CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000048709/1-1420 MLLPSDVARLVLGYLQQENLTSTCQTFILESSNLKEYAEHCTDEGFIPACLLSLFGKNLT ENSRNOP00000047149/1-1415 MLLPSDVARLVLGYLQQENLTSTCQTFILESSNLKEYAEHCTDEGFIPACLLSLFGKNLT ENSP00000278612/1-1427 MLLPSDVARLVLGYLQQENLISTCQTFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLT ENSCPOP00000009449/1-1420 IFLCSTTCCFLLGYLQQENLTSTCQTFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLT XP_004856570.1/1-1422 MLLPSDVARLVLGYLQQENLTSTCQTFILESSDLKEYAEHCTDEGFIPACLLSLFGKNLT ::* * .. ::********* ***********:*************************** ENSMUSP00000048709/1-1420 TILNEYVAMKAKETSNDVPTIMSSLWKKLDHTLSQIRSMHSSPGFAAHQRARTRNGIAEI ENSRNOP00000047149/1-1415 TILNEYVAMKAKETSNDVPTIMSSLWKKLDHTLSQIRSMQSSPGFAAHQRARTRNGIAEI ENSP00000278612/1-1427 TILNEYVAMKTKETSNNVPAIMSSLWKKLDHTLSQIRSMQSSPRFAGSQRARTRTGIAEI ENSCPOP00000009449/1-1420 TILNEYVAMKAKETSNDVPAIMSSLWKKLDHTLSQIRSMQSSPGLAASQRVRTRNGIAEI XP_004856570.1/1-1422 TILNEYVAMKAKETSNDVPAILSSLWKKLDHTLSQIRSMQSSPGLAANQRVRTRNGIAEI **********:*****:**:*:*****************:*** :*. **.***.***** ENSMUSP00000048709/1-1420 KRQRWLASQAAPVSSELLVLPYASGQFTTSPLVATQAVKPTGPISTPVRSNIVVVNQSQP ENSRNOP00000047149/1-1415 KRQRWLASQAAPVSSELLVLPYASGQFTTSPLAATQTIKPTGQISTPVRSNIVVVNHSQT ENSP00000278612/1-1427 KRQRKLASQTAPASAELLTLPYLSGQFTTPPSTGTQVTRPSGQISDPSRSYFVVVNHSQS ENSCPOP00000009449/1-1420 KRQRRLASQAAPVSSDLLVLPYVSAQFTTAPLTAAQPVQPTGQISAPMRSNFVVVNHSQS XP_004856570.1/1-1422 KRQRRLASQAAPVSSELLILPYVSAQFTTAPLTATQPVQPAGQISTPMRSNFVVVNHSQS **** ****:**.*::** *** *.****.* ..:* :*:* ** * ** :****:**. ENSMUSP00000048709/1-1420 QSTVTNTAGESLNIIPGPQERKTQTSLMSPGRRKSESQKKSLTSSGPHSS-RNFQDPNAF ENSRNOP00000047149/1-1415 QNTVTNTAGESLNIIPGPQERKTQTSLMSPGRRKSESQKKSLPSSGAHSS-RNLQDPNAF ENSP00000278612/1-1427 QDTV--TTGEALNVIPGAQEKKAHASLMSPGRRKSESQRKSTTLSGPHSTIRNFQDPNAF ENSCPOP00000009449/1-1420 QDTV--TTGEPLNIIPGPQEKKSHASLMSPGRRKSESQRKSITLSGPHSTIRNFQDLNAF XP_004856570.1/1-1422 QETV--TTGESLNIIPGTQEKKSHASLMSPGRRKSESQRKSITLSGPHSTIRNFQDLNAF *.** *:**.**:***.**:*:::*************:** . **.**: **:** *** ENSMUSP00000048709/1-1420 AVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDSSVAQVPKQTDSNPTEPETSIDEL ENSRNOP00000047149/1-1415 AVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDSNIAQVPKQTESSLTEPETSIDEL ENSP00000278612/1-1427 AVEKQMVIENAREKILSNKSLQEKLAENINKFLTSDNNIAQVPKQTDNNPTEPETSIDEF ENSCPOP00000009449/1-1420 AVEKQMVIENAREKILNNKSLQEKLAENINKFLTSDNSIAQVPKQTDSNPAEPEASIDEL XP_004856570.1/1-1422 TVEKQMVIENAREKILNNKSLQEKLAENINKFLTSDNNIVQVPKQTDSNPAEPEASIDEL :***************.*******************..:.******:.. :***:****: ENSMUSP00000048709/1-1420 LGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNMPQ-ISSQPMETNSNI ENSRNOP00000047149/1-1415 LGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQSVSSQSVETNPNI ENSP00000278612/1-1427 LGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNNKNISQSISSQPMESNPSI ENSCPOP00000009449/1-1420 LGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYGKTKNCKNISQSISNQ------HI XP_004856570.1/1-1422 LGLPSEIHMSEEAIQDILEQTESDPAFQALFDLFDYDKTKNSKNISQSISNQ------QI ************************************.**** **:.* :*.* * ENSMUSP00000048709/1-1420 VLPEETNLTIKSSFETEESDGQSGQPPFCTSYQNEDVLLNDLKSGNSHDVLPQESQENFS ENSRNOP00000047149/1-1415 VIPEETNLTIKSSFETEESDGQSGQPPFCTSYQNEDVVLNDLKSGNNHDVLPQESQGNFS ENSP00000278612/1-1427 VLADETNLAVKGSFETEESDGQSGQPAFCTSYQNDDP-LNALKNSNNHDVLRQEDQENFS ENSCPOP00000009449/1-1420 VLPEETNLVVKSSFEIQESDGQSGQPA-CTSCQNEEA-LDVLKNGSSHEALRQEAQDGFP XP_004856570.1/1-1422 VLSEETNLVVKSSFEREESDGQPGQPP-CTSYQNEDA-LNALKNGSNHEVLRQEAQEDFS *:.:****.:*.*** :*****.***. *** **:: *: **....*:.* ** * .*. ENSMUSP00000048709/1-1420 QISSNIQKKTFKTAIPAEQKCALDITLESVSNLSDFNQRGSS-AECNEHCSELFASQIPT ENSRNOP00000047149/1-1415 QISANIQ----KTAVPAEQKCALDITFESVSNLSDFNQRGSA-TECDEHCSELYTSQMPT ENSP00000278612/1-1427 QISTSIQKKAFKTAVPTEQKCDIDITFESVPNLNDFNQRGNSNAECNPHCAELYTNQMST ENSCPOP00000009449/1-1420 QIEPSIQKKSVKTVAPTEQKCDLDITFESVPSLSDFNQTGNSHAECNQHCTELYTSQIPP XP_004856570.1/1-1422 QIDSCIQKKAIKTAAPMEEKCDLDITFQSVPNLNDFNQRGNSHAECNQHCAELYNSQIPP **.. ** **. * *:** :***::**..*.**** *.: :**: **:**: .*:.. ENSMUSP00000048709/1-1420 EAEVAVG-EKNSLSADILSQSQYQPDQPSVPVTSFVSLGGETNDKNLVLSGKNSQLLSQS ENSRNOP00000047149/1-1415 DAGAAVG-EESSLSPDSLNQSQYQPDQPRVPVTSFVSLGGETNDKNLILSGKNSQLLSQS ENSP00000278612/1-1427 ETEMAIGIEKNSLSSNVPSESQLQPDQPDIPITSFVSLGCEANNENLILSGKSSQLLSQD ENSCPOP00000009449/1-1420 ETERAMEVGKNTVSPNVPCESQLQPSQSEVPVTSFVTLGVEMNSENLSLSGKSSQLLSQN XP_004856570.1/1-1422 ETERAMEVEKNSLSPNVPSESQLQPHQSAIPVTSLVTLGGEMNNENLILSGKSCQLLSQN :: *: :.::*.: :** ** *. :*:**:*:** * *.:** ****..*****. ENSMUSP00000048709/1-1420 TPLTTKPSK-SQLCENSNNIIKVKTNPQASESADSSETANRKTETNTVSPAAAQPQADCQ ENSRNOP00000047149/1-1415 TPLTGKPSK-SQFCENSNNIIKVKTNSHASESPDSSDTHSSKDETNSKSPVAAQTQPDCQ ENSP00000278612/1-1427 TSLTGKPSKKSQFCENSNDTVKLKINFHGSKSSDSSEVHKSKIEINVLEPVMSQ-LSNCQ ENSCPOP00000009449/1-1420 TPLTGKPSKNSQLCESLNNTVKPKTSFHSSKSQDPGELQKSKIEMSNVLPVVSPQLPVCQ XP_004856570.1/1-1422 PPLTGKASKNSQFCENLN-TVRLKTNFHGSKSPDSSEIYKSKIEINNVLPVVSQQLPECQ ..** *.** **:**. * :: * . :.*:* *..: . * * . *. : . ** ENSMUSP00000048709/1-1420 DNSPLQSKPPPGIGESLGVNVTE-KIEIHLEEPAPSDKQLSNDAASVDLNPTESKTEPLQ ENSRNOP00000047149/1-1415 DNSPLQSRTSPVIIEGLGVNVTE-KIEISIEETSPSDKQLPNDSASVDLNPMGSESEPLQ ENSP00000278612/1-1427 DNSCLQSEILPVSVESSHLNVSG-QVEIHLGDSLSSTKQPSNDSASVELNHTENEAQASK ENSCPOP00000009449/1-1420 TN-LLQSEILPVSVGSSALHVSEQQIEVCLEDSVSSVKQPYDGSTAVELSHAQNETEPHK XP_004856570.1/1-1422 DNSSLQSKMLPVSVESSALHVSE-QIEICLEDS-DSIKQPYN-STAIELNHMENETEPHN * ***. * . ::*: ::*: : :. * ** : :::::*. .:::. : ENSMUSP00000048709/1-1420 SA----SAQEPEPPSVKDGDTIFLSLSEHNSCEEVALVLGEGNPVKNNNSLSSESG-GSV ENSRNOP00000047149/1-1415 SE----NTQEPPS--VKDGDTIFLSLSGHNGCEEVALVPGEGNPVKNNHSLSSESG-GSV ENSP00000278612/1-1427 SE----NSQEPSSS-VKEENTIFLSLGGNANCEKVALTPPEGTPVENSHSLPPESVCSSV ENSCPOP00000009449/1-1420 SDKAAVEPQEPSSP-VKGGDNIFLSLVSTDSCGEVAQIPPEGNCMKNSHSVPSEPGCSSV XP_004856570.1/1-1422 SEEVILDSQEPSSS-VKEGDNIFLSLGRTDNCGEIALIPPEGNSIKNNHSLPSESGCSSV * ..*** . ** :.***** .* ::* **. ::*.:*:..*. .** ENSMUSP00000048709/1-1420 GVS-PETQNTDGKTS--NSTEVDASSIVSLKIIISDDPFVSSDAELNSAVSSISGENLPT ENSRNOP00000047149/1-1415 GVS-AETQNTDGKAS--DPAEVDASSIVSLKIIISDDPFVSSDAELNSAVSSISGENLPT ENSP00000278612/1-1427 GDSHPESQNTDDKPSSNNSAEIDASNIVSLKVIISDDPFVSSDTELTSAVSSINGENLPT ENSCPOP00000009449/1-1420 GDPHSESQNLGDKPCSDNSAEVDASNIVSLKIIISDDPFVSSDTELTSAVSSISGENLPT XP_004856570.1/1-1422 GDSHPESPNPGDKPSSDNSAEIDSSNIVSLKIIISDDPFVSSDTELNNAVSSISGENLPT * . .*: * ..*.. :.:*:*:*.*****:***********:**..*****.****** ENSMUSP00000048709/1-1420 IILSS--KSPAKNAEFVTCLSSEETASAVVSVEVGDSGSMEQNLLVLKPEEPMVNNTQNE ENSRNOP00000047149/1-1415 IILSS--KSPAKNAEFVTCLSSEETASAVVSVEVGDSGSMEQNLLVLKPEEPTVNSTQNE ENSP00000278612/1-1427 IILSSPTKSPTKNAELVKCLSSEETVGAVVYAEVGDSASMEQSLLTFKSEDSAVNNTQNE ENSCPOP00000009449/1-1420 IILSSPDKSPTKNAELVKDLSAEGIAGSVVSAAVEGSASVEQSLLTLKPEDTKVNDTQSE XP_004856570.1/1-1422 IILSSPAKSPAKNGELVKGLSSEESAGTVVSAAVKDSASVEESLLTLKPEDSSVNNVQSD ***** ***:**.*:*. **:* ..:** . * .*.*:*:.**.:*.*:. **..*.: ENSMUSP00000048709/1-1420 DGIAFSANVAPCVPKDGGYIQLMPTTSTAFGNSSNILIATCMTDSTALGPTVSQSNVVVL ENSRNOP00000047149/1-1415 DGIAFSANVAPCVPKDGGFIQLMPATSTAFGNSSNILIATCMTDPTALGPTVSQSNVVVL ENSP00000278612/1-1427 DGIAFSANVTPCVSKDGGYIQLMPATSTAFGNSNNILIATCVTDPTALGTSVSQSNVVVL ENSCPOP00000009449/1-1420 EGSTFSASITPCVSKEGGFIQLMPATSTTFGNSNNILIATCVTDPTSLGTTVSQSNVVVL XP_004856570.1/1-1422 DSTTFSASVTPCVSKEGGFIQLMPATSTTFGNSNNILIATCVTDPAALGTTVSQSNVVVL :. :***.::***.*:**:*****:***:****.*******:**.::**.:********* ENSMUSP00000048709/1-1420 PGSSAPMTAQPPQQQLQTPPKSNSAFAVSQAVSPNFSQGSAIIIASPVQPVLQGMVGMIP ENSRNOP00000047149/1-1415 PGSSAPLTAQPPPQQLQTPPKSNSAFAVSQAVSPNFSQGSAIIIASPVQPVLQGMVGMIP ENSP00000278612/1-1427 PGNSAPMTAQPLPPQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMIP ENSCPOP00000009449/1-1420 PGNSATMTSQPPPPKLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMVP XP_004856570.1/1-1422 PGNSAPMTAQPPPPQLQTPPRSNSVFAVNQAVSPNFSQGSAIIIASPVQPVLQGMVGMVP **.**.:*:** :*****:***.***.*****************************:* ENSMUSP00000048709/1-1420 VSVVGQNGNTFSTPPQQVLHMPLAAPVCNRSIAQLPIPQKSQKAQGLRNKLITGKQVNNL ENSRNOP00000047149/1-1415 VSVVGQNGNTFSTPPQQVLHMPLAAPVCNRSITQFPIPQKSQKAQGLRNKPITGKQVNNL ENSP00000278612/1-1427 VSVVGQNGNNFSTPPRQVLHMPLTAPVCNRSIPQFPVPPKSQKAQGLRNKPCIGKQVNNL ENSCPOP00000009449/1-1420 VSVVGQNGNTFSAPPQQVLHVPLAAPVCNRSIPQFPVPPKSQKAQGLRNKTCTGKQINNS XP_004856570.1/1-1422 VSVVGQNGNTFSAPPQQVLHMPLAAPVCNRSIPQFPVPPKSQKAQGLRNKACIGKQVNNL *********.**:**:****:**:********.*:*:* *********** ***:** ENSMUSP00000048709/1-1420 TNLSSLSEACHTQRTEASDKNIATELGKKMEDTTISLSGERVAPPSKPFESHRRVLCFDS ENSRNOP00000047149/1-1415 TSLSSLSEACHTQRTEASDKNTATELGKKMEDTTIPLSAERVAPPSRPFESHRRVLCFDS ENSP00000278612/1-1427 VDSSGHSVGCHAQKTEVSDKSIATDLGKKSEETTVPFPEESIVPAAKP--CHRRVLCFDS ENSCPOP00000009449/1-1420 ADSSNHSVGCHAQRTEVSDKNMVTGLGKKMEEITVTFSGESTVPASKPFESHRRVLCFD- XP_004856570.1/1-1422 ADSSSYSVGCHAQRTEVSDKNKATGLGKKMEEITVPFSEESMVPVSRPFESHRRVLCFDS .. *. * .**:*:**.***. .* **** *: *:.:. * .* ::* .******** ENSMUSP00000048709/1-1420 TVSSVANTQGSLYKMTSENKEKKEASFSHLDSPILSSTLKPPPNNAIKREREKT-VPKIL ENSRNOP00000047149/1-1415 TVSSVANTQGPLYKVTSQNKEKKETSFPRLDSPILSSTLKSPTNNAIKREREKT-VPKIL ENSP00000278612/1-1427 TTAPVANTQGPNHKMVSQNKERNAVSFPNLDSPNVSSTLKPPSNNAIKREKEKPPLPKIL ENSCPOP00000009449/1-1420 TTSSVANTQGSGQKMTSQNRERSEVASSHLDSPIASSMLKPSSN--------STPMPRIL XP_004856570.1/1-1422 TTSPVANTQGSSHKMVSQHKDRSEVSFSHLDSPIVSCTLKPPSN-ATKKEREKTPMPKIL *.:.******. *:.*:::::. .: ..**** *. **...* .. :*:** ENSMUSP00000048709/1-1420 SKSETASSRHTTVKEVQSEKKVSPTEVALESLHKATANKENELCGDGERPKNADTSKLPG ENSRNOP00000047149/1-1415 SKSETASSRHTTVKEVQSEKKVSPIETTLESFHKATANKENELCSDGERPKNPDTSKLPG ENSP00000278612/1-1427 SKSESAISRHTTIRETQSEKKVSPTEIVLESFHKATANKENELCSDVERQKNPENSKLSI ENSCPOP00000009449/1-1420 SKPEIAIIRHTTVKEAESEKKVSPTEMVLESFHKATANKENELRSDIERQKNSDTSKLSV XP_004856570.1/1-1422 SKSETAISRHTTIREAQSEKKVAPTETVFESFHKATANKENELCSDVDRPKNSDTSKLSI **.* * ****::*.:*****:* * .:**:*********** .* :* **.:.***. ENSMUSP00000048709/1-1420 GQQNGSLRNEKAIASLQELTKKQATPSNNKNATSVGGTVKDQKQEQSKPASSLIGAEILQ ENSRNOP00000047149/1-1415 GQQNGSLKNEKAMASLQELTRKQATPSNNKNATTVSGTVKDQKQEQSKPAGSLTGLETLQ ENSP00000278612/1-1427 GQQNGGLRSEKSIASLQEMTKKQGTSSNNKNVLSVGTAVKDLKQEQTKSASSLITTEMLQ ENSCPOP00000009449/1-1420 GQQHGSLRSEKAVSSLQELTKRQATSSNSKNLISVSTAMKDLKQEQTKTVNSLNTTEILH XP_004856570.1/1-1422 GQQNGSLRNEKAVASLQELTKKQATSSNSKNVISVGTAMKELKQEQTKSTNSLSTTEILH ***:*.*:.**:::****:*::*.*.**.** :*. ::*: ****:*...** * *: ENSMUSP00000048709/1-1420 DVPIHSPANRSAD-TDLPVPRTPGSGAGEKHKEEPSDSMKAPASRRCGEEGSMPRVMIPP ENSRNOP00000047149/1-1415 DVPLHNPANRTAD-SDLPGPRTTGAGAGEKHKEEPTDSMKAPASRRCGEEGSVPRAMIPA ENSP00000278612/1-1427 DIQRHSSVSRLADSSDLPVPRTPGSGAGEKHKEEPIDIIKAPSSRRFSEDSSTSKVMVPP ENSCPOP00000009449/1-1420 DVQLQSPVNRLTDSSDSPVPRTPGSGAGEKHREEPSDVIKAPSSRRLGDDSSTAKVMIPP XP_004856570.1/1-1422 DVQLHSPVNRLADSSDLPVPRTPGSGTGEKHK-EPTDVIKPPSSRRFGDDSSTPKVMIPP *: :....* :* :* * ***.*:*:****: ** * :*.*:*** .::.* .:.*:*. ENSMUSP00000048709/1-1420 VTADLPACSPASETGSENSVSMAAHTLMILSRAAIARTTAT-PLKDNTQQFRTSSRSTTK ENSRNOP00000047149/1-1415 VTADLPACSPASETGSENSVSMAAHTLMILSRAAIARTTAT-PLKDNTQQFRTSSRSTTK ENSP00000278612/1-1427 VTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSATPLKDNTQQFRASSRSTTK ENSCPOP00000009449/1-1420 VAPDLPACSPASETGSENSVSMAAHTLMILSRAAISRTASTTPLKDNTQQFRTSSRNTTK XP_004856570.1/1-1422 VTPDLPACSPASETGSENSVNMAAHTLMILSRAAISRTTSTTPLKDNTQQFRTSSRSTTK *:.*****************.**************:**::: **********:***.*** ENSMUSP00000048709/1-1420 KRKIEELDECERNSRTSGKNLANSSVPMKKKKI--KKKKLPSSFPAGMDVDKFLLSLHYD ENSRNOP00000047149/1-1415 KRKIEELDECERNSRTSSKNLANSSVPMKKKKI--KKKKLPSSFPAGMDVDKFLLSLHYD ENSP00000278612/1-1427 KRKIEELDERERNSRPSSKNLTNSSIPMKKKKI--KKKKLPSSFPAGMDVDKFLLSLHYD ENSCPOP00000009449/1-1420 KRKIEELDERERNSRTSSKSLAHSSIPMFKSMLPPQKKKLPGSFPAGMDVDKFLLSLHYD XP_004856570.1/1-1422 KRKIEELDERERNSRTSSKSLANSSIPMKKKKI--KKKKLPASFPAGMDVDKFLLSLHYD ********* *****.*.*.*::**:** *. : :*****.****************** ENSMUSP00000048709/1-1420 E ENSRNOP00000047149/1-1415 E ENSP00000278612/1-1427 E ENSCPOP00000009449/1-1420 E XP_004856570.1/1-1422 E *