CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000124909/1-1306 MESPSCIQDEPFPHPLEPEPSAPAQPGATKPGDKRFRLWYVGGSCLDRRTTLPMLPWLMA ENSRNOP00000012600/1-1308 MESPSCIQDEPFPHPLEPEPIALAQPGATKPGDKRFRLWYVGGSCLDRRTTLPMLPWLMA ENSP00000366863/1-1298 MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMA ENSCPOP00000009567/1-1014 ----------------------------GQPG---------------------------- XP_004845307.1/1-1237 MEPPSCIQNEPFPHPLEPEPSAPGQLGLGKPGDKRFRLCYVGGSCLDRRTTLPMLPWLMA :*. ENSMUSP00000124909/1-1306 EIRRRSQKPDAGGCGAPAAREVILVLSAPFLRCVPAPGAGVGGGAGSGAVQPNTGVFIFE ENSRNOP00000012600/1-1308 EIRRRSLKPEAGGCGAPAAREVLLVLSAPFLRCVPAPGVGVGGGAGSGAVQPNTGVFIFE ENSP00000366863/1-1298 EIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFE ENSCPOP00000009567/1-1014 ------------------------------------------------------------ XP_004845307.1/1-1237 EIRRRSQKPEAGGCGAPAAREVLLVLSAPFLRCVPAPGSGGTGGAGPAATQPNPAVFIFE ENSMUSP00000124909/1-1306 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPNQVPDVISSIRQLSKA ENSRNOP00000012600/1-1308 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPNQVPDVISSIRQLSKA ENSP00000366863/1-1298 HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKA ENSCPOP00000009567/1-1014 ------------------------------------------------------------ XP_004845307.1/1-1237 HKAQHISRFIHNSQDLTYFAYLIKAQPDDPESQMACHVFRATDPNQVPDVISSIRQLSKA ENSMUSP00000124909/1-1306 AMKEDSKPSKDNEDAFYNSQKFEVLYCGRVIVTHKKAPSSLIDDCKDKFSLHEQQRLKLQ ENSRNOP00000012600/1-1308 AMKEDAKPSKDNEDAFYNSQKFEVLYCGRVIVTHKKAPSSLIDDCKDKFSLHEQQRLKLQ ENSP00000366863/1-1298 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQ ENSCPOP00000009567/1-1014 ------------------------------------------------------------ XP_004845307.1/1-1237 AMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVAHKVAQSSLIDDCIEKFSLHEQQRLRLQ ENSMUSP00000124909/1-1306 GE-RGGDP--GDEMGVLEVESPVSPDDSLP---EKADGTVNSPRALPSLASLPALASQPA ENSRNOP00000012600/1-1308 GE-RGGDPGDGDEMGVLEAESPVSPDDGLP---EKPDGLVNCPRALPSLASLPALASQPA ENSP00000366863/1-1298 GEQRGPDP--GEDLADLEVVVPGSPGDCLP---EEADGTDTHL-------GLPAGASQPA ENSCPOP00000009567/1-1014 ------------------------------------------------------------ XP_004845307.1/1-1237 GE-RAADP--GEELV-LEGEALGSPRDSLPEEEEEEEAENSHP-------ALPALASQPV ENSMUSP00000124909/1-1306 LASSRVCFPERILEDCGFDEQQEFRSRCSSVTGVMQKKVHENNQKTQPRRRHASAPSHVQ ENSRNOP00000012600/1-1308 LASSRVCFPERILEDCGFDEQQEFRSRCSSVTGVMQKKVPSNNQKTQPRRRHASAPSHVQ ENSP00000366863/1-1298 LTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGV-QRRVHEGSQKSQPRRRHASAPSHVQ ENSCPOP00000009567/1-1014 PAGARVCVPERIVEDCGGAEQQRFRSRCSSVAGALQRRVHDGSQKPQARRRHASAPSHVQ XP_004845307.1/1-1237 PSSARVCFPERILEDCGFDEQQEFRSRCSSVTGVLQRKVHENGQKPQPRRRHASAPSHVQ :.:***.****:**.* ***.********:*. *::* ...**.*.************ ENSMUSP00000124909/1-1306 PSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPE ENSRNOP00000012600/1-1308 PSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESLE ENSP00000366863/1-1298 PSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPE ENSCPOP00000009567/1-1014 PSDAEQNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPE XP_004845307.1/1-1237 PSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPE ***:*:**************************************************** * ENSMUSP00000124909/1-1306 PGLSQYICYVFQCANESLVDEVMLTLKQAFSTAAALQSAKTQIKLCETCPMHSLHKLCER ENSRNOP00000012600/1-1308 PGLSQYICYVFQCANESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCER ENSP00000366863/1-1298 PGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCER ENSCPOP00000009567/1-1014 PGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCER XP_004845307.1/1-1237 PGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCER **************.********************************:************ ENSMUSP00000124909/1-1306 IEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPISDQEENELVILHLRQLCEAKQR ENSRNOP00000012600/1-1308 IEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPISDQEENELVILHLRQLCEAKQK ENSP00000366863/1-1298 IEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQK ENSCPOP00000009567/1-1014 IEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPISDQEENELVILHLRQLCEAKQK XP_004845307.1/1-1237 IEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPISDQEENELVILHLRQLCEAKQK *************************************:*********************: ENSMUSP00000124909/1-1306 THVHIGEGPAIISNSTIPENVTSGGRFKLDVLKNKAKRSLTSSLENIFSRGANRMRGRLG ENSRNOP00000012600/1-1308 THVHIGEGQAIISNSTIPENSTSGGRFKLDVLKNKAKRSLTSSLENIFSRGANRMRGRLG ENSP00000366863/1-1298 THVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLG ENSCPOP00000009567/1-1014 THVHIGEGPLTVSNNTVPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLG XP_004845307.1/1-1237 THVHIGDGPLTISNSAVPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLG ******:* :**.::*** **.******:***************************** ENSMUSP00000124909/1-1306 SMDSFERANSLASEKDFSPGDSPPGTPPASPLSSAWHAFPEEDSDSPQFRRRAHTFSHPP ENSRNOP00000012600/1-1308 SVDSFERSNSLASEKDFSPGGSPP-TPPASPLSSAWHTFPEEDSDSPQFRRRAHTFSHPP ENSP00000366863/1-1298 SVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPP ENSCPOP00000009567/1-1014 SVDSFERSNSVASEKDYSPGDSPPGTPPASPLSSAWQVFPEEDSDSPQFRRRAHTFSHPP XP_004845307.1/1-1237 SVDSFERSNSLASEKDYSPGDSPPGTPPASPLSSAWQAFPEEDSDSPQFRRRAHTFSHPP *:*****:**:*****:***.*** ****** ****:.********************** ENSMUSP00000124909/1-1306 SSSRRKLNLQDGKAHGLRSPLLRQSSSEQCSIVPSARRMYKESNSSCSLPSLHTSFSAPS ENSRNOP00000012600/1-1308 SSSRRKLNLQDGKAHGLRSPLLRQNSSEQCSVLPSARRMCKESNSSSSLPSLHTSFSAPS ENSP00000366863/1-1298 SSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPS ENSCPOP00000009567/1-1014 SSSKRKLNLQDLRA-GVRSPLLRQSSSEQCSLLPSVRRMHKEYNSSSSLPSLHTSSSVPS XP_004845307.1/1-1237 SSSKRKLNLQDLRAHGVRSPLLRQSSSEQC------------------------------ **::******* :* *:*******.***** ENSMUSP00000124909/1-1306 FTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLNAGGTPVTP ENSRNOP00000012600/1-1308 FTASSFLKSFYQSSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSAGGTPVTP ENSP00000366863/1-1298 FTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTP ENSCPOP00000009567/1-1014 FSAPSFLKSFYQNSGRLSPQYEHEIRQDTASESSDGEGRKRTSSTCSNESLNAGGTPVTP XP_004845307.1/1-1237 ---------------------------------SDGEGRKRTSSTCSNESLSVGGTPVIP ******************..***.* * ENSMUSP00000124909/1-1306 RRVSWRQRIFLRVASPVNKSPSAMQQQKDGLDRTELLPLSPLSPTMEEEPLIIFLSGDED ENSRNOP00000012600/1-1308 RRISWRQRIFLRVASPVNKSPSAMQQQKDGLDRTELLPLSPLSPTMEEEPLVIFLSGDED ENSP00000366863/1-1298 RRISWRQRIFLRVASPMNKSPSAMQQQ-DGLDRNELLPLSPLSPTMEEEPLVVFLSGEDD ENSCPOP00000009567/1-1014 RRISWRQRIFLRVASPMNKSPSAMQHQ-DGLDSNELLPLSPLAPTMEEEPLVIFLSSDDD XP_004845307.1/1-1237 RRISWRQRIFLRVASPMNKSPSAMQHP-DGLDRNELLPLSPLAPTMEEEPLVIFLSSDDD **:*************:********: **** .********:********::***.::* ENSMUSP00000124909/1-1306 TEKVEEKKKSKELKSLWKKAIHQQILLLRMEKENQKL-EARRDELQSRKVKLDYEEVGTC ENSRNOP00000012600/1-1308 TEKVEEKKKSKEIKSLWKKAIHQQILLLRMEKENQKLEEARRDELQSRKVKLDYEEVGTC ENSP00000366863/1-1298 PEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKL-EASRDELQSRKVKLDYEEVGAC ENSCPOP00000009567/1-1014 SEKVEEKKKSKELKSLWKKAIHQQILLLRMEKENQKL-EARRDELQSRKVKLDYEEVGVC XP_004845307.1/1-1237 PGKVEEKKKSKELKSLWKKAIHQQILLLRMEKENQKL-EARRDELQSRKVKLDYEEVGVC . *:**:*****::***:******************* ** *****************.* ENSMUSP00000124909/1-1306 QKEILIAWDKKLLNCRTKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKH ENSRNOP00000012600/1-1308 QKEVLIAWDKKLLNCRTKIRCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLRHRLPNKH ENSP00000366863/1-1298 QKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQ ENSCPOP00000009567/1-1014 QKEVLITWDKKLLNCRAKIRCDMEDMHSVLKEGVPKSRRGEIWQFLALQYRLRHRLPNKH XP_004845307.1/1-1237 QKEVLITWDKKLLNCRAKIRCDMEDIHTTLKEGVPKSRRGEIWQFLALQYRLRHRLPNKH ***:**:*********:********:*: ******************************: ENSMUSP00000124909/1-1306 QPPDTSYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGAGQLSLFNLLKAYSLLDKEV ENSRNOP00000012600/1-1308 QPPDTSYKELLKQLTAQQHAILVDLGRTFPTQPYFSVQLGAGQLSLFNLLKAYSLLDKEV ENSP00000366863/1-1298 QPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEV ENSCPOP00000009567/1-1014 QPPDTSYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGAGQLSLFNLLKAYSLLDKEV XP_004845307.1/1-1237 QPPDTSYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGAGQLSLFNLLKAYSLLDKEV **** **************************:********.******************* ENSMUSP00000124909/1-1306 GYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDY ENSRNOP00000012600/1-1308 GYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDY ENSP00000366863/1-1298 GYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDY ENSCPOP00000009567/1-1014 GYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMTSLQIQMYQLSRLLHDY XP_004845307.1/1-1237 GYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMTSLQIQMYQLSRLLHDY ******************************************* **************** ENSMUSP00000124909/1-1306 HRELYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLS ENSRNOP00000012600/1-1308 HRDLYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLS ENSP00000366863/1-1298 HRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLS ENSCPOP00000009567/1-1014 HRELYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLS XP_004845307.1/1-1237 HRELYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLS **:****************************.**************************** ENSMUSP00000124909/1-1306 SQEALIMECENFENIVEFLKSTLPDMNTTEMEKIITQVFEMDISKQLHAYEVEYHVLQDE ENSRNOP00000012600/1-1308 SQEALVMECENFENIVEFLKSTLPDMNTTEMEKIITQVFEMDISKQLHAYEVEYHVLQDE ENSP00000366863/1-1298 SQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDE ENSCPOP00000009567/1-1014 SQETLIMECENFENIVEFLKSKLPDMNTSETEKIINQVFEMDISKQLHAYEVEYHVLQDE XP_004845307.1/1-1237 SQETLIMQCENFESIVEFLKSRLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDE ***:*:*:**.**.******. ******:* ****.************************ ENSMUSP00000124909/1-1306 LLESSYACEDNESLEKLERANNQLKRQNMDLLEKLQVAHAKIQALESNLETLLTRETKMK ENSRNOP00000012600/1-1308 LLESSYACEDNESLEKLERANNQLKRQNMDLLEKLQVAHAKIQALESNLETLLTRETKMK ENSP00000366863/1-1298 LQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMK ENSCPOP00000009567/1-1014 LQESSYACEDNESLEKLERANSQLKRQNMDLLEKLQVAHAKIQALESNLENLLTRETKMK XP_004845307.1/1-1237 LQESSYACEDNEPLEKLERANSQLKRQNMDLLEKLQVAHAKIQSLESNLENLLTRETKMK * ****:***.*.********.*****************:***:******.********* ENSMUSP00000124909/1-1306 ALIRTLEQDKMAYQKTVEQIRKLLPADALANCELLLKDLTHPTNDKAKAGNKP ENSRNOP00000012600/1-1308 ALIRTLEQDKMAYQKTVEQIRKLLPADALANCELLLKDLSYPTNDKAKAGNKP ENSP00000366863/1-1298 SLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP ENSCPOP00000009567/1-1014 TLIRTLEQEKAVYQKTVEQIRKLLPADALANCESLLRELNCNPNNKAKTGNKP XP_004845307.1/1-1237 TLIRTLEQEKMAYQKTVEQIQKLLPADALANCESLLRELNCNPNNKAKTGNKP :*******:* .*******::********.**: **::*. .*:*** ****