CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000010322/1-1587 MSVTSWFLVSSSGTRHRLPRELIFVGRDECELMLQSRSVDKQHAVINYDPDRDEHWVKDL XP_004836904.1/1-1583 MSVTSWFLVSSSGTRHRLPRELIFVGRDECELMLQSRSVDKQHAVINYDQDRDEHWVKDL ENSP00000407238/1-1590 MSATSWFLVSSSGARHRLPRELIFVGREECELMLQSRSVDKQHAVINYDQDRDEHWVKDL ENSMUSP00000098580/1-1574 MSVTSWFLVSSSGTRHRLPRELIFVGRDECELMLQSRSVDKQHAVINYDQDRDEHWVKDL ENSRNOP00000033816/1-1575 MSVTSWFLVSSSGTRHRLPRELIFVGRDDCELMLQSRSVDKQHAVINYDQDRDEHWVKDL **.**********:*************::******************** ********** ENSCPOP00000010322/1-1587 GSLNGTFVNDVRIPDQKYITLKLNDVVRFGYDTVPHSNMYVLERVQHRVPEEALRHEKYT XP_004836904.1/1-1583 GSLNGTFVNDVRIPDQKYITLKLNDVIRFGYD----SNMYVLERVQHRVPEEALKHEKYT ENSP00000407238/1-1590 GSLNGTFVNDMRIPDQKYVTLKLNDVIRFGYD----SNMYVLERVQHRVPEEALKHEKYT ENSMUSP00000098580/1-1574 GSLNGTFVNDVRIPDQKYITLKLNDVIRFGYD----SNMYVLERVQHRVPEEALKHEKYT ENSRNOP00000033816/1-1575 GSLNGTFVNDVRIPDQKYITLKLNDVIRFGYD----SNMYVLERVQHRVPEEALKHEKYT **********:*******:*******:***** ******************:***** ENSCPOP00000010322/1-1587 SQLQVGVKSPAPRRNEAPPEFTAYCESSHPRPEKGDRRP-TESVVYRTPLYGQPSWWGED XP_004836904.1/1-1583 SQLQVGVKNPAPRKSEAPPEFTAYCETLHPRLEKGDRRPGTESVVYRTPLYGQPSWWGED ENSP00000407238/1-1590 SQLQVSVKGLAPKRSEALPEHTPYCEASNPRPEKGDRRPGTEAASYRTPLYGQPSWWGED ENSMUSP00000098580/1-1574 SQLQVSVKVSAPKRGDALPDHTPYCESSQPRPEKGDRRHGAEAVAYRTPLYGQPSWWGED ENSRNOP00000033816/1-1575 SQLQVSVKVSAPKRSDTLPDHTPYCESSQPRPEKGDRRHGAEAVAYRTPLYGQPSWWGED *****.** **::.:: *:.*.***: :** ****** :*:. *************** ENSCPOP00000010322/1-1587 DSGTPPEDRRQEDPYP-ERAKESAQQDGELGAPPASFCTPVEPQGYSFRREPSYFEIPTK XP_004836904.1/1-1583 DSGTAPEDQRQEEPYP-ERAKESGQRDSELDGPPAGFRGPVEPQGYSFRREPSYFEIPTK ENSP00000407238/1-1590 DGSTLPDAQRQGEPYPAERPKGPVQQDGELH----GFRAPAEPQGCSFRREPSYFEIPTK ENSMUSP00000098580/1-1574 DSGAPSEDRHQEEPYS-ERPKDLAQQNGELD----SCRAPAEPPDYSFRREPSYFEIPTK ENSRNOP00000033816/1-1575 DSGAPSEDRHQQEPYP-ERPKDLTQQDSELD----SCRAPAEPPDYSFRREPSYFEIPTK *..: .: ::* :**. **.* *::.** . *.** . ************** ENSCPOP00000010322/1-1587 EAPPPPSRPPEVPEREVPTKDEEVMGGSGAAPVVQSHASFTIEFDDCSPGKVKIKDHITK XP_004836904.1/1-1583 EARPPPSQPPEVLEHEPPTKDEEAGSG-GAGPVVQSHASFTIEFDDCSPGKVKIKDHITK ENSP00000407238/1-1590 ETPQPS-QPPEVPAHEMPTKDAEAGGG-GAAPVVQSHASFTIEFDDCSPGKMKIKDHITK ENSMUSP00000098580/1-1574 ETPQPP-RLPEVPTQEVPTKDQEAGVG-GTAPVVQSHASFTIEFDDCSPGKVKIKDHITK ENSRNOP00000033816/1-1575 EAPQPP-RLPEVPTQEMPTKDQEACTG-GTAPVVQSHASFTIEFDDCSPGKVKIKDHITK *: *. : *** :* **** *. * *:.********************:******** ENSCPOP00000010322/1-1587 FALRQRRPTGKDATPTEMVSAETKVADWLVQNDPSLLRRAGPADDRHSTKSDLPMHTRTL XP_004836904.1/1-1583 FALRQRRQPCKEATPVEMVSAESKVADWLVQNDPSLLRRAGPGDDRHGAKSDLPVHTRTL ENSP00000407238/1-1590 FSLRQRRPPGKEATPGEMVSAETKVADWLVQNDPSLLHRVGPGDDRHSTKSDLPVHTRTL ENSMUSP00000098580/1-1574 FSLRQRRAPSKETTPVETVSAETKVADWLVQNDPSLLRRDGPGDDRHSTKSDLPVHTRTL ENSRNOP00000033816/1-1575 FSLRQRRPPSKETTPVEMVSAETKVADWLVQNDPSLLRRDGPGDDRHSTKSDLPVHTRTL *:***** . *::** * ****:**************:* **.****.:*****:***** ENSCPOP00000010322/1-1587 KGHKHEDGTQSDSEDPLVKAAPVAGTPVEAGGEQMRLQRQIKRDPQELLHNQQAFVIQFF XP_004836904.1/1-1583 RGHKHEDGTQSDSEDPPAKAASVAGAPVEASGEQVRLQRQIKRDPQELLHNQQAFVIQFF ENSP00000407238/1-1590 KGHKHEDGTQSDSEDPLAKAASAAGVPLEASGEQVRLQRQIKRDPQELLHNQQAFVIEFF ENSMUSP00000098580/1-1574 KGHKHEDGTQSDSEDPLAKTASVSGASAEASGEQVRLQRQIKRDPQELLHNQQAFVIEFF ENSRNOP00000033816/1-1575 KGHKHEDGTQSDSEDPLAKTASVSGAPTEASGEQVRLQRQIRRDPQELLHNQQAFVIEFF :*************** .*:*..:*.. **.***:******:***************:** ENSCPOP00000010322/1-1587 DEDTPRKKRSQSFTHTPPGDPKADKRRGPGSTDRERPGTPARGTAGS-SLGSQRASSLKR XP_004836904.1/1-1583 DEDTPRKKRSQSFTHTPPGDPKADKRRGPGPTDRERPGAPARGVAGS-SSGSQRASSLKR ENSP00000407238/1-1590 DEDTPRKKRSQSFTHSPSGDPKADKRRGPTPADRDRPSVPAPVQAGGRSSGPQRAGSLKR ENSMUSP00000098580/1-1574 DGDTPRKKRSQSFTHTPPADPKADKRRGPGTSDRDRPGVSVR-ATGS-SSGPQRASSLKR ENSRNOP00000033816/1-1575 DEDTPRKKRSQSFTHTPPADPKADKRRVTGAADRERPGVTVR-TTGS-SSGPQRASSLKR * *************:*..******** . .:**:**.... :*. * *.***.**** ENSCPOP00000010322/1-1587 EKTEERLASASLATRTPARPFGSVGRRSRLAQDFMAQCMRESSPATRSSAEKVSPGPPAP XP_004836904.1/1-1583 EKTEERLSSASPAPRALARPFGSVGRRSRLAQDFMAQCMRESSPAARPSPEKVPLDPPAP ENSP00000407238/1-1590 EKTEERLGSPSPASRTPARPFGSVGRRSRLAQDFMAQCLRESSPAARPSPEKVPPVLPAP ENSMUSP00000098580/1-1574 EKTEERLGNTSPVPRASTRSFGSVGRRSRLAQDFMAQCMRDSSPATRPAPEKTPPVLPAP ENSRNOP00000033816/1-1575 EKTEERLGNTSPVPRASTRPFGSVGRRSRLAQDFMAQCMRDSSPATRPGPEKTPPVLPAP *******...* ..*: :*.******************:*:****:*...**.. *** ENSCPOP00000010322/1-1587 LTSCGASPMASPATPPPPAEPQLLKAHRQDEDDSLSDAGTYTIETEAQDREVEEARKMID XP_004836904.1/1-1583 PTRCGASPGASPTPPLPPSEPQLTKGHRQDEDDSLSDAGTYTIETEAQDREVEEARQMID ENSP00000407238/1-1590 LTPHGTSPVGPPTPPPAPTDPQLTKARKQEEDDSLSDAGTYTIETEAQDTEVEEARKMID ENSMUSP00000098580/1-1574 LTPRGASPVTPSTTPPPPTDPQLTKARKQEEDDSLSDAGTYTIETEAQDQEVEEARRMID ENSRNOP00000033816/1-1575 LTPRGASPVTPSSTPPPPTDPQLTKARRQEEDDSLSDAGTYTIETEAQDQEVEEARKMID * *:** ..:.* .*::*** *.::*:******************* ******:*** ENSCPOP00000010322/1-1587 QVFGVLESPELSRVSSATFRPVIRGD----SDGGMAQRMALLQEFASRPLGVNPSLEHQG XP_004836904.1/1-1583 QVFGVLESPELSRVSSATFRPVIRGDRDESNDGGVAQRMALLQEFASRPLGVGPSAEHQG ENSP00000407238/1-1590 QVFGVLESPELSRASSATFRPVIRGDRDESDDGGVAQRMALLQEFASRPLGAAPQAEHQG ENSMUSP00000098580/1-1574 QVFGVFESPELSRVSSATFRPVIRGDKDESSDGGMAQRMALLQEFASRAPGMAPQMEQQS ENSRNOP00000033816/1-1575 QVFGVFESPELSRVSSATFRPVIKGDKDECSDGGMAQRMALLQEFASRTPGMAAQMEQQS *****:*******.*********:** .***:*************. * .. *:*. ENSCPOP00000010322/1-1587 LMVPGCPGGQKWVSRWASLADSYSDPSLAEDSLRHRAGEPEGAPPTRTRRLLPQLPSDRA XP_004836904.1/1-1583 LMVPGCPGGQKWVSRWASLADSYSDPGLSEDGLRHRAGEPEGPLPVRTRRLLPQLPSDRA ENSP00000407238/1-1590 LPVPGSPGGQKWVSRWASLADSYSDPGLTEDGLGRRGGEPEGSLPVRMRRRLPQLPSERA ENSMUSP00000098580/1-1574 LLVPGSPGGQKWVSRWASLADSYSDAGLPEDGPGRRTGEPEGPLPVRTRRLLPQLPSGRA ENSRNOP00000033816/1-1575 LLVPGSPGGQKWVSRWASLADSYTDAGLAEDGPGRRTGEPEGPLPVRTRRLLPQLPSDRA * ***.*****************:*..*.**. :* *****. *.* ** ****** ** ENSCPOP00000010322/1-1587 DSPSGPEATRRNGLGLPEQGIEQPTHLVSQEDLDPDSLSDASGSDGGQGSELGTEQLEDR XP_004836904.1/1-1583 DSPAGLEVTRRSGPGPPEPGIEQASHQVGQEDLDPDSLSDASGSDGGRGPELSVEQQEVR ENSP00000407238/1-1590 DSPAGPESSRRSGPGPPELDSEQPSRLFGQEELDPDSLSDASGSDGGRGPEPGVEPQDSR ENSMUSP00000098580/1-1574 DSPAGLEAARRNGPGPPELGSEPANCLIGQEDLDPDSLSDASGSDGGRGPEPGTERQED- ENSRNOP00000033816/1-1575 DSPAGLEAARRNGPGPPELSGDPANCLIGQEDLDPDSLSDASGSDGGRGPEPGTERQED- ***:* * :**.* * ** . : .. ..**:***************:*.* ..* : ENSCPOP00000010322/1-1587 HRTPQEGLAWAKGRRSPKAPGEPAPVSFYIGDQN-EAVGSRKPLAPPREAEGPRRVTQAS XP_004836904.1/1-1583 RRSPQEGPAWPKGRCSPRGPREPAPVSFFIGN---ESEGLRKPMAAPGEVEGPGRVPQAS ENSP00000407238/1-1590 RRSPQEGPTWSRGRRSPRAPGEPTPASFFIGDQNGDAVLSRKPLAAPGDGEGLGQTAQPS ENSMUSP00000098580/1-1574 -------LAWVRGRRSPRAPGELVPTSFFIGDQNGEATFPKKSFVGPGEVDGPGRVVQTS ENSRNOP00000033816/1-1575 -------LAWVRGRRSPRAPGELAPTSFFIGDQNGEATFPKKSFVAPGEADGPGRVVQTS :* :** **:.* * .*.**:**: :: :*.:. * : :* :. *.* ENSCPOP00000010322/1-1587 PSARDGLYMSSSGRMVIQLHTGCSPEPSSSGPILPQEAPGFVRQESFTKEPASGSPTPGK XP_004836904.1/1-1583 PPARGGLCMSSSEQMVMQMHTG----PSSSSLVPPREALGFVRQESFTKEPASSSAAPNK ENSP00000407238/1-1590 PPARDGVYVSANGRMVIQLRPGRSPEPD--GPAPA-----FLRQESFTKEPASGPPAPGK ENSMUSP00000098580/1-1574 PSARDGLYVSSNGRMVIQLRSGRSPEPD---PAPPKETLTFARQESFTKEPTSGPPAPGK ENSRNOP00000033816/1-1575 PSARDSLYISSNGRMVIQLRSGRSPEPD---PAPPKETLTFARQESFTKEPTSGPPAPGK *.**..: :*:. :**:*::.* *. . * *********:*...:*.* ENSCPOP00000010322/1-1587 LPHIPSHPLLQDLTAVRATRMDLHAQDTHLILKETETALAALEAQLLSKTTDKEDEGGSI XP_004836904.1/1-1583 LPHISSHPLLQDLTAVRAARMDLHTQDTHLILKETETALAALEARLLSKTADEEGEGGRT ENSP00000407238/1-1590 PPHISSHPLLQDLAATRAARMDFHSQDTHLILKETETALAALEARLLSNSVDAECEGGST ENSMUSP00000098580/1-1574 LPHISSHPLLQDLAAARASRLDFHAQDTHLILKETETALAALEARLRSKSAD-ECDGGST ENSRNOP00000033816/1-1575 LPHISSHPLLQDLAAARASRMDFHTQDTHLILKETETALAALEARLRSKSAD-ECEGGST ***.********:*.**:*:*:*:*******************:* *::.* * :** ENSCPOP00000010322/1-1587 PRQPDDSLSGDSDVDTASTISLLSGKNGPSPTTPQPLGPQKERLPSPPVAQDPGAITLGS XP_004836904.1/1-1583 PRPPDDSLSGDSDVDTASTVSLLSGKNGPSPTTPQPAGPQKERLPPPSVAQDPGSAALGS ENSP00000407238/1-1590 PRPPEDALSGDSDVDTASTVSLRSGKSGPSPTTPQPLRAQKEMSPSPPAAQDPGGTALVS ENSMUSP00000098580/1-1574 PRPPEDSLSGDSDVDTASTISLLSGKNGPSPTTPQTPGPQKESPLSPPTVPDPGGATPGS ENSRNOP00000033816/1-1575 PRPPEDSLSGDSDVDTASTISLLSGKNGPSPTTPQTPGPQKESLLSPPAVPDPGVMTPGS ** *:*:************:** ***.********. .*** .*... *** : * ENSCPOP00000010322/1-1587 ARERLSEKQHRSTGPGDLGRGEAARHLAVRRGQGPRGSQDWP-EDRGSNLTHLPRADTGT XP_004836904.1/1-1583 SRERLSEKQHLLTSPADQGRGEPGRHLAARRGHRPRGSLDWA-EERGSNLTHLPNTDIVT ENSP00000407238/1-1590 AREQSSERQHHPLGPTDMGRGEPVRRSAIRRGHRPRGSLDWPSEERGPVLAHLPSSDVMA ENSMUSP00000098580/1-1574 ARERMSERQHRPT-PADLGPGDTSRRAAMRRGHGSRGSLDWPEEERGSGLAHLPSS---- ENSRNOP00000033816/1-1575 ARERLSERQHRPP-PADLGHGDPSRRLAMRRGHGSRGSLDWPEEERGSGLAHLPNS---- :**: **:** * * * *:. *: * ***: .*** **. *:**. *:*** : ENSCPOP00000010322/1-1587 PNHETPETTGAGRPGPRRKPVAP-PSLAAQEEQSRGSTSVQKVQQALTRSNSLSTPRPTR XP_004836904.1/1-1583 PNHETPEATGAGRPGTRRKPVPPSPSLAAREEQSHGSTSVQKVQQALTRSNSLSTPRPTR ENSP00000407238/1-1590 SNHETPEATGAGRLGSRRKPAAPPPSPAAREEQSRSSASSQKGPQALTRSNSLSTPRPTR ENSMUSP00000098580/1-1574 -NHETPEATLAGRQGPRRKPAAPPPSPAAREEQSRSSATAQKVQQALTRSNSLSTPRPTR ENSRNOP00000033816/1-1575 -NHETPEATVSGRQGPRRKPVAPPPSPAAREEQSRSSTTAQKVQQVLTRSNSLSTPRPTR ******:* :** *.****..* ** **:****:.*:: ** *.************** ENSCPOP00000010322/1-1587 ASRLRRARLGDTSDTEVTDSDRGATGNPEPVSRPAAEQAKKLSRLDILAMPRKRAGSFTG XP_004836904.1/1-1583 ASRLRRARLGDTSDTEVTDSDRGAPAHPEPVGRPAAEQAKKLSRLDILAMPRKRAGSFTG ENSP00000407238/1-1590 ASRLRRARLGDASDTEAADGERGSLGNPEPVGRPAAEQAKKLSRLDILAMPRKRAGSFTG ENSMUSP00000098580/1-1574 ASRLRRARLGDASDTEAVDGERGTAANPEPANRAAPEQAKKLTRLDILAMPRKRAGSFTG ENSRNOP00000033816/1-1575 ASRLRRARLGDASDTEAVDGERGTTANPEPVNRAAPEQAKKLTRLDILAMPRKRAGSFTG ***********:****..*.:**: .:***..*.*.******:***************** ENSCPOP00000010322/1-1587 PSDSEAAPARTGFSGRSVDLCCANRKPTMADARVAARKAAATAT-AGSRQPFSRARPGSA XP_004836904.1/1-1583 PSDSEAAPARTGFSGRSVELYCANRKPTVADAHAAARKAAATATSTGSRQPFSRARPGSA ENSP00000407238/1-1590 TSDPEAAPARTSFSGRSVELCCASRKPTMAEARAVSRKAANTATTTGPRQPFSRARSGSA ENSMUSP00000098580/1-1574 PSDSETAPARTGFSGRSAELYSTSRKPTIAEARAAAKKAAATAANTGPRQPFSRARPGSA ENSRNOP00000033816/1-1575 PSDSETTPARTGFSGRSAELYSTSRKPTIAEARAAAKKAAATAANPGPRQPFSRARPGSA .**.*::****.*****.:* .:.****:*:*:..::*** **: .*.********.*** ENSCPOP00000010322/1-1587 RYSSNTRRRQQGSDYTSTSEEEYGSHHSSPKHARSHTSTATQTLRASSVGRVRSRAPGPR XP_004836904.1/1-1583 RYSSNTRRRQQGSDYTSTSEEEYGSHHGSPKHARSHTSTATQTPRAGSASRACSRAPGPR ENSP00000407238/1-1590 RYTSNTRRRQQGSDYTSTSEEEYGSRHGSPKHTRSHTSTATQTPRAGSSSRARSRAPGPR ENSMUSP00000098580/1-1574 RYSSNTRRRQQGSDYTSTSEEEYGSHHSSPKHTRSHASTATQTPRGSSSTRARSQ--GPR ENSRNOP00000033816/1-1575 RYSSSTRRRQQGSDYTSTSEEEYGSHHSSPKHTRSHASTATQTPRGSSSVRARSQ--GPR **:*.********************:*.****:***:****** *..* *. *: *** ENSCPOP00000010322/1-1587 DTDDDEEEPDPYGFIVQTAEIAEIARLSQTLVKDVATLAQEIHDVTADGDPMGSSGLARS XP_004836904.1/1-1583 DTDDDDEEPDPYGFIVQTAEIAEIARLSQTLVKDVAILAREINDVAADGDSLGSAGPTRS ENSP00000407238/1-1590 DTDDDEEEPDPYGFIVQTAEIAEIARLSQTLVKDVAILAQEIHDVAGDGDTLGSSEPAHS ENSMUSP00000098580/1-1574 DTDDDEEEPDPYGFIVQTAEIAEIARLSQTLVKDVAILAREIHDVAGDGDSLGSPGPTRS ENSRNOP00000033816/1-1575 DTDDDEEEPDPYGFIVQTAEIAEIARLSQTLVKDVAILAREIHDVAGDGDSLGSPGPTRS *****:****************************** **:**:**:.***.:**. ::* ENSCPOP00000010322/1-1587 PSLGNMPSTPASTISAREELVQRIPEASLNFQKVPPGALTSR-DLDQNMNNSHEDAFGNK XP_004836904.1/1-1583 PSLGNVPSTPASTISAREELVQRIPEASLNFQKVPPGTLTSQ-DLDQNMNNSHEDALGNK ENSP00000407238/1-1590 ASLSNMPSTPASTISAREELVQRIPEASLNFQKVPPGSLNSR-DFDQNMNDSCEDALANK ENSMUSP00000098580/1-1574 PSLGNVPNTPASTISAREELVQRIPEASLNFQKVPPGSMNSH-NLDQNMNDSRDDALTNK ENSRNOP00000033816/1-1575 PSLGNVPNTPASTISAREELVQRIPEASLNFQKVPPGSMNSHNNLDQNMNDSPEDALANK .**.*:*.*****************************::.*: ::*****:* :**: ** ENSCPOP00000010322/1-1587 TRPRNREEVIFDNLMLNPVSQLSHAIRENTEHLTEKMKILFQNTGRAWEDLEARINAENE XP_004836904.1/1-1583 TRPRNREEVIFDNLMLNPVSQLSHAIRENTEHLTEKMKVLFQNTGRSWEDLEARINAENE ENSP00000407238/1-1590 TRPRNREEVIFDNLMLNPVSQLSQAIRENTEHLAEKMKILFQNTGRAWEDLEARINAENE ENSMUSP00000098580/1-1574 TRPRNREEVIFDNLMLNPVSQLSHAIRENTEHLAEKMKVLFQNTGRAWEDLEARINSENE ENSRNOP00000033816/1-1575 TRPRNREEVIFDNLMLNPVSQLSHAIRENTEHLAEKMKILFQNTGRAWEDLEARINAENE ***********************:*********:****:*******:*********:*** ENSCPOP00000010322/1-1587 VPILKTSNKEISCILKELRRVQKQLEVINAIVDPSISLDLLTGNRTPTGPTAQGLGKG-- XP_004836904.1/1-1583 VPILKTSNKEISCILKELRRVQKQLEVINAIVDPNVNLDLLTGNRAPTGSTTQGLGKG-- ENSP00000407238/1-1590 VPILKTSNKEISSILKELRRVQKQLEVINAIVDPSGSLDLLTGNRSLASSAQPGLGKGRV ENSMUSP00000098580/1-1574 VPILKTSNKEISSILKELRRVQKQLEVINAIVDPSLNLDLLMGNRAPSGSGQPGLGKARP ENSRNOP00000033816/1-1575 VPILKTSNKEISSILKELRRVQKQLEVINAIVDPSMNLDLLMGNRAPAGSVQPGLGKARP ************.*********************. .**** ***: :.. ****. ENSCPOP00000010322/1-1587 ----PTVPAPAESLL---PLRGFPPRATCGPPSLPEPAFLPDAEHFLI XP_004836904.1/1-1583 ----PPVPTLAESLL---PLRGFPPRATCGPPSLAEPAFLPDAESFLI ENSP00000407238/1-1590 AAQSPPSPASAEALLPALPLRNFPQRASCGPPSLPDPTFLPDAERFLI ENSMUSP00000098580/1-1574 AAQSSTSPASVDTLLPALPLRSFPQRANCGPPGLPEPAFLPDAERFLI ENSRNOP00000033816/1-1575 AAQSSASPASVDTLLPAMPLRSFPQRANCGPPGLPEPAFLPDAERFLI .. *: .::** ***.** **.****.*.:*:****** ***