CLUSTAL W(1.81) multiple sequence alignment ENSP00000269392/1-1083 MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE ENSMUSP00000101836/1-1060 MKGSRTITATPEGSPEAVDLSLIGLPPPMSQRPGSASATRSIFRSMSVATGSEPRKKALE ENSRNOP00000005977/1-1069 MKGSRTISATPEGSPEGMDLSLIGLPLPMSQRPGSASAAKSIFRSVSVATGSEPRKKALE ENSCPOP00000008543/1-1070 MKSSRAIRSAPEGSPECADLSLTGLPPPLSRRPSSASATKPFVRSVSVAAGSEPRRKALE XP_004860967.1/1-1070 MKGCRAIRSAPEGSPDCAGLSLTGLPPPLSRRPSSASASKPFVRSVSVAAGSEPRRKALE **. *:* :.** ** .*** *** *:*:**.**::::.:.**:**.:*** ::*.** ENSP00000269392/1-1083 ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS ENSMUSP00000101836/1-1060 ATGPGGPRAINNLRRSNSTTQVNQSWTGSPRPAEPTDFLMLFEGSTSGRRRVASLSKASS ENSRNOP00000005977/1-1069 ATGPGGPRAINNLRRSNSTTQVNQSWTGSPRPAEPTDFLMLFEGSTSGRRRVASFSKVSS ENSCPOP00000008543/1-1070 ATGPGNSRAINNLRRSNSATQVNQPWTGSPRPVESPDFLTLFESIPSGRRRLVGLSKASG XP_004860967.1/1-1070 AAGPGGSSAINNLRRSNSTTQVNQPWAGSPRLAESPDFLTLFEGSPAGRRRLVGLSKASG *:***.. **********:***.*. :**** .*..*** ***. .:*::* ..:*.... ENSP00000269392/1-1083 EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN ENSMUSP00000101836/1-1060 EKEATWNVLDEQPRGLALPASAQSPSTLDSALGPRRKECP--LAPSFTANNRSNKGAVGN ENSRNOP00000005977/1-1069 EKGATWNVLDDQPRDFASPANSQSPSTLDSALGPRRKECS--LAPSFTANNRSNKGAVGN ENSCPOP00000008543/1-1070 EKAATWNVLDEQPRGCGLPANTQNPSAPNAPGGPRRKECT--LAPCFTANNRSNKGAVGN XP_004860967.1/1-1070 EKAATWNVLDEQPRGLGLQANAQNSRAFDAPMGPRRKECT--LAPSFTANNRSNKAAVGN ** *******:***. :.::.. : ::. *******. *** *********.**** ENSP00000269392/1-1083 CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA ENSMUSP00000101836/1-1060 CVTTMVHNHYASSKMVSPPKSSNQTAPSLNNIVKAAAREGGEGSDLGKPRKNLSSASQSA ENSRNOP00000005977/1-1069 CVTTMVHNHYASSKKVSPPKSSNQTAPSLNNIVKAAAREGGEGSDFGKPRKNFSSVSQST ENSCPOP00000008543/1-1070 CVTSMVHNRYTPSEKVHPLKSSNQTTPSLNNIIKAATSEGSEGSSFG---KNLASSSHTA XP_004860967.1/1-1070 CVTSMVHNHYTPSEKAHPLKSSNQTTPSLNNIIKAATSEGSEGSSFG---KNFSSGNQAA ***:****:*:.*: . * ******:******:***: **.*.*.:* **.:* .::: ENSP00000269392/1-1083 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK ENSMUSP00000101836/1-1060 R----GTTGLLRRREVTEEEAERFIHQVNQAAVTIQRWYRCQVQRRRAGAAALEHLLASK ENSRNOP00000005977/1-1069 R----GTTGLLRRKEVTEEEAERFIQQVNQAAVTIQRWYRCQVQRRRTGAASLEHLLASK ENSCPOP00000008543/1-1070 PSGAAGSSTPLRRKEVTEEEAERFICQVNQAAVTIQRWYRRQMQQRHAGARSLKHLLASK XP_004860967.1/1-1070 QSAPAGSSTPLRRKEVTEEEAERFICQVNQAAITIQRWYRRQVQWHHAGARSLEHLLTSK *:: **:*********** *****::******* *:* : :** *:*** :* ENSP00000269392/1-1083 REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG ENSMUSP00000101836/1-1060 REGQRQRLGGGNLLELHRQEEAARKKAREEKARQARQAAIQVLQQK---RAQKASEAEHR ENSRNOP00000005977/1-1069 REGQRQRLGSGNLLDLHRQEEAARKKAREEKARQARQAAIQELQQK---RAQKAREVEHR ENSCPOP00000008543/1-1070 REEQQQRLGNGNLLELHRQKEAARKKAREEKAHQARQAAIQELREK---RAQKSGKAEL- XP_004860967.1/1-1070 REEQRQRLGGGNLLELHQQKEVARRKAREEKARQARRAAIQELREK---RAQKSGEAAL- ** *:** * *.**:**:*:*.**:*******:***:**** *::* ****: . ENSP00000269392/1-1083 PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP ENSMUSP00000101836/1-1060 RPKDRPETRAPEQPRPMQE----PGCVTHP--KANNAGASIYPTGPADPCPPASESSPEQ ENSRNOP00000005977/1-1069 PPKERPETRALEQPRPTQEPPSMPSSVTHP--KANNAGASLYPTGPADPCPPASESFPER ENSCPOP00000008543/1-1070 -PKKSPETRLPGRPLPTQEPVPMPGSPACQDLKTSNTGASIHPASPRDPCLPDSKSSPEP XP_004860967.1/1-1070 -PKESLETRALGRPPPAQGPLPLPGSAARQGLKASNAGASVQPASPRDPCPPISSSSPEP *:. *** * * *. : *:.*:*..: .:.* * * * *.* ** ENSP00000269392/1-1083 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH ENSMUSP00000101836/1-1060 WQSPEDKPQDIHSQGEARQDLAVSGSSRGKARARATLDDLLDTLKLLEEEPEPLPHPKAY ENSRNOP00000005977/1-1069 QPSLEDKPQDAHSQVEAREDLAALASTRSKTRARATLDDLLDTLKLLEEEPEPLLHPKAY ENSCPOP00000008543/1-1070 QQPPEDKRQDTHSQDLVSQDLETVASVRNKAKSRATLDQLLDSLRLLEEEPEPLPCPRTY XP_004860967.1/1-1070 QQSREDKLQGIHPQDVASEDVVTAAPVRSRAKSRATLDELLDTLQLLEEEPEPLPHPRGY . **: *. .* . ::: .. *. :::*..*::**.:*:***:**: * *: : ENSP00000269392/1-1083 HRGRYAWASEVTTEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEME ENSMUSP00000101836/1-1060 HKDRYAWTDE---EEDANSLTADNLEKFGKLSAAPGPPDDGTLLSEAKLQSIMTFLDEME ENSRNOP00000005977/1-1069 RQDRYAWMDE---EEDTNPLTADNLEKFGKLSAAPGPPDDGTLLSEAKLQSIMTFLDEME ENSCPOP00000008543/1-1070 QKDKYAWIDE---EDDTSSLTADNLEKFGKLITPPGPPEEGTLLSEAKLKSIMSFLDEME XP_004860967.1/1-1070 QKEKYAWLDE---EDDTSSLTADNLEKFGKLSALPGPPEDGTLLSEAKLQSIMSFLDEME :: :*** .* *:*:..************ : * **::*********:***:****** ENSP00000269392/1-1083 KSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDL ENSMUSP00000101836/1-1060 KSGQERPAPWRESLVLEAGSG-----SEGSTSVMRLKLELEEKKQAMALLQRALAQQRDL ENSRNOP00000005977/1-1069 KSGQERPAPWRESLVLEAGPRSLELGSEGTTSVMRLKLELEEKKQAMVLLQRALAQQRDL ENSCPOP00000008543/1-1070 KSEQSRLAPQQERLVPEVGWGHPELATRGNASVMRLKLEVEEKKQAMVLLQRALAQQRDL XP_004860967.1/1-1070 KSEQSRLAPQRERLVPQAGQGHPELASSRNVSEMRLKLEVEEKKQAMVLLQRALAQQRDL ** *.: . :* * :.* : ..* ******:******* ************ ENSP00000269392/1-1083 TARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQ ENSMUSP00000101836/1-1060 TVRRVKETEKELTRQLRQQKEQYEATIQRHLSFIDQLIEDKKVLSEKCEAVVAELKHGDQ ENSRNOP00000005977/1-1069 ATRRVKETEKELSRQLRQQKEQYEATIQRHLSFIDQLIEDKKVLSEKCEAVVAELKQGDQ ENSCPOP00000008543/1-1070 TVRRVKETEKELSRQLRQQREHYEATIQRHLTFIDQLIEDKKVLSEKCEAVVAQLKQGDQ XP_004860967.1/1-1070 TVRRVKETEKELSRQMQQQKEHYEATIQRHLTFIDQLIEDKKALSEKCEAVVAELKRGDE :.******** *:**:::*:*:*********:**********.**********:**: *: ENSP00000269392/1-1083 RCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIA ENSMUSP00000101836/1-1060 RCRERVAQMQEQHELEIKKLKELMSATEKIRREKWINEKTKKIKEITVRGLEPEIQKLIA ENSRNOP00000005977/1-1069 RCRERVAQVQEQHELEIKKLKELMSATEKIRREKWINEKTKKIKEITVRGLEPEIQKLIA ENSCPOP00000008543/1-1070 RCREHLAQMQEQHELEIKKLKELMSATEKVRREKWINEKTKKIKEITVRGLEPEIQKLIA XP_004860967.1/1-1070 RCRERLAQMQQQHELEIKKLKELMSATEKVRREKWISEKTKKIKEITVRGLEPEIQKLIA ** *::** * ****************** ******.********:************** ENSP00000269392/1-1083 RHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQ ENSMUSP00000101836/1-1060 KHKQEVRRLRGLHEAELQQREEQAAQRHLRQAEELRQHLDREREVLGQQERERAQQRFEQ ENSRNOP00000005977/1-1069 KHKQEVRRLRGLHEAELQQREEQAAQRHLRQAEELREHLEREREALGQQERERAQQRLEQ ENSCPOP00000008543/1-1070 KHKQEVRRLRDLHEAELLQREEQAAQRYLRQAEELRENAEREKEALGQQERERARQRFEQ XP_004860967.1/1-1070 KHKQEVRRLRDLHEAELLEREEQTAQRYLLQAEELRENAEREKEALGQQERERAQQRFEQ :********:.****** : :*:::** * ******:: :**:*.*********:**::* ENSP00000269392/1-1083 HLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEF ENSMUSP00000101836/1-1060 HLEQEQRALEQQRRRLYNEVAEEKERLGQQAARQRAELEELRQQLEESSAALTRALRAEF ENSRNOP00000005977/1-1069 HLEQEQRALEQQRRRLYTEVAEEKERLGQQAARQRVELEELRQQLEESSAALTRALRAEF ENSCPOP00000008543/1-1070 HLEQEQRALEQQRRRLYSEVAEERERLGQQAARCMGALTPHTGPLAWPLPVSTRALRAEF XP_004860967.1/1-1070 HLEQEQRALEQQRRRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEF ****** **:***:***.*****:********* * * . .. ******** ENSP00000269392/1-1083 EKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEI ENSMUSP00000101836/1-1060 ERSREEQERRHQMELKALKDQLEAERQAWVASCAKKEEAWLLTRERELKEEIRKGRDQEI ENSRNOP00000005977/1-1069 ERSREEQERRHQMELKALKDQLEAERQAWVASCAKKEEAWLLTRERELKEEIRKGRDQEI ENSCPOP00000008543/1-1070 EKGREEQEQRHQMELKALKDQLEVEHQTWAACCAKKEEAWLLNRERELKEEIRKGRDQEI XP_004860967.1/1-1070 EKGREEQERRHQMELKTLKDQLEVERQAWTASCAKKEEAWLLNRERELKEEIRKGRDQEI *:.*****:******::**:*** *:*:* * ::*******.**:**:********:** ENSP00000269392/1-1083 ELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGE ENSMUSP00000101836/1-1060 ELVIHRLEADMTLAKEESERAAESRVKRVRDKYETELSELEQSERKLQERCSELKGRLGE ENSRNOP00000005977/1-1069 ELVIHRLEADMTLAKEESERAAENRVKRVRDKYETELSELEQSERKLQERCTELKGRLGE ENSCPOP00000008543/1-1070 ELVIHRLEADMTLAKEETERAAESRVKRVRDKYETELLELEQSERKLQERCTELKGRLGE XP_004860967.1/1-1070 ELVIRRLEADMTLAKEETERAAEGRVKRVRDKYETELSELEQSERKLQERCTELKGRLGE ****:******:*****:*:***.*:**:*****:** *************:****:*** ENSP00000269392/1-1083 AEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKA ENSMUSP00000101836/1-1060 AEGEKERLQSLVRQKEKELEDLRAVNTQMCSERASLAQVVRQEFAEQLAASQEETQRVKV ENSRNOP00000005977/1-1069 AEGEKERLQSLLRQKEKELDDLRVVNTQMCSERASLAQVVRQEFAEQLAASQEETQRVKA ENSCPOP00000008543/1-1070 VEGEKERLQALVRQKEKELEDMRAENAQLSGERSSVTQVVRQEFADRLAASEEENRQVKA XP_004860967.1/1-1070 AEGEKERLQALVRQKEKELEDVRAVNSQLAGERSSVTQLVRQEFAEQLAASEEENRQVKA .***: ***.*:****: *:* :. * *:..**:.::*::**** ::****:**.::.*. ENSP00000269392/1-1083 ELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTP ENSMUSP00000101836/1-1060 ELAELQARQQVELDEVHRRVKTALARKEAAVNSLRKQHEAAVKRADHLEELLEQHKGSSL ENSRNOP00000005977/1-1069 ELAELRARQQMELDEVHRRVKTALARKEAAVNSLRKQHEAAEKRADHLEELLEQHKGPSL ENSCPOP00000008543/1-1070 ELAELQARQQLELDEVHRRVKMALAKKEEAVSSLRRRHEAAVRRADHLEELLEQHKQSPL XP_004860967.1/1-1070 ELAKLQARQQLELDEVHRRVKTALAKKEEAVSNLRRQHEAAVRRADHLEELLEQHRRPPL *** *:****:**:******* ***:** **..** :**** :************: .. ENSP00000269392/1-1083 STK ENSMUSP00000101836/1-1060 SSK ENSRNOP00000005977/1-1069 SSK ENSCPOP00000008543/1-1070 SGK XP_004860967.1/1-1070 SAK * *