CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000109144/1-1345 -------MESKALLAVALWFCVETRAASVGLPGDFLHPPKLSTQKDILTILANTTLQITC ENSRNOP00000066886/1-1216 -------MESRALLAVALWFCVETRAASVGLPGDSLHPPKLSTQKDILTILANTTLQITC ENSP00000263923/1-1356 -------MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITC ENSCPOP00000008975/1-1357 APRARCRMESRALLAIALWLCVETRAASVGLPSVALDPPTLSIEKDILTIMANTTLQITC XP_004849899.1/1-1211 -------MESKALLTLALWFCVETGATSVGLPSVALDPPSLSIQKNILAIMANTTLHITC *:*:.**::***:**** *:*****. *. * ** :*:**:* *****:*** ENSMUSP00000109144/1-1345 RGQRDLDWLWPNAQRDSEERVLVTECGGGDSIFCKTLTIPRVVGNDTGAYKCSYRDVDIA ENSRNOP00000066886/1-1216 RGQRDLDWLWPNTPRDSEERVLVTEC--GDSIFCKTLTVPRVVGNDTGAYKCFYRDTDVS ENSP00000263923/1-1356 RGQRDLDWLWPNNQSGSEQRVEVTEC--SDGLFCKTLTIPKVIGNDTGAYKCFYRETDLA ENSCPOP00000008975/1-1357 RGQQDLDWLWPNSQSGSEERVEVTEC--SDDFFCKTLTIPKVIGNDTGAYKCFYRGTNMT XP_004849899.1/1-1211 RGQRDLDWLWPNNQSGSEERVEVTEC--SDDLFCKTLRIPKVIGNDTGAYKCFYRDTNVT ***:******** .**:** **** .*.:***** :*:*:********* ** .::: ENSMUSP00000109144/1-1345 STVYVYVRDYRSPFIASVSDQHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFV ENSRNOP00000066886/1-1216 SIVYVYVQDHRSPFIASVSDEHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFV ENSP00000263923/1-1356 SVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFV ENSCPOP00000008975/1-1357 SVIYVYVQDYRSPFIASVSDEHGVVYLTENKNKTVVIPCRGSISNLNVSLYARYPEKRFV XP_004849899.1/1-1211 SVVYVYVQDYRSPFIASVSDEHDVVYITENKNKSVVVPCRGSISNLNVSLYARYPERRFV * :****:*:**********:*.:**:******:**:** ********** *****:*** ENSMUSP00000109144/1-1345 PDGNRISWDSEIGFTLPSYMISYAGMVFCEAKINDETYQSIMYIVVVVGYRIYDVILSPP ENSRNOP00000066886/1-1216 PDGNRISWDSEKGFTIPSYMISYAGMVFCEAKINDETYQSIMYIVLVVGYRIYDVVLSPP ENSP00000263923/1-1356 PDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPS ENSCPOP00000008975/1-1357 PDGNRIFWDSEIGFTIPSYMISYAGVVICEAKINDEVYQSIMYIVVIVGYKIYDVSLSPL XP_004849899.1/1-1211 PDGNRIFWDSEKGFTIPGYMISYAAMVICEAKINDENYQSIVYIVVVVGYKIYDVVLSPP ****** ***: ***:*.******.:*:******** ****:***::***:**** *** ENSMUSP00000109144/1-1345 HEIELSAGEKLVLNCTARTELNVGLDFTWHSPPSKSHHKKIVNRDVKPFPGTVAKMFLST ENSRNOP00000066886/1-1216 HEIELSAGEKLVLNCTARTELNVGLDFSWQFPSSKHQHKKIVNRDVKSLPGTVAKMFLST ENSP00000263923/1-1356 HGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLST ENSCPOP00000008975/1-1357 HGIELSVGEKLVLNCTARTELNVGLDFNWQCPSLKHQHRKIVNRDIKPLPGTEIKKFLST XP_004849899.1/1-1211 HGIELSVGEKLVLNCTAKTELNVGLVFSWQCPSLK------------------------- * ****.**********:******: *.*. *. * ENSMUSP00000109144/1-1345 LTIESVTKSDQGEYTCVASSGRMIKRNRTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIP ENSRNOP00000066886/1-1216 LTIDSVTKSDQGEYTCTAYSGLMTKKNKTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIP ENSP00000263923/1-1356 LTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIP ENSCPOP00000008975/1-1357 LTIDGVTRNDQGWYTCSASSGRMTKRNSTYVRVHAKPFVAFGSGMESLVEATVGDCVKIP XP_004849899.1/1-1211 --------------------------------------MFFGK------ESEVKSKSAWP : **. *: * . * ENSMUSP00000109144/1-1345 VKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVTERDAGNYTVILTNPISMEKQSH ENSRNOP00000066886/1-1216 VKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVSERDAGNYTVILTNPISMEKQSH ENSP00000263923/1-1356 AKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSH ENSCPOP00000008975/1-1357 VKYLGYPAPEIKWYKNGRLIESNYTIKVGHVLMIMEVSEKDAGNYTVILTNPISKEKQSH XP_004849899.1/1-1211 ------------------------------------------------------------ ENSMUSP00000109144/1-1345 MVSLVVN--VPPQIGEKALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYR ENSRNOP00000066886/1-1216 MVSLVVN--VPPQIGEKALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYR ENSP00000263923/1-1356 VVSLVVY--VPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANE ENSCPOP00000008975/1-1357 VVSLVVNASVPPEIGEKALISPVDSYQYGTTQTLTCTVYANPPLHHIQWYWQLEEECSYE XP_004849899.1/1-1211 ---------VPPQIGEKALISPMDSYQYGTTQTLTCTVYANPPLHHIHWYWQLEEECSYE ***:****:****:******* ********* ** ***:******* *: . ENSMUSP00000109144/1-1345 PGQ----TSPYACKEWRHVEDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYK ENSRNOP00000066886/1-1216 PSQ----TNPYTCKEWRHVKDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYK ENSP00000263923/1-1356 PSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYK ENSCPOP00000008975/1-1357 SSQAM--TNPYICKKWRTVEDFQGGNKIEVNKNQYAIIEGRNKTVSTLVIQAANVSALYK XP_004849899.1/1-1211 PSQAVLTANPYICKEWRTVEDFQGGNKIEVNKNQYALIEGRNKTVSTLVIQAANVSALYK ..* :.** *::** *:**********.***:*:***:******************* ENSMUSP00000109144/1-1345 CEAINKAGRGERVISFHVIRGPEITVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQ ENSRNOP00000066886/1-1216 CEAINKAGRGERVISFHVIRGPEITVQPATQPTEQESVSLLCTADRNTFENLTWYKLGSQ ENSP00000263923/1-1356 CEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQ ENSCPOP00000008975/1-1357 CEAVNKAGRGERVISFHVTKGPEITLQPAPQPTEQENVSLWCHADRATFENLTWYKVGPQ XP_004849899.1/1-1211 CEAVNKAGRGERVISFHVTKGPEITLQPTTQPTEQESVSLWCHADRATLESLTWYKVGPQ ***:**.*********** :*****:** ******.*** * *** *:*.*****:*.* ENSMUSP00000109144/1-1345 ATSVHMGESLTPVCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKT ENSRNOP00000066886/1-1216 ATSVHMGESLTPVCKNLDALWKLNGTVFSNSTNDILIVAFQNASLQDQGNYVCSAQDKKT ENSP00000263923/1-1356 PLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKT ENSCPOP00000008975/1-1357 PPLVHMGEQLTPVCKNLDALWKLNATMFSNSTNDVLVMEFQNVSLQDQGEYVCSAQDRKT XP_004849899.1/1-1211 PPLVHMEEQLTPICKNLDALWKLNATMFSNSTNDILVMEFQNVSLQDQGEYVCSAQDRKT . :*: * **:*****:*****.*:*******:*:: ::*.******:*** ***:** ENSMUSP00000109144/1-1345 KKRHCLVKQLIIL---ERMAPMITGNLENQTTTIGETIEVTCPASGNPTPHITWFKDNET ENSRNOP00000066886/1-1216 KKRHCLVKQLVIL---ERMAPMITGNLENQTTTIGETIEVVCPTSGNPTPLITWFKDNET ENSP00000263923/1-1356 KKRHCVVRQLTVL---ERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNET ENSCPOP00000008975/1-1357 KKRHCMVRQLTVLVCTERMAPVITGNLENQTTSTGETIEVACTAFANPPPQITWFKDNET XP_004849899.1/1-1211 KKKHCMVWQLTVL---ERMAPVITGNLENQTTSIGETIEVACTAFGNPPPQITWFKDNET **:**:* ** :* **:** **********: **:*** *.: .**.* * ******* ENSMUSP00000109144/1-1345 LVEDSGIVLRDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVI ENSRNOP00000066886/1-1216 LVEDSGIVLKDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVI ENSP00000263923/1-1356 LVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEII ENSCPOP00000008975/1-1357 LVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACNVLGCARVETFFIIEGAHAKTNLEVI XP_004849899.1/1-1211 LVEDSGIVLKDGNQNLTIRRVRKEDEGLYTCQACNVLGCSRVETFFIIEGAQAKTSLEVI *********:***:*********** ********.****::.*::******: **.**:* ENSMUSP00000109144/1-1345 ILVGTAVIAMFFWLLLVIVLRTVKRANEGELKTGYLSIVMDPDELPLDERCERLPYDASK ENSRNOP00000066886/1-1216 ILVGTAVIAMFFWLLLVIVLRTVKRANEGELKTGYLSIVMDPDELPLDERCERLPYDASK ENSP00000263923/1-1356 ILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASK ENSCPOP00000008975/1-1357 ILVGTAVIAMFFWLLLVIILRTVKRASEGELKTGYLSIVMDPDEMPLDERCERLPYDASK XP_004849899.1/1-1211 ILVGTAVIAMFFWLLLVIILRTVKRASEGELKTGYLSIVMDSDELPLDEHCERLPYDANK ******************:*******. *************.**:****:********.* ENSMUSP00000109144/1-1345 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSEL ENSRNOP00000066886/1-1216 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSEL ENSP00000263923/1-1356 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSEL ENSCPOP00000008975/1-1357 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSEL XP_004849899.1/1-1211 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSEL ************************************:*********************** ENSMUSP00000109144/1-1345 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGARFR ENSRNOP00000066886/1-1216 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGARFR ENSP00000263923/1-1356 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFR ENSCPOP00000008975/1-1357 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKTKGARFR XP_004849899.1/1-1211 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKTKGARFR *******************************************.*********:****** ENSMUSP00000109144/1-1345 QGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLI ENSRNOP00000066886/1-1216 SGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLI ENSP00000263923/1-1356 QGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLI ENSCPOP00000008975/1-1357 QGKDYVGELSLDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLI XP_004849899.1/1-1211 QGKDYVGEISVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLI .****** :.:**********************************.*:************ ENSMUSP00000109144/1-1345 CYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDAR ENSRNOP00000066886/1-1216 CYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDAR ENSP00000263923/1-1356 CYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDAR ENSCPOP00000008975/1-1357 CYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDAR XP_004849899.1/1-1211 CYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDAR ************************************************************ ENSMUSP00000109144/1-1345 LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMR ENSRNOP00000066886/1-1216 LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMR ENSP00000263923/1-1356 LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMR ENSCPOP00000008975/1-1357 LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMR XP_004849899.1/1-1211 LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMR ************************************************************ ENSMUSP00000109144/1-1345 APDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHLGNLLQANAQQDGKDYIVLPMSETLSM ENSRNOP00000066886/1-1216 APDYTTPEMYQTMLDCWHEDPNQRPAFSELVEHLGNLLQANAQQDGKDYIVLPMSETLSM ENSP00000263923/1-1356 APDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSM ENSCPOP00000008975/1-1357 SPDYTTPEMYQTMLDCWHEEPNQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSM XP_004849899.1/1-1211 APDYTTPEMYQTMLDCWHEEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSM :***************** :*.***:***************************:****** ENSMUSP00000109144/1-1345 EEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISHYLQNSKRKSRPVSVKTFEDIPLEE ENSRNOP00000066886/1-1216 EEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGI-------------------------- ENSP00000263923/1-1356 EEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEE ENSCPOP00000008975/1-1357 EEDSGLSLPTSPVSCTEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEE XP_004849899.1/1-1211 EEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNNKRKSRPVSVKTFEDIPLEE *************** ****************** ENSMUSP00000109144/1-1345 PEVKVIPDDSQTDSGMVLASEELKTLEDRNKLSPSFGGMMPSKSRESVASEGSNQTSGYQ ENSRNOP00000066886/1-1216 ------------------------------------------------------------ ENSP00000263923/1-1356 PEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQ ENSCPOP00000008975/1-1357 PEVKVILDDNQTDSGMVLASEELKTLEDRSKLAASFSGMMPSKSRESVASEGSNQTSGYQ XP_004849899.1/1-1211 PEVKVIPDDNQTDSGMVLASEELKTLEDRTKLAPSFSGMKPSKSRESVASEGSNQTSGYQ ENSMUSP00000109144/1-1345 SGYHSDDTDTTVYSSDEAGLLKMVDAAV---------HADSGTTLRSPPV ENSRNOP00000066886/1-1216 -------------------------------------------------- ENSP00000263923/1-1356 SGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV ENSCPOP00000008975/1-1357 SGYHSDDTDTTVYSSEEAELLKLVQAAQ---------QPDSGTALSSPPV XP_004849899.1/1-1211 SGYHSDDTDTTVYSSEEAELLKLVEATQ---------QPDSGTVLSSPPA