CLUSTAL W(1.81) multiple sequence alignment ENSP00000352575/1-1177 ---MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILP ENSMUSP00000127941/1-1191 MPAMVPGWNHGNITRSKAEELLSRAGKDGSFLVRASESIPRAYALCVLFRNCVYTYRILP ENSRNOP00000040111/1-1190 MPAMVPGWNHGNITRSKAEELLSRAGKDGSFLVRASESIPRAYALCVLFRNCVYTYRILP ENSCPOP00000010214/1-1182 TPTMVSSWNHGNITRSKAEELLSRAGKDGSFLVRASESISRAYALCVLYRNCVYTYRILP XP_004868143.1/1-1191 ---MVPGWNHGNITRSKAEELLSRAGRDGSFLVRASESISRAFALCVLYRNCVYTYRILP **. *****************:*:************.**:*****:*********** ENSP00000352575/1-1177 NEDDKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTV ENSMUSP00000127941/1-1191 NEDDKFTVQASEGVPMRFFTKLDQLIDFYKKENMGLVTHLQYPVPLEEEDAIDEAEEDTV ENSRNOP00000040111/1-1190 NEDDKFTVQASEGVPMRFFTKLDQLIEFYKKENMGLVTHLQFPVPLEEEDAIDEPEEDT- ENSCPOP00000010214/1-1182 NEDDRFTVQASEGVPVRYFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDAGDDPEEDTV XP_004868143.1/1-1191 SEEDKFTVQASEGVPVRYFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDAGDDPEEDT- .*:*:*********.:*:********:**************:********: *:.**** ENSP00000352575/1-1177 ESVVSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLP ENSMUSP00000127941/1-1191 ESVMSPPELPPRNIPMSAGPSEAKDLPLATENPRAPEVTRLSLSETLFQRLQSMDTSGLP ENSRNOP00000040111/1-1190 ESVMSPPELPPRNIPVSAGPCEAKDLPLPTENPRAPEVTRLSLSETLFQRLQSMDTSGLP ENSCPOP00000010214/1-1182 ESVASPPELPPRNIPLSTGPCETKELLGPAENPRAPEASRPSLSETLFQRLQTMDTSGLP XP_004868143.1/1-1191 ESVTSPPELPPRNIPFSAGPCETKELPVPAENLRAPEASRPSLSETLFQRLQTMDTSGLP *** ***********.::...*:*:: . ** **.*.:* ***********:******* ENSP00000352575/1-1177 EEHLKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGQMLRTVPGIGK---- ENSMUSP00000127941/1-1191 EEHLKAIQDYLSTQLLLDSDFLKTGSSNLPHLKKLMSLLCKELHGEVIRTLPSLESLQRL ENSRNOP00000040111/1-1190 EEHLKAIQDYLSTQLMLDSDFLKTGSSNLPHLKKLTSLLCKELHGEVIRTLPSLESLQRL ENSCPOP00000010214/1-1182 EEHLRAIQEYLGTQLALDSEFAKTGSSSLPSLKKLISQLCKELHGEVVRTLPSLESLQRL XP_004868143.1/1-1191 EEHLKAIQEYLSSQLALDSDFVKTGSSSLPHLKKLTSQLCKELHGEVVRTLPSLESLQRL ****:***:**.:** **:* *****.** **** : *****:*:::**:*.: . ENSP00000352575/1-1177 --------VKEEDHVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIP ENSMUSP00000127941/1-1191 FDQQLSPGLRPRPQVPGEASPITMVAKLSQLTSLLSSIEDKVKSLLHEGSESTNRRSLIP ENSRNOP00000040111/1-1190 FDQQLSPGLRPRPQVPGEANPITMVAKLSQLTSLLSSIEDKVKALLHEGSESTNRRSLIP ENSCPOP00000010214/1-1182 FDQQLSPGLRPRPQVPCEASPVTMVAKLSQLTSLLSSIEDKVKALLHEGPESPHWRSLIP XP_004868143.1/1-1191 FDQQLSPGLRPRAQVPCEASPASMVAKLSQLTSLLSSIEDKVKALLHEGPEPPHWRSLIP :: . :** **.* .**:*****************:*****.*..: **** ENSP00000352575/1-1177 PVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKL ENSMUSP00000127941/1-1191 PVTFEVKSESLGIPQKMHLKVDVESGKLIVKKSKDGSEDKFYSHKKILQLIKSQKFLNKL ENSRNOP00000040111/1-1190 PVTFEVKSESLGIPQKMHLKVDVESGKLIIKKSRDGSEDKFYSHKKILQLIKSQKFLNKL ENSCPOP00000010214/1-1182 PVTFEVKAESLGIPQKLQLKVDVESGKLIIKKSKDGSDDKFYSHKKILQLIKSQKFLNKL XP_004868143.1/1-1191 PVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDSSDDKFYSHKKILQLIKSQKFLNKL *******:********::***********:***:*.*:********************** ENSP00000352575/1-1177 VILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAP ENSMUSP00000127941/1-1191 VILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAP ENSRNOP00000040111/1-1190 VILVETEKEKILRKEYVFSDSKKREGFCQLLQQMKNKHSEQSEPDMITIFIGTWNMGNAP ENSCPOP00000010214/1-1182 MILVETEKEKTLRKEYIFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAP XP_004868143.1/1-1191 VILVETEKEKTLRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAP :********* *****:*:**********************.****************** ENSP00000352575/1-1177 PPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTF ENSMUSP00000127941/1-1191 PPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLGEKEWLELLRHSLQEVTSMTF ENSRNOP00000040111/1-1190 PPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLGEKEWLEILRHSLQEVTSMTF ENSCPOP00000010214/1-1182 PPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLGEKEWLEILRHSLREVTSMNF XP_004868143.1/1-1191 PPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLGEKEWLEILRHSLQEVTSMTF ***************************************.******:*:***:*:**:.* ENSP00000352575/1-1177 KTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGF ENSMUSP00000127941/1-1191 KTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGF ENSRNOP00000040111/1-1190 KTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGF ENSCPOP00000010214/1-1182 KPIAVHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGF XP_004868143.1/1-1191 KTVAIHTLWNIRIVVLAKPEHENRISHICTSNVKTGIANTLGNKGAVGVSFMFNGTSLGF *.:*:*************************.***************************** ENSP00000352575/1-1177 VNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTW ENSMUSP00000127941/1-1191 VNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWLGDLNYRVELPTW ENSRNOP00000040111/1-1190 VNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWLGDLNYRVELPTW ENSCPOP00000010214/1-1182 VNSHLTSGSEKKLRRNQNYMNILRFLALGDRKLSSFNITHRFTHLFWLGDLNYRVDLPTW XP_004868143.1/1-1191 VNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWLGDLNYRVDLPTW ******************************:***.************:*******:**** ENSP00000352575/1-1177 EAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYT ENSMUSP00000127941/1-1191 EAEAIIQKIKQQQYSDLLAHDQLLLERKDQKVFLHFEEEEITFAPTYRFERLTRDKYAYT ENSRNOP00000040111/1-1190 EAEAIIQKIKQQQYSDLLAHDQLLLERKEQKVFLHFEEEEITFAPTYRFERLTRDKYAYT ENSCPOP00000010214/1-1182 EAEAIIQKIRQQQYADLLAHDQLLTERKEQRVFLHFEEEEITFAPTYRFERLTRDKYAYT XP_004868143.1/1-1191 EAEAIIHKIRQQQYADLLAHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYT ***:**:**:****:***:***** **::*:***************************** ENSP00000352575/1-1177 KQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFV ENSMUSP00000127941/1-1191 KQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFV ENSRNOP00000040111/1-1190 KQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFV ENSCPOP00000010214/1-1182 KQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFV XP_004868143.1/1-1191 KQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFV ************************************************************ ENSP00000352575/1-1177 SKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELV ENSMUSP00000127941/1-1191 SKNGPGTVDSQGQIEFLACYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELV ENSRNOP00000040111/1-1190 SKNGPGAVDSQGQIEFLACYATLKTKSQTKFYLELHSSCLESFVKSQEGENEEGDEGELV ENSCPOP00000010214/1-1182 SKNGPGTGDSQGQIEFLACYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELV XP_004868143.1/1-1191 SKNGPGTVDSQGQIEFLACYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELV ******: ********* ****************:*******************.***** ENSP00000352575/1-1177 VKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPL ENSMUSP00000127941/1-1191 VRFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLETTEAQHPIYTPL ENSRNOP00000040111/1-1190 VRFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLETTESQLPIYTPL ENSCPOP00000010214/1-1182 VKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPL XP_004868143.1/1-1191 VKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPVYTPL *:**********************************************:**:* *:**** ENSP00000352575/1-1177 THHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTS ENSMUSP00000127941/1-1191 THHGEMTGHFRGEIKLQTSQGKMREKLYDFVKTERDESSGMKCLKNLTSHDPMRQWEPSG ENSRNOP00000040111/1-1190 THHGEMTGHFRGEIKLQTSEGKMREKLYDFVKTERDESSGMKCLKNLTSHDPMRQWEPAG ENSCPOP00000010214/1-1182 THHGEMTGHFRGAIKLQTSQGKKREKLYDFVKTERDEPSGPKCPKSLTIQDPVKQWEPAG XP_004868143.1/1-1191 THIGEMTGHFQGAIKLQTSQGKKREKLYDFVKTERDEPSGPKCLKSLTSHDSMKQWEPAA ** **:****:* ******:** **************.** * *.** :*.::*** :. ENSP00000352575/1-1177 RAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSP--DQQPTAWSYDQPPKDSPLGP ENSMUSP00000127941/1-1191 RVPACGVSSLNEMINPNYIGMGPFGQ--PLHGKSTLSP--DQQLTAWSYDQLPKDSSLGP ENSRNOP00000040111/1-1190 RVPACGISSLNEIINPNYIGMGPFGQ--PLHGKSTLSP--DQQLTAWSYDQLPKDSSLGP ENSCPOP00000010214/1-1182 RASF----GLTDIMNPSYI---PVRQ--PVTAKLPMSPLPDQPLPAWSYDPQPKDPSLGP XP_004868143.1/1-1191 RAPLCSAPSITDIVNPSYIGVGPFGQ--PLHPKLALSPTLDQPFPAWSYDPLPKDSSLGL *.. .:.:::**.*: *. *: * .:** ** .***** ***..** ENSP00000352575/1-1177 CRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPE ENSMUSP00000127941/1-1191 GRGEGPPTPPSQPPLSPKKFSSSTANRGPCPRVQEARPGDLGK--VEALLQEDLLLTKPE ENSRNOP00000040111/1-1190 GRGEGPPTPPSQPPLSPKKFSSSTANRGSCPRVQETRPGDLGK--VEALPQEDLPLTKPE ENSCPOP00000010214/1-1182 GRGDSPPTPPSQPPLSPKKFTSASANRGPCPRVQESRPSEQGKGSTEA-PQEDLLLSKPE XP_004868143.1/1-1191 GRGDSPPTPPSQPPLSPKKLASAMANRGPCPRAQEPRPSELGKGAAEA-LQEDLPLTKPE **:.*****.***:****: .: **** **.**.**.: ** :: **** *:*** ENSP00000352575/1-1177 MFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPG ENSMUSP00000127941/1-1191 MFENPLYGSVSSFPKLVPRKEQESPKMLRKEPPPCPDPGISSPSIVLPKAQEVESVKGTS ENSRNOP00000040111/1-1190 MFENPLYGSVSPFPKLVPRKEQESPKMMRKEPPPCPDPGVSSPSIMLPKAQEVENVKGTS ENSCPOP00000010214/1-1182 MFENPLYGSVSAFPKLVPRKEQESPKMLRKEPTPCPE-----PSISFSKAPEAEGSKGPG XP_004868143.1/1-1191 MFENPLYGSVSTFPKLVPRKEQESPKMLRKEPPPCPEPTAMLPSVLLPKAPEAEGSKGIA *********:*.*** .***:****** ****.***: **: :.** *.: :* . ENSP00000352575/1-1177 KQV------PAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEI ENSMUSP00000127941/1-1191 KQAPVPVLGPTPRIRSFTCSSSAEGRMTSGDKSQGKPKASASSQAPVPVKRPVKPSRSEM ENSRNOP00000040111/1-1190 KQAPVPVFGPTPRIRSFTCSSSAEGRMPSGDKSQGKPKAPASSQAPVPVKRPVKPSRSEM ENSCPOP00000010214/1-1182 KQAPTTFLSPTPRLRSFTCSASTEGKATSGDRGQGKPKGPASSQAPVPAKRPIKPSRSEV XP_004868143.1/1-1191 KQASTPFLSPAPRLRSFTCSASPEPRAAGGDRSQGKPKGPAGSQAPVAAKRPIKPSRSEV **. *:**:******:*.* : ..**:.***** ...*****..***:******: ENSP00000352575/1-1177 NQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ ENSMUSP00000127941/1-1191 SQQTTPIPAPRPPLPVKSPAVLQLQHSKGRDYRDNTELPHHGKHRQEE---GLLGRTAMQ ENSRNOP00000040111/1-1190 SQQTTPIPAPRPPLPVKSPAVLQLQHSKGRDYRDNTELPHHGKHRQEE---SLLGRTAMQ ENSCPOP00000010214/1-1182 SQQSTPTPAPRPPLPVKSPAVLQLQHAKSRDYRDNSELPHHGKHRPEE---GLLGRTAMQ XP_004868143.1/1-1191 SQQSTPTPALRPPLPVKSPAVLQLQHAKGRDYRDNSEFPHHGKHRPEE---GLLGRTTMQ .**:.* *: ************:***:*.******:*:******* ** . ****:** ENSP00000352575/1-1177 - ENSMUSP00000127941/1-1191 - ENSRNOP00000040111/1-1190 - ENSCPOP00000010214/1-1182 - XP_004868143.1/1-1191 Q