553 VRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKS-SLSLAFFRMVDIFDGKIVIDGIDI ENSP00000261200/1-1549 VRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKS-SLSLAFFRMVDIFDGKIVIDGIDI XP_004845826.1/1-1548 VRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKS-SLSLAFFRMVDIFDGKIVIDGIDI :: . * *. :. :* *: .: . .. * .:: .:: :..* ********** ENSRNOP00000052402/1-1544 SKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGG ENSMUSP00000084805/1-1546 SKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGG ENSCPOP00000010378/1-1553 SKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGG ENSP00000261200/1-1549 SKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGG XP_004845826.1/1-1548 SKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLTGG *********************************************************.** ENSRNOP00000052402/1-1544 --LDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAF ENSMUSP00000084805/1-1546 --LDATVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAF ENSCPOP00000010378/1-1553 LDLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAF ENSP00000261200/1-1549 --LDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAF XP_004845826.1/1-1548 --LDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAF ***.****************************************************** ENSRNOP00000052402/1-1544 ADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVRADM ENSMUSP00000084805/1-1546 ADRTVVTIAHRVSSIVDAGLVLVFSEGILVECDTGPNLLQHKNGLFSTLVMTNK ENSCPOP00000010378/1-1553 ADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAREDGIFASFVRADM ENSP00000261200/1-1549 ADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVRADM XP_004845826.1/1-1548 ADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEDGVFASFVRADM ************ :*: *.**:*:..* ::* ** .** :::*:*:::* ::