CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000035415/1-1049 MLKPQPPQQTSQPQQPPPTQQAVARRSPGGTSPPNGGLPGPLTATAAPPGPPAAVSPCLG ENSRNOP00000059876/1-1072 MLKPQPPQQTSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLPATAAPPGPPTVVSPCLG ENSP00000378917/1-1097 MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLG XP_004856113.1/1-1036 --------------------------------------------------MVFAAALCLG ENSCPOP00000009448/1-950 ------------------------------------------------------------ ENSMUSP00000035415/1-1049 PAAAAGSGLRRGAESILAA--SAPPQHQERPGA--VAIGSVRGQTTGKGPPQSPVFEGVY ENSRNOP00000059876/1-1072 PAAAAGSGLRRGAESILAA--PAPQQHQERPGA--VAIGSVRGQTTGKGPPQSPVFEGVY ENSP00000378917/1-1097 PVAAAGSGLRRGAEGILAPQPPPPQQHQERPGA--AAIGSARGQSTGKGPPQSPVFEGVY XP_004856113.1/1-1036 PIS-----------GPLFALFYRRLHQPSRSGVTWLLVTPAEGQSTGKGPPQSPVFEGVY ENSCPOP00000009448/1-950 -----------------------------------------RGQSTGKGPPQSPVFEGVY .**:*************** ENSMUSP00000035415/1-1049 NNSRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRRED ENSRNOP00000059876/1-1072 NNSRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRRED ENSP00000378917/1-1097 NNSRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRRED XP_004856113.1/1-1036 NNSRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRRED ENSCPOP00000009448/1-950 NNSRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRRED ************************************************************ ENSMUSP00000035415/1-1049 IVDTMVFKPSDVLLVHFRNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNS ENSRNOP00000059876/1-1072 IVDTMVFKPSDVLLVHFRNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNS ENSP00000378917/1-1097 IVDTMVFKPSDVMLVHFRNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNS XP_004856113.1/1-1036 IVDTMVFKPSDVMLVHFRNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNS ENSCPOP00000009448/1-950 IVDTMVFKPSDVMLVHFRNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNS ************:*********************************************** ENSMUSP00000035415/1-1049 DDYDLESDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQ ENSRNOP00000059876/1-1072 DDYDLESDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQ ENSP00000378917/1-1097 DDYDLESDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQ XP_004856113.1/1-1036 DDYDLESDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQ ENSCPOP00000009448/1-950 DDYDLESDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQ ************************************************************ ENSMUSP00000035415/1-1049 LAREIESSPQYRLRIAMENDDGRTEEEKHSAVQRQGSGRESPSLVSREGKYIPLPQRVRE ENSRNOP00000059876/1-1072 LAREIESSPQYRLRIAMENDDGRTEEEKHSAVQRQGSGRESPSLVSREGKYIPLPQRVRE ENSP00000378917/1-1097 LAREIESSPQYRLRIAMENDDGRTEEEKHSAVQRQGSGRESPSLASREGKYIPLPQRVRE XP_004856113.1/1-1036 LAREIESSPQYRLRIAMENDDGRTEEEKHSAVQRQGSGRESPSLVAREGKYIPLPQRVRE ENSCPOP00000009448/1-950 LAREIESSPQYRLRIAMENDDGRTEEEKHSAVQRQGSGRESPSLASREGKYIPLPQRVRE ********************************************.:************** ENSMUSP00000035415/1-1049 GPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRG ENSRNOP00000059876/1-1072 GPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRG ENSP00000378917/1-1097 GPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRG XP_004856113.1/1-1036 GPRGGVRCSSSRGGRPGLSSLPPRGPHHLDSSSPGPGSEARGVNGGPSRMSPKAQRPLRG ENSCPOP00000009448/1-950 GPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRG ******************************.***********:***************** ENSMUSP00000035415/1-1049 AKTLSSPSNRPSGEASVPPTSAALPFLPVGRMYPPRSPKSAAPAPVSASCPEPPIGSAVA ENSRNOP00000059876/1-1072 GKTLSSPNNRPSGEASVPPTSA------VGRMYPPRSPKSAAPAPVSASCPEPPIGSAVA ENSP00000378917/1-1097 AKTLSSPSNRPSGETSVPPPPA------VGRMYPPRSPKSAAPAPISASCPEPPIGSAVP XP_004856113.1/1-1036 AKTLSSPSSRPSGETSVPPPPA------VGRMYPPRSPKSAAPAPLSASCPEPPMGSAVA ENSCPOP00000009448/1-950 AKTLSSPNSRPSGEASVPPPSAALPFLPVGRMYPPRSPKSAAPAPISASCPEPPMGSAVA .******..*****:****..* *****************:********:****. ENSMUSP00000035415/1-1049 -SSASIPVTSSVVDPGAGSISPASPKLSLTPTDVKELPTKEPSRNLEAQELARIAGKVPG ENSRNOP00000059876/1-1072 -SSASIPVTSSVVDPGAGSISPASPKLSLAPTDVKELPTKEPSRSLEAQELARIAGKVPG ENSP00000378917/1-1097 TSSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRTLEPQELARIAGKVPG XP_004856113.1/1-1036 ASSASIPVTSSVTDPGVGSISPASPKISLTPTDVKELPTKEPGRTLESQELARIAGKVPG ENSCPOP00000009448/1-950 TSSASIPVTSSVTDPGVGSISPASPKISLTPTDVKELPTKEPGRTLEPQELARISGKVPG *********** ***.*********:**:*******.****.*.**.******:***** ENSMUSP00000035415/1-1049 LQNEQKRFQLEELRKFGAQFKLQPSSSPETGLDPFPSRILKEEAKGKEKEVDGLLTSDPM ENSRNOP00000059876/1-1072 LQNEQKRFQLEELRKFGAQFKLQPSSSSETGLDPFPSRILKEEAKGKEKEVDGLLTSDPM ENSP00000378917/1-1097 LQNEQKRFQLEELRKFGAQFKLQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPM XP_004856113.1/1-1036 LQNEQKRFHLEELRKFGSQFKLQPSSSPETSMDPFPPRILKEEAKGKEKE-DALLTSEPM ENSCPOP00000009448/1-950 LQNEQKRFHLEELRKFGSQFKLQPSSSPETTMDPFPPRILKEEAKGKEKE-DVLLTSETM ********:********:*********.*. :****.******.****** * ****:.* ENSMUSP00000035415/1-1049 GSPVSSKTESILDKEDKVPMAGVGGTEGPEQLPAPCPSQTGSPPVGLIKGDEKEEGPVTE ENSRNOP00000059876/1-1072 GSPVSSKAESILDKEDKVPLAAVAGSEGPEQLQPPCPSQTGSPPVGLIKGDDKEEGPVTE ENSP00000378917/1-1097 GSPVSSKTESVSDKEDKPPLAPSGGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEGPVAE XP_004856113.1/1-1036 GSPVSSKTESVSEKEDKAPLAPSGATEGQEQPLPPCPSQTGSPPVGL-KGDDKDEGPVAE ENSCPOP00000009448/1-950 GSPVSSKTESGSEKDDKPPLAPTGATEGPEQPLPPCPSQTGSPPVGL-KGDEKDEGPVNE *******:** :*:** *:* ..:** ** .************* **::*:**** * ENSMUSP00000035415/1-1049 QVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYIS ENSRNOP00000059876/1-1072 QVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYIS ENSP00000378917/1-1097 QVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYIS XP_004856113.1/1-1036 QVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYIS ENSCPOP00000009448/1-950 QVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYIS ************************************************************ ENSMUSP00000035415/1-1049 YIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAK------------------------ ENSRNOP00000059876/1-1072 YIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAK------------------------ ENSP00000378917/1-1097 YIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAK------------------------ XP_004856113.1/1-1036 YIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGERGREGPAVLPGSLQVELELCTV ENSCPOP00000009448/1-950 YIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAK------------------------ ************************************ ENSMUSP00000035415/1-1049 -----GSLPPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMM ENSRNOP00000059876/1-1072 -----GSLPPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMM ENSP00000378917/1-1097 -----GSLPPQRSDQHQPASAPPMMQ-AAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMM XP_004856113.1/1-1036 CLPSAGSLPPQRTDQHQPASAPPMMQ-AAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMM ENSCPOP00000009448/1-950 -----GSLPPQRSDQHQPASAPPMMQ-AAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMM *******:************* ********************************* ENSMUSP00000035415/1-1049 QPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYP ENSRNOP00000059876/1-1072 QPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYP ENSP00000378917/1-1097 QPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYP XP_004856113.1/1-1036 QPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYP ENSCPOP00000009448/1-950 QPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYP *****************************************:****************** ENSMUSP00000035415/1-1049 HHATQLHGHQPQPATTPTGSQPQSQHAAPSPV---------------------------- ENSRNOP00000059876/1-1072 HHATQLHGHQPQPATTPTGSQPQSQHAAPSPV---------------------------- ENSP00000378917/1-1097 HHATQLHAHQPQPATTPTGSQPQSQHAAPSPV---------------------------- XP_004856113.1/1-1036 HHATPLHAHQPQPATTPTGSQPQSQHAAPSPVQVPAMGHVAGAGLGAGETGWYSRLPLLL ENSCPOP00000009448/1-950 HHATPLHAHQPQPATTPTGSQPQSQHAAPSPV---------------------------- **** **.************************ ENSMUSP00000035415/1-1049 -QHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHPHQQ ENSRNOP00000059876/1-1072 ---QAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHPHQQ ENSP00000378917/1-1097 -QHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIH-HQQ XP_004856113.1/1-1036 PQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHPHQQ ENSCPOP00000009448/1-950 -QHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHPHQQ ***************************************************** *** ENSMUSP00000035415/1-1049 LPHGFTNMAHVTQAHVQTGVTAAPPPHPGAPHPPQVMLLHPPQGHGGPPQGAVPPSGVPA ENSRNOP00000059876/1-1072 LPHGFTNMAHVTQAHVQTGVTAAPPPHPGAPHPPQVMLLHPPQGHGGPPQGAVPPSGVPA ENSP00000378917/1-1097 LPHGFTNMAHVTQAHVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPA XP_004856113.1/1-1036 LPHSFTNMAHVTQAHVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPA ENSCPOP00000009448/1-950 LPHSFTNMAHVTQAHVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPA ***.***************:***********************.********** ***** ENSMUSP00000035415/1-1049 LSASTPSPYPYIGHPQ-------------------------------------------- ENSRNOP00000059876/1-1072 LSASTPSPYPYIGHPQGEQPGQAPGFPGGADDRI-----------REFSLAGGIWHGRAE ENSP00000378917/1-1097 LSASTPSPYPYIGHPQGEQPGQAPGFPGGADDRILCRVGRSHSRRRQGLAPGSVLCFPPS XP_004856113.1/1-1036 LSASTPSPYPYIGHPQ-------------------------------------------- ENSCPOP00000009448/1-950 LSASTPSPYPYIGHPQ-------------------------------------------- **************** ENSMUSP00000035415/1-1049 -VQSHPSQQLPFHPPGN-------- ENSRNOP00000059876/1-1072 GLQVGQDARVL---GGD-------- ENSP00000378917/1-1097 SLSCDPAAPLPTASPALSDPDCLLT XP_004856113.1/1-1036 -ALSDPDCLLT-------------- ENSCPOP00000009448/1-950 -VQSHPSQQLPFHPPGN-------- :