CLUSTAL W(1.81) multiple sequence alignment ENSP00000289547/1-1359 MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSN ENSMUSP00000004505/1-1333 -MAAAWQGWLLWALLLNSAQGELYTPTHKAGFCTFYEECGKNPELSGGLTSLSNISCLSN ENSRNOP00000065524/1-1331 -MAAAWLGWLLWALLLSAAQGELYTPKHEAGVCTFYEECGKNPELSGGLTSLSNVSCLSN ENSCPOP00000008843/1-1290 -MASCWHGWLLWALLLCSARGELYTPIHRAGYCTSYEECGPNPELSGGLTSLSNVSCLSN XP_004839970.1/1-1290 -MAAGLQGWLLWALLLCSARGELYTPIHKPGYCTSYEECGSNPELSGGLTSLSNVSCLSN : ********* *:.* **. *..* *: *:*** ******.* :***:***** ENSP00000289547/1-1359 TPARKITGDHLILLQKICPRLYTGPNTQ-ACCSAKQLVSLEASLSITKALLTRCPACSDN ENSMUSP00000004505/1-1333 TPARHVTGDHLALLQRVCPRLYNGPNDTYACCSTKQLVSLDSSLSITKALLTRCPACSEN ENSRNOP00000065524/1-1331 TPARHVTGEHLALLQRICPRLYNGPNTTFACCSTKQLLSLESSMSITKALLTRCPACSDN ENSCPOP00000008843/1-1290 TPARLITGDHLALLQRICPRLYNGSGTTYACCSTKQLLSLEMSMSITKALLTRCPACSDN XP_004839970.1/1-1290 TPARLLTGDHLALLQRICPRLYAGPNTTYACCSTKQLVSLEMSMTITKALLTRCPACSDN **** :**:** ***::***** *.. ****:***:**: *::*************:* ENSP00000289547/1-1359 FVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPA ENSMUSP00000004505/1-1333 FVSIHCHNTCSPDQSLFINVTRVVQRDPGQLPAVVAYEAFYQRSFAEKAYESCSRVRIPA ENSRNOP00000065524/1-1331 FVSLHCHNTCSPDQSLFINVTRVVERGAGEPPAVVAYEAFYQRSFAEKAYESCSQVRIPA ENSCPOP00000008843/1-1290 FVSLHCQNTCSPDQSLFINVTRVAPRGTGQPPAVVAYEAFYQRSFAERAYESCSRVRIPA XP_004839970.1/1-1290 FVSLHCQNTCSPNQSLFINVTRVVPREASKPPAVVAYEAFYQRSFAEAAYESCSQVRIPA **.:**:*****:**********. ..: ***********:**** :*:***:**:** ENSP00000289547/1-1359 AATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEG ENSMUSP00000004505/1-1333 AASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALADGMKPLDGK ENSRNOP00000065524/1-1331 AASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALPDGIQPLNGK ENSCPOP00000008843/1-1290 AATLAVGSMCGVYGSDLCNAQRWLNFQGDTGNGLAPLDITFHLTEPSQTLRDGMQPLDAM XP_004839970.1/1-1290 AASLAVGTMCGVYGSALCNAERWLNFQGDTGNGLAPLEITFHLCEPGQALRDGMQPLDAM **:****:******* ****:****************:***** **.*:: .*::**: ENSP00000289547/1-1359 VARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVT ENSMUSP00000004505/1-1333 ITPCNESQGEDSAACSCQDCAASCPVIPPPPALRPSFYMGRMPGWLALIIIFTAVFVLLS ENSRNOP00000065524/1-1331 IAPCNESQGDDSAVCSCQDCAASCPVIPPPEALRPSFYMGRMPGWLALIIIFTAVFVLLS ENSCPOP00000008843/1-1290 ITPCNEAQGNGTVACSCQDCAASCPVIPPPSNLRPFFYLGLLPGWAVIIIIFSCVFLLLT XP_004839970.1/1-1290 IVGCNETQGNGTAACSCQDCAASCPTIPPPSSLRPFFYMGHLPGWVVLIVIFCSVFVLLI :. ***:**:. ..***********.*. * * . **:* :** .:*:*: .** :: ENSP00000289547/1-1359 ILLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLS ENSMUSP00000004505/1-1333 VVLVYLRVASNRNKNKTAGSQEAPNLPRKRRFSPHTVLGRFFESWGTRVASWPLTVLALS ENSRNOP00000065524/1-1331 AVLVRLRVVSNRNKNKAEGPQEAPKLPHKHKLSPHTILGRFFQNWGTRVASWPLTVLALS ENSCPOP00000008843/1-1290 TILAQLRVTARRKKARSQGPPVSPVTSEKHRCSPNTVLARFFERWGRTVASWPLTVLAVS XP_004839970.1/1-1290 AILARLRAISER-RARTQGPPGAPSPPKKRSCSPHTVLGRFFESWGRTVASWPLTVLTLS :*. :*. . * : : .. .. . * *.:*:*.:**: ** *******:*.:* ENSP00000289547/1-1359 VIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSS ENSMUSP00000004505/1-1333 FIVVIALSVGLTFIELTTDPVELWSAPKSQARKEKAFHDEHFGPFFRTNQIFVTAKNRSS ENSRNOP00000065524/1-1331 FIVVIALAAGLTFIELTTDPVELWSAPKSQARKEKSFHDEHFGPFFRTNQIFVTARNRSS ENSCPOP00000008843/1-1290 LVGVVALASGLTFLELTTDPVDLWSAPNSQARQEKEFHDQHFGPFFRTNQVFLTATNRSS XP_004839970.1/1-1290 LMVALGLASGLTFVKLTTDPVDLWSAPKSQARQEKEFHDQHFGPFFRTNQAFLTATNRSS .: .:.*: **.* :******:*****:****.** ***:********** ::** **** ENSP00000289547/1-1359 YRYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDN ENSMUSP00000004505/1-1333 YKYDSLLLGPKNFSGILSLDLLQELLELQERLRHLQVWSHEAQRNISLQDICYAPLKPHN ENSRNOP00000065524/1-1331 YKYDSLLLGSKNFSGILSLDFLLELLELQERLRHLQVWSPEAERNISLQDICYAPLNPYN ENSCPOP00000008843/1-1290 YMYDSLLLGPKNFSGILSLDLLLELLDLQERLRHLQVWSPEAQRNISLRDICYAPLKPHN XP_004839970.1/1-1290 YKYNSLLLGPKNFSGILSLDLVLEVLELQERLRHLQVWSPKAQRNISLPDVCYAPLNPHN * *:*****.*******.**:: *:*:************ :*:***** *:*****:* * ENSP00000289547/1-1359 TSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALA ENSMUSP00000004505/1-1333 TSLTDCCVNSLLQYFQNNHTLLLLTANQTLNGQTSLVDWKDHFLYCANAPLTYKDGTALA ENSRNOP00000065524/1-1331 TSLSDCCVNSLLQYFQNNRTLLMLTANQTLNGQTSLVDWKDHFLYCANAPLTFKDGTSLA ENSCPOP00000008843/1-1290 TSLSDCCINSLLQYFQSNRTLLLLTANQTLMGQTAQVDWRDHFLYCANSPLTFKDGTSLA XP_004839970.1/1-1290 ASLSDCCVNSLLQYFQNNRTLLLLVANQTLLGQTAEVDWRDHFLYCSNAPLTFKDGTALG :** ***:********.*:***:*.***** ***: ***:******:*:***:****:*. ENSP00000289547/1-1359 LSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEE ENSMUSP00000004505/1-1333 LSCIADYGAPVFPFLAVGGYQGTDYSEAEALIITFSINNYPADDPRMAHAKLWEEAFLKE ENSRNOP00000065524/1-1331 LSCMADYGAPVFPFLAVGGYQGTDYSEAEALIITFSLNNYPADDPRMAQAKLWEEAFLKE ENSCPOP00000008843/1-1290 LSCMADYGAPVFPFLAVGGYQGKEYSEAEALIMTFSVNNYPVDDPRLAQAKLWEEAFVQE XP_004839970.1/1-1290 LSCMADYGAPVFPFLAMGGYQGEEYSEAEALIMTFSLNNYPADDPRLAQAKLWEEAFVQE ***:************:***:* :********:***:****..***:*:********::* ENSP00000289547/1-1359 MRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSR ENSMUSP00000004505/1-1333 MQSFQRSTADKFQIAFSAERSLEDEINRTTIQDLPVFAISYLIVFLYISLALGSYSRWSR ENSRNOP00000065524/1-1331 MESFQRNTSDKFQVAFSAERSLEDEINRTTIQDLPVFAVSYIIVFLYISLALGSYSRCSR ENSCPOP00000008843/1-1290 LQAFQQRMAGTFQVAFMAERSLEDEINRTTLKDLPIFAISYLVIFVYITLALGSYSRCDR XP_004839970.1/1-1290 LKAFQQRMAGTFQVAFMAERSLEDEINRTTLTDLPVFAVSYIVIFLYIFLALGSYSRCEL :.:**: :. **::* ************* ***:** **:::*:** ******* . ENSP00000289547/1-1359 VMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVL ENSMUSP00000004505/1-1333 VAVDSKATLGLGGVAVVLGAVVAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVL ENSRNOP00000065524/1-1331 VAVESKATLGLGGVIVVLGAVLAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVL ENSCPOP00000008843/1-1290 VLVESKVTVGLGGVAVVLGSVVAAMGFYSYLGVPSSLVILQVVPFLVLAVGADNIFIFVL XP_004839970.1/1-1290 VPVECKATLGLGGVAVVLGSVVAAMGFYSYLGVPSSLVIFQVVPFLVLAVGADNIFIFVL * *:.*.*:***** ****:*:*****:****: *****:********:*********** ENSP00000289547/1-1359 EYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLA ENSMUSP00000004505/1-1333 EYQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLA ENSRNOP00000065524/1-1331 EYQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLA ENSCPOP00000008843/1-1290 EYQRLPWIPGESREAHIGRALGSVGPSMLLCSLSETICFFLGALTPMPAVRTFALTSGLA XP_004839970.1/1-1290 EYQRLPRRPGEGREAHIGRALGSVGPSMLLCSLSETICFFLGALTPMPAVRTFALTSGLA ****** *** **.****:** *.**********:*********.************** ENSP00000289547/1-1359 VILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPF ENSMUSP00000004505/1-1333 IIFDFLLQMTAFVALLSLDSKRQEASRPDVVCCFSSRNLPPPKQKEGLLLCFFRKIYTPF ENSRNOP00000065524/1-1331 IILDFLLQMTAFVALLSLDSKRQEASRPDVLCCFSTRKLPPPKEKEGLLLRFFRKIYAPF ENSCPOP00000008843/1-1290 VFLDFLLQITAFVALLSLDSKRQEALRPDVLCCMGPRKLPASEQSAGLLLCFFRKIYVPF XP_004839970.1/1-1290 VFLNFLLQMTAFVALLSLDSKRQEALRPDIFCCLAPRKVAPSDQKEGLLLSFFRKRYIPF ::::****::*************** * *: **. .:::... : **** **:* * ** ENSP00000289547/1-1359 LLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAP ENSMUSP00000004505/1-1333 LLHRFIRPVVLLLFLVLFGANLYLMCNISVGLDQDLALPKDSYLIDYFLFLNRYLEVGPP ENSRNOP00000065524/1-1331 LLHRFIRPVVMLLFLTLFGANLYLMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPP ENSCPOP00000008843/1-1290 LLHRVTRWVVLLLFLILFGVSLYFISHLIVGLDQELALPKDSYLLDYFLSLNRYFEVGPP XP_004839970.1/1-1290 LLHGFIRPVVLLLFLALFAGSLYCMSHLVVGLDQELALPKDSYLLDYFLFLNRYFEVGPP *** . * **:**** **. .** :.:: *****:*********:**** ****:***.* ENSP00000289547/1-1359 VYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFID ENSMUSP00000004505/1-1333 VYFDTTSGYNFSTEAGMNAICSSAGCESFSLTQKIQYASEFPNQSYVAIAASSWVDDFID ENSRNOP00000065524/1-1331 VYFVTTSGFNFSSEAGMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFID ENSCPOP00000008843/1-1290 VYFVTTSGYNFSSVYGMNAICSSAGCDPFSLTQKIQYATEFPDQSYLAIPASSWVDDFID XP_004839970.1/1-1290 VYFVTTSGYNFSSEAGMNGICSSAGCDPFSMTQKIQYATRFPDQSYLAIPASSWVDDFID *** ** *:***: ***. ******. **:*******:.**:***:**.********** ENSP00000289547/1-1359 WLTP-SSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLND ENSMUSP00000004505/1-1333 WLTPSSSCCRIYTRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTTEQFHKYLPWFLND ENSRNOP00000065524/1-1331 WLTPSSSCCRLYIRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLND ENSCPOP00000008843/1-1290 WLTP-SPCCRLYTSGPNRDEFCPSTESALRCLKYCMSFTSGPVRPTVEQFHKYLPSFLSD XP_004839970.1/1-1290 WLTP-SSCCRLYTSGPHKDEFCPSTESAFRCLKNCMSFTTGPLRPTVEEFHKYLPIFLTD **** *.***:* **::*:***** .::.*** **. * *.:**:.*:****** **.* ENSP00000289547/1-1359 RPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSTSRFMA ENSMUSP00000004505/1-1333 TPNIRCPKGGLAAYRTSVNLSSDGQII---------------------------ASQFMA ENSRNOP00000065524/1-1331 PPNIRCPKGGLAAYRTSVNLSSDGQVI---------------------------ASQFMA ENSCPOP00000008843/1-1290 LPNINCPKGGMAAYSTSVNLSADGQVV---------------------------ASQFMA XP_004839970.1/1-1290 LPNINCPKGGMAAYGTSVNLSADGQVI---------------------------ASQFMA ***.*****:*** *****::***:: :*:*** ENSP00000289547/1-1359 YHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPE ENSMUSP00000004505/1-1333 YHKPLRNSQDFTEALRASRLLAANITAELRKVPGTDPNFEVFPYTISNVFYQQYLTVLPE ENSRNOP00000065524/1-1331 YHKPLRNSQDFTEALRASRLLAANITADLRKVPGTDPNFEVFPYTISNVFYQQYLTVLPE ENSCPOP00000008843/1-1290 YHKPLKNSQDFTEALQAAHLLATNITEELRKVPGTDPAFEVFPYTVTNVFYQQYVTVLPE XP_004839970.1/1-1290 YHKPLKNSQDFTEALLAMRVLANNITAELRKVPGTDPAFKVFPYTLTNVFYQQYLTVLPE *****:****:**** * : ** *** :********* *:*****::****:**:*:*** ENSP00000289547/1-1359 GLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINL ENSMUSP00000004505/1-1333 GIFTLALCFVPTFVVCYLLLGLDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINL ENSRNOP00000065524/1-1331 GIFTLALCFVPTFVVCYLLLGLDMCSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINL ENSCPOP00000008843/1-1290 GIFMLALCFLPTFVVCYFLLGLDLRSGLLNLLVIIMILVDTIGLMAMWDITYNAVSLINL XP_004839970.1/1-1290 GVFTLALCFLPTFVVCYFLLGLDIRSGLLNLLVIIMILVDTIGLMAMWGISYNAVSLINL *:* *:**::***.*. :*****: **:**** *:******:*:**:*.*:********* ENSP00000289547/1-1359 VSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAK ENSMUSP00000004505/1-1333 VTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATIFMGSAVFAGVAMTNFPGILILGFAQ ENSRNOP00000065524/1-1331 VTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATVFMGSAVFAGVAMTNFPGILILGFAQ ENSCPOP00000008843/1-1290 VAAVGMSVEFVSHITRSFAISTKPSRLERAREATVSMGSAVFAGVAMTNLPGILILGLAE XP_004839970.1/1-1290 --AVGMSVEFVSHITRSFAISTKPSRLERAREATISMGSAVFAGVAMTNLPGILVLGLAQ *****************:****: ****::**: *************:****:**:*: ENSP00000289547/1-1359 AQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVAS ENSMUSP00000004505/1-1333 AQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVLEEKLATEA-AMVSEPS ENSRNOP00000065524/1-1331 AQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVQEEKLASEA-AVAPEPS ENSCPOP00000008843/1-1290 AQLIQIFFFRLNLLITMMGLVHGLVFLPVILSYLGPDVNSALALEKECMQRV-ATAPKAS XP_004839970.1/1-1290 AQLIQIFFFRLNFLITMVGLVHGLIFLPVILSYLGPDVNPALVLEQERVQGA-ATAPKAS ************:***::**:***:****:***:***** **. *:: . * . .* ENSP00000289547/1-1359 CPNHPSRVSTADNIYVNHSFEGS-IKGAGAISNFLPNNGRQF ENSMUSP00000004505/1-1333 CPQYPFPADANTSDYVNYGFNPEFIPEINAASSSLPKSDQKF ENSRNOP00000065524/1-1331 CPQYPSPADADAN--VNYGFAPELAHGANAARSSLPKSDQKF ENSCPOP00000008843/1-1290 ------------------------------------------ XP_004839970.1/1-1290 CPK---------------------------------------