CLUSTAL W(1.81) multiple sequence alignment ENSP00000400908/1-1173 -----------MPEP---------------------------------TKKEENEVPAPA ENSCPOP00000010052/1-1177 -----------TPCP---------------------------------LSSAETEAPAPT XP_004845133.1/1-1211 MTALNAERARAQPCRAVTRSAQLWGEAGLGQGTAFCGSRKRPQLGRQWLKPRENEAPAPV ENSMUSP00000112699/1-1127 -----------MPEP---------------------------------TKKEENEVSAPA ENSRNOP00000035289/1-1167 -----------MPEP---------------------------------TKKEENEVPAPA * . *.*..**. ENSP00000400908/1-1173 -PPPEEPSKEKEAGTTPAK-------------------------DWTLVETPP----GEE ENSCPOP00000010052/1-1177 -PPPTEPNTEKDSGSAPAKDEEDVSPPSALPPGLGSRALERKDSEWSLGEAPGGGTGGEE XP_004845133.1/1-1211 PPPPEEPNKEKEAGSGPAKDEEEASPPSALPP------------EWSIGESPGG---GEE ENSMUSP00000112699/1-1127 -PPPE---------------------------------------EWSLGESPAG---GEE ENSRNOP00000035289/1-1167 -PPPEEPNKDKEAGTTPAKEEDEASPPSALPPGLGSRALERKDSEWSLGESPAG---GEE *** :*:: *:* *** ENSP00000400908/1-1173 QAKQNANSQLSILFIEKPQGGTVKVGEDITFIAKVKAEDLLRKPTIKWFKGKWMDLASKA ENSCPOP00000010052/1-1177 QNKQNDSSQQSLLFVEKPQSGTVKVGENITFMAKVKAEDLLRKPTVKWFKGKWMDLASKA XP_004845133.1/1-1211 QDKQNANSQPSILFVEKPQTGTVKVGENITFVAKVKAEDLLRKPTIKWFKGKWMDLASKA ENSMUSP00000112699/1-1127 QDKQNANSQLSTLFVEKPQTGSVKVGANITFVAKVRAEDLLRKPTVKWFKGKWMDLASKA ENSRNOP00000035289/1-1167 QDKQNANSQLSTLFVEKPQTGSVKVGANITFIAKVKAEDLLRKPTVKWFKGKWMDLASKA * *** .** * **:**** *:**** :***:***:*********:************** ENSP00000400908/1-1173 GKHLQLKETFERHSRVYTFEMQIIKAKDNFAGNYRCEVTYKDKFDSCSFDLEVHESTGTT ENSCPOP00000010052/1-1177 GKHLQLKETFERQTRMYTFEMQIIKAKENYAGNYRCEVTYKDKFDSCSFDLEVHESTGTT XP_004845133.1/1-1211 GKHLQLKETFERHSRIYTFEMQIIKAKENYAGNYRCEVTYKDKFDSCSFDLEVHESTGTT ENSMUSP00000112699/1-1127 GKHLQLKETFERQTRVYTFEMQIIKAKENYAGNYRCEVTYKDKFDSCSFDLEVHESTGTT ENSRNOP00000035289/1-1167 GKHLQLKETFERQTRIYTFEMQIIKAKENYAGNYRCEVTYKDKFDSCSFDLEVHESTGTT ************::*:***********:*:****************************** ENSP00000400908/1-1173 PNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPQVDVWELLKNAKPSEYEKIA ENSCPOP00000010052/1-1177 PNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPEVDVWELLKNANPSEYEKIA XP_004845133.1/1-1211 PSIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPEVDVWELLKNANPSEYEKIA ENSMUSP00000112699/1-1127 PNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPEIDVWELLKNANPNEYEKIA ENSRNOP00000035289/1-1167 PNIDIRSAFKRSGEGQEDAGELDFSGLLKRREVKQQEEEPEIDVWELLKNANPNEYEKIA *.**************************************::*********:*.****** ENSP00000400908/1-1173 FQYGITDLRGMLKRLKRMRREEKKSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWY ENSCPOP00000010052/1-1177 FQYGITDLRGMLKRLKRMRRVEKKSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWF XP_004845133.1/1-1211 FQYGITDLRGMLKRLKRMRRVEKKSAAFAKILDPAYQVDKGGRVRFVVELADPKLEVKWY ENSMUSP00000112699/1-1127 FQYGITDLRGMLKRLKRMRRVEKKSAAFAKILDPAYQVDKGGKVRFVVELADPKLEVKWF ENSRNOP00000035289/1-1167 FQYGITDLRGMLKRLKRMRRVEKKSAAFAKILDPAYQIDKGGRVRFVVELADPKLEVKWF ******************** ****************:****:****************: ENSP00000400908/1-1173 KNGQEIRPSTKYIFEHKGCQRILFINNCQMTDDSEYYVTAGDEKCSTELFVR--EPPIMV ENSCPOP00000010052/1-1177 KNGQEIRPSTKYIFEHKGCERIMFINNCSLTDDSEYYVTAGDEKCSTELFVRALEPPIMV XP_004845133.1/1-1211 KNGQEIRPSTKYIFEHKGCERIMFINNCALTDDSEYYVTAGDEKCSTELFVR--EPPIMV ENSMUSP00000112699/1-1127 KNGQEIRPSTKYIFEHKGNERIMFINNCSLTDDSEYYVTAGDEKCSTELFVR--EPPIMV ENSRNOP00000035289/1-1167 KNGQEIRPSTKYIFEHKGNERIMFINNCALTDDSEYYVTAGDEKCSTELFVR--EPPIMV ****************** :**:***** :********************** ****** ENSP00000400908/1-1173 TKQLEDTTAYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYRIRVEGKKHILIIEG ENSCPOP00000010052/1-1177 TKQLEDTNTYCGERVELECEVSEDDANVKWFKNGEEIIPGPKSRYKIKVEGKKHILVIEG XP_004845133.1/1-1211 TKQLEDTNAYCGERVELECEVTEDDANVKWFKNGEEIIPGPKSRYRIKVEGKKHTLIIDG ENSMUSP00000112699/1-1127 TKQLEDMNAYCGERVEMEVEVSEDDANVKWFKNGEEIFPGPKSRYKIKVEGKKHTLIIEG ENSRNOP00000035289/1-1167 TKQLEDMNAYCGERVELEVEVSEDDANVKWFKNGEEIVPGPKSRYRIKVEGKKHTLIIEG ****** .:*******:* **:***************.*******:*:****** *:*:* ENSP00000400908/1-1173 ATKADAAEYSVMTTGGQSSAKLSVDLKPLKILTPLTDQTVNLGKEICLKCEISENIPGKW ENSCPOP00000010052/1-1177 ATKADSAEYSVMTTGGQSTAKLSVDLKPLKIMTPLTDQTVKLGKEICLKCEISENVPGKW XP_004845133.1/1-1211 AAKADSAEYSVMTTGGQSSAKLSVGLRPLKIMTPLTDQTVKLGKEICLKCEISENVPGKW ENSMUSP00000112699/1-1127 ATKADSAEYSAMTTGGQSSAKLSVDLRPLKITTPLTDQTVKLGKEVCLKCEISENVPGKW ENSRNOP00000035289/1-1167 ATKADSAEYSVMTTGGQSSAKLSVDLRPLKITTPLTDQTVKLGKEVCLKCEISENVPGKW *:***:****.*******:*****.*:**** ********:****:*********:**** ENSP00000400908/1-1173 TKNGLPVQESDRLKVVHKGRIHKLVIANALTEDEGDYVFAPDAYNVTLPAKVHVIDPPKI ENSCPOP00000010052/1-1177 TKNGLPVQETDRLKVVHKGRIHKLVIANALPEDEGDYVFTPDAYNIPMPAKVRVIDPPKI XP_004845133.1/1-1211 TKNGLPVQESDRLKVIHKGRIHKLVIANALVEDEGDYVFTPDAYNIPMPAKVRVIDPPKI ENSMUSP00000112699/1-1127 TKNGLPVQEGERLKVVHKGRIHKLVIANALIEDEGEYVFTPDAYNVPLSAKVHVIDPPKI ENSRNOP00000035289/1-1167 TKNGLPVQEGERLKVVHKGRIHKLVIANALIEDEGEYVFTPDAYNVPLSAKVHVIDPPKI ********* :****:************** ****:***:*****:.:.***:******* ENSP00000400908/1-1173 ILDGLDADNTVTVIAGNKLRLEIPISGEPPPKAMWSRGDKAIMEGSGRIRTESYPDSSTL ENSCPOP00000010052/1-1177 ILDGLDADNTVTVVAGNKLRLEIPISGEPPPKALWSRADKAIMEGSGRIRSENYPDSSTL XP_004845133.1/1-1211 ILDGLDADNTVTVIAGNKLRLEIPVTGEPPPKALWSRADKAIMEGSGRIRAENYPDSSTL ENSMUSP00000112699/1-1127 ILDGLDADNTVTVIAGSKLRLEIPVTGEPPPKAIWSRADKAIMEGSGRIRAESYPDSSTL ENSRNOP00000035289/1-1167 ILDGLDADNTVTVIAGSKLRLEIPVTGEPPPKAIWSRADKAIMEGSGRIRAESYPDSSTL *************:**.*******::*******:***.************:*.******* ENSP00000400908/1-1173 VIDIAERDDSGVYHINLKNEAGEAHASIKVKVVDFPDPPVAPTVTEVGDDWCIMNWEPPA ENSCPOP00000010052/1-1177 VIDVAERDDSGVYHINLKNEAGEAHASIKIKVVDIPDPPVAPNVTEVGDDWCVMTWEPPV XP_004845133.1/1-1211 VIDVAERDDSGVYNINLKNEAGEAHASIKIKVVDIPDPPVAPNVTEVGDDWCVMNWEAPA ENSMUSP00000112699/1-1127 VIDVAERDDSGVYNINLKNEAGEAHASIKIKVVDIPDPPVAPNVTEVGDDWCIMNWEPPA ENSRNOP00000035289/1-1167 VIDVAERDDSGVYNINLKNEAGEAHASIKIKVVDIPDPPVAPNVTEVGDDWCIMNWEPPV ***:*********:***************:****:*******.*********:*.**.*. ENSP00000400908/1-1173 YDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISK ENSCPOP00000010052/1-1177 YDGGSPILGYFIERKKKQSSRWMRLNFELCKETTFEPKKMIEGVAYEVRIFAVNAVGISK XP_004845133.1/1-1211 YDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISK ENSMUSP00000112699/1-1127 YDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISK ENSRNOP00000035289/1-1167 YDGGSPILGYFIERKKKQSSRWMRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISK ***************************:***************************:**** ENSP00000400908/1-1173 PSMPSRPFVPLAVTSPPTLLTVDSVTDTTVTMRWRPPDHIGAAGLDGYVLEYCFEGSTSA ENSCPOP00000010052/1-1177 PSMPSKPFVPLAVTSPPTLLAVDSVTDTTVTMKWRPPDQIGAAGLDGYVLEYCFEGS--- XP_004845133.1/1-1211 PSMPSKPFVPLAVTSPPTLLAVDSVTDTTVTMKWRPPDQIGAAGLDGYVLEYCFEGT--- ENSMUSP00000112699/1-1127 PSMPSKPFVPLAVTSPPTLLAVDSVTDSSVTMKWRPPDQIGAAGLDGYVLEYCFEGT--- ENSRNOP00000035289/1-1167 PSMPSKPFVPLAVTSPPTLLAVDSVTDSSVTMKWRPPDQIGAAGLDGYVLEYCFEGSTSA *****:**************:******::***:*****:*****************: ENSP00000400908/1-1173 KQSDENGEAAYDLPAEDWIVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYY ENSCPOP00000010052/1-1177 ---------------DNWITANTDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYY XP_004845133.1/1-1211 ---------------EDWIVANTDLIDKTKFTITGLPTDAKIFVRVKAVNKAGSSEPKYY ENSMUSP00000112699/1-1127 ---------------EDWIVANTDLIDKTKFTINGLPTDAKIFVRVKAINAAGASEPKYY ENSRNOP00000035289/1-1167 KQSNENGEAAYDLPAEDWITANTDLIDKTKFTITGLPTDAKIFVRVKAINAAGASEPKYY ::**.**.**********.**************:* **:****** ENSP00000400908/1-1173 SQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQ ENSCPOP00000010052/1-1177 SQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGQEIDKNQ XP_004845133.1/1-1211 SQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGNEIDKSQ ENSMUSP00000112699/1-1127 SQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGEEIDKNQ ENSRNOP00000035289/1-1167 SQPILVKEIIEPPKIRIPRHLKQTYIRRVGEAVNLVIPFQGKPRPELTWKKDGAEIDKNQ ***************************************************** ****.* ENSP00000400908/1-1173 INIRNSETDTIIFIRKAERSHSGKYDLQVKVDKFVETASIDIQIIDRPGPPQIVKIEDVW ENSCPOP00000010052/1-1177 INIRNSETDTIIFIRKAERSHSGKYDLQVKVEKYVETATIDIRIVDRPGPPQMVKIEDVW XP_004845133.1/1-1211 INIRNSETDTIIFIRKAERSHSGKYDLQVKVDKYVETASIDIQIVDRPGPPQIVKIEDVW ENSMUSP00000112699/1-1127 INIRNSETDTIIFIRKAERSHSGKYDLQVKVDKYVENASIDIQIVDRPGPPQTVTIEDVW ENSRNOP00000035289/1-1167 INIRNSETDTIIFIRKAERSHSGKYDLEVKVDKYVENASIDIQIVAFSGGDRNVTKKEVP ***************************:***:*:**.*:***:*: .* : *. ::* ENSP00000400908/1-1173 GENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTSATITELVIGNEYYFR ENSCPOP00000010052/1-1177 GENVALTWTPPKDDGNTAITGYTIQKADRKSMEWFTVIEHYHRTNATITELVIGNEYYFR XP_004845133.1/1-1211 GENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTNASITELVIGNEYYFR ENSMUSP00000112699/1-1127 GENVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTNATITELVIGNEYYFR ENSRNOP00000035289/1-1167 XXNVALTWTPPKDDGNAAITGYTIQKADKKSMEWFTVIEHYHRTNATITELVIGNEYYFR **************:***********:***************.*:************* ENSP00000400908/1-1173 VFSENMCGLSEDATMTKESAVIARDGKIYKNPVYEDFDFSEAPMFTQPLVNTYAIAGYNA ENSCPOP00000010052/1-1177 VFSENMCGLSEDATMTKESAVIAKDGKIYKNPVYEDFDFTEAPMFTQPLVNTYAVAGYNA XP_004845133.1/1-1211 VFSENMCGLSEDATMTKESAVIAKDGKIYKNPVYEDFDFTEAPMFTQPLVNTFAIAGYNA ENSMUSP00000112699/1-1127 VFAENMCGLSEDATMTKESAVIAKDGKIYKNPVYEDFNFTEAPMFTQPLVNTYAIAGYNA ENSRNOP00000035289/1-1167 VFAENMCGLSEDATMTKESAVIAKDGKIYKNPVYEDFDFTEAPMFTQPLVNTYAIAGYNA **:********************:*************:*:************:*:***** ENSP00000400908/1-1173 TLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND ENSCPOP00000010052/1-1177 TLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNE XP_004845133.1/1-1211 TLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVNN ENSMUSP00000112699/1-1127 TLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND ENSRNOP00000035289/1-1167 TLNCSVRGNPKPKITWMKNKVAIVDDPRYRMFSNQGVCTLEIRKPSPYDGGTYCCKAVND ***********************************************************: ENSP00000400908/1-1173 LGTVEIECKLEVK--VIYQGVNTPG-QPVFLEGQQQVGSPSADSSCKAYLQT ENSCPOP00000010052/1-1177 LGTVEIECKLEVK--VIYQGVNTPG-QPVLLEGQPQDLNSRRN--------- XP_004845133.1/1-1211 LGTVEIECKLEVKGGLSFCRLLLQGVPPNIIDSYLRDLQSSNPDEY------ ENSMUSP00000112699/1-1127 LGTVEIECKLEVK--VIYQGVNTPG-QPVSLEGQQQS--------------- ENSRNOP00000035289/1-1167 LGTVEIECKLEVK-----------G-TPA----------------------- ************* * *