CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000008566/1-1104 ------------------------------------------------------------ XP_004868177.1/1-1096 ------------------------------------------------------------ ENSP00000264057/1-1214 MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGML ENSMUSP00000027517/1-1220 MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTILKEGML ENSRNOP00000030332/1-1172 ------------------------------------------------IREMTILKEGML ENSCPOP00000008566/1-1104 --------------------------------------------------------VITP XP_004868177.1/1-1096 ------------------------------------------------------------ ENSP00000264057/1-1214 TKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITP ENSMUSP00000027517/1-1220 TKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITP ENSRNOP00000030332/1-1172 TKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITP ENSCPOP00000008566/1-1104 CRKLILCADNRKEMEDWIAALKTVQSREHFEPTQYSMDHFSGTHNWYACSHARPTYCNVC XP_004868177.1/1-1096 -------------MEDWIAALKTVQNREHFEPTQYSMDHFSGTHNWYACSHARPTYCNVC ENSP00000264057/1-1214 CRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVC ENSMUSP00000027517/1-1220 CRKLILCADNRKEMEDWIAALKTVQNKEHFEPTQYSMDHFSGMHNWYACSHARPTYCNVC ENSRNOP00000030332/1-1172 CRKLILCADNRKEMEDWIAALKTVQNKEHFEPTQYSMDHFSGTHNWYACSHARPTYCNVC ************.:*************** ***************** ENSCPOP00000008566/1-1104 REALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGIAMPHQWLE XP_004868177.1/1-1096 REALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGIAMPHQWLE ENSP00000264057/1-1214 REALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLE ENSMUSP00000027517/1-1220 REVLSGVTSHGLSCEVCKFKAHKRCAVRATSNCKWTTLASIGKDIIEDEDGIAMPHQWLE ENSRNOP00000030332/1-1172 REVLSGVTSHGLSCEVCKFKAHKRCAVRATSNCKWTTLASIGKDIIEDEDGIAMPHQWLE **.***************************.***************** *********** ENSCPOP00000008566/1-1104 GNLPVSAKCTVCEKTCGSVLRLQDWRCLWCKAMVHTSCKESLMTKCPLGLCKVSVIPPTA XP_004868177.1/1-1096 GNLPVSAKCTVCEKTCGSVLRLQDWRCLWCKAMVHTVCKESLVTKCPLGLCKVSVIPPTA ENSP00000264057/1-1214 GNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSVIPPTA ENSMUSP00000027517/1-1220 GNLPVSAKCIVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLVMKCPLGLCKVSVIPPTA ENSRNOP00000030332/1-1172 GNLPVSAKCIVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLVMKCPLGLCKVSVIPPTA ********* **:*********************** *****: **************** ENSCPOP00000008566/1-1104 LNSIDSDGFWKATCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH XP_004868177.1/1-1096 LNSIDSDGFWKATCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH ENSP00000264057/1-1214 LNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH ENSMUSP00000027517/1-1220 LNSIDSDGFWKATCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH ENSRNOP00000030332/1-1172 LNSIDSDGFWKATCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH ************:*********************************************** ENSCPOP00000008566/1-1104 LGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGA XP_004868177.1/1-1096 LGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGA ENSP00000264057/1-1214 LGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGS ENSMUSP00000027517/1-1220 LGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGS ENSRNOP00000030332/1-1172 LGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGS ***********************************************************: ENSCPOP00000008566/1-1104 ACDDDTQLPQILAKLERASTKMLDRWSVMAYETKLPRQTSSSTVTEDFSEDSEVQQILFY XP_004868177.1/1-1096 ACDDDTQLPQILAKLERASTKMLDRWSVMAYETKLPRQASSSTVTEDFSEDSEVQQILFY ENSP00000264057/1-1214 ACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILFY ENSMUSP00000027517/1-1220 ACDDDTQLPQILAKLERASTKMLDRWSVMAYETKLPRQASSSTVTEDFSEDSEVQQILFY ENSRNOP00000030332/1-1172 ACDDDTQLPQILAKLERASTKMLDRWSVMAYETKLPRQASSSTVTEDCSEDSEVQQILFY ************ *******************:*****:******** ************ ENSCPOP00000008566/1-1104 EDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCS XP_004868177.1/1-1096 EDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCS ENSP00000264057/1-1214 EDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCS ENSMUSP00000027517/1-1220 EDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSQESEVMAKKCS ENSRNOP00000030332/1-1172 EDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSQESEVMAKKCS *************************************************:********** ENSCPOP00000008566/1-1104 VLKEKLDSLLKTLDDESQASSSLPNPPPTIAEETEDGDGAGNVCGSAGDRLVGPTCPARP XP_004868177.1/1-1096 VLKEKLDLLLKTLDDESQASSSLPNPPPTIAEEAEDGDGAGNVCGSAGDRLVGSACPARP ENSP00000264057/1-1214 VLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARP ENSMUSP00000027517/1-1220 VLKEKLDSLLKTLDDESQASSSLSNPPPTIAEEAEDGDGSGNICSSTGDHLVGSACPSRP ENSRNOP00000030332/1-1172 VLKEKLDSLLKTLDDESQASSSLSNPPPTIAEEAEDGDGSGNICSSTGDHLVGSACPSRP ******* ***************.*********:*****:*.:*.*:**:**..:**:** ENSCPOP00000008566/1-1104 QIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQAQEGFVLGLPTTEEKRDPRKE XP_004868177.1/1-1096 QIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSASEEKKDPRKD ENSP00000264057/1-1214 QIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEK----MD ENSMUSP00000027517/1-1220 QIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQQGFVLGLSESEKK-DLKTD ENSRNOP00000030332/1-1172 QIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQQGFVLGLSESEKK-DLKTD *************************************** *:******. :*:* : ENSCPOP00000008566/1-1104 DKACPPLAHSEGCGVPKGRGHRK--VSRSPCEKLMGKGGLSVGSSASLPPQTGSRDGLPA XP_004868177.1/1-1096 DKVCPLPAHGEGCGVPKGRSHRKGTASRSPCEKLMSKGALSVGSSASLPPQTGSRDGLPA ENSP00000264057/1-1214 HRVCPPLSHSESFGVPKGRSQRK--VSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPA ENSMUSP00000027517/1-1220 NRVCTSSVHSESCVIAKGRSQRK--ASRAPCEKLVSKG-LSLGSSASLPPGTGSRDSLPA ENSRNOP00000030332/1-1172 NRVCTSSAHSESCVVAKGRSHRK--ASRTPCEKLMSKG-LSLGSSASLPPNTGSRDSLPA .:.*. *.*. :.***.:** .*::*****:.** **:******** .****.*** ENSCPOP00000008566/1-1104 LNTKILYPSVRAGMSGSLPGGSVISRLLLNADPFNTEPEHLELYTEKCVMNNYFGIGLDA XP_004868177.1/1-1096 LNTKILYPSVRAGMSGSLPGGSVISRLLINADPFNAEPENLEYYTEKCVMNNYFGIGLDA ENSP00000264057/1-1214 LNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDA ENSMUSP00000027517/1-1220 LNTKILYPSVRAGMSGSLPGGSVISRLLINADPFNAEPENLEYYTEKCVMNNYFGIGLDA ENSRNOP00000030332/1-1172 LNTKILYPSVRAGMSGSLPGGSVISRLLINADPFNAEPENLEYYTEKCVMNNYFGIGLDA ********.*******************:******:*** ** ***************** ENSCPOP00000008566/1-1104 KISLDFNNKRDEHPEKCRSRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPL XP_004868177.1/1-1096 KISLDFNNKRDEHPEKC--RSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPL ENSP00000264057/1-1214 KISLDFNNKRDEHPEKC--RSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPL ENSMUSP00000027517/1-1220 KISLDFNNKRDEHPEKC--RSRTKNMMWYGVLGTKELLHRTYRNLEQKVLLECDGRPIPL ENSRNOP00000030332/1-1172 KISLDFNNKRDEHPEKC--RSRTKNMMWYGVLGTKELLHRTYRNLEQKVLLECDGRPIPL ***************** ***********************:***************** ENSCPOP00000008566/1-1104 PSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIKLQ XP_004868177.1/1-1096 PSLQGIAVLNIPSYAGGTNFWGGTKEDDTFTAPSFDDKILEVVAVFGSMQMAVSRVIKLQ ENSP00000264057/1-1214 PSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQ ENSMUSP00000027517/1-1220 PSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIKLQ ENSRNOP00000030332/1-1172 PSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIKLQ ******************************:**************************:** ENSCPOP00000008566/1-1104 HHRIAQCRTVKISILGEEGVPVQVDGEAWIQPPGYIRIVHKNRAQTLTRDRAFENTLKSW XP_004868177.1/1-1096 HHRIAQCRTVKISILGDEGVPVQVDGEAWIQPPGYIRIVHKNRAQTLTRDRAFENTLKSW ENSP00000264057/1-1214 HHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSW ENSMUSP00000027517/1-1220 HHRIAQCRTVKISILGDEGVPVQVDGEAWIQPPGYIRIVHKNRAQTLTRDRAFENTLKSW ENSRNOP00000030332/1-1172 HHRIAQCRTVKISILGDEGVPVQVDGEAWIQPPGYIRIVHKNRAQTLTRDRAFENTLKSW ****************:************:************************.***** ENSCPOP00000008566/1-1104 EDKQKCELPRPPSFSLHPEILSEEEAMQMDQFCQAAGVLIHSIREIAQSHQAVEQELAHA XP_004868177.1/1-1096 EDKQKCELPRPPSFSLHLEILSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHA ENSP00000264057/1-1214 EDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHA ENSMUSP00000027517/1-1220 EDKQKCELSRPPSFSLHPEILSEEEATQMDQFGQAAGGLIHSIREIAQSHRAMEQELAHA ENSRNOP00000030332/1-1172 EDKQKCELPRPPSFSLHPEILSEEEATQMDQFGQAAGSLIHSIREIAQSHRDMEQELAHA ********.**** *** *:****** ***** **** ************: :******* ENSCPOP00000008566/1-1104 VNASSKAMDRVYGKARTAEGLNYSFVQEIVNNVRALRSETELLLAGKMALQLDLPQKERL XP_004868177.1/1-1096 VNASSKAMDRVYGKPRTAEGLNCSFVQEMVNNIRALRSETELLLAGKMALQLDPPQKERL ENSP00000264057/1-1214 VNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQL ENSMUSP00000027517/1-1220 VNASSKAMERVYGKPRTAEGLNCSFVLEMVNNIRALRSETELLLAGKMALQLDPPQKERL ENSRNOP00000030332/1-1172 VNASSKAMERVYGKPRAAEGLNCSFVLEMVNNIRALRSETELLLAGKMALQLDPPQKERL ******:*:*****.*::**** *** *:***.***********:******** ****:* ENSCPOP00000008566/1-1104 GAALTEMDRQLRKLADMHWLCQPVEPGDEE----NVMLDLAKRSRSGKFRLVTKFKKEKN XP_004868177.1/1-1096 GAALAEMDRQLGKLADAPWLCQPVEPGDEE----NVMLDLSKRSRSGKFRLVTKFKKEKN ENSP00000264057/1-1214 GSALAEMDRQLRRLADTPWLCQSAEPGDEE----SVMLDLAKRSRSGKFRLVTKFKKEKN ENSMUSP00000027517/1-1220 GAALIEMDQQLRKLTDTPWLCQPLEPGEEESLQQNVMLDLTKRSRSGKFRLVTKFKKEKN ENSRNOP00000030332/1-1172 GAALVEMDQQLRKLTDTPWLCQPMEPGEEESLQQNVMLDLTKRSRSGKFRLVTKFKKEKN *:** ***:** :*:* ****. ***:** .*****:******************* ENSCPOP00000008566/1-1104 NKNREAHSSLGGPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLG XP_004868177.1/1-1096 NKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKVLH ENSP00000264057/1-1214 NKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLG ENSMUSP00000027517/1-1220 NKNKEVHSNLGGPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLG ENSRNOP00000030332/1-1172 NKNKEVHSYLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLG ***:*.** **.********************************************* * ENSCPOP00000008566/1-1104 VTKVGHMKRILYGIKELSRSAPATEA----------- XP_004868177.1/1-1096 -RHLPH-GSLLPFFPAWPRPGTTACSPFFSASVCTLG ENSP00000264057/1-1214 VTKVGHMKRILCGIKELSRSAPAVEA----------- ENSMUSP00000027517/1-1220 VTKVGHMKRILCGIKELSRSSPAAEA----------- ENSRNOP00000030332/1-1172 VTKVGHMKRILCGIKELSRSSPAAEA----------- :: * :* : .*...:. :