CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000008875/1-1500 MERVLAELCGTSPARPLPLWEGDTAGHCFTQLVLSALPHAFLAVLSACHWGTPRSPDYVL XP_004846554.1/1-1507 MERVLAQLCGTSAVQPLPLWERDTAGHCFTQLVLSALPHALLAVLSACHWGTPRSPDYVL ENSP00000361608/1-1492 MERLLAQLCGSSAAWPLPLWEGDTTGHCFTQLVLSALPHALLAVLSACYLGTPRSPDYIL ENSMUSP00000038041/1-1526 MEGLLAQLCGTDAARPLPLWEGDTTGHCFTQLVLSALPHALLAVLSACHLGTPRTTNHSP ENSRNOP00000025598/1-1494 MEGLLAQLCGTDAARPLPLWEGDTTGHCFTQLVLSVLPHALLAVLSACHLGTPRTNNIIQ ** :**:***:... ****** **:**********.****:*******: ****: : ENSCPOP00000008875/1-1500 PASPGWRLRLAAAFLLSIFPLLDLLPVVLPPGAGPGPIGLEVLAGCVAAVAWTSHSLALW XP_004846554.1/1-1507 LCCPGWRLRLTAALLLSIFPLLDLLPVLLPPGAGPGPTGLEVLAGCVAAVAWSSHSLALW ENSP00000361608/1-1492 PCSPGWRLRLAASFLLSVFPLLDLLPVALPPGAGPGPIGLEVLAGCVAAVAWISHSLALW ENSMUSP00000038041/1-1526 ALNPGWRLRLAASFLLSIFPLLDLLPVVLPPGSRPGPLWLEVLAGCVTAVAWFTHSLALW ENSRNOP00000025598/1-1494 PFNPGWRLRLTASFLLSVFPLLDLLPVVLPPVSHPGPLWLEVLAGCVTAVAWFTHSLALW *******:*::***:********* *** : *** ********:**** :****** ENSCPOP00000008875/1-1500 ALSHSPHGRSRGPWALALAAFLPAPALVLTLLWHCQQGTFLPPVLPGPLARLCLLILQLA XP_004846554.1/1-1507 VLAHSPNGRSRGPWALSLAAFLPAPALVLTLLWHCQQDTFLPPLHPGPLARLCLLILQLA ENSP00000361608/1-1492 VLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQRGTLLPPLLPGPMARLCLLILQLA ENSMUSP00000038041/1-1526 ALVHSPHGRSRGPLALALAAFLPTPALVLTLLWHCQRGTFLPPLLPGPLGRVCLLILQLA ENSRNOP00000025598/1-1494 ALVHSPHGHSRGPLALALAAFLPTPALVLTLLWHCQRGTFLPPLLPGPLGRVCLLILQLA .* ***:*:**** **:*.*:**:******:*****:.*:***: ***:.*:******** ENSCPOP00000008875/1-1500 AVLAYGLGWAAPGGPSPEPWTHEPFLSSVGQESEVAEDGESWLSRLSYAWLGPLLRVGL- XP_004846554.1/1-1507 AVLAYGLGWAAPGGPPLEPWTHEPFMSSGSREPEVAEDGESWLSRFSYAWLAPLLARGAR ENSP00000361608/1-1492 ALLAYALGWAAPGGPR-EPWAQEPLL-PEDQEPEVAEDGESWLSRFSYAWLAPLLARGAC ENSMUSP00000038041/1-1526 AVLAYGLGWAAPGGPQ-EPWTHDPFLSSESQETEVAEDGESWLSRFSYAWLAPLLARGVR ENSRNOP00000025598/1-1494 AVLAYGLGWAAPGGPR-EPWTHDPFLSPESQEREVAEDGESWLSRFSYAWLAPLLARGVR *:***.********* ***:::*:: . .:* ************:*****.*** * ENSCPOP00000008875/1-1500 GELRQPEDTCRLPHRLHPAYVARAFQAHWQEDTQLWRALYGAFGRCYLALGLLKLVGTML XP_004846554.1/1-1507 GELRQPQDTCRLPYRLHPAYVARVFQAHWQEGAQLWRTLYGAFGRCYLALGLLKLVGTML ENSP00000361608/1-1492 GELRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRALYGAFGRCYLALGLLKLVGTML ENSMUSP00000038041/1-1526 GELQQPRDTCRLPRRLHPAFLARVFQAHWKEGAQLWRALYRAFGCCYLALGLLKMVGTML ENSRNOP00000025598/1-1494 GELRQPQDTCRLPRRLHPAYLARAFQAHWKEGAQLWRALYGAFGCCYIALGLLKMVGTML ***:**.* **** **:*:::**.*****:*.::***:** *** **:******:***** ENSCPOP00000008875/1-1500 GFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGSAVLGAVLQNQYGYEVRKVTLQARGA XP_004846554.1/1-1507 GFSGPLLLSLLVGFLEDRQEPLSQGLLYALGLAGGAVLGAVLQNQYGYEVRKVTLQARGT ENSP00000361608/1-1492 GFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGA ENSMUSP00000038041/1-1526 GFSGPLLLSLLVGFLEEGQEPLSHGLLYVLGLAGGTVISAVLQNQYGYEVRKVTLQARVA ENSRNOP00000025598/1-1494 GFSGPLLLSLLVGFLEEGQEPLSHGLLYVLGLASGSVISAVLQNQYGYEVRKVTLQARVA ****************: *****:****.****..:*:.*********** ******* : ENSCPOP00000008875/1-1500 VLNILYRKALHLGPRRPPTGEVLNFLGTDSERLLNFTGSFHEAWGLPLQLAITLYLLYQQ XP_004846554.1/1-1507 VFNVLYHKALHLGPRRPPAGEVLNLLGTDSERLLNFTGSFHEAWGLPLQLAITLYLLYQQ ENSP00000361608/1-1492 VLNILYCKALQLGPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQ ENSMUSP00000038041/1-1526 VLSTLYRKALKLGPSRPPTGEVLNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQ ENSRNOP00000025598/1-1494 VLSILYRKTLKLGPSRPPTGEVLNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYEQ *:. ** *:*:*** ***:**.**:***********:*********************:* ENSCPOP00000008875/1-1500 VGLAFVGGLVLALLLVPVNKVIATRIMASNQEMLQHKDARVKLMTELLSGIRVIKFFGWE XP_004846554.1/1-1507 VGLAFVGGLVLALLLVPVNKVIATRIMASNQEMLQHKDARVKLMTELLSGIRVIKFFGWE ENSP00000361608/1-1492 VGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWE ENSMUSP00000038041/1-1526 VGMAFLAGLVLALLLVPVNKVIATRIMASNQEMLRHKDARVKLMTELLSGIRVIKFFRWE ENSRNOP00000025598/1-1494 VGVAFLAGLVLALLLVPVNKVIATRIMANNQEMLRHKDARVKLMTELLSGIRVLKFFRWE **:**:.**:******************.*****:********:*********:** ** ENSCPOP00000008875/1-1500 QAMATRVEACRAQELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVF XP_004846554.1/1-1507 QVLATRVEACRAQELGRLKVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVF ENSP00000361608/1-1492 QALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVF ENSMUSP00000038041/1-1526 QALGDRVKACRTKELGRLRVIKYLDAACVYLWAALPVVICITIFITYVLMGHQLTATKVF ENSRNOP00000025598/1-1494 QALGDRVKACRTQELGRLRVIKYLDAACVYLWAALPVVICIVIFITYVLLGHQLTATKVF *.:. **:***::*****:********************.*.*******:********** ENSCPOP00000008875/1-1500 TALALVRMLILPLNNFPWVINGLLEAKVSLDRIQRFLDLPNYNPQAYYSPEPPSEPSTVL XP_004846554.1/1-1507 TALALVRMLILPLNNFPWVINGLLEAKVSLERIQRFLNLPNYNPQAYYSPEPPSEPSTVL ENSP00000361608/1-1492 TALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDPPAEPSTVL ENSMUSP00000038041/1-1526 TALALVRMLILPLNNFPWVINGLLESKVSLDRIQRFLDLPSYSPEAYYSPDPPAEPSTAL ENSRNOP00000025598/1-1494 TALALVHMLILPLNNFPWVINGLLESKVSLDRIQRFLDLPSYSPEAYYSPDPPTEPSTVL ******:******************:****:*** **:**.:.*:*****:**:****.* ENSCPOP00000008875/1-1500 ELHEALFSWDPIGSSQETFISHLKVKKGTLVGIVGKVGCGKSSLLAAITGELHRLGGRVA XP_004846554.1/1-1507 ELHEAVFSWDPTGTSQETFISHLEVKKGALVGIVGKVGCGKSSLLAAITGELHRLRGRVA ENSP00000361608/1-1492 ELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVA ENSMUSP00000038041/1-1526 ELHEALFSWDPIGASQKTFISHLQVKKGMLVGIVGKVGCGKSSLLAAITGELHRLCGWVA ENSRNOP00000025598/1-1494 ELHEALFSWDPTGTSQKTFISHLQVKKGMLVGIVGKVGCGKSSLLAAITGELHRLCGWVA *** *:***** *:* :******:**** *******************:****** * ** ENSCPOP00000008875/1-1500 VWGLSKGFGLATQEPWIQFATIRDNILFGKMFNAQLYREVLEACALNEDLSVLPAGDQTE XP_004846554.1/1-1507 VWGLSKGFGLATQEPWIQFATIRDNILFGKTFDAHLYREVLEACALNEDLSVLPAGDQTE ENSP00000361608/1-1492 VRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTE ENSMUSP00000038041/1-1526 VSELSKGFGLATQEPWIQCATIRDNILFGKTFDAQLYREVLEACALNDDLSILPAGDQTE ENSRNOP00000025598/1-1494 VSDLSKGFGLATQEPWIQCATIRDNVLFGKTFDAQLYREVLEACALNDDLSILPAGDQTE * *************** ******:**** *:*:**:*********:***:******** ENSCPOP00000008875/1-1500 VGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVASHLLHKCILGVLSHTTR XP_004846554.1/1-1507 VGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDADVANHLLHRCILGVLSHTTR ENSP00000361608/1-1492 VGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTR ENSMUSP00000038041/1-1526 VGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDADVANHLLHRCILGVLSHTTR ENSRNOP00000025598/1-1494 VGEKGVTLSGGQRARIALARAVYQEKTLYLLDDPLAAVDADVANHLLHRCILGVLGHTTR ************************** ****************.****:****:*.:*** ENSCPOP00000008875/1-1500 LLCTHRTEYLEKADVVLLLEAGRLVQAGPPSEILPLVQAVPKTQAEDGQVPGSAKAPLEQ XP_004846554.1/1-1507 LLCTHHTEYLEKADLVLLLEAGRLVQAGPPSQILPLVQAVPKTQAKDGQEPGSARAPLIQ ENSP00000361608/1-1492 LLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQSVQ ENSMUSP00000038041/1-1526 LLCTHRTEYLERADVVLLMEAGQLVRTGPPSEILPLVQAVPTAWAEKEQVATSGQSPSVC ENSRNOP00000025598/1-1494 LLCTHRTEYLERADLVLLMEAGRLVRAGPPSEILPLVQAAPTALADKEQVTDSGQSPSVH *****:*****:** ***:***:*:::****:*******.*.: *.. * . *. : ENSCPOP00000008875/1-1500 SLEDTS-EGPAVEQSTCGRLLQEESKKEGAVALHVYRAYWRAVGCVLALVILLSLLLMQA XP_004846554.1/1-1507 SLEDMK-EGLEAEQSTCGRLLQDESKKEGAVALQVYQTYWRAVGCALALATLFSLLLMQA ENSP00000361608/1-1492 NPEKTK-EGLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQA ENSMUSP00000038041/1-1526 DLERTTEEELEVEQSTCGCLVQEESKSEGAVALHVYRAYWRAMGSGLAAAILVSLLLMQA ENSRNOP00000025598/1-1494 NLEKTT-EELDVAQNTSGRLVQEESKSEGAVALHVYRAYWRAMGSGLATAILISLLLMQA . * . * *.*.* *:*:***.******:**::**:*:* ** . *.******* ENSCPOP00000008875/1-1500 TRNAADWWLSYWISQLRAGGNGSGEVPASATQGPSGLFSPKLLLFSPASLCTPVF--PLP XP_004846554.1/1-1507 TRNGADWWLSYWISQLRAGGNGSGEVSAPATQSPSGLFSPQLLLFSPGSLCAPVF--PLP ENSP00000361608/1-1492 TRNAADWWLSHWISQLKA-ENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVF--PLP ENSMUSP00000038041/1-1526 TRNGADWWLAHWLSQLKAGRNGSREDPASCSPGSTALFSPRLLLFSPGNLYTPLLSTPLH ENSRNOP00000025598/1-1494 TRNGADWWLAHWLSQLKAGRNSSEERPASSSPRSMGFFSPRLLLFSPGNLYI-----PLH ***.*****::*:***:* *.* * .. : . .:***:******..* ** ENSCPOP00000008875/1-1500 TVAPNGSSDVSFYLTVYATIAGINSLCTLLRAVLFAAGTLRAAATLHCRLLRRVLQAPVS XP_004846554.1/1-1507 KATPNGSSDVRFYLTVYATIAGINSLCTLLRAVLFAAGTLRAAATLHCRLLQRVLQAPVS ENSP00000361608/1-1492 KAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVT ENSMUSP00000038041/1-1526 KAASNGTADVHFYLIVYATIAGVNSLCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVT ENSRNOP00000025598/1-1494 KATSNGSSDVHFYLTVYATIAGVNSLCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVT ..:.**::*: *** *******:***************:*:***:** ***:*:* ***: ENSCPOP00000008875/1-1500 FFDSTPTGRVVNRFSSDVACVDDSLPFLLNILLANAAGLLGLLAVLGSGLPWLLLLLPPL XP_004846554.1/1-1507 FFDSTPTGRVVNRFSSDVACVDDSLPFLLNILLANAVGLLGLLVMLGFGLPWLLLLLPPL ENSP00000361608/1-1492 FFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPL ENSMUSP00000038041/1-1526 FYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLLGLLAVLGSGLPWLLLLLPPL ENSRNOP00000025598/1-1494 FYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLLGLLAVLGSGLPWLLLLLPPL *:::**:**::*********.******:*******:.******.:** ************ ENSCPOP00000008875/1-1500 SIVYYRVQRHYRASSRELRRLSSLTLSPLYTHLADTLAGLPVLRAAGATYRFEEENQHLL XP_004846554.1/1-1507 SVLYYRVQRHYRASSRELRRLGSLTLSPLYTHLADTLGGLPVLRAAGATYRFEEENQRLL ENSP00000361608/1-1492 SIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLL ENSMUSP00000038041/1-1526 SFVYYSVQGYYRASFRELRRLGSLTWSPLYSHLADTLAGLPVLRAAGATYRFEEENQRLL ENSRNOP00000025598/1-1494 SFIYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLAGLPVLRAAGATYRFEEENQRLL *.:** ** **** ******.*** ****:******.**.****:********** :** ENSCPOP00000008875/1-1500 ELNQRCQFASCATIQWLDIRLQLIGAVVVSAIAGIALVQHQQGLANPGLVGLVLSYALSL XP_004846554.1/1-1507 ELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALVQHEQGLANPGLVGLALSYALSL ENSP00000361608/1-1492 ELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSL ENSMUSP00000038041/1-1526 ELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLVLSYALSL ENSRNOP00000025598/1-1494 ELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLVLSYALSL *********: **:*********:**.*************:*********** ******* ENSCPOP00000008875/1-1500 TGLLSGLVSSFTQTEVMLVSVERLEEYSRDLAQEPQGRRLQVHHPPPQLASWLTQGSVEF XP_004846554.1/1-1507 TGLLSGLVSSFTQTEVMLVSVERLEEYSCDLAQEPRGCPLQ-------ANSWLTRGSVEF ENSP00000361608/1-1492 TGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQ------LGTGWLTQGGVEF ENSMUSP00000038041/1-1526 TGLLSGLVSSFTQTEAMMVSVERLEEYSCDVPQEPHSQPLQ--SPHQQRISWLTQGSVEF ENSRNOP00000025598/1-1494 TGLLSGLVSSFTQTEAMMVSVERLEEYSCDIPQEPHGQPPQ--SPH-QRVSWLTQGSVEF ***************.*:*********: *:.***:. * .***:*.*** ENSCPOP00000008875/1-1500 QDVVLVYRPGLPHALDGVTFRVQPGEKLGIVGRTASGKSSLFLVLFRLVEPSAGRVLLDG XP_004846554.1/1-1507 QDVVLVYRPGLPPALNGVTFRVQPGEKLGIVGRTGSGKSSLFLVLFRLVEPSAGRVLLDD ENSP00000361608/1-1492 QDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDG ENSMUSP00000038041/1-1526 QDVVLVYRPGLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLDN ENSRNOP00000025598/1-1494 QDVVLVYRPGLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPSAGQVLLDG *****.****** **:**** *:***********.******:******:**.:*:****. ENSCPOP00000008875/1-1500 VDTSQLDLTELRSQLAIIPQEPFLFSGTVRENLDPWGQHEDRALWQVLEQCHLSEVVVSI XP_004846554.1/1-1507 TDTSQLELAELRSQLAIIPQEPFLFSGTIRENLDPQGLHEDGALWQVLEQCHLSEVVIFM ENSP00000361608/1-1492 VDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM ENSMUSP00000038041/1-1526 VDTSQLELAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVAVAM ENSRNOP00000025598/1-1494 VDTSQLELAELRSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQCHLSEVAMAI .*****:*::******:***********:****** * *:* ****.*:******* : ENSCPOP00000008875/1-1500 G-------------------------GLDSEVGERGRSLSLGQRQLLCLARALLTDAKIL XP_004846554.1/1-1507 G-------------------------GLDSELGEGGRSLSLGQRQLLCLARALLTNAKIL ENSP00000361608/1-1492 G-------------------------GLDGELGEGGRSLSLGQRQLLCLARALLTDAKIL ENSMUSP00000038041/1-1526 GESQACQRSQREAKNGHWQCSALLTGGLDGELGERGQNLSLGQRQLLCLARALLTDAKIL ENSRNOP00000025598/1-1494 G-------------------------GLDGELGERGRDLSLGQRQLLCLARALLTDAKIL * ***.*:** *:.*****************:**** ENSCPOP00000008875/1-1500 CIDEATASVDQKTDQLLQQTICQRFANKTVLTIAHRLNTILNSDRVLVLHAGRVIGLDTP XP_004846554.1/1-1507 CIDEATASVDHKTDQLLQQTICQRFANKTVLTIAHRLNTILNSDRVLVLHAGRVVGLDSP ENSP00000361608/1-1492 CIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSP ENSMUSP00000038041/1-1526 CIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSP ENSRNOP00000025598/1-1494 CIDEATASVDQKTDQLLQQTICRRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSP **********:***********:**************************:****: **:* ENSCPOP00000008875/1-1500 TSLHDQGHSMFQQLLQSGLEEATAPPEQP------------- XP_004846554.1/1-1507 TALCDQGHSVFRQLLQSGLEEAAAPPGDPEPQVVAPRTLPSL ENSP00000361608/1-1492 ATLRNQPHSLFQQLLQSSQQGVPASLGGP------------- ENSMUSP00000038041/1-1526 SALRNQPHSLFQQLLQSSQQGAHSGPSGC------------- ENSRNOP00000025598/1-1494 SALRNQPHSLFRQLLQSSQQGAHSLPAAC------------- ::* :* **:*:*****. : . :