CLUSTAL W(1.81) multiple sequence alignment ENSP00000366513/1-981 ------------------------------------------------------------ ENSMUSP00000036962/1-979 ------------------------------------------------------------ ENSRNOP00000047223/1-952 ------------------------------------------------------------ ENSCPOP00000008989/1-899 ------------------------------------------------------------ XP_004863980.1/1-1287 MSSAGSEPGTGAVTAKGHTKVAWEVCVPSEYRCTSPLYNGAAESQGAVPQRGTLLGSGSE ENSP00000366513/1-981 ------------------------------------------------------------ ENSMUSP00000036962/1-979 ------------------------------------------------------------ ENSRNOP00000047223/1-952 ------------------------------------------------------------ ENSCPOP00000008989/1-899 ------------------------------------------------------------ XP_004863980.1/1-1287 KGRRAGTQGEGTTPDVPGVLCVWGAVAPSQAPRIPQEEPAPPPRVPVPVPDLSRLTPASD ENSP00000366513/1-981 ------MLRRP------------------------------------------------- ENSMUSP00000036962/1-979 ------MLRRP------------------------------------------------- ENSRNOP00000047223/1-952 ------MLRRP------------------------------------------------- ENSCPOP00000008989/1-899 ------NL---------------------------------------------------- XP_004863980.1/1-1287 ASPDPSSLRSPPSAEDAAEVQGGTGRPAGRRWGVRAPPGCEGGEPGSFGCRGGAPRAWRP * ENSP00000366513/1-981 ------------------------------------------------------------ ENSMUSP00000036962/1-979 ------------------------------------------------------------ ENSRNOP00000047223/1-952 ------------------------------------------------------------ ENSCPOP00000008989/1-899 ------------------------------------------------------------ XP_004863980.1/1-1287 QHRSEARVGNEGTATRGARLAGPGGGAALGANGEPALGRAPSGRALPRPPGARAPGAAPC ENSP00000366513/1-981 ---------------------------------------------------------APA ENSMUSP00000036962/1-979 ---------------------------------------------------------APA ENSRNOP00000047223/1-952 ---------------------------------------------------------APA ENSCPOP00000008989/1-899 ------------------------------------------------------------ XP_004863980.1/1-1287 PPPPARRARPAPPCRSPCRTEARADAAAILVAAAASAKRCSRREGAAAGAGPGLGTAPPA ENSP00000366513/1-981 LAPAAR----------LLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPP ENSMUSP00000036962/1-979 LAPAVR----------LLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPP ENSRNOP00000047223/1-952 LARAVR----------LLLAGLLYGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPP ENSCPOP00000008989/1-899 --------------------------------VNKHKPWLEPTYHGIVTENDNTVLLDPP XP_004863980.1/1-1287 LPPAARRAAPQRPAAGLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPP **************************** ENSP00000366513/1-981 LIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDC ENSMUSP00000036962/1-979 LIALDKDSPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGIIRSKEKLDC ENSRNOP00000047223/1-952 LIALDKDSPLRFA----------GEICGFKIHGQNVPFDAVVVDKSTGEGIIRSKEKLDC ENSCPOP00000008989/1-899 LIALDKDAPLRFA----------GEICGFKIHGQNVPFDAVVVDKSTGEGIIRSKEKLDC XP_004863980.1/1-1287 LMALDKDAPLRFAESYEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGIIRSKEKLDC *:*****:***** ***************************:********* ENSP00000366513/1-981 ELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQ ENSMUSP00000036962/1-979 ELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAPVFKEKSYKAAVVEGKQ ENSRNOP00000047223/1-952 ELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAPVFKEKSYKAAVVEGKQ ENSCPOP00000008989/1-899 ELQKDYTFTIQAYDCGKGPDGAGVKKSHKATVHIQVNDVNEYAPVFKEKSYKATATEGKQ XP_004863980.1/1-1287 ELQKDYTFTIQAYDCGKGPDGTSMKKSHKSTVHIQVNDVNEYAPVFKEKSYKATVTEGKQ ******:**************:.:*****:***********************:. **** ENSP00000366513/1-981 YDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVT ENSMUSP00000036962/1-979 HSSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVT ENSRNOP00000047223/1-952 HGSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVT ENSCPOP00000008989/1-899 HDSILRVEAVDADCSPQFSQICSYEIVTPNVPFAVDKDGYIRNTEKLSYGKEQQYKLSVT XP_004863980.1/1-1287 YDSILRVEAVDADCSPQFSQICSYDIVTPDVPFAVDKDGYIKNTEKLNYGKERQYKLTVT :.**********************:*:**:***:*******:*****.****:****:** ENSP00000366513/1-981 AYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVAS ENSMUSP00000036962/1-979 AYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPGTGALAVFPSIHLETCDEPVAS ENSRNOP00000047223/1-952 AYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPGTGALAVFPSIHLETCDEPVAS ENSCPOP00000008989/1-899 AYDCGKKRAAEDVLVKISIKPTCTPGWQGWSNRVEYEPGTGALAVFPNIHLETCDEPVAL XP_004863980.1/1-1287 AYDCGKKRATEDVLVKISIKPACTPGWQGWSNRVEYEPGTGALAVFPNIHLETCDEPVAS *********:********:**:*:******..*:*************.*********** ENSP00000366513/1-981 VQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHD ENSMUSP00000036962/1-979 VQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSSFNWTVGLPTDNGHD ENSRNOP00000047223/1-952 VQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSSFNWTVGLPTDNGHD ENSCPOP00000008989/1-899 VQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSSSLNWTIGLPTDNGHD XP_004863980.1/1-1287 VQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPGSSFNWTVGLPTDNGHD ************************************:******..*:***:********* ENSP00000366513/1-981 SDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHY ENSMUSP00000036962/1-979 SDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHY ENSRNOP00000047223/1-952 SDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHY ENSCPOP00000008989/1-899 SDQVFEFNGTQAVRIPDGVVSINPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHY XP_004863980.1/1-1287 SDQVFEFNGTQAVRIPDGVVSISPKEPFTISVWMRHGPFGRRKETILCSSDKTDMNRHHY ********************::.******************:****************** ENSP00000366513/1-981 SLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTS ENSMUSP00000036962/1-979 SLYVHGCRLVFLLRQDPSEEKKYRPAEFHWKLNQVCDEDWHHFVLNVEVPSVTLYVDGIP ENSRNOP00000047223/1-952 SLYVHGCRLIFLLRQDPSEEKKYRPAEFHWKLNQVCDEDWHHFVLNVEVPSVTLYVDGVS ENSCPOP00000008989/1-899 SLYVHGCRLIFLLRQDPSEEKRYRPAEFHWKLNQVCDAEWHHFVLNVELPSATLYVDGVP XP_004863980.1/1-1287 SLYIHGCRLIFLLRQDPSEEKKYKPAEFHWKLNQVCDEEWHHFVLNVELPSVTLYVDGVS ***:*****:**:********:*:************* :***:*****.**.****** . ENSP00000366513/1-981 HEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGN ENSMUSP00000036962/1-979 HEPFSVTEDYPLHPTKIETQLVVGACWQEYSGVESGNETEPATMASAGGDLHMTQFFRGN ENSRNOP00000047223/1-952 HEPFSVTEDYPLHPTKIETQLVVGACWQ-------------------GGDLHMTQFFRGN ENSCPOP00000008989/1-899 HEPFSVTEDYPLHPSKIDTQLVVGACWQEYSGVESDNDTEPVTVASAGGDLHMAQFFRGN XP_004863980.1/1-1287 HEPFSVTEDYPLHPSKIDTQLVVGACWQEYSGVENDNDTEPVTVASAGGDLHMTQFFRGN **************:**:********** ******:****** ENSP00000366513/1-981 LAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGEL ENSMUSP00000036962/1-979 LAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDANRGVQIQASSSQAVLTLEGDNVGEL ENSRNOP00000047223/1-952 LAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDGNRGVQIQTSSSQAVLTLEGENVGEL ENSCPOP00000008989/1-899 LAGLTVRSGKLTDKKVIDCLYTCKEGLGLQGPEDSG-GVQIRAGPSQSVLTLEGDDIGEL XP_004863980.1/1-1287 LAGLTVRTGKLADKKVIDCLYTCKEGLDLQVPEDSS-AVQVRPSPGQSVLTLEGDDIGEL *****:*:***:***************.** **.. .**::. ..* ******:::*** ENSP00000366513/1-981 DKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEAT-CISVPPVDGYVMVLQPEEPKISL ENSMUSP00000036962/1-979 DKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAA-CIEVPPVEGYVMVLQPEEPKISL ENSRNOP00000047223/1-952 DKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAA-CIEVPPVEGYVMVLQPEEPKISL ENSCPOP00000008989/1-899 DRAMQHLSYLNSRQFPTPGIRRLRVTSTAKCFNEAATCIEIPVVEGYVMVLQPEEPKISL XP_004863980.1/1-1287 DKAMQHLSYLNSRQFPTPGIRRLRVTSTVKCFHEATTCIQVPPVEGYVMVLQPEEPKISL *:****:****************::*** ***:**: **.:* *:*************** ENSP00000366513/1-981 SGVHHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDL ENSMUSP00000036962/1-979 SGVHHFARAASEFESAEGISLFPELRIISTITREVEPEADGSEDPTVQESLVSEEIVHDL ENSRNOP00000047223/1-952 SGVHHFARAASEFESPEGVSLFPELKIISTITREVEPEADGAEDPTVQESLVSEEIVHDL ENSCPOP00000008989/1-899 SGIHHFARAASEFESPEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEVVHDL XP_004863980.1/1-1287 SGVHHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEVVHDL **:************.**: *****:************.**:*************:**** ENSP00000366513/1-981 DTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRY ENSMUSP00000036962/1-979 DTCEVTVEGDELNAEQESLEVDVTRLQQKGIEASHSDLGVVFTGVETMASYEEVLHLLRY ENSRNOP00000047223/1-952 DTCEVTVEGEELNAEQESLEVDVARLQQKGIEVNHSDLGVVFTGVETMASYEEVLHLLRY ENSCPOP00000008989/1-899 DTCEVTVEGEELNPEQESLEVDAVRLQQKGIEVSHSDLGVVLRGVDTMASYEEVLHLLRY XP_004863980.1/1-1287 DTCEVTVEGEELNLEQESLEVDEARLQQKGIEVSRSGLGMVLRGVETMVSYEEVLHLLRY *********:*** ******** .********.. * **:.: **:**.*********** ENSP00000366513/1-981 RNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHR ENSMUSP00000036962/1-979 RNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTANPVEHANHMAAQPQFVHPEHR ENSRNOP00000047223/1-952 RNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTANPVEHANHMAAQPQFVHPEHR ENSCPOP00000008989/1-899 RNWHASSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTASPVEHASHMAAQPQFVHPEHR XP_004863980.1/1-1287 RNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTANPVEHANHMAAQPQFVHPEHH ****: ******************:**************.*:***.*************: ENSP00000366513/1-981 SFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGK ENSMUSP00000036962/1-979 SFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGK ENSRNOP00000047223/1-952 SFVDLSGHNLASPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGK ENSCPOP00000008989/1-899 SFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDSGK XP_004863980.1/1-1287 SFVDLSGHNLASPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQRTMRDQDTGK ***********.*************************************:*******:** ENSP00000366513/1-981 ENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDG-----EEEDDITSAESES ENSMUSP00000036962/1-979 ENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDG-----EEEEDITSAESES ENSRNOP00000047223/1-952 ENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDG-----EEEEDITSAESES ENSCPOP00000008989/1-899 ENEMDWDDSALTITVNPMETYEDQHS-------------------------NITSAESES XP_004863980.1/1-1287 ENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEEEEESEDGEEEEEEDITSAESES ************************** :******** ENSP00000366513/1-981 SEEEEGEQGDPQNATRQQQLEWDDSTLSY ENSMUSP00000036962/1-979 SEEEEGGPGDGQNATR--QLEWDDSTLSY ENSRNOP00000047223/1-952 SEEEEGGPGDGQNTTRQQQLEWDYSTLSY ENSCPOP00000008989/1-899 SEEEE------------------------ XP_004863980.1/1-1287 S-EEEGGPGDGQNATRQQQLEWDDSTLSY * ***