CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000050172/1-1089 MTDDSLKIGNGLPLVGPGTDVGISSLPMLGYLGKNYASAKVTTDGHCPACRAKGKLSALK ENSRNOP00000064429/1-1069 MTDDSLKIGNGLPLVGPGTDIGISSLPMLGYLGKNYASAKVPADGYCPTCRAKGKLNTLK ENSP00000255304/1-1092 -MMDSPKIGNGLPVIGPGTDIGISSLHMVGYLGKNFDSAKVPSDEYCPACREKGKLKALK ENSCPOP00000008916/1-611 ------------------------------------------------------------ XP_004854840.1/1-885 ------------------------------------------------------------ ENSMUSP00000050172/1-1089 PYRISFQESVFLCEDLQCIYPLGSESLTNLISPDSEDCPTPSKPQKRKRLETNCRNSPLP ENSRNOP00000064429/1-1069 TYRISFQESIFLCEDLQCIYPLGSESLTNLISPDSEDCHTPNKPQKRKRLEDNCKNSSLP ENSP00000255304/1-1092 TYRISFQESIFLCEDLQCIYPLGSKSLNNLISPDLEECHTPHKPQKRKSLESSYKDSLLL ENSCPOP00000008916/1-611 ------------------------------------------------------------ XP_004854840.1/1-885 ------------------------------------------------------------ ENSMUSP00000050172/1-1089 VHSKKTRSHIVTDSEPIVNGKYNGEVCDDFSASFPDTSAHQDPASTAASVEQSEALEA-D ENSRNOP00000064429/1-1069 VHSKKTRGHLVTDSDQIVNGECNGEVCGDFSASFPGDSAHQDPARTAASVGQNGTLEAND ENSP00000255304/1-1092 ANSKKTRNYIAIDGGKVLNSKHNGEVYDETSSNLPDSSGQQNPIRTADSLERNEILEA-D ENSCPOP00000008916/1-611 ------------------------------------------------------------ XP_004854840.1/1-885 ------------------------------------------------------------ ENSMUSP00000050172/1-1089 DVVVAATEDPATV-------------SVTSELEMPAKSRCLPLCQTLCVQWKNTQALCWL ENSRNOP00000064429/1-1069 NVVMATTEDPAAV-------------GVTPELEMPSESRCLSLCQPLCVQWRNTQALCWL ENSP00000255304/1-1092 TVDMATTKDPATVDVSGTGRPSPQNEGCTSKLEMPLESKCTSFPQALCVQWKNAYALCWL ENSCPOP00000008916/1-611 -----------------------------------------SFCQTSCVQWRNTNALCWL XP_004854840.1/1-885 ---------------------------------MPWERTCSSFCHTSCVQWRNANALCWL .: :. ****:*: ***** ENSMUSP00000050172/1-1089 DCILSALVHLEVLRKTVLEACSREECVFGRLFEMYHQADELLHTHHLHGVTGEDCKKLTS ENSRNOP00000064429/1-1069 DCILSALVHLEVLRDAVLEVCSREECVFGKLFETYHQADKLLYTHHLHGVTGEDCKKMTT ENSP00000255304/1-1092 DCILSALVHSEELKNTVTGLCSKEESIFWRLLTKYNQANTLLYTSQLSGVKDGDCKKLTS ENSCPOP00000008916/1-611 DSILSALVHLEALKNTVTELCSK-DSVFWRLFEKYNQANKLLYTSQLDEVKDGEYKKLTS XP_004854840.1/1-885 DSILTALVHLEALKNIVTDLCPK-DSVFWRLFEKYNQANKLLHTSQSDEVKGGNYKKLTS *.**:**** * *:. * *.: :.:* :*: *:**: **:* : *.. : **:*: ENSMUSP00000050172/1-1089 EIFTEIDTCLNKVRDEIFAKLQPKLRCTLGDMESPVFALPVLLKLEPHVESLFTYSFSWN ENSRNOP00000064429/1-1069 EIFTEIDTSLNKIRDEIFAKLQPKLRCTLGDMESPVFALPVLLKLEPHVENLFTYSFSWN ENSP00000255304/1-1092 EIFAEIETCLNEVRDEIFISLQPQLRCTLGDMESPVFAFPLLLKLETHIEKLFLYSFSWD ENSCPOP00000008916/1-611 EIFAEIETYLNEVRDEIFAKLQPQLRCTLGERESPVFAFPLLLRIDVHIEKLFTYSFSWD XP_004854840.1/1-885 EISAEIETCLNEIRDEVFTKLQPQLRCTLGERESPVFAFPLLLRTEARVEKLFTYSFSWE ** :**:* **::***:* .***:******: ******:*:**: : ::*.** *****: ENSMUSP00000050172/1-1089 FECSHCGHQYQNRCVKSLVTFTNIVPEWHPLNAAHFGPCNSCNSKSQIRKMVLERASPIL ENSRNOP00000064429/1-1069 FECSHCGHQYQNRCVKSLVTFTNVVPEWHPLNAAHFGPCNSCNSKSQIRKMVLERASPII ENSP00000255304/1-1092 FECSQCGHQYQNRHMKSLVTFTNVIPEWHPLNAAHFGPCNNCNSKSQIRKMVLEKVSPIF ENSCPOP00000008916/1-611 FECSQCGHRYQNRCVKNLVTFTNVIPKWHPLNAAHFGPCNRCNSKSQIRKMVLEKVSPIF XP_004854840.1/1-885 FECSQCGHRYQNRCVKNLVTFTNVIPEWHPLNAAHFGPCNSCSSKSQRRKMVLERMSPIF ****:***:**** :*.******::*:************* *.**** ******: ***: ENSMUSP00000050172/1-1089 MLHFVEGLPRRDLQHYAFHFEGSLYQVTSVIQYQANNHFITWFLDADGSWLECDDLKGPC ENSRNOP00000064429/1-1069 MLHFVEGLPRKDLQHYAFHFEGSLYQVTSVIQYRAKNHFITWTVDADGSWLECDDLKGPC ENSP00000255304/1-1092 MLHFVEGLPQNDLQHYAFHFEGCLYQITSVIQYRANNHFITWILDADGSWLECDDLKGPC ENSCPOP00000008916/1-611 MVHFVEGLPRNDLQHYAYHYDCCLYQVASVIQXXXXXXXXXSLFCPSGSWLECDDLKGLC XP_004854840.1/1-885 MLHFVEGLPRSDLQHYAFHFEGCLYQITSVIQYQANDHFITWNLHADGSWLECDDLKGLC *:*******: ******:*:: .***::**** . ..*********** * ENSMUSP00000050172/1-1089 AKRHVTCEVPASETHIVIWERK-SQVPIEEAACLPCMKPNVQPVSGEEQPTCPALCSLAG ENSRNOP00000064429/1-1069 AKRHEACEVPASETHIVIWERK-SQVPVEGAACLPHMKLHVQSVSGEEQPSS-----LAG ENSP00000255304/1-1092 SERHKKFEVPASEIHIVIWERKISQVTDKEAACLPLKKTNDQHALSNEKPVSLTSCSVGD ENSCPOP00000008916/1-611 AQKHEKFEVPASEIHIVIWERKTAEASDEEAACLALAKTNEQQASGEAPPASPVSHPLGQ XP_004854840.1/1-885 AQRHEKLEVPASEIHIVIWERKTSQATDEEAACLPLKKTNDQPASSEEKPASPALHSVGQ :::* ****** ******** ::.. : ****. * : * . .: * . :. ENSMUSP00000050172/1-1089 TATSE-PSVAHPTSMAGAPQTLPEIQAVAHGDSVLSGAKGMVDS-ILPSALEETIQETAS ENSRNOP00000064429/1-1069 TATSE-PSVAHPTPMAVAPQILPATQAVAHGDSVLSGTGGLLDS-VSPSALEETIQETAS ENSP00000255304/1-1092 AASAETASVTHPKDISVAPRTLSQDTAVTHGDHLLSGPKGLVDN-ILPLTLEETIQKTAS ENSCPOP00000008916/1-611 AASAEASSGTLPTAVSLASHAVPQHRDVAHEDCVCPDPKVLADNSISPLTLEGSVLKTAS XP_004854840.1/1-885 AASAGATSVILPTSLTLAPHTLPQDKAVAHEDCILSDPKVWVDNNILPLTLQGTVWKTAS :*:: .* *. :: *.: :. *:* * : ... *. : * :*: :: :*** ENSMUSP00000050172/1-1089 VSQVDSKDCLLEDKPVAGSAALVRVLAFQPQDSPGSSGSSLVSSLCEGKLV-APCVDSSF ENSRNOP00000064429/1-1069 VSQIDSKDCLLEDKPVVGSAGPVRTLTFQPQDSL---GSSLVLNLCEGMLV-APCVDSRF ENSP00000255304/1-1092 VSQLNSEAFLLENKPVAENTGILKTNTLLSQESL---MASSVSAPCNEKLIQDQFVDISF ENSCPOP00000008916/1-611 VTS------LPENTPVAENTALGKMSTSQLKGSP---VDSSVSAPCK-----AQAVDLSF XP_004854840.1/1-885 VFQVSTEAFLPENMPVAENKEFVKTNTLQSQKSP---VSSSLSAPCKEKLIQAQFMDLSF * . * *: **. . : : : * * : *: :* * ENSMUSP00000050172/1-1089 PSQAVSTDLQAVLSQAGDTVVPNPVTDAPVPVLVQELKSLATEKDSQ-TQLLPLKTEKLD ENSRNOP00000064429/1-1069 PSQAVSTGLQAVPSQAGDTVVPKPVTDAPVPVLVQELKSMATE-DSQ-TQLLPLKTDRLN ENSP00000255304/1-1092 PSQVVNTNMQSVQLNTEDTVNTKSVNNTDATGLIQGVKSVEIEKDAQLKQFLTPKTEQLK ENSCPOP00000008916/1-611 PLQVVNTHTQLVPLNREDSAGAQPVSNGCATGLVQVVKPVEVKKDTQLKQSLPWKIEKLK XP_004854840.1/1-885 PLQIVNTNTQLVQLSTEDTAVTQPENNTYVAGLIQGIKSVEVEKDTQLKQSVSWKTEKLE * * *.* * * . *:. .:. .: .. *:* :*.: : *:* .* :. * ::*. ENSMUSP00000050172/1-1089 PEQ-PGKSQASNLRKRETTASSKTVAARSAQNQPRKEDQKRAFVGSWVKGLLSRGGAFMP ENSRNOP00000064429/1-1069 PGQPPGKTQASNLRKRENAASSKPVAARSAQNQPRKDEQKKAFVGSWVKGLLSRGGAFMP ENSP00000255304/1-1092 PER--VTSQVSNLKKKETTADSQTTTSKSLQNQSLKENQKKPFVGSWVKGLISRGASFMP ENSCPOP00000008916/1-611 PDS-PSLSHISNLTKKEATADPQTIKAKSSLNQPPKENQKKPFVGSWVKGLLSRGASFMP XP_004854840.1/1-885 PEQ-PSISQVSNLKKK-ATADPHSVTASSSQNQPLKENQKKPFVGSWVKGLLSRGASFMP * :: *** *: :*..:. : * **. *::**:.*********:***.:*** ENSMUSP00000050172/1-1089 TCVLSQSRA-VSDLQPSVKGASNFDGFKTKSISRRSKRMSRKAKHMEELSPRNSSPPLS- ENSRNOP00000064429/1-1069 PCVSAQSRA-VTDLQPSVKGANNFDGFKTKSINRRSKRMSRKAKHVEEASPGSSPPLSG- ENSP00000255304/1-1092 LCVSAHNRNTITDLQPSVKGVNNFGGFKTKGINQKASHVSKKARKSASKPPPISKPPAGP ENSCPOP00000008916/1-611 ACVSAHNRN--TDLQPSVKGASHFGGFKTKRAKQKASHESKKAHRSAAKPSAAGSPPPGL XP_004854840.1/1-885 SCVSAHSRNTVTNLQPSVKGANNFGGFKTKSIKQKTSHVSKKACRSADKSSAFSNPPPGL ** ::.* ::*******..:*.***** .:::.: *:** : .. . * . ENSMUSP00000050172/1-1089 ----WTAALTQAAENATSALLREQEG-SRPAPLRHRSPGNESAISPASRGDAAEDQVHKL ENSRNOP00000064429/1-1069 ----STAALPQAAGNASSAQLKEQEG-SRSAPLSHRPPSDESAMSPAGRAEAAEDQVHKL ENSP00000255304/1-1092 PSSNGTAAHPHA--HAASEVLEKSGSTSCGAQLNHSSYG--NGISSANHEDLVEGQIHKL ENSCPOP00000008916/1-611 PRPEDTAAAP-------------------------------------------------- XP_004854840.1/1-885 PLSENTAAHSHTNENAASELLKKRESTSHGAYLNHPSHRRENGTSSANHGDSAEGQIHKL *** . ENSMUSP00000050172/1-1089 RLKLLKKLKAKKKKLAALISSPHREPSLSDHSEPASHCGTPASDQSEPVSHCGSPNDCES ENSRNOP00000064429/1-1069 RLRLLKKLKAKKKKLAALMSSPRREPSVSDH--------------SEPASHCGSPNDCDA ENSP00000255304/1-1092 RLKLRKKLKAEKKKLAALMSSPQSRTVRSEN--------------LEQVPQDGSPNDCES ENSCPOP00000008916/1-611 ------------------------------------------------------------ XP_004854840.1/1-885 RLKLLKKLKAKKKKLAALMSSPQSETLPSEN--------------LEHGPPCESPNDCES ENSMUSP00000050172/1-1089 IEDLLKELQHQIDLADSKSGCTSAPDATSNNSQSHEEILAELLSPTAMS-EPSESGELEL ENSRNOP00000064429/1-1069 VEDLLRELQYQIDLADNKSGCTSAPDGTSCNSQSHEEILAELLSPTALS-EPSESGEPEL ENSP00000255304/1-1092 IEDLLNELPYPIDIA-SESACTTVPGVSLYSSQTHEEILAELLSPTPVSTELSENGEGDF ENSCPOP00000008916/1-611 ------------------------------------------------------------ XP_004854840.1/1-885 IEDLLNELQYQIDIADSKSGCATISSMSSYNNQTHEEILAELLSPTSISTEFSENGETDF ENSMUSP00000050172/1-1089 RYLEMGDS-TPAQAPSEFSVVSQNTCLKQDHDYCSP-EKGQREVDLHSVMDSACIRTLNL ENSRNOP00000064429/1-1069 RYLEMGDNSTPTPAPSEFSAVSQNTCLNQEHNYCSP-EKSQCEVDLHSVIDSACVRALNL ENSP00000255304/1-1092 RYLGMGDSHIPPPVPSEFNDVSQNTHLRQDHNYCSPTKKNPCEVQPDSLTNNACVRTLNL ENSCPOP00000008916/1-611 ------------------------------------------------------------ XP_004854840.1/1-885 RYLEMGDDHIPAPKPTELIDNSQNIQLKQEHNYCSPPKRNQCEVQPVSQINNACVRTLNL ENSMUSP00000050172/1-1089 GSPMKTDIFDDFFSTSALNSLTNDTLDIPHFDDSLFENC ENSRNOP00000064429/1-1069 GSPMKTDIFDDFFPTSALNSLTNDTLDIPHFDDSLFENC ENSP00000255304/1-1092 ESPMKTDIFDEFFSSSALNALANDTLDLPHFDEYLFENY ENSCPOP00000008916/1-611 --------------------------------------- XP_004854840.1/1-885 ESPMKTDIFDEFFST-ALTSSANDTLDLPHFDEYLFENY