CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000116668/1-1146 MDQTSSTTKIVHITVTNGYDLKGFKGDTPVTFVRAEFNQTVLGDSSKVTVSPEGTAKYNF ENSRNOP00000030551/1-1141 MDQPSSAVRTVNITVTNGYDLKGFKGDTPVTFVRAEFNQAVLGDSSKITVSPEGTAKYNF ENSP00000310829/1-1121 MEQVPSAGRLVQITVTEGYDLKGFKGDTPVTFIRAEFNQVVLGDSAKITVSPEGSAKYNF ENSCPOP00000009588/1-1124 MDQAPSAGRVVQITVTDGYDLKGSKGDSPVTAIRAEFNQVVLGDSAKITVFPDGTAKYNF XP_004846330.1/1-1124 MEQVASVGRVVQITVTDGYDLKGSKGDTPVTIIRAEFNQVVLGDSAKITVSPDGTAKYNF *:* .*. : *:****:****** ***:*** :******.*****:*:** *:*:***** ENSMUSP00000116668/1-1146 TSNIDLSPDGGGALDDLAHKPLFLTVTEVLPKEKKQKDEKTLILGQAVVDLLPLLEGEES ENSRNOP00000030551/1-1141 TCNIDLNPDGGVTVDDLAHKPLFLTVTEVLPREKKQKDEKTLTLGQAVVDLLPLLEGEES ENSP00000310829/1-1121 TSSFEFNPEGGITSDDLAHKPVFLTVTEVLPKEKKQKEEKTLILGQAVVDLLPLLEGQSS ENSCPOP00000009588/1-1124 TSSFEFNPEGGITLDDLAHKPVFLTMTEVLPKEKKQKEEKTLVLGQAVVDLLPLLEGETS XP_004846330.1/1-1124 TSRFEFNPEGGITLDDVAHKPVFLTMTEVLPKEKKQKDEKTLVLGQAVVDLLPLLEGETS *. :::.*:** : **:****:***:*****:*****:**** **************: * ENSMUSP00000116668/1-1146 FETTVPLHPVPGSPLETPLPGSKQCSLDVKVFVAEPLLTPAQVSASNLLKVTLEAAYSVP ENSRNOP00000030551/1-1141 FETTVPLHPVQGSPLETTLPGSKPCSLDVKVFVTEPLLTPAQVAASNLLKVTLEAAYSVP ENSP00000310829/1-1121 FQTTVPLHPVQGSPLETPRSSAKQCSLEVKVLVAEPLLTTAQISGGNLLKVTLEAAYSVP ENSCPOP00000009588/1-1124 FEMMLPLHPVQGSPLETPRPGYKQCSLEVKVFVAEPLLTAAQALGSNLLKVTLEAAYSVP XP_004846330.1/1-1124 LEVIVPLHPMQGSPLETPQPGFKQCSLEVKVFVAEPLLTTAQAAGSNLLKVTLEAAYSVP :: :****: ******. .. * ***:***:*:*****.** ..************** ENSMUSP00000116668/1-1146 ESFIPVGPQQNYMVGLQVPSVGEKDYTMIFKNGNLKLGGEKEPVPRPKKWPIANILAPGA ENSRNOP00000030551/1-1141 ESFMPVGPQQNYMVGLQVPSVGEKDYSMIFKNGNLKLGGEREPVPRPKKWPIANILAPGA ENSP00000310829/1-1121 ESFIPTGPGQNYMVGLQVPSLGEKDYPILFKNGTLKLGGEREPVPRPKKWPIANILAPGA ENSCPOP00000009588/1-1124 ECFNPLGPPQNYLVGLQVPAQGEKDYPILFKNGTLKPGGEREPVPRPKKWPIANILAPGA XP_004846330.1/1-1124 ESFNPLGPPQNYMVGLQVPAHGEKDYPILFKNGTLKLGGEREPVPRPKKWPIANILAPGA *.* * ** ***:******: *****.::****.** ***:******************* ENSMUSP00000116668/1-1146 SNIPDEFIVGGPYEEEEGELNHPEDREFRNQAECTKKRIVWDLESRCFLHPFAVASFQKR ENSRNOP00000030551/1-1141 NNIPDEFIVGGPYEEEEGELNHPEDRELRNQAECLKKRIVWDLESRCFLHPSAVASFQKR ENSP00000310829/1-1121 NNIPDAFIVGGPYEEEEGELNHPEDSEFRNQAECIKKRIIWDLESRCYLDPSAVVSFQKR ENSCPOP00000009588/1-1124 NNIPEAFIEGGPYEEEEGELNHPEDREFRSHAECAKKRIVWDLESRCYLDPPAVSSFQKR XP_004846330.1/1-1124 NNILDAFIVGGPYEEEEGELNHPEDREFRSQAECIKKRIIWDLESRCYLDSHAVSSFQKR .** : ** **************** *:*.:*** ****:*******:*.. ** ***** ENSMUSP00000116668/1-1146 IADCRLWPVEITRVPLVVMPKAKPGK--QIDDENQLSFHGVAYINMVPLLYPGVKKIRGA ENSRNOP00000030551/1-1141 IADCRLWPVEITRVPLIVVPKAKPGKLEKIEDENQLSFHGVAYVNMVPLLYPGVKRIRGA ENSP00000310829/1-1121 IADCRLWPVEITRVPLVTIPKGKAGKTEKTDEEAQLSFHGVAYVNMVPLLYPGVKRIRGA ENSCPOP00000009588/1-1124 IADCRLWPVEITRVPLVNVPKGKAGKVDKNEDESQLSFHGVAYVNMVPLLYPGVRRIRGA XP_004846330.1/1-1124 IADCRLWPVEITRVPLINVPKGKAGKFDKNEDESQLSFHGVAYVNMVPLLYPGVRRIRGA ****************: :**.*.** : ::* *********:**********::**** ENSMUSP00000116668/1-1146 FHVYPYLDGTVFEKTKCLFSLFRDTGHHLVQNNKAGGLNSPLSKPL-SKNLKEEKPGKDK ENSRNOP00000030551/1-1141 FHVYPYLDGTVFEKTKCLFSLFRDTGHHLVHNNKAGGLNSPLSKPL-SKNLKEERTGKDK ENSP00000310829/1-1121 FHVYPYLDSVVHEKTKCLLSLFRDIGHHLIHNNKIGGINSLLSKQAVSKNLKEDKPVKEK ENSCPOP00000009588/1-1124 FHIHPYLDSTVYEKTKCLFSLLRDTGHHLIQNNKVGAVTASLPKSLVPKTPKEDKTGKEK XP_004846330.1/1-1124 FHIYPYLDSTVYEKTKCLFSLFRDAGHHLIQNNKTGAVNSPVLKSVVSKTLKEDRSVKEK **::****..*.******:**:** ****::*** *.:.: : * .*. **::. *:* ENSMUSP00000116668/1-1146 DTEGRPRLGELQAPSIKSQSSDTPLESEAPLSHNLEGQQYIEAGTYIVLEIQLEKALVPK ENSRNOP00000030551/1-1141 DIDGRPRLGELQAPSIKSQSSDTPLESEAPLSHNLEGQQYVEAGTYIVLEIQLDKALVPK ENSP00000310829/1-1121 DIDGRPRPGDVQAPSIKSQSSDTPLEGEPPLSHNPEGQQYVEAGTYIVLEIQLDKALVPK ENSCPOP00000009588/1-1124 DTDGKLKPGEGQVPSVKSQSSDTPVEGEASLSHNPEGQQYLEAGTYIVLEIELDKALVPK XP_004846330.1/1-1124 DIDGKLKPGDMQVSSVKSQSSDTPVEGEPPLSHNLEGQQYLEAGTYIVLEVQLDKALVPR * :*: : *: *..*:********:*.*..**** *****:*********::*:*****: ENSMUSP00000116668/1-1146 RMPEELARRYRVKEMIPPRPPLTRRTGGAQKAVSDYHTQIKSISRAILNEYYRMFGKQGP ENSRNOP00000030551/1-1141 RMPEELAR--RVKDMIPPRPPLTRRTGGAQKAVSDYHSQIKSISRAILNEYHRMFGKHRP ENSP00000310829/1-1121 RMPEELAR--RVKEMIPPRPPLTRRTGGAQKAMSDYHIQIKNISRAILDEYYRMFGKQVA ENSCPOP00000009588/1-1124 RLPEELAG--RVKEMIPPRPPLTRRTGGAQKAVSDYHTQIKNISRAILDEYHKMFGTQAA XP_004846330.1/1-1124 RLPEELAR--RVKEMIPPRPPLTRRTGGAQKAVSDYHTQIKNISRAILDEYHKMFGKQVA *:***** ***:******************:**** ***.******:**::***.: . ENSMUSP00000116668/1-1146 KLESDIDNETMEERKCQLNYELNCSGKYFAFKEQLKHAVVKIVREKYLKTTAFESQEELQ ENSRNOP00000030551/1-1141 KEESDIDNETMEEQKCQLNYELNCSGKYFAFKEQLKHAVVKIVREKYLKTTAFESQEELQ ENSP00000310829/1-1121 KLESDMDSETLEEQKCQLSYELNCSGKYFAFKEQLKHAVVKIVRDKYLKTTSFESQEELQ ENSCPOP00000009588/1-1124 KLGCDIDSETLEEQKCQLNYELNCSGKYFAFKEQLKHAVVKIVREKYLKTTSFESQEELQ XP_004846330.1/1-1124 KLGNDIDSETLEDQKCRLNYELNCSGKYFAFKEQLKHAVVKIVREKYLKTTSFESQEELQ * *:*.**:*::**:*.*************************:******:******** ENSMUSP00000116668/1-1146 TFISELYVFLVDQMHVALNQDLNDKAVPDDVPSSTSTIQTSSEQLRLFAFEAEVNEKFEI ENSRNOP00000030551/1-1141 TFISELYVFLVDQMHVALNQ-----AMPEDAPSSTSTIQTSSEQLRLFAFEAEVDEKFEM ENSP00000310829/1-1121 TFISELYVFLVDQMHVALNQ-----TMPDDVQGTVATIYTSSEQLQLFAFEAEVNENFEM ENSCPOP00000009588/1-1124 TFISELYVFLVDQMHVALNQ-----IMLDDIQGSTVTIPSSNEQLRLFAFEAEVNENFDM XP_004846330.1/1-1124 AFISELYVFLVDQMHVALNQ-----TMPDEVQGSTAAIATSSEQLRLFAFEAEVNEDFDV :******************* : :: .:. :* :*.***:********:*.*:: ENSMUSP00000116668/1-1146 AAMYYEERLVREPQNLENWLDYGAFCLLTEDNIKAQECFRKALSLNESHVDSLLLCGVLA ENSRNOP00000030551/1-1141 AAVYYEERLVREPQNLENWLDYGSFCLLTEDNIKAQECFRKALSLNESHVHSLLLCGVLA ENSP00000310829/1-1121 AAAYYKERLVREPQNLDHWLDYGAFCLLTEDNIKAQECFQKALSLNQSHIHSLLLCGVLA ENSCPOP00000009588/1-1124 ATVYYEERLVREPQNLEHWLDYGAFCLLTEDNIKAQECFRKALSLNENHIHSLLLCGVLA XP_004846330.1/1-1124 AAAHYEERLVREPQNLEHWLDYGAFCLLTEDNIKAQECFRKALSLNESHIHSLLLCGVLA *: :*:**********::*****:***************:******:.*:.********* ENSMUSP00000116668/1-1146 ILLENYEQAEIFFEDATCLEPTNVIAWTLLGLFYEIQNNDIRMEMAFHEAFKQLQARTLQ ENSRNOP00000030551/1-1141 VLLENYEQAEIFFEDATCLEPTNVVAWTLLGLFYEIQNNDIRMEMAFHEAFKQLQARTLQ ENSP00000310829/1-1121 VLLENYEQAEIFFEDATCLEPTNVVAWTLLGLYYEIQNNDIRMEMAFHEASKQLQARMLQ ENSCPOP00000009588/1-1124 VLMENYEQAEIFFEDATCLDPANVVAWTLLGLYYEIQNNDIRMEMAFHEASKQLQAQMFQ XP_004846330.1/1-1124 VLMENYEQAEIFFEDATCLDPTNVVAWTLLGLYYEIQSNDIRMEMAFHEASKQLQAQTFQ :*:****************:*:**:*******:****.************ *****: :* ENSMUSP00000116668/1-1146 TKL---KSTVTIENMEEGVKVEPSFGPWGVVQE-STTAIKTEGLSGMRPQSSHQLSPHTN ENSRNOP00000030551/1-1141 TKL---KSTATVQNIEEGVKTEPSFGPWGITQE-SSTAIKSEGQTGIRPRTSHPLSPRPT ENSP00000310829/1-1121 AQVTKQKSTG-VEDTEERGKRESSLGPWGITNG-SATAIKVEA----------------- ENSCPOP00000009588/1-1124 AQLTKQKSIGTIEDTEEGKKIEPNSTTRGSMKDPSVTILKMEA----------------- XP_004846330.1/1-1124 AQVMKQKCTGTIEDIEEGRKIEANLGTWGTTKDASVTVLKVEA----------------- ::: *. ::: ** * *.. . * : * * :* *. ENSMUSP00000116668/1-1146 MELHPQPQGPNTALSSLDEFLEESPKAQSESQEPMATGQPLEPSLVQRSSNALLKELTSK ENSRNOP00000030551/1-1141 VELHPQPQGPNTALSSLDEFLEESSKAQSDSQEPIITVQPLESSLTQKSSNALLKELTSK ENSP00000310829/1-1121 ------PAGPGAALSILDKFLEESSKLQSDSQEPILTTQTWDPSISQKPSNTFIKEIPTK ENSCPOP00000009588/1-1124 ------PQGPGAVFSTVEEVPEDSPKLQSESQEPLMTGQYQDISIGPKLSSMGFKELPAK XP_004846330.1/1-1124 ------PPGPAAVFSTVDDILEDSPKLQSESKEPILTTQYQDSSVGPKLSSMAFKEIPAK * ** :.:* ::.. *:*.* **:*:**: * * : *: : *. :**:.:* ENSMUSP00000116668/1-1146 KDISKCQDSSAFSPPTQHV-IAQPPVTIFMETIRFLMKVNAVQFVHRVLAHELLCPQGGP ENSRNOP00000030551/1-1141 KETSKCQDSSAFFSPT-HQAIPQPPVTIFMETIRFLMKVNAVQFVHRVLAHELLCPQGGP ENSP00000310829/1-1121 KEASKCQDSSALLHPGLHYGVSQT-TTIFMETIHFLMKVKAVQYVHRVLAHELLCPQGGP ENSCPOP00000009588/1-1124 KEASKCQDPAPFPHAAPHLGVSQTPHSIFMETIRFLMKVNAVQYVHRVLAHELLCPQGGP XP_004846330.1/1-1124 KEASKCQDPAPFLHPTPHYGISQTPVTIFMETIRFLMKVNAVQYVHRVLAHELLCPQGGP *: *****.:.: . * :.*. :******:*****:***:**************** ENSMUSP00000116668/1-1146 SCEYYLVLAQTHLLKKDFAKTEEYLQQAAQMDYLNPNVWGVKGHLYFLSGNHAEAKECYE ENSRNOP00000030551/1-1141 SCEYYLVLAQTHLLKKDFAKTEEYLQQAAQMDYLNPNVWGVKGHLYFLSGNHAEAKECYE ENSP00000310829/1-1121 SCEYYLVLAQTHILKKNFAKAEEYLQQAAQMDYLNPNVWGLKGHLYFLSGNHSEAKACYE ENSCPOP00000009588/1-1124 SCEYFLVLAQTHLLKKDFAKAEEYLQQAAQMDYLNPDVWGLKGHLCFLSGNHTEAKACYE XP_004846330.1/1-1124 SCEYYLVLAKTHLLKKDFAKAEEYLQEAAQMDYLNPNVWGLKGHLCFLSGNHTEAKACYE ****:****:**:***:***:*****:*********:***:**** ******:*** *** ENSMUSP00000116668/1-1146 RTISFVVDASEMHFIFLRLGHIYLEEKEYENAKRTYMHACKRSPSCLTWLGLGIACYRLE ENSRNOP00000030551/1-1141 RTVSFVVDASEMHFIFLRLGHIYLEEKEYDNAKRTYMQACKRSPSCLTWLGLGIACYRLE ENSP00000310829/1-1121 RTISFVVDASEMHFIFLRLGLIYLEEKEYEKAKKTYMQACKRSPSCLTWLGLGIACYRLE ENSCPOP00000009588/1-1124 RTVSFVVDASEMHFILLRLGLIYLEEKEYEKAKKIYLRACKRSPSCLTWLGLGIACYRLI XP_004846330.1/1-1124 RTVSFVVDASEMHFIFLRLGLIYLVEKEYEKAKKTYLQACKRSPSCLTWLGLGIACYRLD **:************:**** *** ****::**: *::********************* ENSMUSP00000116668/1-1146 ELTEAEDALSEANALNNCNAEVWAYLALVCLKVGRQLEAEQAYKYTIKLKLKDQALLEEI ENSRNOP00000030551/1-1141 ELTEAEDALSEANALNNCNAEVWAYLALVCLKVGRQLEAEQAYKYTVKLKLKDQALLEEI ENSP00000310829/1-1121 ELTEAEDALSEANALNNYNAEVWAYLALVCLKVGRQLEAEQAYKYMIKLKLKDEALLAEI ENSCPOP00000009588/1-1124 SFFQSKLILEETNALNNCNAEVWAYLALVCLKAGRQLEAEQAYKYTVKLKLKDEALLAEI XP_004846330.1/1-1124 ELTEAEDALSEANALNNYNAEVWAYLALVCLKAGRQLEAEQAYKYTVKLKLKDEALLAEI .: ::: *.*:***** **************.************ :******:*** ** ENSMUSP00000116668/1-1146 HTVQEMVGFGNPSF ENSRNOP00000030551/1-1141 HSVQEMVGFGNPSF ENSP00000310829/1-1121 HTLQETVGFGNPSF ENSCPOP00000009588/1-1124 HMVQEMVGFGDPSF XP_004846330.1/1-1124 RMVQEMVGFGNPSF : :** ****:***