CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000098928/1-1478 MELYPGVSPVGLLLLLLLGQGPSQIHGSSGENTLAWQSQQVFWTLKNFPFPCKPKKLELS ENSRNOP00000057888/1-1178 MESWPGVSLVGLLLLLLLGQGPSQIHGSSGENTS--QPQQVFRTLKNFSFPCKPKKLELS ENSP00000330442/1-1458 MGLRPGIFLLEL--LLLLGQGTPQIHTSPRKSTL--EGQLWPETLKNSPFPCNPNKLGVN ENSCPOP00000009712/1-1462 MGLQPGVLLVG---LLLLGQGITQIHTSSGKSTL--EGQLWPETKKNFPFSCSPKKLGLN XP_004839509.1/1-1450 MAI-----------ATPLVQSLQCVFPHKAADVL-----FQLQTVKNFPFLCNPKKLGVN * * *. :. .. * ** .* *.*:** :. ENSMUSP00000098928/1-1478 VLSESVHSLRPSDIKLVAAIGNPEIPLAPGSGTINMEKPQSIKNQPQDVCMGIMTVLSDI ENSRNOP00000057888/1-1178 VLSKSVHSLRPSDIKLVAAIGNLETPPAPGSGVVNMEKPQSLESELQNVCIGIMTALSDI ENSP00000330442/1-1458 MPSKSVHSLKPSDIKFVAAIGNLEIPPDPGTG--DLEKQDWTER-PQQVCMGVMTVLSDI ENSCPOP00000009712/1-1462 MPSESVHTLTPADIKLIAAIGDMETPPDSGAV--NLDTSERTEKEPWRGCMGMMTVLSDI XP_004839509.1/1-1450 VPSESVHSLTPADIKLIAAIGNMETLPDSGTV--HLEESERIEK-PLSACMGMMTVLSGI : *:***:* *:***::****: * .*: .:: : : *:*:**.**.* ENSMUSP00000098928/1-1478 IRHFSPSVLMPTCSPGKGTAVHTT-AEDLWIQAKELVRRLKDNPQLDFEKDWKLITVFFS ENSRNOP00000057888/1-1178 IRHFNPSVLMPTCSPGKGTAGHTTIAEDLWIQAKELVRHLKDNPELDFEKDWKLITVLFS ENSP00000330442/1-1458 IRYFSPSVPMPVCHTGKRVIPHDG-AEDLWIQAQELVRNMKENLQLDFQFDWKLINVFFS ENSCPOP00000009712/1-1462 ISHFNPSVLLPTCPPWRSAAVRGG-VEELRTQAEELVSSLKKNPQLDFQQDWKLINVFFS XP_004839509.1/1-1450 ISHFNPSVLMPMCPPGNSTAPHNG-VEDLWIQAEELVRSLKQNPQLDFRQDWKLINVFFS * :*.*** :* * . . . : .*:* **:*** :*.* :***. *****.*:** ENSMUSP00000098928/1-1478 NTSQCHLCPSAQQKSHLMRHMEMLWGVLDYLHHEVPRAFVNLVDLSEVLAMDLQHQETGF ENSRNOP00000057888/1-1178 NTSQCHLCSSDQQKRHLMKHMEMLSGVLDYLHREVPRAFVNLVDLSEVLTMAQQHQETGF ENSP00000330442/1-1458 NASQCYLCPSAQQNGLAAGGVDELMGVLDYLQQEVPRAFVNLVDLSEVAEVSRQYHGTWL ENSCPOP00000009712/1-1462 NASLCYLCPSAHENGPLMSNMDKLAGILHYLHQEVPRAFVNLVDLSEVVAMPRWHQGTLL XP_004839509.1/1-1450 NASLCYLCPSDPEDGPL-SDWDKLTGVLHYLHQEVPRAFVNLVDLSEVVAMPRWHQGTWL *:* *:**.* :. : * *:*.**::*************** : :: * : ENSMUSP00000098928/1-1478 S-PAPEVCKCT-ETTTLSKAVMQWSYQEAWEDLLASSKFNKHETFAVVFQPFFDEIEPPL ENSRNOP00000057888/1-1178 S-PAPEICKCSEEITKLSKAVMQWSYQEAWEDLLASSKFNKHETFAVVFQSFFSEVELPL ENSP00000330442/1-1458 S-PAPEPCNCSEETTRLAKVVMQWSYQEAWNSLLASSRYSEQESFTVVFQPFFYETTPSL ENSCPOP00000009712/1-1462 SRPSPEACGCSGETSKLDTVVMQWSYQETWDSLLASSSFNDQESFAVVFQPFFYEVSSPV XP_004839509.1/1-1450 SRPAPGSCGCSGETSKLATVVRQWSYLEAWDRLLASSSFNEQESFAAVFQPFFYEVSPPG * *:* * *: * : * ..* **** *:*: ***** :..:*:*:.***.** * . ENSMUSP00000098928/1-1478 --KRSSPQDPTTLALRIWNSMMEPVGQKDGLLNTAERKTMKCPSEESPYLFTYKNSNYQA ENSRNOP00000057888/1-1178 --ERPSPQDSTTLALRIWNSMMEPVGRKDGTLNEAERKTMKCPSQESPYLFTYRNSNYQA ENSP00000330442/1-1458 HSEDPRLQDSTTLAWHLWNRMMEPAGEKDEPLSVKHGRPMKCPSQESPYLFSYRNSNYLT ENSCPOP00000009712/1-1462 --EEPPSQDPTTLALSLWNNMMKPVGQKDEPFSTIERRPMKCPSQESPYLFTYRNSNYQS XP_004839509.1/1-1450 --EGPQAQDPNTLALSLWNNMMKPVGQKDEPFGAIERRLIKCPSQESPYLFTYRNSNYQS : . **..*** :** **:*.*.** :. . : :****:******:*:**** : ENSMUSP00000098928/1-1478 RRLKPITKLQMKEGSEFTCPDKNPSNSIPTTVHSLRPADIKIIGALGDSLTAGNGAGASP ENSRNOP00000057888/1-1178 RQLKPIGKFQMKEGTKFTCPDKDPSDSIPTTVHRLRPADIKVIGAMGDSLTAGNGAGSSP ENSP00000330442/1-1458 RLQKPQDKLEVREGAEIRCPDKDPSDTVPTSVHRLKPADINVIGALGDSLTAGNGAGSTP ENSCPOP00000009712/1-1462 RLLKRQRQHKEREGTEIRCPDKDPSDSTPTSVHRLKPADIKVIGALGDSLTAGNGAGSRP XP_004839509.1/1-1450 SLLKPQRQPEVREGTETSCPDKSPSNSIPTSVHRLKPADIKVIGALGDSLTAGNGAGSKS * : : :**:: ****.**:: **:** *:****::***:***********: . ENSMUSP00000098928/1-1478 WNILDVLTEYRGLSWSVGGDETIKTVTTLPNILREFNPSLKGFSVGTGKESTSRASFNQA ENSRNOP00000057888/1-1178 GNVLDVLTQYRGLSWSVGGDETIETVTTLANILREFNPSLKGFSVGTGKENTPRASFNQA ENSP00000330442/1-1458 GNVLDVLTQYRGLSWSVGGDENIGTVTTLANILREFNPSLKGFSVGTGKETSPNAFLNQA ENSCPOP00000009712/1-1462 GNILDVLTEYRGLSWSIGGDHNISSVTTLPNILREFNPSLKGFSTGTGKANSVGAFFNQA XP_004839509.1/1-1450 WNLLDVLTQYRGLSWSCGGDQNISTVTTLANILREFNPSLKGFSTGTGKQNDAGAFFNQA *:*****:******* ***..* :****.**************.**** . * :*** ENSMUSP00000098928/1-1478 VAGAKSDGLAGQARKLVDLMKADKTINFQEDWKIITVFIGGNDLCASCSNSTRFSPQNFI ENSRNOP00000057888/1-1178 VAGAKSDGLAAQAKKLVSLMKDDKTQRSQQSDRVLTLCIRKNSMANSDENTARFSPQTFT ENSP00000330442/1-1458 VAGGRAEDLPVQARRLVDLMKNDTRIHFQEDWKIITLFIGGNDLCDFCNDLVHYSPQNFT ENSCPOP00000009712/1-1462 VAGARAGDLIPQARTLVDLMKNHTSINFEEDWKIITVFIGGNDLCDFCSDPVTNSPENFT XP_004839509.1/1-1450 VAGDRAEDLADQARRLVDLMKNDERINFQEDWKIITVFIGGNDLCDFCNDPVRYSPSNFT *** :: .* **: **.*** . . ::. :::*: * *.:. .: . **..* ENSMUSP00000098928/1-1478 DNIKNALDILHAEVPRAFVNMAMVMEITPLRELFNEPTVSCPRNILSRLCPCVLGLGDNS ENSRNOP00000057888/1-1178 DNIKTALDILHAEVPRAFVNMVSVIEITPLRELFNEPKVSCPRMILRSLCPCVLNLGENS ENSP00000330442/1-1458 DNIGKALDILHAEVPRAFVNLVTVLEIVNLRELYQEKKVYCPRMILRSLCPCVLKFDDNS ENSCPOP00000009712/1-1462 DNIRQALDILHAEVPRAFVNMVKVLQIVNLRELYKDSRVSCPRLILRNLCRCVLLPDDNS XP_004839509.1/1-1450 DNIRKALDIFHAEVPRAFVNMVKVLQIVNLRELYKSYRVICPRLFLRSVCPCVLKPADNS *** ****:**********:. *::*. ****::. * *** :* :* *** :** ENSMUSP00000098928/1-1478 EELSSLVQRNRDYQKKTEELINSGRYDTRDNFTVVVQPLFENVSMPRTPEGVPDKSFFAP ENSRNOP00000057888/1-1178 AELAQLVERNRQYQEETGKLIESGRYDTRDDFTVVLQPMFENVVMPRTLEGLPDSSFFAP ENSP00000330442/1-1458 TELATLIEFNKKFQEKTHQLIESGRYDTREDFTVVVQPFFENVDMPKTSEGLPDNSFFAP ENSCPOP00000009712/1-1462 TELESLIDINKKYQERTHQLIESGRYDTREDFTVVLQPFFEKVDIPKTSEGLPDNTFFAP XP_004839509.1/1-1450 AELDSLIDVNKKYQEGTDQLIESGRYDTREDFTVVVQPLFEKVNIPKTSKGFPDKSFFAP ** *:: *:.:*: * :**:*******::****:**:**:* :*:* :*.**.:**** ENSMUSP00000098928/1-1478 DCFHFNAKTHARSAIALWKNMLEPVGHKTRHNNFEIKAPIVCPNQASPFLSTTKNSNLGN ENSRNOP00000057888/1-1178 DCFHFNVKTHARSAIALWKNMLEPVGRKTRHQNFEIKVPIMCPNQTSPFLSTTKNSNLGH ENSP00000330442/1-1458 DCFHFSSKSHSRAASALWNNMLEPVGQKTTRHKFENKINITCPNQVQPFLRTYKNSMQGH ENSCPOP00000009712/1-1462 DCFHFSSKTHARAASALWKNMLEPVGQKTTQNNFENSIDIICPNQAFPYLSTYKNGIEGH XP_004839509.1/1-1450 DCFHFSSKTHARAASALWKNMLEPVGQKATQHNFEIKIDIVCPNEVSPFLRTYKNSIESH *****. *:*:*:* ***:*******:*: :::** . * ***:. *:* * **. .: ENSMUSP00000098928/1-1478 GTWMVCEERAPSASPPTSVHTLRPADIQVVAALGDSLTAGNGISSQEGNLTDVSTQYRGL ENSRNOP00000057888/1-1178 GTSMSCEEKAPSASPPTSVHTLRPADIQVVAALGDSVTAGNGISSQEGDLADVTTQYRGL ENSP00000330442/1-1458 GTWLPCRDRAPSALHPTSVHALRPADIQVVAALGDSLTAGNGIGSKPDDLPDVTTQYRGL ENSCPOP00000009712/1-1462 GTWLTCRERTPSASPPTSVHALRPADVRVVAALGDSLTAGSGIGSKPGDLADVITQYRGL XP_004839509.1/1-1450 GTRLSCKERTPSASPPTSVHALRPADIRVVAALGDSLTAGSGIGSKPGDLPDITTQYRGL ** : *.:::*** *****:*****::********:***.**.*: .:*.*: ****** ENSMUSP00000098928/1-1478 SYSAGGDKTLENVTTLPNILRKFNGNLTGYSVGTGDSSSANAFLNQAVPGAKAENLTSQV ENSRNOP00000057888/1-1178 SYSAGGDKFLENVTTLPNILREFNGNLTGYSVGTGDVNSASAFLNQAVPGAKAENLASQV ENSP00000330442/1-1458 SYSAGGDGSLENVTTLPNILREFNRNLTGYAVGTGDANDTNAFLNQAVPGAKAEDLMSQV ENSCPOP00000009712/1-1462 SYSSGGDGSLMNVTTLPNILREFNSNLTGYAVGTGDASNTNAFLNQAVPGAKAEELMSQV XP_004839509.1/1-1450 SYSSGGDGSLENVTTLSDILLEFNRNLTGYVVGTGDASDANAFLNQAVPGAMAEDLMNQV ***:*** * *****.:** :** ***** ***** ..:.********** **:* .** ENSMUSP00000098928/1-1478 RTLVQKMKSDNRVNFNRDWKVITVMIGASDLCDFCTDSNHYSAANFFDHLQNALDILHKE ENSRNOP00000057888/1-1178 QTLIQKMKNDTRVNFHQDWKVITVMIGASDLCDFCKDSNRYSAANFSDHLRNALDILHKE ENSP00000330442/1-1458 QTLMQKMKDDHRVNFHEDWKVITVLIGGSDLCDYCTDSNLYSAANFVHHLRNALDVLHRE ENSCPOP00000009712/1-1462 KTLVQKMKDDPRINFHEDWKVITVLIGTNDLCNHCTDLDLYSSANFFNHLLNALDILHRE XP_004839509.1/1-1450 QTLVQKMKDDHRIHFHEDWKVITVLIGANDLCHYCTDSILYSADSFLNHLRNALDFLHRE :**:****.* *::*:.*******:** .***..*.* **: .* .** ****.**:* ENSMUSP00000098928/1-1478 VPRALVNLVDFINPSIIREVFLKNPDKCPVNQSSVLCNCVLTPRKDSYELARLEAFTKSY ENSRNOP00000057888/1-1178 VPRALVNLVDFMNPSIIRQVFLKNPDKCPVNQTSVLCNCVLTPGEDSHELARLEAFTKSY ENSP00000330442/1-1458 VPRVLVNLVDFLNPTIMRQVFLGNPDKCPVQQASVLCNCVLTLRENSQELARLEAFSRAY ENSCPOP00000009712/1-1462 VPRALVNLVDFMNPSIMRQVFLGNPDKCPVQQASILCNCVLSLRENSYELARMDALTRAY XP_004839509.1/1-1450 VPRALVNLVDFMNPSVMRQVFLGNPDKCPVQQASTLCNCVLTLRENSHELARLDALTQAY ***.*******:**:::*:*** *******:*:* ******: ::* ****::*::::* ENSMUSP00000098928/1-1478 QSSMLQLVESGRYDTREDFSVVLQPFLLNTKLPVLENGKPDTSFFAPDCIHLNQKFHTQL ENSRNOP00000057888/1-1178 QFSILIAIE-GRKEGRKEVSKILDPVVLMCRLELFQNGNPDTSFFAPDCILLSQKFHTQL ENSP00000330442/1-1458 RSSMRELVGSGRYDTQEDFSVVLQPFFQNIQLPVLADGLPDTSFFAPDCIHPNQKFHSQL ENSCPOP00000009712/1-1462 QSSMRELVESGRYDTREDFSVVLQPFFLNIRLPILEDGRPDTSFFAPDCINPGQKFHSQL XP_004839509.1/1-1450 QSSMHELVESGRYDTHEDFSVVLQPFFLNVVLPVLEDGRPDTSFFAPDCIHPSQKFHSQL : *: : ** : :::.* :*:*.. * :: :* *********** .****:** ENSMUSP00000098928/1-1478 ARALWANMLEPLGKKTDTLDPKGHISLACPTKDQPFLRTFRNSNYKYPTKPAIENWGSDF ENSRNOP00000057888/1-1178 ARALWANMLEPLGKKMDTLDPKELIALACPTKDKPFLRTFRNSNYTYPIKPAIENWGSDF ENSP00000330442/1-1458 ARALWTNMLEPLGSKTETLDLRAEMPITCPTQNEPFLRTPRNSNYTYPIKPAIENWGSDF ENSCPOP00000009712/1-1462 SRALWVNMLEPVGSKTDTLDLTADISLPCPTQEEPFLRTPQNSDYTYPTKPAIENWGSDF XP_004839509.1/1-1450 SRALWVNMLEPLGEKTTTLDLTTDIPLACPTQEKPFLRTPQNSNYTYPTKPAIENWGSDF :****.*****:*.* *** :.:.***:::***** :**:*.** *********** ENSMUSP00000098928/1-1478 LCTEKSPSSQVPTSVHELRPADIKVVAAMGDFLTTATGARPSGYKRLATPWRGLSWSIGG ENSRNOP00000057888/1-1178 LCTEQSPSSKVPTSVHELRPSDIKVVAAMGDFLTTATGARPSESSSLDTPWRGLSWSIGG ENSP00000330442/1-1458 LCTEWKASNSVPTSVHQLRPADIKVVAALGDSLTTAVGARPNNSSDLPTSWRGLSWSIGG ENSCPOP00000009712/1-1462 LCTEWKPSNSVPTSVHKLQPADIKVVAALGDSLTTAVGARASNSSDLLMSWRGLSWSIGG XP_004839509.1/1-1450 SCTEWNPSNSVPTSVHELRPADIKVVAALGDSLTTAMGARPSNSSNLYIPWRGLSWSIGG *** ..*..******:*:*:*******:** **** ***.. . * .********** ENSMUSP00000098928/1-1478 DGKLETHTTLPNILKKFNPSITGFSTGTLDNKAGLNVAEEGARAQDMPAQAKTLVKKMKS ENSRNOP00000057888/1-1178 DGTLETHTTLPNILKKFNPSILGFSTGTLENTAGLNVAEEGARA---------------- ENSP00000330442/1-1458 DGNLETHTTLPNILKKFNPYLLGFSTSTWEGTAGLNVAAEGARARDMPAQAWDLVERMKN ENSCPOP00000009712/1-1462 DGALETHTTLPNILKKFNPSIFGFSTGTWKETAGFNVAVEEARAQDMPAQARDLVEQMKA XP_004839509.1/1-1450 DGALETHTTLPNILKKFNPSIFGFSTGTWEETKGFNVAVEGARARDMPAQARDLIERMKT ** **************** : ****.* . . *:*** * *** ENSMUSP00000098928/1-1478 TPTINLQEDWKLITLLIGNNDLCLYCENPEDNSTKEYVKYIQQALDILYEELPRVFINVV ENSRNOP00000057888/1-1178 ------------------------------------------------------------ ENSP00000330442/1-1458 SPDINLEKDWKLVTLFIGVNDLCHYCENPEAHLATEYVQHIQQALDILSEELPRAFVNVV ENSCPOP00000009712/1-1462 STEINLEMDWKLITLFIGSNDLCHYCDNPENHSAEEYVQHIRQALDILYEELPRAFINVV XP_004839509.1/1-1450 STEINLETDWKLVTLFIGSNDLCQYCENPADHSAEEYVQHIQQALDILYEELPRAFINVV ENSMUSP00000098928/1-1478 EVMELAGLHHVQGGKCAMPLAVQKNCSCLRHSQNLTAMQELKKLNWNLQSGISELSYWHR ENSRNOP00000057888/1-1178 ------------------------------------------------------------ ENSP00000330442/1-1458 EVMELASLYQGQGGKCAM-LAAQNNCTCLRHSQSSLEKQELKKVNWNLQHGISSFSYWHQ ENSCPOP00000009712/1-1462 DIMELAGLHQGQGGHCTALLAAQSTCSCLRHFPSSPVIQELKKVTWNLQSDISRLSYQEK XP_004839509.1/1-1450 EVMELAGLHQGQGGQCAVLLAAQRNCSCLRHFPDSPVMQELKKVNWNLQSGISRLSYQQK ENSMUSP00000098928/1-1478 YMEREDFAVTVQPFFRNTFIPLNEREGLDLTFFSEDCFYFSDRGHAEMAIALWNNMLEPV ENSRNOP00000057888/1-1178 ------------------------------------------------------------ ENSP00000330442/1-1458 YTQREDFAVVVQPFFQNTLTPLNERGDTDLTFFSEDCFHFSDRGHAEMAIALWNNMLEPV ENSCPOP00000009712/1-1462 YTQREDFAVVVQPFFQNTLIPLDKLGSTDPTFFSEDCLHFSERGHAEMAIALWNNMLEPV XP_004839509.1/1-1450 YMQREDFAVVVQPFFQNTFIPLNELGSSSLTFWSEDCLHFSERGHAEMAIALWNNMLEPV ENSMUSP00000098928/1-1478 GWKTSSNNFIYNRTKLKCPSPERPFLYTLRNSQLLPDKAEEPSNALYWAVPVAAIG---- ENSRNOP00000057888/1-1178 ------------------------------------------------------------ ENSP00000330442/1-1458 GRKTTSNNFTHSRAKLKCPSPESPYLYTLRNSRLLPDQAEEAPEVLYWAVPVAAGV---- ENSCPOP00000009712/1-1462 GHKTTFNNFTYNRTKLKCPSTESPYLYTLQNSLSLPVQTEKASGVAPGIVSAAAAGGLLV XP_004839509.1/1-1450 GQKTTFNNFTYSRAKLKCPSPESPYFYTLQNSPLHPDQAAEASSVLYWTVPVAAVGGLMV ENSMUSP00000098928/1-1478 -GLAVGILGVMLWRTVKPVQQEEEEEDTLPNTSVTQDAVSEKRLKAGN ENSRNOP00000057888/1-1178 ------------------------------------------------ ENSP00000330442/1-1458 -GLVVGIIGTVVWRCRRG-GRREDPPMSLRTVAL-------------- ENSCPOP00000009712/1-1462 -GLIVGILAVSLWSSFRR-RQKKSPPESVPVANF-------------- XP_004839509.1/1-1450 GGLMISVLVVSVWRAIGS-HQKKAPPVSRGVSSF--------------