CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000006854/1-1360 MSAGASATGPRRGPPGLEEATSKKKQKDRANLESKDGDARR------------------- ENSRNOP00000067744/1-1357 MSAGTSATGPRRGPPGLEEATSKKKQKDRANQESKDGDPRR------------------- ENSP00000401197/1-1419 MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGD ENSCPOP00000008953/1-1348 MSGGASATGSRRGTPGLEEATSKKKQKDRANQESKDGDPRR------------------- XP_004834065.1/1-1349 MSGGTSATGPRRGPPGLEEATSKKKQKDRANQESKDGDPRR------------------- **.*:****.***.****::*********** ******.*: ENSMUSP00000006854/1-1360 ----------------------------VSLPRKEPTKD---------------ELLLDW ENSRNOP00000067744/1-1357 ----------------------------VSMPRKEPTKD---------------ELLLDW ENSP00000401197/1-1419 PSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDW ENSCPOP00000008953/1-1348 --------------------------GSLSTPREEQIKE---------------ELLLDW XP_004834065.1/1-1349 --------------------------VSLSTPQEEQTKE---------------ELLLDW * *::* *: ****** ENSMUSP00000006854/1-1360 RQSADEVIVKLRVGTGPVRLEDVDAAFTDTDCVVRLPDGRQWGGVFFAEIQSSCTKVQAR ENSRNOP00000067744/1-1357 RQSSDEVVVKLRVGTGPICLEEVDAAFTDTDCVVRLPDGRQWGGVFFAEIQSSCTKVQTR ENSP00000401197/1-1419 RQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCAKVQTR ENSCPOP00000008953/1-1348 RQSADEVIIKLRVGTGPLRLEEVDAAFTDTDCVVRFPGGQQWGGVFYAEIESSCTKVQAR XP_004834065.1/1-1349 RQSADEVIVKLRVGTGPLQLEEVDAAFTDTDCVVRLPGGRQWGGVFYAEIESSCTKVQAR ***::**::*****.**: **:*************:..*:******:***:***:***:* ENSMUSP00000006854/1-1360 KGGLLQLVLPKKVPLLTWPSLL-KPLGTQELVPGLQCQENGQELSPIALEPGSEPRRAKQ ENSRNOP00000067744/1-1357 KGGLLQLALPKKVPLLTWPSLLKKPLGTQELVPGLRCQENGQELSPIALEPGSEPRRAKQ ENSP00000401197/1-1419 KGSLLHLTLPKKVPMLTWPSLLKKPLGTQELVPGLRCQENGQELSPIALEPGPEPHRAKQ ENSCPOP00000008953/1-1348 KGGLLQLALPKKVPLLTWPSLLKKPLETQELATGLWSQENGQELSPVALEPGPEPRRAKQ XP_004834065.1/1-1349 KGGLLQLALPKKVPLLTWPSLLKK-LETQELVSGLRCQENGQELSPIALEPGPEPRRAKQ **.**:*.******:******* * * ****..** .*********:*****.**:**** ENSMUSP00000006854/1-1360 EARNQKRAQGRGEVGSGAGPGTQAGPSAKRAVHLRRGPEGEGSMDGPGPQGDAPSFLSDS ENSRNOP00000067744/1-1357 EARNQKRAQGRGEVGSGASPGAQAGPSAKRAVHLCRGPEGEGSMDGPGPQGDAPSFLSDS ENSP00000401197/1-1419 EARNQKRAQGRGEVGAGAGPGAQAGPSAKRAVHLCRGPEGDGSRDDPGPRGDAPPFVADP ENSCPOP00000008953/1-1348 EARNQKRAQGRGEVGSGAGPGVQAGPSAKRAVHLRRGPEGERSRDGPGPQGDAPSFLADP XP_004834065.1/1-1349 EARNQKRAQGRGEVGSGAGPGVQAGPSAKRAVHLRRGPEGERSRDGPGLQGDAPPFLADL ***************:**.**.************ *****: * *.** :****.*::* ENSMUSP00000006854/1-1360 ATQVEAEEKLCAPPMNTQTSLLSSEKSLALLTVEKTVSPRNDPVAPVMVQDRDPEPEQED ENSRNOP00000067744/1-1357 ATQVEAEEQLHVPPVNPQTSLLGSEKNLALLTVEKTVSPRSDSVSPVMIRNRD--PEKDD ENSP00000401197/1-1419 ATQVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGNDPVSPAMVRSRN--PGKDD ENSCPOP00000008953/1-1348 DTQVEAKEHLHVPPLNPKTCLLGSETNLALLSGEKAVFPRNDTVSSAISQVRD--PGKDG XP_004834065.1/1-1349 DAQVEAEEQLQVPLLNPKTCLLGSETNLALLSGEKAVFPRNDPVPAAIIQSRD--SGKDG :****.*:* * :*.:*.**.** .** *: **:* * .*.*...: : *: . ::. ENSMUSP00000006854/1-1360 QVKEEMALGADPTALVE--EPESMVNLAFVKNDSYEKGPDSVVVHVYVKEIRRDSSRVLF ENSRNOP00000067744/1-1357 HFKEEMAVGADPAALAD--EPESMVNLAFVKNDSYEKGPDSVVVHVYVKESRRDTSRVLF ENSP00000401197/1-1419 CAKEEMAVAADAATLVD--EPESMVNLAFVKNDSYEKGPDSVVVHVYVKEICRDTSRVLF ENSCPOP00000008953/1-1348 CVKEDMAGAANVTDLAD--EPESMVNLAFVKNDSYEKGPDSVVVHVYVKEIQRDTSRVLF XP_004834065.1/1-1349 HVKEEMVEPADVAALSDDKEPESIVNLAFVKNDSYEKGPDSVVVHVYVKEIQRDTSRVLF **:*. *: : * : ****:************************** **:***** ENSMUSP00000006854/1-1360 REQDFTLIFQTRDGNFLRLHPGCGPHTIFRWQVKLRNLIEPEQCTFCFTASRIDICLRKR ENSRNOP00000067744/1-1357 REQDFTLIFQTRDGNFLRLHPGCGPHTIFRWQVKLRNLIEPEQCTFCFTASRIDICLRKR ENSP00000401197/1-1419 REQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCTFCFTASRIDICLRKR ENSCPOP00000008953/1-1348 REQDFTLIFQTRDGNFLRLHPGCGPHTIFRWQVKLRNLIEPEQCTFCFTTSRIDICLHKR XP_004834065.1/1-1349 REQDFTLIFQTRDGNFLRLHPGCGSHTIFRWQVKLRNLIEPEQCTFCFTASRIDICLRKR ************************.** *********************:*******:** ENSMUSP00000006854/1-1360 QSQRWGGLEAPATRGAVGGAKVAVPTGPTPLDSTPPGGGPHPLTGQEEARAVEKEKPKAR ENSRNOP00000067744/1-1357 QSQRWGGLEAPATR--VGGAKVAVPTGPTPLDSTPPGGGPLPLTGQEEARAVEKEKPKAR ENSP00000401197/1-1419 QSQRWGGLEAPAAR--VGGAKVAVPTGPTPLDSTPPGGAPHPLTGQEEARAVEKDKSKAR ENSCPOP00000008953/1-1348 QSQRWGGLEAPAARGAVGGAKVAVPTGPTPLESAPPGGPPHPLTGQEEARTVEKDKAKAR XP_004834065.1/1-1349 QSQRWGGLEAPAARGAVGGAKVAVPTGPTPLESAPPGSPPHPLTGQEEARAVEKDKAKAR ************:* ***************:*:***. * *********:***:*.*** ENSMUSP00000006854/1-1360 SEDSGLDGVVARTPLEHVAPKPDPHLASPKPTCMVPPMPHSPVSGDSVEEDEEEEKKVCL ENSRNOP00000067744/1-1357 SEDSGLDGVVARTPLEHVTPKPEPHLASPKPTCMVPPMPHSPVSGDSVEEDEEEEKKVCL ENSP00000401197/1-1419 SEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCL ENSCPOP00000008953/1-1348 SEDVGLDSMAVRTPLEHVSTKPEPHLASPKPTCMVPPMPHSPVSGDS----------VCL XP_004834065.1/1-1349 SEDVGLDSVAARTPLEHVSPKPEPHLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCL *** ***.:..***:***:.**:.*********************** *** ENSMUSP00000006854/1-1360 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL ENSRNOP00000067744/1-1357 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL ENSP00000401197/1-1419 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL ENSCPOP00000008953/1-1348 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL XP_004834065.1/1-1349 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL ************************************************************ ENSMUSP00000006854/1-1360 LRALWKGTHQAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT ENSRNOP00000067744/1-1357 LRALWKGTHQAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT ENSP00000401197/1-1419 LRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT ENSCPOP00000008953/1-1348 LRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT XP_004834065.1/1-1349 LRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT *********:************************************************** ENSMUSP00000006854/1-1360 ETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP ENSRNOP00000067744/1-1357 ETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP ENSP00000401197/1-1419 ETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP ENSCPOP00000008953/1-1348 ETVDSDGRPDEVVAAEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP XP_004834065.1/1-1349 ETVDSDGRPDEVVAAEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP ************** ********************************************* ENSMUSP00000006854/1-1360 VPLPQKQKVLPIFYFAREPHSKPIK---------------------------FLVSVSKE ENSRNOP00000067744/1-1357 VPLPQKQKVLPIYYFAREPHSKPIK---------------------------FLVSVSKE ENSP00000401197/1-1419 VPLPQKQKVLPVFYFAREPHSKPIK---------------------------FLVSVSKE ENSCPOP00000008953/1-1348 VPLPQKQKVLPIFYFAREPHCKPIK---------------------------FLVSVSKE XP_004834065.1/1-1349 VPLPQKQKVLPIFYFAREPHCKPIKVRSKPFPSELFREPDPSPPLTPPLSPQFLVSVSKE ***********::*******.**** ******** ENSMUSP00000006854/1-1360 NSSASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDAVSPTDVLLCFELLSPE ENSRNOP00000067744/1-1357 NSSASEVLESLSQSVHVKPESLRLAEVIKNRFHRVFLPSHSLDAVSPTDVLLCFELLSPE ENSP00000401197/1-1419 NSTASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSE ENSCPOP00000008953/1-1348 NSSASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSQSLDTVSPSDTLLCFELLSPE XP_004834065.1/1-1349 NSSASEVLDSLSESVHVKPENLRLAEVIKNRFHRVFLPSQSLDTVSPSDILLCFELLSPE **:*****:***:*******.******************:***:***:* ********.* ENSMUSP00000006854/1-1360 LAKERVVVLEVQQRPQVPSIPISKCAACQRKQQSEEEKLKRCTRCYRVGYCNQFCQKTHW ENSRNOP00000067744/1-1357 LAKERVVVLEVQQRPQVPSIPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQFCQKTHW ENSP00000401197/1-1419 LAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHW ENSCPOP00000008953/1-1348 LAKERVVVLEVQQRPQVPSIPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKSHW XP_004834065.1/1-1349 LAKERVVVLEVQQRPQVPSIPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKNHW *******************:***************:*****************:***.** ENSMUSP00000006854/1-1360 PDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQS ENSRNOP00000067744/1-1357 PDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQS ENSP00000401197/1-1419 PDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQS ENSCPOP00000008953/1-1348 PDHKGLCRPENIGYPFLVSVPASRLTYARLTQLLEGYARYSVSVFQPPFQPGRMALESQS XP_004834065.1/1-1349 PDHKGLCRPENIGYPFLVSVPASRLTYARLTQLLEGYARYSVSVFQPPFQPGRMALESQS ******************************:***************************** ENSMUSP00000006854/1-1360 PGCTTLLSTSSLEAGDSEREPIQPSELQLVTPVAEGDTGAHRVWPPADRGPVPSTSGLSS ENSRNOP00000067744/1-1357 PGCTTLLSTSSLEAGDSEREPIQPSELQLVTPVAEGDTGAHRMWPPADRGPVPSTSGISS ENSP00000401197/1-1419 PGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISS ENSCPOP00000008953/1-1348 PGCTTLLSTSSLEAGDSEREPSQSPELQLV---AEGDTGVPRLWAAPDRGPVTSTSGISS XP_004834065.1/1-1349 PGCTTLLSTSSLEAGDSEREPIQPPELQLV---AEGDTGVPRVWVAPDRGPVASTSGISS *********.*********:* *..***** ****** *:* ..*****.****:** ENSMUSP00000006854/1-1360 EMLASGPIEGCPLLAGERVSRPEAAVPGYQHSSESVNTHTPQFFIYKIDASNREQRLEDK ENSRNOP00000067744/1-1357 EMLASGPMEGCSLLAGERVSRPEAAVPGYQHSRESVSAHTPQFFIYKIDASSREQRLEDK ENSP00000401197/1-1419 EMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDK ENSCPOP00000008953/1-1348 EMLTSGPTESSSLPVGERVSRPEAAVHGYQHPSEAINAHTPQFFIYKIDASNREQRLEDK XP_004834065.1/1-1349 EMLTSGTVENGSLPVGERVSRPEAAVPGYQHPSEAINAHTPQFFIYKIDASNREQRLEDK ***:**. * .* .*********** ****. *::.:***********:*.******** ENSMUSP00000006854/1-1360 GETPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNL ENSRNOP00000067744/1-1357 GDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNL ENSP00000401197/1-1419 GDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNL ENSCPOP00000008953/1-1348 GETPLELGEDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNL XP_004834065.1/1-1349 GETPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNL *:******:*************************************************** ENSMUSP00000006854/1-1360 FTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVE ENSRNOP00000067744/1-1357 FTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVE ENSP00000401197/1-1419 FTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVE ENSCPOP00000008953/1-1348 FTRPEVLAPEEAWYCPQCKLHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVE XP_004834065.1/1-1349 FTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVE ******************* **************************************** ENSMUSP00000006854/1-1360 FPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWR ENSRNOP00000067744/1-1357 FPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPSDRSSQRSDVGWR ENSP00000401197/1-1419 FPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWR ENSCPOP00000008953/1-1348 FPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWR XP_004834065.1/1-1349 FPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWR ***********************************************.************ ENSMUSP00000006854/1-1360 LFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRASHSEHHPDLGPAAEAAASQASR ENSRNOP00000067744/1-1357 LFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAAHAEHHPDLGPAAEAAASQASR ENSP00000401197/1-1419 LFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASR ENSCPOP00000008953/1-1348 LFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLDPAAEAAASQASR XP_004834065.1/1-1349 LFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLDPAAEAAASQGL- **************************************.*:******.*********. ENSMUSP00000006854/1-1360 IWQELEAEEEMVPEGPGPLGPWGPQDWVGPPPRGPTTPDEGCLRYFVLGTVAALVALVLN ENSRNOP00000067744/1-1357 IWQELEAEEEMVPEGPGPLGPWGPQDWVGPPPRGPTTSDEGCLRYFVLGTVAALVALVLN ENSP00000401197/1-1419 IWQELEAEEEPVPEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLN ENSCPOP00000008953/1-1348 IWQELEAEEELVPEGPGPMGPWGPQDWVGPPPRGPTTPDEGCLRYFVLGTVAALVALVLN XP_004834065.1/1-1349 --------------GPGQAPEVAPTR--TAPERYAPPVDRPAPTYSNMEEVD-------- *.* .* . * ... *. . * : * ENSMUSP00000006854/1-1360 VFYPLVSQSRWR ENSRNOP00000067744/1-1357 VFYPLVSQSRWR ENSP00000401197/1-1419 VFYPLVSQSRWR ENSCPOP00000008953/1-1348 VFYPLVSQSRWR XP_004834065.1/1-1349 ------------