CLUSTAL W(1.81) multiple sequence alignment ENSP00000254657/1-1255 MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTGRDSQGSDCDD ENSMUSP00000066620/1-1257 MNGYVDFSPSPTSPTKEPGAPQPTQAVLQEDVDMSSGSSGN---ENCSTGRDSQGSDCDD ENSRNOP00000027507/1-1257 MNGYVDFSPSPTSPTQEPGEPQPTQAVLQEDVDMSSGSSGN---ENCSTGRDSQGSDCDD ENSCPOP00000010189/1-1243 MDGFVEFPPSP---TKEPMEPQAGQASMQEDMDMSSGCSGNEAPENSSTGQDSQGSDF-D XP_004868464.1/1-1228 ------------------MEPGPGLASLQEDVDMGSGSSGNEAPESCSTGQDSQGSDCDD * . . :***:**.**.**: *..***:****** * ENSP00000254657/1-1255 SGKELGMLVEPPDAR---QSPDTFSLMMAKSEHNPSTSGCSSDQSSKVDTHKELIKTLKE ENSMUSP00000066620/1-1257 NGKELRMLVESSNTH--PSPDDAFRLMMTEAEHNPSTSGCSSEQSAKADAHKELIRTLKE ENSRNOP00000027507/1-1257 SGKELRMLVESSNTH--PSPDDTFRLMMTEAEHNPSTSGCSSEQSAKADAHKELIRTLRE ENSCPOP00000010189/1-1243 HRKELGMIVEPPNPQRFPKTPSAFSLMLVEPEPNLSTSGCSSKGSPKADTHKELIRTLRE XP_004868464.1/1-1228 HGKELGMLVEPPDPQ------SAFSLMMTEPEPNLSTSGCSSEQSAKADTHKELIKTLRE *** *:**..:.: .:* **:.:.* * *******. *.*.*:*****:**:* ENSP00000254657/1-1255 LKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSEGHPCGADVPSYTVEE ENSMUSP00000066620/1-1257 LKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSESQPCSVDVPSYSMEQ ENSRNOP00000027507/1-1257 LKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSESQPCSVDVPSYTMEQ ENSCPOP00000010189/1-1243 LKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMSSESQPFSVDVPSYTVEQ XP_004868464.1/1-1228 LKVHLPADKKPKGKASTLATLKYALHSVKQVKANEEYYQLLMSSESQPCGLDVPSYTVAQ **********.**************:*******************.:* . *****:: : ENSP00000254657/1-1255 MESVTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVG ENSMUSP00000066620/1-1257 VEGITSEYIVKNADMFAVAVSLVSGKILYISNQVASIFHCKKDAFSDAKFVEFLAPHDVS ENSRNOP00000027507/1-1257 VEGITSEYIVKNSDMFAVAVSLVSGKILYISNQVAPIFHCKKDAFSDAKFVEFLAPHDVS ENSCPOP00000010189/1-1243 VEGVTSEYMGKNSDMFVVAVSLVSGKILYISSQVASIFHCKQDTFSDAKFVEFLAPHDVS XP_004868464.1/1-1228 VEAVTSEYMGKNADMFAAAVSLATGKILYISSQVASIFHCKRDALSDAKFVEFLAPHDVS :*.:***:: **:***..****.:*******.***.*****:*::**************. ENSP00000254657/1-1255 VFHSFTSPYKLPLWSMCSGADSFTQECMEEKSFFCRVSVRKSHENEIRYHPFRMTPYLVK ENSMUSP00000066620/1-1257 VFHSYTTPYKLPPWSVCSGLDSFTQECMEEKSFFCRVSVGKHHENEIRYQPFRMTPYLVK ENSRNOP00000027507/1-1257 VFHSYTTPYKLPPWSVSSGLDSFTQECMEEKSFFCRVSVGKHHENEIRYQPFRMTPYLVK ENSCPOP00000010189/1-1243 VFHSCTTPCRLPSWSMCSGVDSFTQECMEEKSFFCRVSVGKNHENEICYQPFRMTPYLVK XP_004868464.1/1-1228 VFHSFTTPYKLPAWGVCGGIDSFAQECMEEKSFFCRVSVGKNHENEVCYQPFRMTPYLVK **** *:* :** *.:..* ***:*************** * ****: *:********** ENSP00000254657/1-1255 VRDQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYL ENSMUSP00000066620/1-1257 VQEQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQAVDERAVPLLGYL ENSRNOP00000027507/1-1257 VQEQKGAASQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYL ENSCPOP00000010189/1-1243 VQEPLGAESQLCCLLLAERVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYL XP_004868464.1/1-1228 VQEPLGAESQLCCLLLAEKVHSGYEAPRIPPEKRIFTTTHTPNCLFQDVDERAVPLLGYL *:: ** **********:**************************** ************ ENSP00000254657/1-1255 PQDLIETPVLVQLHPSDRPLMLAIHKKILQSGGQPFDYSPIRFRARNGEYITLDTSWSSF ENSMUSP00000066620/1-1257 PQDLIETPVLVQLHPSDRPLMLAIHKKILQAGGQPFDYSPIRFRTRNGEYITLDTSWSSF ENSRNOP00000027507/1-1257 PQDLIETPVLVQLHPSDRPLMLAIHKKILQASGQPFDYSPIRFRTRNGEYITLDTSWSSF ENSCPOP00000010189/1-1243 PQDLIEKPVLLQLHPSDRPLMLAIHKKILQSGGQPFDYSPLRFRARNGEYITLDSSWSSF XP_004868464.1/1-1228 PQDLIETPVLVQLHPSDRPLMLAIHRKILQSSGQPFDYSPIRFRARNGEYITLDTSWSSF ******.***:**************:****:.********:***:*********:***** ENSP00000254657/1-1255 INPWSRKISFIIGRHKVRVGPLNEDVFAAHPCTEEKALHPSIQELTEQIHRLLLQPVPHS ENSMUSP00000066620/1-1257 INPWSRKISFIIGRHKVRVGPLNEDVFAASPCPEEKTPHPSVQELTEQIHRLLMQPVPHS ENSRNOP00000027507/1-1257 INPWSRKISFIIGRHKVRVGPLNEDVFAASPCPEEKTPHPSVQELTEQIHRLLMQPVPHS ENSCPOP00000010189/1-1243 INPWSRKISFIIGRHKVRVGPLNEDVFAVLPCVEEKALHPNIQELTEQIHRLLLQPVPHS XP_004868464.1/1-1228 VNPWSRKISFIIGRHKVRVAPLNEDVFAAPPCVEEKALHPSVQELTEQIHRLLLQPVPHS :******************.********. ** ***: **.:***********:****** ENSP00000254657/1-1255 GSSGYGSLGSNGSHEHLMSQTSSSDSNGHEDSRRRRAEICKNGNKTKNRSHYSHESGEQK ENSMUSP00000066620/1-1257 GSSGYGSLGSNGSHEHLMSQTSSSDSNGQEESHRRRSGIFKTSGKIQTKSHVSHESGGQK ENSRNOP00000027507/1-1257 GSSGYGSLGSNGSHEHLMSQTSSSDSNGQEESHWRRSGIFKTSGKSQSKSHFSPESGGQK ENSCPOP00000010189/1-1243 GSSGYGSLGSNGSHEQLMSQTSSSDSTGHEEARHRRAEICKNSNKTKTKGQFPHESGKQK XP_004868464.1/1-1228 GSSGYGSLGSNGSHEHLMSQTSSSDSNGHEESHRRRADICKNGNKTKTKSQFAHELGKQK ***************:**********.*:*::: **: * *...* :.:.: . * * ** ENSP00000254657/1-1255 KKSVTEMQTNPPAEKKAVPAMEKDSLG-----VSFPEELACKNQPTCSYQQISCLDSVIR ENSMUSP00000066620/1-1257 EASVAEMQSSPPAQVKAVTTIERDSSGASLPKASFPEELAYKNQPPCSYQQISCLDSVIR ENSRNOP00000027507/1-1257 EASVAEMQSSPPAQVRSVTTMERDSSGASLPKASFPEELTYKSQPPCSYQQISCLDSVIR ENSCPOP00000010189/1-1243 KKSVTELQSSALAQVKAVPVAE-DSSGASLPKIGFPEELACKDQPTCSYQQISCLDGVMR XP_004868464.1/1-1228 RKPITEMQSGALAQVKAVPVTVNDSSGASLPKSSFPEELACKDQPTCSYQQISCLDSVIR . .::*:*:.. *: ::*.. ** * .*****: *.**.**********.*:* ENSP00000254657/1-1255 YLESCNEAATLKRKCEFPANVPALRSSDKRKATVSPGPHAGEAEPPSRVNSRTGVGTHLT ENSMUSP00000066620/1-1257 YLESCSEAATLKRKCEFPANIPS------RKATVSPGLHSGEAARPSKVTSHTEVSAHLS ENSRNOP00000027507/1-1257 YLESCNEAATLKRKCEFPANIPS------RKATVSPGLHSGEAARSSKVTSHTEVSAHLS ENSCPOP00000010189/1-1243 YLESCTEATTLKRKCEFPANIPS------RKATVSPGLHTGEAT--SKVSSHAEVSARLS XP_004868464.1/1-1228 YLESCNEAATLKRKCEFPANIPS------RKATVSRGLHAGEAASPSKVSSHAEVSAHLS *****.**:***********:*: ****** * *:*** *:*.*:: *.::*: ENSP00000254657/1-1255 SLALPGKAESVASLTSQCSYSSTIVHVGDKKPQPELEMVEDAASGPESLDCLAGPALACG ENSMUSP00000066620/1-1257 SLTLPGKAESVVSLTSQCSYSSTIVHVGDKKPQPELETVEDMASGPESLDGAAG-----G ENSRNOP00000027507/1-1257 SLALPGKAESVVSLTSQCSYSSTIVHVGDKKPQPELETVEDVASGPESQDDAAG-----G ENSCPOP00000010189/1-1243 SLALPGKAESVVSLTSQCSYSSTIVHVGDKKLQPELETVEDATSGPESLDCLPG-----G XP_004868464.1/1-1228 SLALPSKAESVVSLTSQCSYSSTIVHVGDKKPQPELETVEDAASGPESLDFLPG-----G **:**.*****.******************* ***** *** :***** * .* * ENSP00000254657/1-1255 LSQEKEPFKKLGLTKEVLAAHTQKEEQSFLQKFKEIRKLSIFQSHCHYYLQERSKGQPSE ENSMUSP00000066620/1-1257 LSQEKGPLQKLGLTKEVLAAHTQREEQGFLQRFREVSRLSALQAHCQNYLQERSRAQASD ENSRNOP00000027507/1-1257 LSQEKGSLQKLGLTKEVLAAHTQREEQGFLQRFREVSRLGALQAHCQNYLQERSRAPASD ENSCPOP00000010189/1-1243 HSQEKGPLQRLGLTKEVLASHTQKEEQSFLQKFREVRRLGILQAHCQHYLQERTRGQSSE XP_004868464.1/1-1228 PSQEKGPLQKLGLTKEVLASHTQKEEQSFLQKFREERRLGVLQAHCQHYLQERSRGQSSK **** .:::*********:***:***.***:*:* :*. :*:**: *****::. .*. ENSP00000254657/1-1255 RTAPGLRNTSGIDSPWKKTGKNRKLKSKRVKPRDSSESTGSGGPVSARPPLVGLNATAWS ENSMUSP00000066620/1-1257 R---GLRNTSGLESSWKKTGKNRKLKSKRVKTRDSSESTGSGGPVSHRPPLMGLNATAWS ENSRNOP00000027507/1-1257 R---GLRNASGIESSWKKTGKNRKLKSKRVKTRDSSESTGSGGPVSHRPPLVGLNATAWS ENSCPOP00000010189/1-1243 RVAPGLRNAAGIDSSWKKTGKNRKLKSKWAKPRDSSESTGSGGPPPPRPPLVGLNATAWS XP_004868464.1/1-1228 CVAPGLRNASGMDSSWKKTSKNRKLKSKRAKPRDSSESTGSGGPPPHRPSFVGLNATAWS ****::*::*.****.******** .*.************ . **.::******** ENSP00000254657/1-1255 PSDTSQSSCPAVPFPAPVPAAYSLPVFPAPGTVAA------PPAPPHASFTVPAVPVDLQ ENSMUSP00000066620/1-1257 PSDTSQSSCPSAPFPTAVP-AYPLPVFQAPGIVSTPGTVVAPPAATHTGFTMPVVPMGTQ ENSRNOP00000027507/1-1257 PSDTSQSSCPSAPFPAPVP-AYPLPVFPAPGIVSTPGTVVAPPAAAHTGFTMPVVPMGTQ ENSCPOP00000010189/1-1243 PSDTSQSSCSAVPFPTPVP-SYSLPVFPAPGIVPAPGAT--PPAVPHASFPVPTVAMGTQ XP_004868464.1/1-1228 PSDTSQSSCPTLPFPAPVA-SYSLPVFPAPGIVSAPGAVAPPPAVPHASFAVPAVAMGTQ *********.: ***:.*. :*.**** *** *.: *** .*:.*.:*.*.:. * ENSP00000254657/1-1255 HQFAVQPPPFPAPLAPVMAFMLPSYSFPSGTPNLPQAFFPSQPQFPSHPTLTSEMASASQ ENSMUSP00000066620/1-1257 PEFAVQPLPFAAPLAPVMAFMLPSYPFPPATPNLPQAFLPSQPHFPAHPTLASEITPASQ ENSRNOP00000027507/1-1257 PEFAVQPLPFAAPLAPVMAFMLPSYPFPPATPNLPQAFFPSQPHFPAHPTLASEITPASQ ENSCPOP00000010189/1-1243 HEFAVQPLPFPAPMAPVVAFMLPSYPFP-ATTSLPQAF------FPGHPTLPSEMTPASQ XP_004868464.1/1-1228 PEFAMQPLPFTAPVAPVMAFVLPSYPFP-ATSSLPQAI------FPGQPTPASEMAPASQ :**:** **.**:***:**:****.** .*..****: **.:** .**::.*** ENSP00000254657/1-1255 PEFPSRTSIPRQPCACPATRATPPS---AMGRASPPLFQSRSSSPLQLNLLQLEEAPEGG ENSMUSP00000066620/1-1257 AEFPSRTSTLRQPCACPV---TPPAGTVALGRASPPLFQSRGSSPLQLNLLQLEEAPEGS ENSRNOP00000027507/1-1257 AEFPSRTSMLRQPCACPV---TPPAGTVALGRASPPLFQSRGSSPLQLNLLQLEEAPESS ENSCPOP00000010189/1-1243 PECPSQTSLPQQPCSCPATPATPPAATLATSRASPPLFQSRGSSPLQLNLLQLEEAPEGS XP_004868464.1/1-1228 PEFPSRTSLPQQLCSRPANPATPLSVTVATGRASPPLFQSRGSSPLQLNLLQLEEAPEGS .* **:** :* *: *. ** : * .**********.****************.. ENSP00000254657/1-1255 TGAMGTTGATETAAVGADCKPGTSRDQQPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNE ENSMUSP00000066620/1-1257 TGAAGTLGTTGTAASGLDCTSGTSRDRQPKAPPTCNEPSDTQNSDAISTSSDLLNLLLGE ENSRNOP00000027507/1-1257 TGAAGTLGTTGTAASGLDCTSGASRDRQPKAPPTCSEPSDTQNSDAISTSSDLLNLLLGE ENSCPOP00000010189/1-1243 TGA------TGTVTAGPDCTP--AHDRQPKAPPTHDEPSDAQNSDALSTSSDLLNLLLSE XP_004868464.1/1-1228 TGA------TGTVTAGPDCTP--ARDRQPKAPPTHDEPSDAQNSDALSASSDLLNLLLNE *** * *.: * **.. ::*:***** * .****:*****:*:**.******.* ENSP00000254657/1-1255 DLCSASG--------SAASESLGSGSLGCDASPSGAGSSDTSHTSKYFGSIDSSENNHKA ENSMUSP00000066620/1-1257 DLCSATGSALSRSGASATSDSLGSSSLGFGTSQSGAGSSDTSHTSKYFGSIDSSENNHKA ENSRNOP00000027507/1-1257 DLCSATGSALSRSGASATSDSLGSSSLGCDTSRSGAGSSDTSHTSKYFGSIDSSENNHKA ENSCPOP00000010189/1-1243 DLCSATGSALSGSGASATSDSLGSSSLGCDASRNGAGSSDTSHTSKYFGSIDSSENNHKA XP_004868464.1/1-1228 DLCSATGSALSGSGASATSDSLGSSSLGCDASRSGAGSSDTSHTSKYFGSIDSSENNHKA *****:* **:*:****.*** .:* .************************** ENSP00000254657/1-1255 KMNTGMEESEHFIKCVLQDPIWLLMADADSSVMMTYQLPSRNLEAVLKEDREKLKLLQKL ENSMUSP00000066620/1-1257 KMIPDTEESEQFIKYVLQDPIWLLMANTDDSIMMTYQLPSRDLQAVLKEDQEKLKLLQRS ENSRNOP00000027507/1-1257 KMITDTEESEQFIKYVLQDPIWLLMANTDDNIMMTYQLPSRDLQAVLKEDQEKLKLLQRS ENSCPOP00000010189/1-1243 KVNADAEESKHLIKYVLQDPIWLLMADTNDSVMMTYQLPSRDLESVLKEDREKLQLLQRS XP_004868464.1/1-1228 KLNTDMEESGHFIKYVLQDPIWLLMAEADDSVRMTYQLPSRDLETVLQEDREKLQLLQKS *: .. *** ::** ***********:::..: ********:*::**:**:***:***: ENSP00000254657/1-1255 QPRFTESQKQELREVHQWMQTGGLPAAIDVAECVYCENKEKGNICIPYEEDIPSLGLSEV ENSMUSP00000066620/1-1257 QPRFTEGQRRELREVHPWVHTGGLPTAIDVTGCVYCESEEKGNICLPYEEDSPSPGLCDT ENSRNOP00000027507/1-1257 QPHFTEGQRRELREVHPWVHTGGLPTAIDVTGCVYCESEEKGNLCLPYEEDSPSLGLCDT ENSCPOP00000010189/1-1243 QPRFTEGQRRELREVHPWVQTGGLPAAIDVAECVYCENEEKGNLCVLYDEDVPSMGLSDA XP_004868464.1/1-1228 QPRFTEAQRRELCEVHAWVQTGGLPAAIDVAACVYCESEEKGSVCVPYEEDVPSLGLSDA **:***.*::** *** *::*****:****: *****.:***.:*: *:** ** **.:. ENSP00000254657/1-1255 SDTKEDENGSPLNHRIEEQT ENSMUSP00000066620/1-1257 SEAKEEEGEQLTGPRIEAQT ENSRNOP00000027507/1-1257 SEAKEEESGQLANPRKEAQT ENSCPOP00000010189/1-1243 LDTKEEEKGHPVGHK-EEQL XP_004868464.1/1-1228 LDTKE-KKGHPLGQEKEKRT ::** : . . * :