CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000008513/1-1479 MPSEGSPHCCQTQEQEPVRSPRVGAEEGAPVEQEQEHGGAAEAGECPPSPSSACGPSTSA XP_004874587.1/1-1481 MPSEGSRHSCQTQEQEHSQSPPVRADEDTTG--EQEHGGAVEVGKQLASPPSDCGPSTSA ENSP00000348089/1-1493 MPNEGIPHSSQTQEQDCLQSQPVSNNEEMAI--KQESGGDGEVEEYLSFRSVGDGLSTSA ENSMUSP00000066256/1-1481 MFHEEVPNSTHPQEQDCLPSQHANAYKDMPV--GQENGGVSEAGECLSSTSCEYGPSTSA ENSRNOP00000063005/1-1325 MPHEEIPNSTQPQGQDWLPGQHVSADRDIPA--GQETAGDSEAGKCLSSPSCDHGPSTSA * * :. :.* *: . . . . ** .* *. : . . * **** ENSCPOP00000008513/1-1479 EDCTSAAVRRGPALLHIDRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSALH XP_004874587.1/1-1481 EGCTSAAMRRGPTLVHIDRHQIPAVERNAQALELQGLGVDVYDQTVLEQGVLQQVDSALH ENSP00000348089/1-1493 VGCASAAPRRGPALLHIDRHQIQAVEPSAQALELQGLGVDVYDQDVLEQGVLQQVDNAIH ENSMUSP00000066256/1-1481 EACVLAATRRGPTLLHIDRHQIPAVEPSAQALELQGLGVDVYDQAVLEQGVLQQVDSAMH ENSRNOP00000063005/1-1325 EACVLAATRWGPALLHIDRHQIPAVEPSAQALELQGLGVDVYDQAVLEEGVLQQVDSAMH *. ** * **:*:******* *** .**************** ***:*******.*:* ENSCPOP00000008513/1-1479 EASRATQLADAEKEYHAVLDDLTSCTTSLRQIDKIIEQLSPQAATNRDVNRKLDSVKRQK XP_004874587.1/1-1481 EASRAAQLADAEKEYQSVLDDLMSCMTSLRQINKIIEQLSPQAATNRDINRKLDSVKRQK ENSP00000348089/1-1493 EASRASQLVDVEKEYRSVLDDLTSCTTSLRQINKIIEQLSPQAATSRDINRKLDSVKRQK ENSMUSP00000066256/1-1481 EASCVAQLADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQAASNRDINRKLDSVKRQK ENSRNOP00000063005/1-1325 EASRVAQRADAEKEYQSVLDDLMSCTTSLRQINKIIEQLSPQAASNRDINRKLDSVKRQK *** .:* .*.****::***** ** ******:***********:.**:*********** ENSCPOP00000008513/1-1479 HNKEQQLKKITAKQKRLQAVLGGAAVRVELDH-GSLEQEDAEPGPSCLGSMLMPAQETAW XP_004874587.1/1-1481 YNKEQQLKKITVKQKRLQAVLGRAEVRVELEHAGGLEEEDAEPGPSCLGIMLMPAQKTAW ENSP00000348089/1-1493 YNKEQQLKKITAKQKHLQAILGGAEVKIELDH-ASLE-EDAEPGPSSLGSMLMPVQETAW ENSMUSP00000066256/1-1481 YNKEQQLKKITAKQKRLQAILGGAGVQVELDH-ASLEEDDAEPGPSCLGSMLMPAQETAW ENSRNOP00000063005/1-1325 YNKEQQLKKITAKQKRLQAILGGAEVHVELDH-GSLEEEDAEPGPSCLGSMLMPAQESAW :**********.***:***:** * *::**:* ..** :*******.** ****.*::** ENSCPOP00000008513/1-1479 EELIRTGQMTPFGTQVPQKTEKKPRKLMLNEASGFEKYLADQAKLSFERRKQAASRRASR XP_004874587.1/1-1481 EELIRTGQMTPFGTQVLQKTEKKPRKLMLNEASGFEKYLADQARLSFERKKQAANKRTSR ENSP00000348089/1-1493 EELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLADQAKLSFERKKQGCNKRAAR ENSMUSP00000066256/1-1481 EELIRTGQMTPFGTPAPQKQEKKPRKIMLNEASGFEKYLAEQAQLSFERKKQAATKRTAK ENSRNOP00000063005/1-1325 EELIRTGQMTPFGTPAPQKQEKKPRKIMLNEASGFEKYLADQAQLSFKRKKQAANKRTAK ************** ** ******:*************:**:***:*:**...:*::: ENSCPOP00000008513/1-1479 KAPASAQSEPGAPARESEPKPRSKALSQADRRLQKHLRKLQRRALQLQFQGRPGQPRGKR XP_004874587.1/1-1481 KAAASVKPASNAQSKENKPKQRSQILSKTDWRLKKHIRKLQKKA--LQFQGKVGLPRGKR ENSP00000348089/1-1493 KAPAPVTP-PAPVQNKNKPNKKARVLSKKEERLKKHIKKLQKRA--LQFQGKVGLPKARR ENSMUSP00000066256/1-1481 KAIVISESSRAA--IETKADQRSQVLSQTDKRLKKHSRKLQRRA--LQFQGKVGLPSGKK ENSRNOP00000063005/1-1325 KAVVVSESSRGP--NETKPNQRSQALSQTDKRLKKHIRKLQRRA--LQFQGKVGLQRGKR ** . . . :.:.. ::: **: : **:** :***::* *****: * .:: ENSCPOP00000008513/1-1479 PPEGDSK----GGSEGEEPRACPPEPLELDRAAEGAGEEVG---ASPSAEGADCEPRPVP XP_004874587.1/1-1481 SLGAEARLQAMGNSESEEPRSFP-----MEGEEEGDGEEVG---ADLSGDGADCELRPEL ENSP00000348089/1-1493 PWESDMRPEAEGDSEGEESEYFP-----TEEEEEEEDDEVEGAEADLSGDGTDYELKPLP ENSMUSP00000066256/1-1481 PLEPEVRPEAEGDTEGEESGSSP-----TDGEEEEEQEEEEGV-ASLSSDDVSYELKPLR ENSRNOP00000063005/1-1325 PLEPEERPGAEGDTE-----------------------------AVLSSDDISYELKPLR . : : *.:* * *.:. . * :* ENSCPOP00000008513/1-1479 RAQKRRRKALVQGSDDDFSPSSGEEAEAEAAGKGGGPSRKAVRCRDDGDGEHYKQRLRRW XP_004874587.1/1-1481 RGQKRQKKVPAQENDDDFSPSSGEEAEATERGRGTG--RKVVRCCDDGDEDYYKQRLRRW ENSP00000348089/1-1493 KGGKRQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGGGRKVGRYRDDGDEDYYKQRLRRW ENSMUSP00000066256/1-1481 KRQKYQKKVPVQEIDDDFFPSSEEEDEAME---GRGGGRKVARRQDDGDEDYYKQRLRRW ENSRNOP00000063005/1-1325 KGQKYEKKVPVQEIDDDFFPSSEEEDEAVE---GRGGGRKVSRRPDDGDEDYYKQRLRRW : * .:*. .* **** *** ** ** * * **. * **** ::******** ENSCPOP00000008513/1-1479 NKLRLRDKEERLKLEDDSEESDAEFDEGFKVPGFLFRKLFKYQQTGVRWLWELHCQQAGG XP_004874587.1/1-1481 TKLRLQNKEKHLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRWLWELHCQQAGG ENSP00000348089/1-1493 NKLRLQDKEKRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRWLWELHCQQAGG ENSMUSP00000066256/1-1481 NRLRLQDKEKRLKLEDDSEESDAEFDEGFKVPGFLFKKLFKYQQTGVRWLWELHCQQAGG ENSRNOP00000063005/1-1325 NRLRLQDKEK-LKLEDDSEESDAEFDEGFKVPGFLFKKLFK------------------- .:***::**: *************************:**** ENSCPOP00000008513/1-1479 ILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTMIVCPTTVMHQWVKEFHTW XP_004874587.1/1-1481 ILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHTW ENSP00000348089/1-1493 ILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTVIVCPTTVMHQWVKEFHTW ENSMUSP00000066256/1-1481 ILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGLGPTIIVCPTTVMHQWVKEFHTW ENSRNOP00000063005/1-1325 ----------------------------------FEGLGPTLIVCPTTVMHQWVKEFHTW *******:****************** ENSCPOP00000008513/1-1479 WPPFRVAILHETGSYAHRKEKLIRDIAHCHGILITSYSYVRLMQDDISRHDWHYVILDEG XP_004874587.1/1-1481 WPSFRVAILHETGSCTHRKENLIRDIAHCHGILITSYSYIRLMQDDFSRQNWHYVILDEG ENSP00000348089/1-1493 WPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITSYSYIRLMQDDISRYDWHYVILDEG ENSMUSP00000066256/1-1481 WPPFRVAVLHETGSYTHKKERLIRDIVYCHGVLITSYSYIRLMQDDISRHDWHYVILDEG ENSRNOP00000063005/1-1325 WPPFRVAILHETGSCAHRKERLVRDIVHCHGVLITSYSYIRLMQDDISRHDWHYVILDEG **.****:****** :*:**.*:**:.:***:*******:******:** :********* ENSCPOP00000008513/1-1479 HKIRNPNAAITLACKQFRTPHRIILSGSPMQNNLRELWSLFDFVFPGKLGTLPVFMEQFS XP_004874587.1/1-1481 HKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFVFPGKLGTLPVFMEQFS ENSP00000348089/1-1493 HKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFS ENSMUSP00000066256/1-1481 HKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNLRELWSLFDFIFPGKLGTLPVFMEQFS ENSRNOP00000063005/1-1325 HKIRNPNAAVTLACK---------------QNNLRELWSLFDFTFPGKLGTLPVFMEQFS *********:***** ************* **************** ENSCPOP00000008513/1-1479 VPITMGGYANASPVQVKTAYRCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQVLFCRL XP_004874587.1/1-1481 VPITMGGYANASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQVLFCRL ENSP00000348089/1-1493 VPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQVLFCRL ENSMUSP00000066256/1-1481 VPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQVLFCRL ENSRNOP00000063005/1-1325 VPITMGGYSNASPVQVKTAYKCACVLRDTINPYLLRRMKSDVKMSLSLPDKNEQVLFCRL ********:***********:*************************************** ENSCPOP00000008513/1-1479 TDEQHKVYQNFIDSKEVYQILNGEMQIFSGLVALRKICNHPDLFSGGPKNLGGLPDEELE XP_004874587.1/1-1481 TDEQHKVYQNFINSKEVYKILNGEMQLFSGIVALRKICNHPDLFSGGPKNLGGLPDDELE ENSP00000348089/1-1493 TDEQHKVYQNFVDSKEVYRILNGEMQIFSGLIALRKICNHPDLFSGGPKNLKGLPDDELE ENSMUSP00000066256/1-1481 TDEQHKVYQNFIDSKAVYRILNGENQIFSGLVALRKICNHPDLFSGGPKNASGPPEDELE ENSRNOP00000063005/1-1325 TDEQHKVYQNFIDSKAVYRILNGENQIFSGLVALRKICNHPDLFSGGPKNTSALPEDGLE ***********::** **:***** *:***::****************** . *:: ** ENSCPOP00000008513/1-1479 EGQFGYWKRSGKMIVVESLLKIWHRQGQRVLLFSQSRQMLHILEVFLRARGYSYLKMDGS XP_004874587.1/1-1481 EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLHILEVFLRAQKYSYLKMDGT ENSP00000348089/1-1493 EDQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLDILEVFLRAQKYTYLKMDGT ENSMUSP00000066256/1-1481 EEQFGHWRRSGKMIVVESLLKIWHRQGQRVLLFSQSRQMLHILEVFLRAHKYSYLKMDGT ENSRNOP00000063005/1-1325 EEQFGYWKRSGKMIVVESLLKIWHKQGQRVLLFSQSRQMLHILEVFLRAHKYSYLKMDGT * ***:*:****************:***************.********: *:******: ENSCPOP00000008513/1-1479 TTIASRQPLITRYNQDTSIFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERA XP_004874587.1/1-1481 TTIASRQPLIARYNEDASIFVFLLTTRVGGIGVNLTGANRVIIYDPDWNPSTDTQARERA ENSP00000348089/1-1493 TTIASRQPLITRYNEDTSIFVFLLTTRVGGLGVNLTGANRVVIYDPDWNPSTDTQARERA ENSMUSP00000066256/1-1481 TTIASRQPLITKYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERA ENSRNOP00000063005/1-1325 TTIASRQPLITKYNEDTSIFVFLLTTRVGGLGVNLTGANRVIIYDPDWNPSTDTQARERA **********::**:*:*************:**********:****************** ENSCPOP00000008513/1-1479 WRIGQKRQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLT XP_004874587.1/1-1481 WRIGQKRQVTVYRLLMAGTIEEKIYHRQIFKQFLTNRVLKDPKPRRFFKSNDLYELFTLT ENSP00000348089/1-1493 WRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLT ENSMUSP00000066256/1-1481 WRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLT ENSRNOP00000063005/1-1325 WRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLT ******:******** *************************** **************** ENSCPOP00000008513/1-1479 SPDSTQSTETSAIFAGTGSDVPTPRRHLKRRTPPAFGADQDAPKCGRFPDSATRTGAATP XP_004874587.1/1-1481 SPNGSQSTETSAIFAGIGSDVPTPKRHLKRKILPAFGTDRDVPKCKKFPDSNTLANVATS ENSP00000348089/1-1493 SPDASQSTETSAIFAGTGSDVQTPKCHLKRRIQPAFGADHDVPKRKKFPASNISVNDATS ENSMUSP00000066256/1-1481 SPDASQGTETSAIFAGTGSSIQTPKCQLKKRTSTVLGTD---PKCKKPPVSDTPANAATL ENSRNOP00000063005/1-1325 SPDASQGTETSAIFAGTGSNIQTLKCHFKKRTPPVLQMD---PKRKKPLVSDTSVNGATV **:.:*.********* **.: * : ::*:: ..: * ** : * .. ** ENSCPOP00000008513/1-1479 AKAKPKAIGAEGSTVASGAGGL--GDAHPGGGVTAGDGAGEETGAGSGPEAPLVTSGHGG XP_004874587.1/1-1481 SEHKSKATRAEGIMVTSSPSNRLKTDPHPGGRVTSSDRVSEGTSAASGPEEPPVTSGNGD ENSP00000348089/1-1493 SEEKSEAKGAEVNAVTSNRSDPLKDDPHMSSNVTSNDRLGEETNAVSGPEELSVISGNGE ENSMUSP00000066256/1-1481 IGEKPKAAGATGRSVTSGESGPFKGDHDTNGNRASSVAFGEETDAGSTLEHLSVMSGDGK ENSRNOP00000063005/1-1325 MEEKSQGSGATG-SVPSTESGPLKSDRHTDGSRASSVGFGEEADAGSTLEHLSGLSG--- *.:. * *.* .. * . .. ::. .* :.* * * ** ENSCPOP00000008513/1-1479 SAASLRVSRAPGPPAEEDPTTDQAPSAAGHS-GQVPAEPPWENGQAGSRSWKHKSKTKHQ XP_004874587.1/1-1481 CSDCPRIGGALLLSGEENIAAKQGPSDEGDS-GLVPAEPPRENEQVGSHSYKHKSKRKHQ ENSP00000348089/1-1493 CSNSSGTGKTSMPSGDESIDEKLGLSYKRERPSQAQTEAFWENKQMENNFYKHKSKTKHH ENSMUSP00000066256/1-1481 HSDSPTVDHTSRPPVEASTSEKQGSSYAGAR-CQAQTEPVPMSEQMEGQFSKYKSKRKHD ENSRNOP00000063005/1-1325 --DSPAVDHTSRLSAVASTSEKQGSSYEGEC-CQAQTGPVHLSEQTEGHFSKHKSKRKHD . . : . . . . * . : . . * .. *:*** **. ENSCPOP00000008513/1-1479 AVAEEGALEQ----QRKPGSARHRRDAKFEGTRVPHLVKRRPYHRADAEPEPAAGARSGD XP_004874587.1/1-1481 GVAEEGTLEK----RQKHESTRHRRDAKFEGTRVPHLVKRRRYHRHDLGPDSKARVHSGD ENSP00000348089/1-1493 SVAEEETLEKHLRPKQKPKNSKHCRDAKFEGTRIPHLVKKRRYQKQDSENKSEAKEQSND ENSMUSP00000066256/1-1481 A-SEEETTEKRPQPKQKAKNSKHCRDAKFEGTRVPHLVKKRRYRQQTSEQEGGAKDRSSD ENSRNOP00000063005/1-1325 A-AEEETTEKCPQPKQKAKNSRHHRDAKFEGTRVPHLVKKRRYHQQTTEQESGAKDRSSD . :** : *: ::* .::* *********:*****:* *:: . * :*.* ENSCPOP00000008513/1-1479 DYVLEKLFKKSVGVHSVVRHDAIMDGASPDYVLVEAEANRVAQDALKALRLSRQQCLGAA XP_004874587.1/1-1481 DYVLEKLFKKSVGVHSVVKHDAIMDGASPDYVLVEAEANRVAQDALKALRLSRQQCLGAA ENSP00000348089/1-1493 DYVLEKLFKKSVGVHSVMKHDAIMDGASPDYVLVEAEANRVAQDALKALRLSRQRCLGAV ENSMUSP00000066256/1-1481 DYVLEKLFKKSVGVHSVVRHDAIIDGSSPDYVLVEAEANRVAQDALKALRLSRQQCLGAA ENSRNOP00000063005/1-1325 DYVLEKLFKKSVGVHSVVKHDAIIDGSSPDYVLVEAEANRVAQDALKALRLSRQQCLGAT *****************::****:**:***************************:****. ENSCPOP00000008513/1-1479 SGIPTWTGRQGSRVRPAGSQGGRFGQKRNSSLSGQRPPSSS-AEKCQDGV---------- XP_004874587.1/1-1481 SGVPTWTGHRGARVKS------RFGQKRNSNLSVHRPSSSS-TEECQDGLVKREGKDHMS ENSP00000348089/1-1493 SGVPTWTGHRGISGAPAGKKS-RFGKKRNSNFSVQHPSSTSPTEKCQDGIMKKEGKDNVP ENSMUSP00000066256/1-1481 SGVPTWTGHRGISGAPTGVKN-RFGQKRDSSLPVQHPSSL--TEKTQNNM-KKEGKAHTP ENSRNOP00000063005/1-1325 SGVPTWTGHRGISGAPAG------------------------------------------ **:*****::* . ENSCPOP00000008513/1-1479 EHFSGRVQDPDSSPAALASSSLLARMRARNHLTLPERPESRAT----AEAPTPPPCATEH XP_004874587.1/1-1481 EHFSGKAEDTDSSSGALTSSSLLARMRARNHLILPERLESENGHV--AEVSAPPSCATEH ENSP00000348089/1-1493 EHFSGRAEDADSSSGPLASSSLLAKMRARNHLILPERLESESGHL--QEASALLP-TTEH ENSMUSP00000066256/1-1481 EHFSGK-EDGASVSGAPSSSSLLARMRARNHMILPERLESDSEHL--AEAAAVPPCGTEH ENSRNOP00000063005/1-1325 -----------------------VKMRARNHMILPERLESDGEQLAGAAAAAAPPCSTEH .:******: **** ** ..: . *** ENSCPOP00000008513/1-1479 DELLVEMRNFIAFQARVDGQASTREILQEFESRLSTSQSCVFRELLRNLCSFHRTPSGEG XP_004874587.1/1-1481 DELLVDMRNFIAFQARVDGQASTRELLQEFEPKLSASQSCVFRELLRNLCTFHRTPGGEG ENSP00000348089/1-1493 DDLLVEMRNFIAFQAHTDGQASTREILQEFESKLSASQSCVFRELLRNLCTFHRTSGGEG ENSMUSP00000066256/1-1481 DDLLVDMRNFIAFQAQVDGQASTQEILQEFESKLSVAQSCVFRELLRNLCNFHRTPGGEG ENSRNOP00000063005/1-1325 DALLVDMRNFIAFQAQVDGQASTQEILQAFESKLSVAQSCVFRELLRNLCNFHRTPGGEG * ***:*********:.******:*:** **.:**.:*************.****..*** ENSCPOP00000008513/1-1479 VWRLKPEYC XP_004874587.1/1-1481 VWRLRPEYC ENSP00000348089/1-1493 IWKLKPEYC ENSMUSP00000066256/1-1481 IWKLKPEYC ENSRNOP00000063005/1-1325 IWKLKPEYC :*:*:****